High-flow nasal cannula therapy versus continuous positive airway pressure for non-invasive respiratory support in paediatric critical care: the FIRST-ABC RCTs by Padmanabhan Ramnarayan, Alvin Richards-Belle, Karen Thomas, Laura Drikite, Zia Sadique, Silvia Moler Zapata, Robert Darnell, Carly Au, Peter J Davis, Izabella Orzechowska, Julie Lester, Kevin Morris, Millie Parke, Mark Peters, Sam Peters, Michelle Saull, Lyvonne Tume, Richard G Feltbower, Richard Grieve, Paul R Mouncey, David Harrison, Kathryn Rowan

“…Background Despite the increasing use of non-invasive respiratory support in paediatric intensive care units, there are no large randomised controlled trials comparing two commonly used non-invasive respiratory support modes, continuous positive airway pressure and high-flow nasal cannula therapy. …”
Get full text

Biophysical and nutritional combination treatment for myosteatosis in patients with sarcopenia: a study protocol for single-blinded randomised controlled trial by Maoyi Tian, Ling Qin, Simon Kwoon Ho Chow, Wing Hoi Cheung, A A Welch, Can Cui, Parco M Siu, Meng Chen Michelle Li, Yu Kin Cheng, Ronald Man Yeung Wong, Timothy CY Kwok, Minghui Yang, Clinton Rubin, Sheung Wai Law

“…The findings of this study will demonstrate the effect of combination treatment as an alternative for managing sarcopenia.Methods and analysis In this single-blinded randomised controlled trial, subjects will be screened based on the Asian Working Group for Sarcopenia (AWGS) 2019 definition. 200 subjects who are aged 65 or above and identified sarcopenic according to the AWGS algorithm will be recruited. …”
Get full text

Sparse representation for massive MIMO satellite channel based on joint dictionary learning by Qing yang Guan, Shuang Wu

“…Simulation results demonstrate that the proposed CJDL algorithm provides a more accurate and robust channel representation.…”
Get full text

How we treat polycythemia vera by V. A. Shuvaev, I. S. Martynkevich

“…The discovery of the pathogenetic role of mutations in the Janus kinase II gene has led to the possibility of establishing a diagnosis based not only on morphology, but also on genetic verification and to the development of directed targeted therapy, which is much more effective than previously used methods. The introduction of molecular genetic screening led to the need for a differential diagnosis with familial erythrocytosis, and the lessons of the coronavirus pandemic revealed the presence in the population of a significant proportion of patients with erythrocytosis due to the carriage of gene polymorphisms associated with familial hemochromatosis. …”
Get full text

A Non-Uniformity Correction Method for Uncooled Infrared Polarization Imaging Systems by Cailing Zhao, Zhiguo Fan, Yunxiang Zhang

“…Previous non-uniformity correction (NUC) algorithms usually couple polarization information with FPN correction, resulting in the loss of polarization characteristics. …”
Get full text

In silico assessment of biocompatibility and toxicity: molecular docking and dynamics simulation of PMMA-based dental materials for interim prosthetic restorations by Ravinder S. Saini, Rayan Ibrahim H. Binduhayyim, Vishwanath Gurumurthy, Abdulkhaliq Ali F. Alshadidi, Shashit Shetty Bavabeedu, Rajesh Vyas, Doni Dermawan, Punnoth Poonkuzhi Naseef, Seyed Ali Mosaddad, Artak Heboyan

“…The LigandScout was utilized for pharmacophore modeling, which employs a shape-based screening approach to identify potential ligand binding sites on protein targets. …”
Get full text

Research on the correlation between retinal vascular parameters and axial length in children using an AI-based fundus image analysis system. by Chaoyang Zhao, Huilin Li, Ziyou Yuan, Zihan Yang, Tiantian Wang, Yan Wang, Qian Tong, Shaofeng Hao

“…The findings aim to provide a scientific basis for the prevention, early screening, and formulation of personalized treatment strategies for myopia.…”
Get full text

