Sodium formate induces development-dependent intestinal epithelial injury via necroptosis and apoptosis by Jingjing Wei, Yuan Tian, Meiqi Guan, Jinshu Wei, Yong Ji, Guozhong Tao, Karl G. Sylvester

“…Mice were sacrificed after 24 h of feces collection, and the blood and small intestinal tissues were collected to detect the pathological damage of intestinal tissue, intestinal permeability, oxidative stress indicators including SOD, HO-1, MDA, and 4-HNE, inflammatory cytokines including IL-1β, TNF-α and IL-6, mitochondrial function such as ATP and PGC-1α in mice intestinal tissue, indicators of the cell death modes including necroptosis-related protein RIPK1 and p-MLKL, and apoptosis- related protein cleaved-caspase-3 and p-AKT (S473).Results NaF treatment significantly damaged intestinal epithelial tissue and barrier function, caused mitochondrial dysfunction, manifesting as decreased ATP and PGC-1α levels, increased lipid peroxidation products MDA and 4-HNE, depleted antioxidant enzyme SOD, and upregulated the expression of HO-1. …”
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Urinary Exosomes by Irena Dimov, Ljubinka Jankovic Velickovic, Vladisav Stefanovic

“…Thus, UE have valuable potential as a source of biomarkers for early detection of various types of diseases, monitoring the disease evolution and/or response to therapy. …”
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An effective fluorescence strategy based on xanthine oxidase catalysis and the carbon dots’ specific response to ·OH for aminophylline pharmacokinetic studies by Chenfang Miao, Menghan Zhang, Ying Zheng, Xiaoyan Lin, Shuangying Yang, Linlin Xu, Sitong Lu, Zhengjun Huang, Jianyong Huang, Yanjie Zheng, Shaohuang Weng

“…However, efficient and sensitive detection methods remain limited. In this study, high quantum yield carbon dots (CA/EDA-CDs) were synthesized via a hydrothermal method using riboflavin as the carbon source, citric acid and ethylenediamine as functionalizing agents and dopants. …”
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Agarwood leaf ethanol extract provides neuroprotective properties and promotes cholinergic differentiation of HT22 hippocampal neurons by Kishoree K. Kumaree, James M. Brimson, Kanika Verma, Siriporn Chuchawankul, Tewin Tencomnao, Anchalee Prasansuklab

“…Abstract Neurodegenerative diseases, characterized by the loss or damage of neurons, represent a growing global health concern. Plants are a rich source of naturally occurring compounds with immense therapeutic potential. …”
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Multimodal imaging of dark without pressure in high myopia reveals evidence that photoreceptor microscopic lesions may be reversible by Qingge Guo, Xiuxiu Jin, Xiaoyu Xin, Xiaohong Guo, Shuai Ming, Yuxiang Li, Bo Lei

“…Previous studies have concluded that DWP alone has no impact visual acuity, visual field, or other visual functions. This study aims to reveal the multimodal imaging manifestations of DWP in high myopia and to explore its impact on retinal function. …”
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The Ultrastructure of Olfactory Sensilla Across the Antenna of <i>Monolepta signata</i> (Oliver) by Jiyu Cao, Wanjie He, Huiqin Li, Jiangyan Zhu, Xiaoge Li, Jiahui Tian, Mengdie Luo, Jing Chen

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Transcriptomic Analysis Reveals the Biosynthesis Mechanism of Coixol Under Salicylic Acid Treatment by Yao Wang, Hanli Ye, Xuqin Luo, Ziwei Li, Chuanqi Zheng, Dali Sun

“…Background: Coix (<i>Coix lacryma-jobi</i> L.) is cultivated as medicine and food homologous resources containing various active components. As one of its main ingredients, coixol possesses the biological activities of fever reduction, pain relief, tumor suppression, blood glucose, and pressure decrease. …”
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Genome-Wide Responses of Female Fruit Flies Subjected to Divergent Mating Regimes. by Dave T Gerrard, Claudia Fricke, Dominic A Edward, Dylan R Edwards, Tracey Chapman

“…However, the subtle nature of those effects suggests substantial functional redundancy or parallelism in this gene network, which could buffer females against excessive responses. …”
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IT GOVERNANCE IN THE BANKING SECTOR: EVIDENCE FROM ITALY, GERMANY, FRANCE AND SPAIN by Ida Claudia Panetta, Sabrina Leo, Fabrizio Santoboni, Gianfranco Vento

