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1341
Chromosome-level genome assembly of starry flounder (Platichthys stellatus)
Published 2025-07-01“…Approximately 94.02% of assembled sequences were anchored into 24 pseudochromosomes, and a total of 18 telomeres were detected. Totally 22,835 protein-coding genes and 227.87 Mb repetitive sequences were identified. …”
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1342
Sodium formate induces development-dependent intestinal epithelial injury via necroptosis and apoptosis
Published 2024-12-01“…Mice were sacrificed after 24 h of feces collection, and the blood and small intestinal tissues were collected to detect the pathological damage of intestinal tissue, intestinal permeability, oxidative stress indicators including SOD, HO-1, MDA, and 4-HNE, inflammatory cytokines including IL-1β, TNF-α and IL-6, mitochondrial function such as ATP and PGC-1α in mice intestinal tissue, indicators of the cell death modes including necroptosis-related protein RIPK1 and p-MLKL, and apoptosis- related protein cleaved-caspase-3 and p-AKT (S473).Results NaF treatment significantly damaged intestinal epithelial tissue and barrier function, caused mitochondrial dysfunction, manifesting as decreased ATP and PGC-1α levels, increased lipid peroxidation products MDA and 4-HNE, depleted antioxidant enzyme SOD, and upregulated the expression of HO-1. …”
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1343
In-band network telemetry system based on high-performance packet processing architecture VPP
Published 2021-03-01“…An in-band network telemetry-based system was built based on VPP, a high-performance virtual network forwarding architecture/device, via reorganizing the data plane pipeline processing modules.Moreover, a network-wide telemetry mechanism was further developed via embedding source routing into the probe packet header for specifying the route of probe packets.Finally, a virtual network topology was built with performance evaluation conducted.The evaluation shows that the telemetry system can monitor the network in a high precision of every 0.13 ms, detecting link congestion in real time with minor performance overhead.Given virtual network devices have been widely deployed in data centers, the proposed scheme is expected to improve the reliability of multi-tenancy and network function virtualization in data centers via high-precision, network-wide virtual link telemetry coverage.…”
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1344
Agarwood leaf ethanol extract provides neuroprotective properties and promotes cholinergic differentiation of HT22 hippocampal neurons
Published 2025-03-01“…Abstract Neurodegenerative diseases, characterized by the loss or damage of neurons, represent a growing global health concern. Plants are a rich source of naturally occurring compounds with immense therapeutic potential. …”
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1345
Sensitivity and Specificity of Three Measures of Intrinsic Capacity in Older People Aged 80 and Over in Nursing Homes
Published 2024-12-01“…IC spans five function domains: Locomotor, psychological, cognitive, vitality, and sensory (including vision and hearing). …”
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1346
Methylenetetrahydrofolate Reductase Gene rs1801133 and rs1801131 Polymorphisms and Essential Hypertension Risk: A Comprehensive Analysis
Published 2022-01-01“…Similar associations were also found in subgroups defined by the source of controls and genotype methods. To our regret, based on the limited studies, no association was detected for rs1801131 polymorphism. …”
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1347
The effect of boron mineral on energy metabolism and antioxidant activity in purebred arabian foals
Published 2025-08-01“… Boron mineral is reported to have important functions in lipid and energy metabolism, immune and endocrine systems, and brain activity, positively affecting performance. …”
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1348
MULTI-MODEL STACK ENSEMBLE DEEP LEARNING APPROACH FOR MULTI-DISEASE PREDICTION IN HEALTHCARE APPLICATION
Published 2025-03-01“…These datasets serve two functions: improving illness prediction and examining large data reservoirs to identify previously unknown disease patterns. …”
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1349
Substandard Language Phenomena in Artistic Discourse
Published 2025-12-01“…The substandard is currently becoming a source of replenishment of the stylistically reduced layer of modern colloquial speech.…”
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1350
HERGAI: an artificial intelligence tool for structure-based prediction of hERG inhibitors
Published 2025-07-01“…It also demonstrated superior screening power compared to virtual screening schemes that used existing scoring functions. This model, named “HERGAI,” along with relevant input/output data and user-friendly source code, is available in our GitHub repository ( https://github.com/vktrannguyen/HERGAI ) and can be used to predict drug-induced hERG blockade, even on large data sets.…”
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1351
Clustering nuclear receptors in liver regeneration identifies candidate modulators of hepatocyte proliferation and hepatocarcinoma.
Published 2014-01-01“…Nuclear receptors (NRs) are key players in the control of cellular functions, being ideal modulators of hepatic proliferation and carcinogenesis.…”
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1352
Pathoadaptive Mutations of Escherichia coli K1 in Experimental Neonatal Systemic Infection.
Published 2016-01-01“…Only four single nucleotide polymorphisms (SNPs), in genes (gloB, yjgV, tdcE) or promoters (thrA) involved in metabolic functions, were found: no changes were detected in genes encoding virulence determinants associated with the invasive potential of E. coli K1. …”
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1353
iMeta Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health
Published 2024-12-01Get full text
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1354
Protective role of extracellular vesicles against oxidative DNA damage
Published 2025-03-01“…Abstract Background Oxidative stress, a source of genotoxic damage, is often the underlying mechanism in many functional cell disorders. …”
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1355
Epidemic preparedness and response capacity against infectious disease outbreaks in 186 countries, 2018–2022
Published 2024-11-01“…From the 2022 submissions, 116 (62%) countries reported functional (Level 4 or 5) prevention capacity, 162 (87%) had functional detection capacity, 118 (63%) had functional response capacity, 121 (65%) had functional enabling resources and coordination capacity, and 133 (72%) had functional operational readiness against public health events. …”
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1356
Unveiling the complex double-edged sword role of exosomes in nasopharyngeal carcinoma
Published 2025-01-01“…Exosomes are small membrane vesicles at the nanoscale that transport physiologically active compounds from their source cell and have a crucial function in signal transmission and intercellular message exchange. …”
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1357
Face Recognition Door Security System and Contactless Bell
Published 2024-02-01“…Face recognition uses OpenCV based on an open source library to recognize faces in realtime using the Python programming language. …”
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1358
Synthesis and Production of Sweet-Tasting Protein in E. coli and Purification by Amylose Resin
Published 2011-06-01“…MBP-brazzein system permits large-scale functional expression and purification of recombinant soluble proteins, providing a basis for the future study of structure and function of brazzein.…”
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1359
PPI-GA: A Novel Clustering Algorithm to Identify Protein Complexes within Protein-Protein Interaction Networks Using Genetic Algorithm
Published 2021-01-01“…Any disturbance in proteins interactive network can act as a source for biological disorders and various diseases such as Alzheimer and cancer. …”
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1360