Discontinuation of immune checkpoint inhibitors for reasons other than disease progression and the impact on relapse and survival of advanced melanoma patients. A systematic review... by Konstantinos Lallas, Eftychia Chatziioannou, Derya Durak, Georg Frey, Lina Maria Serna-Higuita, Marie-Lena Rasch, Athanassios Kyrgidis, Eleni Timotheadou, Zoe Apalla, Ulrike Leiter, Lukas Flatz, Lukas Flatz, Aimilios Lallas, Teresa Amaral, Teresa Amaral

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Clinical predictors of 3-month isoniazid rifapentine (3HP)-related adverse drug reactions (ADR) during tuberculosis preventive therapy (PAnDoRA-3HP study): an observational study p... by Turyahabwe Stavia, Barbara Castelnuovo, Christine Sekaggya-Wiltshire, Kelly E Dooley, Grace Banturaki, Irene Mbabazi, Ruth Mirembe Nabisere, Lucy Alinaitwe, Brian Otaalo, Florence Aber, Juliet Nampala, Rogers Owori, Josephine Bayigga, Jonathan Mayito, Eva Agnes Odongpiny Laker, Moorine Penninah Sekadde, Jotam Pasipanodya, Stella Zawedde‐Muyanja

“…ADR evaluation includes clinical assessment and liver function tests. Cases are selected from those who experience ADRs and controls from those who do not. …”
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Examination and Tracing of Stable Isotopes of Carbon and Hydrogen in Diesel Oil from Different Regions by Han-yu ZHANG, Zhao-wei JIE, Han-yang ZHENG, Xiao-han ZHU, Wei-ya XIE, Can HU, Zhan-fang LIU, Hong-ling GUO, Jun ZHU, Hong-cheng MEI

“…Diesel is often used as an accelerant in arson cases, so identifying its source is crucial to the investigation. Stable isotope analysis is a method for detecting molecular elements at the element level. …”
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Analysing the contribution of trees and green spaces to household nutrition security in eThekwini, KwaZulu-Natal, South Africa by Qhelile Ntombikayise Bhebhe, Qhelile Ntombikayise Bhebhe, Muthulisi Siwela, Temitope O. Ojo, Temitope O. Ojo, Simphiwe Innocentia Hlatshwayo, Simphiwe Innocentia Hlatshwayo, Tafadzwanashe Mabhaudhi, Tafadzwanashe Mabhaudhi, Rob Slotow, Mjabuliseni S. C. Ngidi, Mjabuliseni S. C. Ngidi, Mjabuliseni S. C. Ngidi

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Differences in neuronal ciliation rate and ciliary content revealed by systematic imaging-based analysis of hiPSC-derived models across protocols by Walther Haenseler, Melanie Eschment, Melanie Eschment, Beth Evans, Marta Brasili, Marta Brasili, Joana Figueiro-Silva, Fee Roethlisberger, Fee Roethlisberger, Affef Abidi, Affef Abidi, Darcie Jackson, Martin Müller, Martin Müller, Sally A. Cowley, Ruxandra Bachmann-Gagescu, Ruxandra Bachmann-Gagescu, Ruxandra Bachmann-Gagescu, Ruxandra Bachmann-Gagescu

“…Patients suffering from ciliopathies often display prominent neurodevelopmental phenotypes, underscoring the importance of primary cilia during development and for function of the central nervous system (CNS). Human tissues, in particular from the CNS, are very hard to obtain for research. …”
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Assessing eco-physiological patterns of Ailanthus altissima (Mill.) Swingle and differences with native vegetation using Copernicus satellite data on a Mediterranean Island by Flavio Marzialetti, Vanessa Lozano, André Große-Stoltenberg, Maria Laura Carranza, Michele Innangi, Greta La Bella, Simonetta Bagella, Giovanni Rivieccio, Gianluigi Bacchetta, Lina Podda, Giuseppe Brundu

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SentemQC - A novel and cost-efficient method for quality assurance and quality control of high-resolution frequency sensor data in fresh waters [version 2; peer review: 1 approved,... by Sofie Gyritia Madsen van't Veen, Joachim Audet, Eti Ester Levi, Brian Kronvang, Søren Erik Larsen, Erik Jeppesen, Esben Astrup Kristensen, Anders Nielsen, Thomas Alexander Davidson, Jane Rosenstand Laugesen, Peter Mejlhede Andersen

“…The SentemQC method is computationally efficient and features a six-step user-friendly setup for anomaly detection. The method marks anomalies in data using five moving windows. …”
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Distribution, behavior and diet of the Asiatic black bear in human modified landscapes by Hadi Fahimi, Mahmood Soofi, Nahid Ahmadi, Ali T. Qashqaei, Hamidreza Heidari, Haaken Bungum, Bent Rech, Jonas Trepel, Matthias Waltert