“…IT is an intrinsic component of banks’ operational functioning; it is a key resource in developing and supporting banking services, enabling institutions’ strategies, and it is essential for almost all banking processes and distribution channels. …”
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Rapid cohort generation and analysis of disease spectrum of large animal model of cone dystrophy. by Corinne Kostic, Simon Geoffrey Lillico, Sylvain Vincent Crippa, Nicolas Grandchamp, Héloïse Pilet, Stéphanie Philippe, Zen Lu, Tim James King, Jacques Mallet, Chamsy Sarkis, Yvan Arsenijevic, Christopher Bruce Alexander Whitelaw

“…Sixty percent of the piglets were transgenic, with mutant GUCY2D mRNA detected in the retina of all animals tested. Functional impairment of vision was observed among the transgenic pigs at 3 months of age, with a follow-up at 1 year indicating a subsequent slower progression of phenotype. …”
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Distinct repertoires of microRNAs present in mouse astrocytes compared to astrocyte-secreted exosomes. by Ana Jovičić, Aaron D Gitler

“…The exosomal miRNA profiling dataset we have generated will provide a resource to aid in the investigation of this selection mechanism. …”
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Soil pollution and remediation: emerging challenges and innovations by Hao Chen, Bin Gao, Yuncong Li

“…These pollutants pose severe risks to environmental health and agricultural productivity by altering soil functionality and contaminant mobility. This perspective summarizes innovative monitoring and remediation technologies, including advanced sensors and bioremediation strategies, that enable real-time detection and effective management of soil pollutants. …”
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Submillimeter and Mid-infrared Variability of Young Stellar Objects in the M17 H II Region by Zhiwei Chen, Doug Johnstone, Carlos Contreras Peña, Jeong-Eun Lee, Sheng-Yuan Liu, Gregory Herczeg, Steve Mairs, Geumsook Park, Kee-Tae Kim, Mi-Ryang Kim, Keping Qiu, Yao-Te Wang, Xu Zhang, Megan Reiter, The JCMT Transient Team

“…This mid-IR fractional variability as a function of evolutionary stage result is similar to what has previously been found for YSO variability within the Gould Belt and the intermediate-mass star formation region M17 SWex, though overall less variability is detected in M17 in submillimeter and mid-IR. …”
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Socioeconomic Inequity in Access to Medical and Long-Term Care Among Older People by Shohei Okamoto, Atsuhiro Yamada, Erika Kobayashi, Jersey Liang

“…Conclusion Improving the understanding of available resources and strengthening the functions of health centres and communities are required to detect the needs of citizens and facilitate their access to necessary care.…”
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Research on lightweight weed recognition algorithm based on improved YOLOv8 by Zhang Chao, Liu Bin, Li Kun

“…Different scale features are used to improve the performance of target detection. Finally, the MPDIoU loss function is replaced to enhance the convergence and stability of the model. …”
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Enhanced recovery pathway for older people with hip fracture and cognitive impairment in acute hospitals: the PERFECTED research programme including an RCT by Chris Fox, Simon P Hammond, Lee Shepstone, Fiona Poland, Catherine Henderson, Tamara Backhouse, Bridget Penhale, Simon Donell, Martin Knapp, Douglas Lewins, Alasdair MacLullich, Martyn Patel, Opinder Sahota, Toby O Smith, Justin Waring, Jane L Cross

“…In the 12 months after fracture, patients are at increased risk of cognitive and functional decline, admission to long-term care institutions and higher mortality. …”
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Heritage in real life: between appreciation and contempt: why are modern Egyptians continuously losing their heritage? by Medhat Wassef

“…Being a part of the community myself and through direct contact with the people, I detected and extracted aspects of the Egyptian mindset on the grassroots level that played a significant role in the problem of heritage. …”
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Antioxidant potential of tree bark extracts: Insight from the multi-level output of the Antioxidant Power 1 assay. by Johanna Rehrl, Thomas Sepperer, Sissy Häsler Gunnarsdottir, Thomas Schnabel, Gertie Janneke Oostingh, Anja Schuster

“…Tree bark is a complex protective tissue that serves both physiological and defensive functions and is particularly rich in phenolic compounds bearing antioxidant, antimicrobial, anti-inflammatory and wound healing properties. …”
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Optimization of Cross-Border e-Commerce Logistics Supervision System Based on Internet of Things Technology by Pingping Sun, Lingang Gu

“…First of all, the framework adopts the national certification center to supervise the logistics service platform and logistics service platform to supervise the logistics participants of the secondary supervision system. Then, functions such as swarm intelligence contract, legal anonymous identity authentication, intelligent transaction matching, abnormal data analysis and detection, privacy protection, and traceability are realized under the framework of the supervision system. …”
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Investigation of the Application of Machine Learning Algorithms in Credit Risk Assessment of Medium and Micro Enterprises by Yujie Zhao

“…Thus, this proposed method achieves 14.65% high-risk detection with 5.56% financial revisions for the industry considered by the data source.…”
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