TMSB4X is a regulator of inflammation-associated ferroptosis, and promotes the proliferation, migration and invasion of hepatocellular carcinoma cells by Linlin Tang, Yangli Jin, Jinxu Wang, Xiuyan Lu, Mengque Xu, Mingwei Xiang

“…Results 157 genes related to inflammation and ferroptosis in HCC were obtained by WGCNA. rLasso algorithm, with the highest C-index, screened out 29 hub genes, and this model showed good efficacy to predict the prognosis of HCC patients. …”
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Immunotyping of thyroid cancer for clinical outcomes and implications by Jin Xu, Zhen Luo, Dayong Xu, Mujing Ke, Cheng Tan

“…Furthermore, the prognostic model’s utility in predicting immunotherapy response was analyzed. …”
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Novel insights of disulfidptosis-mediated immune microenvironment regulation in atherosclerosis based on bioinformatics analyses by Huanyi Zhao, Zheng Jin, Junlong Li, Junfeng Fang, Wei Wu, J. F. Fang

“…In addition, we established a foam cell model in vitro and an AS mouse model in vivo to verify the expressions of hub genes. …”
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Cadmium Exposure Disrupts Uterine Energy Metabolism and Coagulation Homeostasis During Labor in Institute of Cancer Research Mice: Insights from Transcriptomic Analysis by Yueyang Wang, Yichen Bai, Yi Wang, Yan Cai

“…This study is the first to establish a model of Cd exposure in the uterus of laboring mice and investigate the underlying metabolic mechanisms through transcriptomic analysis. …”
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Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations. by Katherine R Bull, Andrew J Rimmer, Owen M Siggs, Lisa A Miosge, Carla M Roots, Anselm Enders, Edward M Bertram, Tanya L Crockford, Belinda Whittle, Paul K Potter, Michelle M Simon, Ann-Marie Mallon, Steve D M Brown, Bruce Beutler, Christopher C Goodnow, Gerton Lunter, Richard J Cornall

“…Forward genetics screens with N-ethyl-N-nitrosourea (ENU) provide a powerful way to illuminate gene function and generate mouse models of human disease; however, the identification of causative mutations remains a limiting step. …”
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Automated Detection of Reduced Ejection Fraction Using an ECG-Enabled Digital Stethoscope by Ling Guo, PhD, Gregg S. Pressman, MD, Spencer N. Kieu, BS, Scott B. Marrus, MD, PhD, George Mathew, PhD, John Prince, PhD, Emileigh Lastowski, MS, Rosalie V. McDonough, MD, MSc, Caroline Currie, BA, John N. Maidens, PhD, Hussein Al-Sudani, MD, Evan Friend, BA, Deepak Padmanabhan, MD, Preetham Kumar, MD, Edward Kersh, MD, Subramaniam Venkatraman, PhD, Salima Qamruddin, MD

“…Recently, electrocardiogram-based algorithms have shown promise in detecting ALVSD. Objectives: The authors developed and validated a convolutional neural network (CNN) model using single-lead electrocardiogram and phonocardiogram inputs captured by a digital stethoscope to assess its utility in detecting individuals with actionably low ejection fractions (EF) in a large cohort of patients. …”
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Machine learning applications in forecasting patient satisfaction and clinical outcomes after carpal tunnel release: a retrospective study by Zohreh Manoochehri, Sara Manoochehri, Seyed Reza Bagheri, Alireza Abdi, Ehsan Alimohammadi

“…This study aimed to develop a machine learning (ML) model to predict post-CTR patient satisfaction and outcomes, serving as a preoperative screening tool. …”
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Estimation of Canopy Chlorophyll Content of Apple Trees Based on UAV Multispectral Remote Sensing Images by Juxia Wang, Yu Zhang, Fei Han, Zhenpeng Shi, Fu Zhao, Fengzi Zhang, Weizheng Pan, Zhiyong Zhang, Qingliang Cui

“…The estimation models for the SPAD values in different growth stages were, respectively, established through five machine learning algorithms: multiple linear regression (MLR), partial least squares regression (PLSR), support vector regression (SVR), random forest (RF) and extreme gradient boosting (XGBoost). …”
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Leveraging automated time-lapse microscopy coupled with deep learning to automate colony forming assay by Anusha Klett, Anusha Klett, Dennis Raith, Dennis Raith, Paula Silvestrini, Paula Silvestrini, Paula Silvestrini, Matías Stingl, Jonas Bermeitinger, Avani Sapre, Avani Sapre, Avani Sapre, Martin Condor, Roman Melachrinos, Mira Kusterer, Alexandra Brand, Guido Pisani, Guido Pisani, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Marie Follo, Marie Follo, Jesús Duque-Afonso, Roland Mertelsmann, Roland Mertelsmann

