Genetic and Plasma Proteomic Approaches to Identify Therapeutic Targets for Graves’ Disease and Graves’ Ophthalmopathy by Ke C, Yu Y, Li J, Yu Y, Sun Y, Wang Y, Wang B, Lu Y, Tang M, Wang N, Chen Y

“…Then, downstream analyses were performed to detect protein interactions, gene function, cell type-specific expression and druggable information.Results: This study genetically predicted levels of 62 plasma proteins were associated with GD risk. …”
Get full text

Compact and Handheld SiPM-Based Gamma Camera for Radio-Guided Surgery and Medical Imaging by Fabio Acerbi, Aramis Raiola, Cyril Alispach, Hossein Arabi, Habib Zaidi, Alberto Gola, Domenico Della Volpe

“…We characterized the intrinsic position resolution (tested with pulsed light) as being ~200 µm, and the sensitivity and resolution when detecting gamma rays from Tc-99m source measured between 134 and 481 cps/MBq and as good as 1.4–1.9 mm, respectively.…”
Get full text

Identification of Soybean E1-E4 Gene Orthologs in the Guar Genome Using Comprehensive Transcriptome Assembly and Annotation by Luisa Criollo Delgado, Aleksei Zamalutdinov, Elena Potokina

“…Taub.), a well-known source of guar gum (food additive E 412). At high latitudes, e.g., in Russia, the main challenge for guar cultivation is the long photoperiod during summer, which delays flowering and maturation of guar plants. …”
Get full text

Impact of probiotic supplementation on serum levels of brain-derived neurotrophic factor: GRADE-based dose-response meta-analysis by Reza Hashemi, Mohammad M. Hussein M. Raouf, Tanya S. Salih, Marzieh Feyzpour, Maryam Eskandarioun, Najmeh Nezamabadipour, Hossein Gandomkar

“…Abstract Background Brain-derived neurotrophic factor (BDNF) is a key neurotrophin involved in neuroplasticity and cognitive function, with its dysregulation linked to neurodegenerative and psychiatric disorders. …”
Get full text

Vitamin C, Sugar Content, Color Intensity and Some Physicochemical Properties of Watermelon and Orange Peels by Selvican Gökçe, İsa Arslan Karakütük, Memnune Şengül

“…Therefore, orange peel can be used as a natural antioxidant and color source in the food, pharmaceutical, and cosmetic industries.…”
Get full text

Personality and Personality Disorders in Medication-Overuse Headache: A Controlled Study by SWAP-200 by Federica Galli, Annalisa Tanzilli, Alessandra Simonelli, Cristina Tassorelli, Grazia Sances, Micol Parolin, Patrizia Cristofalo, Ivan Gualco, Vittorio Lingiardi

“…At levels of specific PDs, MOH patients showed higher obsessive and dysphoric traits and better overall psychological functioning than SUD and PD patients. Conclusion. Although MOH, SUD, and PD populations have been evaluated in multiple sites with different levels of expertise, the study supported the presence of a specific constellation of personality in MOH patients including obsessive (perfectionist) and dysphoric characteristics, as well as good enough psychological resources. …”
Get full text

Phosphate transporter gene families in rye (Secale cereale L.) – genome-wide identification, characterization and sequence diversity assessment via DArTreseq by David Chan-Rodriguez, Brian Wakimwayi Koboyi, Sirine Werghi, Bradley J. Till, Julia Maksymiuk, Fatemeh Shoormij, Abuya Hilderlith, Anna Hawliczek, Maksymilian Królik, Hanna Bolibok-Brągoszewska

“…Each PHT family has a particular physiological and cellular function. Rye (Secale cereale L.) is a member of Triticeae, and an important source of variation for wheat breeding. …”
Get full text

Prevalence and contributing factors of depression among women with infertility in low-resource settings: a systematic review and meta-analysis by Shimelis Tadesse, Henok Kumsa, Gemeda Wakgari Kitil, Alex Ayenew Chereka, Getnet Gedefaw, Fiker Chane, Esuyawkal Mislu

“…Subgroup and sensitivity analyses were performed to identify the potential source/s of heterogeneity. A p-value of 0.05 was declared as statistically significant. …”
Get full text

