Differential involvement of neurotransmitter pathways in AD, bvFTD and MCI: Whole-brain MRI analysis by Ricardo Félix Morais, José Maria Sousa, Cemal Koba, Leon Andres, Tiago Jesus, Inês Baldeiras, Tiago Gil Oliveira, Isabel Santana

“…In MCI, early serotonergic dysregulation involving SERT occurs before detectable atrophy.…”
Get full text

Exploration of the interaction between antimicrobial peptides and gamma radiation for biosensor development. by Fabiane Modenese Garbim, Marcela Rabelo De Lima, Giulianna Santos Pereira, João Nilton Conceição Bandeira, Álvaro José Mendes-Boareto, Fernando Manuel Araújo-Moreira, N.F.G. Serrano

“…These findings indicate that, although AMPs demonstrate changes in activity as a function of dose and could be explored for biosensing, their functional stability is limited at higher radiation doses. …”
Get full text

Stage-specific metabolic allocation: nutrient investment strategies during Lysiphlebia japonica Ashmead development by Tingting Zhou, Ningbo Huangfu, Li Wang, Junyu Luo, Jinjie Cui, Xiangzhen Zhu, Sumei Wan, Xueke Gao

“…Nutrients, particularly lipids and energy-related metabolites, play a critical role in shaping stage-specific growth and survival strategies in parasitic wasps.MethodsTo analyze the allocation patterns of metabolite resources during development of parasitoid wasps, the multi-omics analysis was employed to systematically investigate nutrient dynamics across three growth periods in Lysiphlebia japonica Ashmead, a major parasitoid of cotton aphid (Aphis gossypii Glover).ResultsHere, a total of 753 metabolites were detected by untargeted metabolomics, with numerous nutritionally critical compounds including amino acids, fatty acids and carbohydrates showed stage-specific variations. …”
Get full text

The neuropeptide sulfakinin is a peripheral regulator of insect behavioral switch between mating and foraging by Hong-Fei Li, Bao Dong, Yuan-Yuan Peng, Hao-Yue Luo, Xiao-Lan Ou, Zheng-Lin Ren, Yoonseong Park, Jin-Jun Wang, Hong-Bo Jiang

“…Further analysis of the mutant flies revealed that sets of odorant receptor (OR) genes were differentially expressed. Functional characterization of the differentially expressed ORs suggested that sulfakinin directly suppresses the expression of ORs that respond to opposite-sex hormones while enhancing the expression of ORs that detect food volatiles. …”
Get full text

Genome-wide identification and expression analyses of CYP450 genes in Chrysanthemum indicum by Yuyuan Chen, Tongjun Zhou, Jian Zhong, Yuxian Xu, Peng Zhang, Xiaoyu Yue, Hua Zhang, Ming Sun, Xuehao Fu

“…Conclusions The genome-wide analyses of cytochrome P450 superfamily offers essential genomic resources for functional studies of CiCYP450 genes, and is significant for the molecular breeding of Chrysanthemum.…”
Get full text

Prognostic value and immunotherapy analysis of immune cell-related genes in laryngeal cancer by Sen Zhang, Jianrui Pan, Huina Guo, Xiaoya Guan, Chenxu Yan, Lingling Ji, Xiansha Wu, Hui Huangfu

“…Key genes were identified through the intersection of differentially expressed genes (DEGs) between normal and LC samples and module genes derived from weighted gene co-expression network analysis (WGCNA), followed by functional enrichment analysis. The prognostic risk model was constructed using univariate Cox and Least Absolute Shrinkage and Selection Operator (LASSO) analyses. …”
Get full text

How to reduce the risk of primary engraftment failure after haploidentical hematopoietic stem cell transplantation in patients with acute myeloid leukemia? by D. K. Zhogolev, S. N. Bondarenko, A. G. Smirnova, Yu. Yu. Vlasova, D. A. Chernyshova, I. S. Moiseev, A. D. Kulagin

“…Optimizing transplantation strategies, including the selection of the graft source and modification of conditioning regimens, may improve haplo‑HSCT outcomes.   …”
Get full text

A novel human pluripotent stem cell gene activation system identifies IGFBP2 as a mediator in the production of haematopoietic progenitors in vitro by Paolo Petazzi, Telma Ventura, Francesca Paola Luongo, Heather McClafferty, Alisha May, Helen Alice Taylor, Michael J Shipston, Nicola Romanò, Lesley M Forrester, Pablo Menendez, Antonella Fidanza

“…A major challenge in the stem cell biology field is the ability to produce fully functional cells from induced pluripotent stem cells (iPSCs) that are a valuable resource for cell therapy, drug screening, and disease modelling. …”
Get full text

Genomic signal selection analysis reveals genes related to the lambing trait of Hotan sheep by XinKun Wang, Wei Li, QiaoYan Huang, HuiPing Sun, LeXiao Zhu, RuoHuai Gu, Feng Xing

“…We identified 290 selected regions and 332 genes across the Hotan sheep genome by using two widely adopted selective scanning detection methods (FST statistics and Piratio). Functional annotation and enrichment analysis of these genes identified 13 genes associated with the lambing rate, which were enriched in pathways such as the transforming growth factor-β signaling pathway (BMPR2, ID2, SMAD7, THBS1, and RBX1), renal cell carcinoma (PAK1, ELOC), inositol phosphate metabolism (PLCZ), non-homologous terminal junction (RAD50), ABC transporters (ABCC4), and the NET pathway (H2B, H4, and H2A). …”
Get full text