Detecting and Explaining Postpartum Depression in Real-Time with Generative Artificial Intelligence by Silvia García-Méndez, Francisco de Arriba-Pérez

“…Moreover, it addresses the black box problem since the predictions are described to the end users thanks to the combination of LLMS with interpretable ML models (i.e. tree-based algorithms) using feature importance and natural language. …”
Get full text

Systematic elucidation of the effective constituents and potential mechanisms of Scrophulariae Radix against neoplasm based on LC-MS, network pharmacology, and molecular docking ap... by Shu-jie Yu, Xiao-bin Kong, Xin Jin, Meng-yi Shan, Gang Cheng, Pei-lu Wang, Wen-long Li, Pei-yuan Zhao, Yun-jie Sheng, Bing-qian He, Qi Shi, Hua-qiang Li, Qi-ming Zhao, Lu-ping Qin, Lu-ping Qin, Xiong-yu Meng, Xiong-yu Meng

“…As a result, the material–liquid ratio was significantly reduced from 100 g/mL to 32 g/mL, and the extraction efficiency was 1.332%, which was close to the predicted value of 1.346% in the response surface method, indicating that the algorithm model had a good fit. Next, a total of 738 compounds, including 161 terpenoids, 144 phenolic acids, 51 alkaloids, 24 flavonoids, 34 saccharides, 32 lignans and coumarins, 45 amino acids and derivatives, 23 organic acids, 134 lipids, 22 nucleotides and derivatives, and 59 other ingredients, were characterized from Scrophulariae Radix based on the accurate precursor and product ions, retention time, standards, fragmentation patterns, and previous publications. …”
Get full text

Genome-wide identification and expression analysis of phytochrome gene family in Aikang58 wheat (Triticum aestivum L.) by Zhu Yang, Zhu Yang, Wenjie Kan, Wenjie Kan, Ziqi Wang, Caiguo Tang, Yuan Cheng, Yuan Cheng, Dacheng Wang, Dacheng Wang, Yameng Gao, Lifang Wu, Lifang Wu

“…Additionally, the least absolute shrinkage and selection operator (LASSO) regression algorithm in machine learning was used to screen transcription factors such as bHLH, WRKY, and MYB that influenced the expression of TaAkPHY genes. …”
Get full text

Comprehensive Analysis of Programmed Cell Death-Related Genes in Diagnosis and Synovitis During Osteoarthritis Development: Based on Bulk and Single-Cell RNA Sequencing Data by Zhou J, Jiao S, Huang J, Dai T, Xu Y, Xia D, Feng Z, Chen J, Li Z, Hu L, Meng Q

“…Using machine learning algorithms, Hub PCD-related differentially expressed genes (Hub PCD-DEGs) were identified. …”
Get full text

Sleepiness, fatigue, anxiety and depression in Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea - Overlap - Syndrome, before and after continuous positive airways... by Nicholas-Tiberio Economou, Ioannis Ilias, Lemonia Velentza, Yiannis Papachatzakis, Paul Zarogoulidis, Anastasios Kallianos, Georgia Trakada

Get full text

Integrated single-cell and transcriptome sequencing data reveal the value of IL1RAP in gastric cancer microenvironment and prognosis by Weifeng Yang, Xiaohua Wu, Jian Wang, Wenquan Ou, Xing Huang

“…Immunotherapy prediction models suggested a more favorable response to PD-1 treatment in the low IL1RAP expression group. …”
Get full text

The clinical utility and safety of biomarker-guided immunosuppression withdrawal in liver transplantation: the LIFT prospective RCT by Julien Vionnet, Rosa Miquel, Juan G Abraldes, Juan-Jose Lozano, Pablo Ruiz, Miquel Navasa, Aileen Marshall, Frederik Nevens, William Gelson, Joanna Leithead, Steven Masson, Elmar Jaeckel, Richard Taubert, Phaedra Tachtatzis, Dennis Eurich, Kenneth Simpson, Eliano Bonaccorsi-Riani, James Ferguson, Alberto Quaglia, Maria Elstad, Marc Delord, Abdel Douiri, Alberto Sánchez-Fueyo