Research note: Harnessing the potential of chicken blastodermal cells as a new frontier in poultry science and biotechnology – Establishment of embryonic stem cells and their diffe... by Małgorzata Duda, Patrycja Maciak, Grzegorz Tylko, Kamil Wartalski, Monika Trzcińska, Marek Romek, Marcin Samiec

“…Further research exploring the functional attributes of B-ESC-derived SC-LCs is required to elucidate their therapeutic potential in nerve reconstruction/repair.…”
Get full text

Targeted proteomics for absolute quantification of glucose transporter 1 in mammalian brain cells using liquid chromatography-mass spectrometry by Yash Mehta, Dhavalkumar Patel, Iqra Pervaiz, Ulrich Bickel, Abraham Jacob Al-Ahmad

“…Glucose represents a major source of energy for mammalian brains. Its uptake is tributary to a functional glucose transporter (GLUT1) expression at the blood-brain barrier (BBB). …”
Get full text

Effects of aspirin and omega-3 fatty acids on age-related macular degeneration in ASCEND-Eye: a randomised placebo-controlled trial in a population with diabetes by Praveen Patel, Rory Collins, Richard Peto, Mark Davies, Sanjiv Banerjee, David Simpson, John Anderson, Louise Bowman, Peter Scanlon, Amanda Adler, Andrew Farmer, Helen Cook, Laura Evans, Elizabeth Williamson, Louis Bolter, Jane Armitage, Peter Sandercock, Richard Gray, Nilesh Samani, Tasso Gazis, Richard Haynes, Arun Sachdev, Eric Wu, Elizabeth Wincott, Peter Sleight, Colin Baigent, Marion Mafham, Sarah Parish, Gavin Brown, Susan Hurley, Lynne Allsop, William Stevens, Theingi Aung, Allen Young, Emily Sammons, Georgina Buck, Imen Hammami, Jill Barton, Jonathan Bodansky, Roger McPherson, Lucy Fletcher, Murphy Kevin, Ryonfa Lee, Sandra Pickworth, Monica Willett, Michael Lay, Ola Murawska, Karen Melham, Jonathan Latham-Mollart, Anna Brewer, Mike Olson, Jude Kay, Alisha Griffiths, Helen Clayton, Philip Kirby, Mike Pennington, Dominic Clarke, Jenny Anslow, Alex Hallam, Jenny Witts, Sarah Egan, Alex Wharton, Amy Derbyshire, Katherine Hepplestone, Sujit Mithra, Su Oliver, Pauline Wiatrak-Olszewska, Kelly Alvey, Nick Gregory, Priyai Parkinson, Prema Maharajan, Rachel McFee, Donna Sowter, John Featonby, Richard Furnival, Helen Lipinski, Hazel Benjamin, Tanisha McAfee, Emma Payne Payne, Liz Still

“…Reports of AMD diagnoses were sourced from 6 monthly ASCEND follow-up questionnaires and a Visual Function Questionnaire.Participants 15 480 UK adults at least 40 years of age with diabetes but no evident cardiovascular disease.Interventions 100 mg aspirin daily versus placebo and, separately, 1 g omega-3 FAs daily versus placebo.Main outcome measure The first post-randomisation reports of AMD.Results During 7.4 years of follow-up, 122 (1.6%) participants randomised to aspirin were reported as having AMD, compared with 138 (1.8%) randomised to placebo (rate ratio 0.88; 95% CI 0.69 to 1.12; p=0.31). …”
Get full text

Repair of aircraft engine parts made of heat-resistant nickel alloys using additive plasma technologies by Konstantin Balushok, Sergey Chigileychik

“…No wear of the labyrinth ridges or cracks was detected. The functionality of the restored disk has been confirmed. …”
Get full text

Software para el control epidemiológico de la mortalidad por enfermedades crónicas no transmisibles y otros daños a la salud by Rolando Sánchez Montero, Enrique Félix Vázquez Ochoa

“…ABSTRACT   Introduction: the epidemiological control of general mortality and its selected causes in a municipality is a complex statistical process that hinders their realization in a manual way. …”
Get full text

