Integrated analysis of single-cell RNA-seq and spatial transcriptomics to identify the lactylation-related protein TUBB2A as a potential biomarker for glioblastoma in cancer cells... by Yifan Xu, Chonghui Zhang, Jinpeng Wu, Pin Guo, Nan Jiang, Chao Wang, Yugong Feng

“…Notably, the expression levels of these three hub genes and the lactylation level of TUBB2A in GBM tissues were significantly higher compared to those in normal tissues.ConclusionsWe propose and validate a IQR lactylation screening method that provides potential insights for GBM therapy and an effective framework for developing gene screening models applicable to other diseases and pathogenic mechanisms.…”
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Machine learning-based identification of exosome-related biomarkers and drugs prediction in nasopharyngeal carcinoma by Zhengyu Wei, Guoli Wang, Yanghao Hu, Chongchang Zhou, Yuna Zhang, Yi Shen, Yaowen Wang

“…Results Through the application of three machine learning algorithms, five key genes (LTF, IDH1, ITGAV, CCL2, and LGALS3BP) were identified for the construction of a diagnostic model. …”
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Emergency scheduling strategy of integrated electricity-gas energy system considering wind-power fluctuation in typhoon disaster by JIN Haixiang, BIAN Xiaoyan, HUANG Ruanming, ZHOU Qibin, XU Ling

“…The adaptive-alternating direction method of multipliers (AT-ADMM) algorithm is adopted to solve the model. An example is given to verify the effectiveness of the proposed method.…”
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Intelligent Evaluation Method for Scoliosis at Home Using Back Photos Captured by Mobile Phones by Yongsheng Li, Xiangwei Peng, Qingyou Mao, Mingjia Ma, Jiaqi Huang, Shuo Zhang, Shaojie Dong, Zhihui Zhou, Yue Lan, Yu Pan, Ruimou Xie, Peiwu Qin, Kehong Yuan

“…Therefore, based on computer vision technology, this paper puts forward an evaluation method of scoliosis with different photos of the back taken by mobile phones, which involves three aspects: first, based on the key point detection model of YOLOv8, an algorithm for judging the type of spinal coronal curvature is proposed; second, an algorithm for evaluating the coronal plane of the spine based on the key points of the human back is proposed, aiming at quantifying the deviation degree of the spine in the coronal plane; third, the measurement algorithm of trunk rotation (ATR angle) based on multi-scale automatic peak detection (AMPD) is proposed, aiming at quantifying the deviation degree of the spine in sagittal plane. …”
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Fault Location and Route Selection Strategy of Distribution Network Based on Distributed Sensing Configuration and Fuzzy C-Means by Bo Li, Guochao Qian, Lijun Tang, Peng Sun, Zhensheng Wu

“…The results show that, compared with the traditional fault section location and route selection strategy, this method can reduce the number of measurement devices optimally configured by 19–36% and significantly reduce the number of algorithm iterations. In addition, it can realize rapid fault location and precise line screening at a low equipment cost under multiple fault types and different fault locations, which significantly improves fault location accuracy while reducing economic investment.…”
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Technical Code Analysis of Geomagnetic Flaw Detection of Suppression Rigging Defect Signal Based on Convolutional Neural Network by Gang Zhao, Changyu Han, Zhongxiang Yu, Zhipan Li, Guoao Yu, Hongmei Zhang, Dadong Zhao, Zhengyi Jiang

“…The single-stage object detection algorithm YOLOv5 (You Only Look Once) based on convolutional neural network model calculation is used, the scale detection layer and positioning loss function of the YOLOv5 algorithm are improved and optimized, and the improved YOLOv5 algorithm is used for experiments. …”
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Global trends in machine learning applications for single-cell transcriptomics research by Xinyu Liu, Zhen Zhang, Chao Tan, Yinquan Ai, Hao Liu, Yuan Li, Jin Yang, Yongyan Song

“…Research hotspots concentrated on random forest (RF) and deep learning models, showing transition from algorithm development to clinical applications (e.g., tumor immune microenvironment analysis). …”
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Thirty-day mortality risk prediction for geriatric patients undergoing non-cardiac surgery in the surgical intensive care unit by Mengke Ma, Jiatong Liu, Caiyun Li, Yingxue Chen, Huishu Jia, Aijie Hou, Hongzeng Xu

“…The least absolute shrinkage selection operator (LASSO) regularization algorithm and the extreme gradient boosting (XGBoost) for feature importance evaluation were used to screen important predictors. …”
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3D Film Animation Image Acquisition and Feature Processing Based on the Latest Virtual Reconstruction Technology by Siwei Wu, Shan Xiao, Yihua Di, Cheng Di

“…Finally, the target 3D face is reconstructed using the feature points of the target face for model matching. The experimental results show that the algorithm reconstructs faces with high realism and accuracy, and the algorithm can reconstruct expression faces.…”
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Machine Learning and Deep Learning Techniques for Prediction and Diagnosis of Leptospirosis: Systematic Literature Review by Suhila Sawesi, Arya Jadhav, Bushra Rashrash

“…MethodsUsing Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, Checklist for Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies (CHARMS), and Prediction model Risk of Bias Assessment Tool (PROBAST) tools, we conducted a comprehensive review of studies applying ML and DL models for leptospirosis detection and prediction, examining algorithm performance, data sources, and validation approaches. …”
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Optimization of the fermentation process for fructosyltransferase production by Aspergillus niger FS054 by Yingzi Wu, Yuewen Zhang, Xiaoyu Zhong, Huiling Xia, Mingyang Zhou, Wenjin He, Yi Zheng

