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Antiretroviral drug therapy does not reduce neuroinflammation in an HIV-1 infection brain organoid model
Published 2025-03-01“…Abstract Background HIV-1-associated neurocognitive impairment (HIV-1-NCI) is marked by ongoing and chronic neuroinflammation with loss and decline in neuronal function even when antiretroviral drug therapy (ART) successfully suppresses viral replication. …”
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Comparative nutrient and sensory analysis of eight different commercial Chlorella powders
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Analysis of the Stability of the Banking Sector of Azerbaijan in Conditions of Economic Crisis Based on the Econometric Model
Published 2024-05-01“…Information was taken from a number of sources: 1) Official website of the Central Bank of Azerbaijan; 2) Official website of Ministry of Finance; 3) Official website of Azerbaijan State Statistics Committee; 4) Reports on the development of the banking sector and banking supervision. …”
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Transcription Factor LjWRKY50 Affects Jasmonate-Regulated Floral Bud Duration in <i>Lonicera japonica</i>
Published 2025-07-01“…<i>Lonicera japonica</i> Thunb. is a traditional Chinese medicinal herb whose floral buds are the primary source of pharmacological compounds that require manual harvesting. …”
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Identification and characterization of the powdery mildew resistance in cultivated emmer wheat accession Lxd-682 via bulked segregant RNA sequencing
Published 2025-05-01“…Molecular markers JS717/JS718 and WGRC1096 were confirmed to be available for marker-assisted selection (MAS) of PmLxd-682 in breeding practices. …”
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BDNF Val66Met polymorphism moderates associations between physical activity and neurocognitive outcomes in older adults
Published 2025-04-01“…In moderated mediation analyses examining cognitive outcomes, plasma p‐tau181 selectively mediated the relationship between PA and executive function in Val/Val participants. …”
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Rapid parameter estimation for merging massive black hole binaries using continuous normalizing flows
Published 2024-01-01“…Detecting the coalescences of massive black hole binaries (MBHBs) is one of the primary targets for space-based gravitational wave observatories such as laser interferometer space antenna, Taiji, and Tianqin. …”
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Key technologies of efficient extraction of coalbed methane (gas) in Guizhou coal mine area
Published 2025-03-01“…It innovated and explored the following high efficiency extraction technology of “four zones” linked Wells in coal mining areas with Guizhou characteristics: ① By laying multi-functional pumping vertical Wells or small inclination oriented Wells in the goaf, it was the first time in Guizhou to realize efficient extraction and development of pressure relief gas in the overlying coal-covered strata and coal-bed methane in the sweet coal seam below the goaf; ② Taking advantage of the characteristics of spatial and temporal dislocation in the production area, the multi-mode extraction mode of “coalbed methane well + relief well + underground drilling” is adopted for the first coal seam mined in the upper protective layer, which realizes the purpose of the upper and lower vertical combined extraction of coalbed methane (gas) Wells and effectively solves the problem of multi-source gas flooding into coal mining roadway and gas accumulation in the upper corner during coal mining under the condition of coal seam group development in Guizhou; ③ In the preparation area and planning area, combined with the terrain and geological characteristics of the two areas, the horizontal well “well factory” + “two pairs of right and wrong” overlapping well layout mode is adopted to realize the efficient extraction of coal bed methane in the plane in advance and pre-pumping of the sweet coal seam and the pressure relief gas in the overlying coal-laden rock in the subsequent mining process, and at the same time to achieve the goal of “replacing the roadway with Wells”; ④ In view of the development of multi-thin coal seam groups in the study area and the development characteristics of “three zones” in the overlying strata after mining, due to the continuous change of the role of “four zones”, the surface coalbed methane Wells are initially deployed in the production area or preparation area, and the “bridge plug bottom sealing + layer selection perforation” technology is adopted to innovate the “transformation” technology of well structure to achieve the purpose of “multi-purpose in one well”; It also provides new technical ideas and accumulated valuable engineering experience for gas management in coal mine area under the condition of multi-thin coal seam group development in Guizhou.…”
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Long-read sequencing of 945 Han individuals identifies structural variants associated with phenotypic diversity and disease susceptibility
Published 2025-02-01“…Abstract Genomic structural variants (SVs) are a major source of genetic diversity in humans. Here, through long-read sequencing of 945 Han Chinese genomes, we identify 111,288 SVs, including 24.56% unreported variants, many with predicted functional importance. …”
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Evaluating Factors Affecting Interior Architectural Space Quality to Enhance Spatial Resilience and Human Productivity: An Application of Maslow’s Hierarchy of Needs
Published 2025-06-01“…</p> <p style="text-align: left;"><strong>Methodology.3</strong></p> <p style="text-align: left;">In the present study, the data and information was collected through document analysis, in-depth semi-structured interviews and formation of a focus group. The sample selection was done using snowball sampling method. …”
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Direct-fed microbials optimize ruminal fermentation, microbial ecosystem and milk quality to enhance the lactation performance of Sanhe dairy cows
Published 2025-07-01“…Dairy cows are the most important source of milk production, with billions of microorganisms present in the rumen. …”
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Frontotemporal lobar degeneration changes neuronal beta-frequency dynamics during the mismatch negativity response
Published 2024-01-01“…Across bvFTD and PSP groups, the beta response to deviant stimuli (relative to standard stimuli) correlated with clinical severity, but not with atrophy of the prefrontal source region. These findings confirm the proposed importance of higher-order cortical regions, and their beta-power generators, in sensory change detection and context-updating during oddball paradigms. …”
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Establishing a long-term predictive model for aggressive behavior in schizophrenia: a 21-year longitudinal study in rural China
Published 2025-08-01“…A clinically practical nomogram was built to assess the risk of aggressive behavior in individuals with schizophrenia in rural China, which may facilitate early detection and intervention of these individuals, particularly in rural areas with limited resources. …”
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A pan-cancer analysis of the prognostic and immunological roles of zinc finger protein 514 in human tumors
Published 2025-06-01“…We also used the Tumor Immune Estimation Resource 2.0 (TIMER 2.0) database to investigate the association between ZNF514 expression and immune checkpoint genes and immune infiltration. …”
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