Exploring Autophagy-Related Gene Expression in Hepatocellular Carcinoma via TCGA, GEPIA2, and HPA Databases: Implications for Prognosis by Gu X, Chen Y, Hu X, Li Y, Zhu R, Li H, Yuan Z, Wang Y

“…RT-qPCR analysis further confirmed significant upregulation of mRNA expression levels of randomly selected BAG3, EIF2AK2, KIF5B, and RAB24 in HCC cell lines, consistent with the bioinformatics analysis findings.Conclusion: This study showed that the 41 obtained ARGs, such as ATG16L1, ATG4B, BAG3, KIF5B, MAPK1, RAB24, and SOGA1, these findings suggest that ARGs may serve as prognostic biomarkers for HCC, warranting further validation in clinical cohorts and functional studies.Keywords: hepatocellular carcinoma, bioinformatics, autophagy, prognostic markers, TCGA…”
Get full text

Humic acids as drivers of plant growth: regulating root development and photobiology through redox modulation by Daniel Basílio Zandonadi, Hiarhi Monda, Jason Gralian, Aletia James, Richard T. Lamar, Mirella Pupo Santos

“…Abstract Background Humic acids (HA) influence plant growth and development through various mechanisms that depend on the source and concentration of HA, as well as the specific plant organ and its developmental stage. …”
Get full text

Unlocking health insights: exploring intention to adopt district health information systems in Bahir Dar City, northwest Ethiopia by Habtamu Alganeh Guadie, Amarech Kindie, Hunegnaw Almaw Derseh, Desta Debalkie Atnafu

“…BackgroundDistrict Health Information System version 2 (DHIS2) is an open-source platform designed for data collection, processing, analysis, and visualization within healthcare systems. …”
Get full text

Features of Visual Dysfunctions in Patients with Primary Hypothyroidism and Thyrotoxicosis by V. G. Likhvantseva, V. N. Trubilin, E. V. Korosteleva, S. G. Kapkova, V. A. Vygodin

“…The pattern of photosensitivity disorders, the topography of the location of the loci of local defects revealed by the short-wave infrared perimetry, indicate that the earliest signs of optical neuropathy are manifested at the level of photoreceptors — selectively in the S-cones. Decreased sensitivity to blue stimulus (440 nm) refers to an acquired color anomaly called tritanopia; which can be present with high visual function, is most often associated with a decrease in the number of S-cones and a deficiency of retinol (the source of cyanolab synthesis).…”
Get full text

Methods for Adaptive Transformation of Content in Hypertext Format on Corporate TV and Information Kiosks of Educational Institutions by D. S. Filippov

“…An analysis of some potential solutions and their compatibility was carried out, taking into account browser support for CSS3 and HTML5 standards, and working solutions were selected that can be used in the design of individual templates for displaying content in hypertext format and CSS designs (rules) that work for the purpose of the study. …”
Get full text

An Evaluation of the Possibility of Using Buckwheat Hulls as an Addition to Bread by Joanna Maria Klepacka, Marta Czarnowska-Kujawska

“…Due to the high nutritional value of buckwheat hulls, which can be a great source of fibre, phenolics, minerals and some vitamins, the aim of the study was to assess the possibility of using it as a functional addition in bread production. …”
Get full text

Healthcare professional perspective on barriers and facilitators of multidisciplinary team working in acute care setting: a systematic review and meta-synthesis by Giovanna Artioli, Gloria Anderson, Lucia Pradelli, Camilla Risoli, Elena Summer, Giulia Bellini, Fabio Mozzarelli, Massimo Guasconi, Antonio Bonacaro, Leopoldo Sarli

“…The aim of this study is to synthesise the factors that may act as barriers and facilitators to the work of multidisciplinary teams in managing labour within acute care settings.Design A systematic qualitative review and meta-synthesis was conducted following the five-step methodology proposed by Sandelowski et al.Data source Three databases (Medline, Embase and Scopus) were systematically searched without time restrictions up to 25 May 2024.Eligibility criteria for selecting studies Qualitative studies exploring perspectives, experiences and other similar factors were included. …”
Get full text