“…Elevation, precipitation, village density, and PA size did not substantially influence occupancy. Black bear detection probability became 100 % only above 14 km survey effort, indicating its overall rarity, and bears were much more easily detected during and after rainfall. …”
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Landscape Planning and Design of Urban Rivers with Environmental Approach (Case Study: Farahzad River Valley in Tehran) by Zahra Sadrazamnouri, Jafar Nouri, Farah Habib, Mojtaba Rafieian

“…At the present time, structure and function of these valuable elements have been ruined due to non-planning growth and regardless to environmental subjects in municipal management and landscape planning that they have been converted to the runoff canal network or effluent. …”
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Isolation of a novel manganese-oxidizing bacterium Lysinibacillus xylanilyticus M125: characterization, structural evolution, and Cd-adsorption activity of biogenic Mn oxides produ... by Xiaoju Li, Xinyi Yuan, Yuxia Wei, Lianqi He, Yuanyuan Li, Meiquan Qiu, Yang Liu, Nannan Dong, Chengjia Zhang, Xin Pang, Xin Pang, Xin Pang

“…Over 99.5% of cadmium ions in water are adsorbed and removed by strain M125, highlighting its potential for cadmium pollution remediation.DiscussionOverall, this work introduces a new bacterial resource for Mn and Cd bioremediation and offers detailed insights into the structural and functional characteristics of BioMnOx, supporting its application in environmental biotechnology.…”
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Exploring the role of mitochondrial metabolism and immune infiltration in myocardial infarction: novel insights from bioinformatics and experimental validation by Jingyi Hou, Jingyi Hou, Jingyi Hou, Lihan Wang, Lihan Wang, Naiqiang Zhu, Xueli Li

“…This study aimed to clarify the roles of mitochondrial metabolism and immune infiltration in MI, using a combination of bioinformatics analyses and experimental validation.MethodsMI chip data (GSE96561, GSE181872, and GSE183272) were obtained from the Gene Expression Omnibus (GEO) database, and mitochondrial gene data were sourced from the MitoCarta3.0 database. Differentially expressed genes (DEGs) were identified and subjected to functional enrichment analyses. …”
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Antiretroviral drug therapy does not reduce neuroinflammation in an HIV-1 infection brain organoid model by Samuel Martinez-Meza, Thomas A. Premeaux, Stefano M. Cirigliano, Courtney M. Friday, Stephanie Michael, Sonia Mediouni, Susana T. Valente, Lishomwa C. Ndhlovu, Howard A. Fine, Robert L. Furler O’Brien, Douglas F. Nixon

“…Abstract Background HIV-1-associated neurocognitive impairment (HIV-1-NCI) is marked by ongoing and chronic neuroinflammation with loss and decline in neuronal function even when antiretroviral drug therapy (ART) successfully suppresses viral replication. …”
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Expression and structural analysis of taste receptor genes in Iberian and Duroc pigs by Cristina Óvilo, Rita Benítez, Yolanda Núñez, Ramón Peiró-Pastor, Fabian García, Eduardo De Mercado, Emilio Gómez-Izquierdo, Juan García-Casco, Clemente López-Bote, María Muñoz

“…The objectives of this work were to deepen the understanding of the regulation of the function of taste receptor genes in the circumvallate papillae of obese Iberian pigs in comparison to Duroc pigs, and to characterize their genetic variation and associations with relevant production traits. …”
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Establishing the best step-up treatments for children with uncontrolled asthma despite inhaled corticosteroids: the EINSTEIN systematic review, network meta-analysis and cost-effec... by Sofia Cividini, Ian Sinha, Giovanna Culeddu, Sarah Donegan, Michelle Maden, Katie Rose, Olivia Fulton, Dyfrig Hughes, Stephen Turner, Catrin Tudur Smith

“…We examined model fit by the posterior mean of the residual deviance and the deviance information criterion to select models. Pairwise MA and NMA were also carried out with a frequentist framework using the R functions ‘netmetabin’ and ‘netmeta’. …”
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Reviews and syntheses: Current perspectives on biosphere research 2024–2025 – eight findings from ecology, sociology, and economics by F. J. Bohn, F. J. Bohn, A. Bastos, R. Martin, A. Rammig, N. S. Koh, G. B. Sioen, G. B. Sioen, B. Buscher, L. Carver, F. DeClerck, M. Drupp, M. Drupp, R. Fletcher, M. Forrest, A. Gasparatos, A. Godoy-Faúndez, G. Hagedorn, M. C. Hänsel, J. Hetzer, T. Hickler, T. Hickler, C. B. Krug, S. Koot, S. Koot, X. Li, A. Luers, S. Matevich, H. D. Matthews, I. C. Meier, M. Migliavacca, A. Mohamed, S. O, D. Obura, B. Orlove, R. Orth, L. Pereira, M. Reichstein, L. Thakholi, P. H. Verburg, Y. Yoshida