Error Analysis and Compensation of 3‒PTT Parallel Robot by CHEN Mingfang, LIANG Hongjian, WEI Songpo, HE Chaoyin

“…Then, the improved particle swarm optimization algorithm is utilized to optimize the error correction objective function, where the slider compensation is obtained, and the servo driver is utilized to complete the error compensation. …”
Get full text

Photonics-Aided THz Integrated Sensing and Communication System Based on a Subcarrier-Chirp Inter-Embedded Waveform by Junhao Zhang, Mingzheng Lei, Min Zhu, Qingzhi Zhou, Bingchang Hua, Yuancheng Cai, Hao Li, Jiao Zhang, Zhengyi Liang, Yang Li, Xingyu Chen, Junjie Ding, Qing Zhong, Sha Zhu, Jianjun Yu

“…Simultaneously, multi-user detection with an 8-mm ranging resolution is also realized. …”
Get full text

IT: An interpretable transformer model for Alzheimer's disease prediction based on PET/MR images by Zhaomin Yao, Weiming Xie, Jiaming Chen, Ying Zhan, Xiaodan Wu, Yingxin Dai, Yusong Pei, Zhiguo Wang, Guoxu Zhang

“…These insights significantly bolster the arsenal of tools available for AD diagnostics and contribute to the broader narrative of deciphering brain functionality through state-of-the-art imaging modalities.…”
Get full text

Optimisation of bioaerosol sampling using an ultralight aircraft: A novel approach in determining the 3-D atmospheric biodiversity by Maria P. Plaza, Athanasios Charalampopoulos, Vivien Leier-Wirtz, Pia Viuf Ørby, Mathilde Kloster, Michael Dines Christiansen, Claudia Traidl-Hoffmann, Athanasios Damialis, Ulrich Gosewinkel

“…Moreover, biomonitoring campaigns often take place in urban environments, although sources can be located outside cities’ borders with ampler vegetation. …”
Get full text

Rapid flips between warm and cold extremes in a warming world by Sijia Wu, Ming Luo, Gabriel Ngar-Cheung Lau, Wei Zhang, Lin Wang, Zhen Liu, Lijie Lin, Yijing Wang, Erjia Ge, Jianfeng Li, Yuanchao Fan, Yimin Chen, Weilin Liao, Xiaoyu Wang, Xiaocong Xu, Zhixin Qi, Ziwei Huang, Faith Ka Shun Chan, David Yongqin Chen, Xiaoping Liu, Tao Pei

Get full text

TET3-facilitated differentiation of human umbilical cord mesenchymal stem cells into oligodendrocyte precursor cells for spinal cord injury recovery by Yubo Zhang, Zhibin Peng, Man Guo, Yangyang Wang, Jingsong Liu, Yishu Liu, Mi Li, Tianli Wei, Pengfei Li, Yingwei Zhao, Yansong Wang

“…Owing to the poor regenerative capabilities of endogenous oligodendrocyte precursor cells (OPCs) following SCI, there is a growing interest in alternative sources, such as human umbilical cord mesenchymal stem cells (HUCMSCs). …”
Get full text

Research Progress on the Effect of Dissolved Organic Matter on the Environmental Behavior of Cadmium in Environmental Remediation by Jiabao MA, Siwen LIU, Bo WANG, Di WU, Jixin WEI, Qing SUN, Chenge MA, Yi HUANG, Taotao YAN

“…The various active functional groups contained in DOM, such as carboxyl, hydroxyl, and phenolic groups, are ligands and migration carriers for many heavy metals in the environment. …”
Get full text

WEB SERVICE OF WORKS PLANNING USING NETWORK GRAPH by Інна Грод, Надія Балик, Ярослав Василенко, Сергій Мартинюк, Василь Олексюк, Ольга Барна

“…During the study, a set of theoretical, empirical, and modeling methods were applied, in particular: systematic analysis of scientific and methodological sources, the results of domestic and foreign experience on the problem, review of existing software to determine the problem solution state and select development tools of web service, analysis of methods and technologies network graphs construction, generalization of information on the problem. …”
Get full text

Bioinformatics analysis of potential pathogenesis and risk genes of neuroinflammation-promoted brain injury in intracerebral hemorrhage by Ilgiz Gareev, Ozal Beylerli, Elmar Musaev, Chunlei Wang, Valentin Pavlov

“…TargetScan, miRDB, and RNA22 were used to investigate the miRNAs regulating the DEGs. The functional annotation of DEGs was performed using Gene Ontology (GO) resources, and the cell signaling pathway analysis of DEGs was performed using the Kyoto Encyclopedia of Genes and Genomes (KEGG). …”
Get full text

Cloning and expression of a C3H-type zinc finger protein gene BoCCCH2 from Brassica oleracea var. italica by JIANG Ming, LIU Qing’e, ZHANG Yanru, ZHU Qi, GONG Xiu, YU Keke, ZHOU Xiuqian

“…Cloning and expression analysis of BoCCCH2 provide evidence for further studies on gene function.…”
Get full text

A novel acidic laminarinase derived from Jermuk hot spring metagenome by Ani Paloyan, Tigran Soghomonyan, Mariam Karapetyan, Hasmik Grigoryan, Anna Krüger, Fiona Cuskin, Jon Marles-Wright, Christin Burkhardt, Garabed Antranikian

“…Abstract Laminarinase, an enzyme with a specific affinity for laminarin—a complex polysaccharide found in the cell walls of brown algae and select marine organisms—was investigated in this study. …”
Get full text