“…This was done by enrolling patients more than 3 years after transplantation and allocating them at random to two groups. …”
Get full text

Multidimensional Evaluation Framework and Classification Strategy for Low-Carbon Technologies in Office Buildings by Hongjiang Liu, Yuan Song, Yawei Du, Tao Feng, Zhihou Yang

“…The method includes four core components: (1) establishing three archetypal models—low-rise (H ≤ 24 m), mid-rise (24 m < H ≤ 50 m), and high-rise (50 m < H ≤ 100 m) office buildings—based on 99 office buildings in Beijing; (2) classifying 19 key technologies into three clusters—Envelope Structure Optimization, Equipment Efficiency Enhancement, and Renewable Energy Utilization—using bibliometric analysis and policy norm screening; (3) developing a four-dimensional evaluation framework encompassing Carbon Reduction Degree (CRD), Economic Viability Degree (EVD), Technical Applicability Degree (TAD), and Carbon Intensity Degree (CID); and (4) conducting a comprehensive quantitative evaluation using the AHP-entropy-TOPSIS algorithm. …”
Get full text

Community-based COVID-19 active case finding and rapid response in the Democratic Republic of the Congo: Improving case detection and response. by John Otokoye Otshudiema, Gervais Léon Tengomo Folefack, Justus M Nsio, Cathy H Kakema, Luigino Minikulu, Aimé Bafuana, Joel B Kosianza, Antoine K Mfumu, Edith Nkwembe, Yannick Munyeku-Bazitama, Sheila Makiala-Mandanda, Noé Guinko, Gisèle Mbuyi, Jean-Marie K Tshilumbu, Guy N Saidi, Moreau-Serge Umba-di-Masiala, Amos K Ebondo, Jean-Jacques Mutonj, Serge Kalombo, Jad Kabeya, Taty K Mawanda, Faustin N Bile, Gaby K Kasereka, Placide Mbala-Kingebeni, Steve Ahuka-Mundeke, Humphrey Cyprian Karamagi, Karl Njuwa Fai, Amédée Prosper Djiguimde

“…This pilot study was modeled on the DRC's National COVID-19 Response Plan and the COVID-19 Ag-RDT screening algorithm defined by the World Health Organization (WHO), with case findings implemented in 259 health areas, 39 health zones, and 9 provinces. …”
Get full text

Neurological post-COVID syndrome is associated with substantial impairment of verbal short-term and working memory by Jeyanthan Charles James, Hannah Schulze, Nadine Siems, Christian Prehn, Daniel R. Quast, Nadine Trampe, Ralf Gold, Simon Faissner

“…Neurologic PCS patients had more complaints with significantly higher fatigue scores as well as higher levels of depressive and anxiety symptoms compared to Non-PCS and HC. …”
Get full text

Extracellular mRNA detected by molecular beacons in tethered lipoplex nanoparticles for diagnosis of human hepatocellular carcinoma. by Xinmei Wang, Kwang Joo Kwak, Zhaogang Yang, Aili Zhang, Xiaoli Zhang, Rachael Sullivan, Dan Lin, Robert L Lee, Carlos Castro, Kalpana Ghoshal, Carl Schmidt, L James Lee

Get full text

Improvement of Business Analysis Method of E-Commerce System from the Perspective of Intelligent Recommendation System by Ruihua Shao

“…In recent years, with the continuous development of the country’s Internet platforms, China has gradually entered the e-commerce era of national online shopping, and more and more e-commerce platforms and stores have adopted intelligent recommendation systems to increase transaction rates. …”
Get full text

The Role of Three Plasma Proteins in the Diagnosis of Ovarian Tumors by Valeria Racheva, Adelaida Ruseva, Svetlana Mateva, Ivan Malkodanski

“…Ovarian cancer is not common, but it is still the fifth leading cause of death from malignant diseases among women worldwide. More than 200,000 women are diagnosed with ovarian cancer each year globally. …”
Get full text