“…Brightfield images were used to train a YOLOv8 object detection network, achieving a mAP50 score of 86% for identifying single cells, clusters, and colonies, and 97% accuracy for Z-stack colony identification with a multi-object tracking algorithm. The detection model accurately identified the majority of objects in the dataset.ResultsThis AI-assisted CFA was successfully applied for density optimization, enabling the determination of seeding densities that maximize plating efficiency (PE), and for IC50 determination, offering an efficient, less labor-intensive method for testing drug concentrations. …”
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Early breast cancer detection via infrared thermography using a CNN enhanced with particle swarm optimization by Riyadh M. Alzahrani, Mohamed Yacin Sikkandar, S. Sabarunisha Begum, Ahmed Farag Salem Babetat, Maryam Alhashim, Abdulrahman Alduraywish, N. B. Prakash, Eddie Y. K. Ng

“…An Enhanced Particle Swarm Optimization (EPSO) algorithm is integrated to automatically fine-tune CNN hyperparameters, thereby minimizing manual effort and enhancing computational efficiency. …”
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Golden eagle optimized CONV-LSTM and non-negativity-constrained autoencoder to support spatial and temporal features in cancer drug response prediction by Wesam Ibrahim Hajim, Suhaila Zainudin, Kauthar Mohd Daud, Khattab Alheeti

“…Advanced machine learning (ML) and deep learning (DL) methods have recently been utilized in Drug Response Prediction (DRP), and these models use the details from genomic profiles, such as extensive drug screening data and cell line data, to predict the response of drugs. …”
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Investigating the Complexity of Multidimensional Symptom Experiences in Patients With Cancer: Systematic Review of the Network Analysis Approach by Vincent Richard, Allison Gilbert, Emanuela Pizzolla, Giovanni Briganti

“…Several NA approaches were used: network visualization (n=1), Bayesian network (n=1), pairwise Markov random field and IsingFit method (n=1), unregularized Gaussian graphical model (n=2), regularized partial correlation network (n=6), network visualization and community NA (n=1), network visualization and Walktrap algorithm (n=1), undirected network model with the Fruchterman-Reingold and edge-betweenness approaches (n=4), biased correlation and concise pattern diagram (n=1), extended Bayesian information criterion graphical LASSO method (n=3), cross-lagged panel network (n=1), and unspecified NA (n=3). …”
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Mechanical positioning of multiple nuclei in muscle cells. by Angelika Manhart, Stefanie Windner, Mary Baylies, Alex Mogilner

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Spatial and temporal distribution patterns and factors influencing hepatitis B in China: a geo-epidemiological study by Kang Fang, Na Cheng, Chuang Nie, Wentao Song, Yunkang Zhao, Jie Pan, Qi Yin, Jiwei Zheng, Qinglin Chen, Tianxin Xiang

“…Spatial autocorrelation analysis and spatiotemporal scanning were used to analyze the spatiotemporal distribution characteristics. The random forest algorithm was used to screen the potential influencing factors. …”
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Integration of machine learning and bulk sequencing revealed exosome-related gene FOSB was involved in the progression of abdominal aortic aneurysm by Xianlu Ma, Xianlu Ma, Hongjie Zhou, Hongjie Zhou, Ren Wang, Ren Wang

“…The CIBERSORT algorithm was utilized to analyze the correlation between these genes and immune cell infiltration. …”
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Plasma metabolite biomarker identification study for the early detection of gastric cancer by Juan Zhu, Yida Huang, Bin Liu, Xue Li, Li Yuan, Le Wang, Kun Qian, Yingying Mao, Lingbin Du, Xiangdong Cheng

“…Ultra-performance liquid chromatography–mass spectrometry–based metabolomics methods were used to characterize the subjects’ plasma metabolic profiles and to screen and validate the GC biomarkers. Five machine learning algorithms (neural network, support vector machine, ridge regression, lasso regression and Naïve Bayes) were used to build a diagnostic model. …”
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Ekyeyo Mobile Application by Nkuba, Blair, Kansiime, Daniel

“…The app incorporates advanced search algorithms, tailored job recommendations, and streamlined candidate screening to improve job-matching accuracy. …”
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Efficient evidence selection for systematic reviews in traditional Chinese medicine by Yizhen Li, Zhe Huang, Zhongzhi Luan, Shujing Xu, Yunan Zhang, Lin Wu, Darong Wu, Dongran Han, Yixing Liu

“…Methods We integrated an established deep learning model (Evi-BERT combined rule-based method) with Boolean logic algorithms and an expanded retrieval strategy to automatically and accurately select potential evidence with minimal human intervention. …”
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Prediction of additional hospital days in patients undergoing cervical spine surgery with machine learning methods by Bin Zhang, Shengsheng Huang, Chenxing Zhou, Jichong Zhu, Tianyou Chen, Sitan Feng, Chengqian Huang, Zequn Wang, Shaofeng Wu, Chong Liu, Xinli Zhan

“…The intersections of the variables screened by the aforementioned algorithms were utilized to construct a nomogram model for predicting AHD in patients. …”
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A hybrid super learner ensemble for phishing detection on mobile devices by Routhu Srinivasa Rao, Cheemaladinne Kondaiah, Alwyn Roshan Pais, Bumshik Lee

“…Furthermore, many of these techniques are unsuitable for mobile devices, which face additional constraints, such as limited RAM, smaller screen sizes, and lower computational power. To address these limitations, this paper proposes a novel hybrid super learner ensemble model named Phish-Jam, a mobile application specifically designed for phishing detection on mobile devices. …”
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