“…Further optimization of cultivation conditions using a hybrid backpropagation neural network–genetic algorithm (BP–GA) model identified optimal parameters as pH 5.5, a liquid volume of 96.6 mL (in a 250 mL shaker), and inoculum size of 2.4 $$\times$$ × $$10^{4}$$ 10 4 spores/mL, achieving a final enzyme activity of 3422.14 ± 36.86 U/L (1.1% deviation from the predicted 3460 U/L), representing a 4.2-fold increase over initial conditions. …”
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Deep learning for smartphone-aided detection system of Helicobacter Pylori in gastric biopsy by Guanmeng Gao, Zihan Wei, Fei Pei, Yajie Du, Beiying Liu

“…All stained slides were scanned for analysis by the Faster-R-CNN with ResNet 50 or VGG16, then the model performance was evaluated. Furthermore, the real-time microscopic field, smartphone and AI algorithm were connected through 5G networks and the AI results were sent back to the smartphone for confirmation by the pathologists. …”
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Multimodal ultrasound radiomics containing microflow images for the prediction of central lymph node metastasis in papillary thyroid carcinoma by Jiangyuan Ben, Jiangyuan Ben, Qiying Yv, Pengfei Zhu, Junhao Ren, Pu Zhou, Guifang Chen, Ying He, Ying He

“…The same methods were applied to screen clinical features. Nine ML algorithms were used to construct clinical models, radiomics models and fusion models. …”
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Time-Distributed Vision Transformer Stacked With Transformer for Heart Failure Detection Based on Echocardiography Video by Mgs M. Luthfi Ramadhan, Adyatma W. A. Nugraha Yudha, Muhammad Febrian Rachmadi, Kevin Moses Hanky Jr Tandayu, Lies Dina Liastuti, Wisnu Jatmiko

“…This study proposed a novel deep learning model consisting of a time-distributed vision transformer stacked with a transformer. …”
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Oxidative stress gene expression in ulcerative colitis: implications for colon cancer biomarker discovery by Ting Yan, Ting Su, Miaomiao Zhu, Qiyuan Qing, Binjie Huang, Jun Liu, Tenghui Ma

“…Subsequently, we performed Gene Ontology (GO) analysis and Kyoto encyclopedia of genes and genomes (KEGG) analyses, followed by immune infiltration analysis using the single-sample gene-set enrichment analysis (ssGSEA) and CIBERSORT algorithms. By constructing a multivariate Cox prognostic model using Kaplan–Meier curves and least absolute shrinkage and selection operator (LASSO) regression analysis, we assessed the model’s prognostic capability. …”
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Bioinformatics analysis of potential targets influencing the prognosis of OSCC by ZOU Xian, SONG Tao

“…The Timer website was used to analyze the relationship between hub genes and immune cell infiltration and immune checkpoints. Based on Lasso-Cox algorithm, a prognostic risk model of related genes was constructed. …”
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Design and optimization of planetary gear train pendulum type sugarcane seeding mechanism based on spatial offset trajectory by Jiaodi Liu, Chaoyuan Luo, Qingli Chen, Jianhao Chen, Jianlong Chen, Yihao Xing

“…Based on the speed requirements of the sugarcane seeds at the critical motion points, a forward kinematics model of this seeding mechanism is established. A multi-objective genetic algorithm combined with the entropy-weight TOPSIS method is used to optimize and screen the installation dimensions of the components of the mechanism so as to keep the motion of the sugarcane seeds stable at the critical positions. …”
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Integrated multiomics analysis and machine learning refine molecular subtypes and prognosis for thyroid cancer by Peng Zhang, Meizhong Qin, Fen Li, Kunpeng Hu, He Huang, Cuicui Li

“…Abstract Background Thyroid cancer (THCA) exhibits high molecular heterogeneity, posing challenges for precise prognosis and personalized therapy. Most existing models rely on single-omics data and limited algorithms, reducing robustness and clinical value. …”
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Optimization of the Canopy Three-Dimensional Reconstruction Method for Intercropped Soybeans and Early Yield Prediction by Xiuni Li, Menggen Chen, Shuyuan He, Xiangyao Xu, Panxia Shao, Yahan Su, Lingxiao He, Jia Qiao, Mei Xu, Yao Zhao, Wenyu Yang, Wouter H. Maes, Weiguo Liu

“…Point cloud preprocessing was refined through the application of secondary transformation matrices, color thresholding, statistical filtering, and scaling. Key algorithms—including the convex hull algorithm, voxel method, and 3D α-shape algorithm—were optimized using MATLAB, enabling the extraction of multi-dimensional canopy parameters. …”
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The CD163 + tissue-infiltrating macrophages regulate ferroptosis in thyroid-associated ophthalmopathy orbital fibroblasts via the TGF-β/Smad2/3 signaling pathway by Xuemei Li, Siyi Wang, Hanwen Cao, Simin Xu, Chao Xiong, Jinhai Yu, Yunxiu Chen, Zhangjun Ren, Min Li, Ying Hu, Puying Gan, Qihua Xu, Yaohua Wang, Hongfei Liao

“…Finally, potential clinical drugs targeting CD163 + macrophages with high ferroptosis activity in TAO were predicted using the Random Walk with Restart (RWR) algorithm combined with the DGIdb database. Results We first utilized TAO-related datasets from the GEO database, combined with the FerrDb ferroptosis database, to identify changes in iron metabolism genes during TAO progression through differential expression analysis, screening 7 key ferroptosis-related proteins. …”
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