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Comparative nutrient and sensory analysis of eight different commercial Chlorella powders by Felix Melcher, Tillmann Peest, Tillmann Peest, Diego Garay, Diego Garay, Florian Utz, Florian Utz, Michael Paper, Andrea Spaccasassi, Andrea Spaccasassi, Lisa Obermaier, Jennifer Schneiderbanger, Max Koch, Daniel Garbe, Tom Nilges, Thomas Becker, Michael Rychlik, Corinna Dawid, Corinna Dawid, Wolfram M. Brück, Nikolaus I. Stellner, Nikolaus I. Stellner, Thomas B. Brück

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Rapid parameter estimation for merging massive black hole binaries using continuous normalizing flows by Bo Liang, Minghui Du, He Wang, Yuxiang Xu, Chang Liu, Xiaotong Wei, Peng Xu, Li-e Qiang, Ziren Luo

“…Detecting the coalescences of massive black hole binaries (MBHBs) is one of the primary targets for space-based gravitational wave observatories such as laser interferometer space antenna, Taiji, and Tianqin. …”
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Species-level enumeration of low-concentration lactic acid bacteria in breast milk by Yue Sun, Qiming Li, Mengling Hu, You Wu, Yunchao Wa, Hai Lu, Shilong Jiang, Hui Wang, Qiaosi Wei, Yujun Huang, Ruixia Gu, Chenchen Zhang

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Association mapping of lignin response to Verticillium wilt through an eight-way MAGIC population in Upland cotton by Xiao-min TIAN, Peng HAN, Jing WANG, Pan-xia SHAO, Qiu-shuang AN, Nurimanguli AINI, Qing-yong YANG, Chun-yuan YOU, Hai-rong LIN, Long-fu ZHU, Zhen-yuan PAN, Xin-hui NIE

“…Two key candidate genes, Ghi_D05G01046 and Ghi_D05G01221, were selected within the QTLs through the combination of variations in the coding sequence, induced expression patterns, and function annotations. …”
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Key technologies of efficient extraction of coalbed methane (gas) in Guizhou coal mine area by Wang YI, Longjun LIANG, Lichong YAN, Zhihua YAN, Jie CHEN, Wei GAO, Yi LOU, Fuqin YANG, Haiyang HU, Jiawei ZHU

“…It innovated and explored the following high efficiency extraction technology of “four zones” linked Wells in coal mining areas with Guizhou characteristics: ① By laying multi-functional pumping vertical Wells or small inclination oriented Wells in the goaf, it was the first time in Guizhou to realize efficient extraction and development of pressure relief gas in the overlying coal-covered strata and coal-bed methane in the sweet coal seam below the goaf; ② Taking advantage of the characteristics of spatial and temporal dislocation in the production area, the multi-mode extraction mode of “coalbed methane well + relief well + underground drilling” is adopted for the first coal seam mined in the upper protective layer, which realizes the purpose of the upper and lower vertical combined extraction of coalbed methane (gas) Wells and effectively solves the problem of multi-source gas flooding into coal mining roadway and gas accumulation in the upper corner during coal mining under the condition of coal seam group development in Guizhou; ③ In the preparation area and planning area, combined with the terrain and geological characteristics of the two areas, the horizontal well “well factory” + “two pairs of right and wrong” overlapping well layout mode is adopted to realize the efficient extraction of coal bed methane in the plane in advance and pre-pumping of the sweet coal seam and the pressure relief gas in the overlying coal-laden rock in the subsequent mining process, and at the same time to achieve the goal of “replacing the roadway with Wells”; ④ In view of the development of multi-thin coal seam groups in the study area and the development characteristics of “three zones” in the overlying strata after mining, due to the continuous change of the role of “four zones”, the surface coalbed methane Wells are initially deployed in the production area or preparation area, and the “bridge plug bottom sealing + layer selection perforation” technology is adopted to innovate the “transformation” technology of well structure to achieve the purpose of “multi-purpose in one well”; It also provides new technical ideas and accumulated valuable engineering experience for gas management in coal mine area under the condition of multi-thin coal seam group development in Guizhou.…”
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