High-performance computing for static security assessment of large power systems by Venkateswara Rao Kagita, Sanjaya Kumar Panda, Ram Krishan, P. Deepak Reddy, Jabba Aswanth

“…We perform extensive experiments to evaluate the efficacy of the proposed algorithm. As a result, we establish that the proposed parallel algorithm with high-performance computing (HPC) computing is much faster than the traditional algorithms. …”
Get full text

Evaluation of three commercial rapid immunoassays for the diagnosis of Clostridioides difficile infection by Hannes Bjarki Vigfússon, Theresa Ennefors, Torbjörn Norén, Martin Sundqvist

“…The C. diff Quik Chek Complete performed the best of the three immunoassays, and when used in combination with NAAT, is a viable option for the laboratory diagnosis of CDI.IMPORTANCELaboratory diagnosis of Clostridioides difficile infection is complex, and current guidelines recommend a two-step diagnostic algorithm with a sensitive screening test and a more specific confirmatory test. …”
Get full text

Identifying Data-Driven Clinical Subgroups for Cervical Cancer Prevention With Machine Learning: Population-Based, External, and Diagnostic Validation Study by Zhen Lu, Binhua Dong, Hongning Cai, Tian Tian, Junfeng Wang, Leiwen Fu, Bingyi Wang, Weijie Zhang, Shaomei Lin, Xunyuan Tuo, Juntao Wang, Tianjie Yang, Xinxin Huang, Zheng Zheng, Huifeng Xue, Shuxia Xu, Siyang Liu, Pengming Sun, Huachun Zou

“…We trained a supervised machine learning model and developed pathways to classify individuals before evaluating its diagnostic validity and usability on an external cohort. …”
Get full text

Bioinformatics analysis of ferroptosis-related biomarkers and potential drug predictions in doxorubicin-induced cardiotoxicity by Jian Yu, Jian Yu, Jiangtao Wang, Xinya Liu, Xinya Liu, Cancan Wang, Cancan Wang, Li Wu, Yuanming Zhang, Yuanming Zhang

“…Utilized LASSO regression, SVM-RFE, and RF algorithms to identify key genes, followed by validation using external datasets (GSE232331, GSE230638) and ROC curve plotting to determine the diagnostic value of key genes. …”
Get full text

Optimized Landing Site Selection at the Lunar South Pole: A Convolutional Neural Network Approach by Yongjiu Feng, Haoteng Li, Xiaohua Tong, Pengshuo Li, Rong Wang, Shurui Chen, Mengrong Xi, Jingbo Sun, Yuhao Wang, Huaiyu He, Chao Wang, Xiong Xu, Huan Xie, Yanmin Jin, Sicong Liu

“…The combined use of CNN and SHAP enables more effective potential site screening and a deeper understanding of the factors influencing selection. …”
Get full text

Bioinformatic analysis, clinical implications and experimental validation of ferroptosis-related feature gene in IgA nephropathy: focus on DUSP1 by Tingting Liu, Tingting Pan, Mingxin Chang, Shaojie Fu, Hongzhao Xu, Hao Wu, Zhonggao Xu, Yanli Cheng

“…Among them, dual specificity phosphatase 1 (DUSP1) was screened as FFG by three machine learning algorithms. …”
Get full text

Identifying neural substrates of competitive interactions and sequence transitions during mechanosensory responses in Drosophila. by Jean-Baptiste Masson, François Laurent, Albert Cardona, Chloé Barré, Nicolas Skatchkovsky, Marta Zlatic, Tihana Jovanic

Get full text

Machine learning approach effectively discriminates between Parkinson’s disease and progressive supranuclear palsy: Multi-level indices of rs-fMRI by Weiling Cheng, Xiao Liang, Wei Zeng, Jiali Guo, Zhibiao Yin, Jiankun Dai, Daojun Hong, Fuqing Zhou, Fangjun Li, Xin Fang

“…Various rs-fMRI indices were extracted, followed by a comprehensive feature screening for each index. We constructed fifteen distinct combinations of indices and selected four machine learning algorithms for model development. …”
Get full text

PRKDC regulates cGAMP to enhance immune response in lung cancer treatment by Zhanghao Huang, Zhanghao Huang, Zhanghao Huang, Runqi Huang, Runqi Huang, Runqi Huang, Jun Zhu, Jun Zhu, Youlang Zhou, Youlang Zhou, Jiahai Shi, Jiahai Shi

“…This study aimed to investigate the antitumor effects of 2’,3’-cGAMP in LUAD.MethodHerein, patients with LUAD were screened for prognostic biomarkers, which were then assessed for sensitivity to immunotherapy and chemotherapy utilizing the “TIDE” algorithm and CellMiner database. …”
Get full text

Molecular epidemiology of enteroviruses from Guatemalan wastewater isolated from human lung fibroblasts. by Leanna Sayyad, Chelsea Harrington, Christina J Castro, Hanen Belgasmi-Allen, Stacey Jeffries Miles, Jamaica Hill, María Linda Mendoza Prillwitz, Lorena Gobern, Ericka Gaitán, Andrea Paola Delgado, Leticia Castillo Signor, Marc Rondy, Gloria Rey-Benito, Nancy Gerloff

“…Murine recombinant fibroblast L-cells (L20B) and human rhabdomyosarcoma (RD) cells are used for the isolation of polioviruses following a standard detection algorithm. Though non-polio-Enteroviruses (NPEV) can be isolated, the algorithm is optimized for the detection of polioviruses. …”
Get full text

Supporting self-management with an internet intervention for low back pain in primary care: a RCT (SupportBack 2) by Adam W A Geraghty, Taeko Becque, Lisa C Roberts, Jonathan Hill, Nadine E Foster, Lucy Yardley, Beth Stuart, David A Turner, Gareth Griffiths, Frances Webley, Lorraine Durcan, Alannah Morgan, Stephanie Hughes, Sarah Bathers, Stephanie Butler-Walley, Simon Wathall, Gemma Mansell, Malcolm White, Firoza Davies, Paul Little

“…We also wanted to know whether adding phone calls from a physiotherapist made the website more effective. Finally, we explored whether these options would represent ‘good value for money’ for the National Health Service. …”
Get full text

Association between the development of sepsis and the triglyceride-glucose index in acute pancreatitis patients: a retrospective investigation utilizing the MIMIC-IV database by Lin Xu, Xuejing Li, Na Zhang, Chunmei Guo, Pan Wang, Min Gao, Yanhui Zhang, Lixin Zhao

“…Utilizing the formula ln[(triglycerides mg/dl) × (glucose mg/dl)/2], the TyG index was calculated. The Boruta algorithm and Xgboost model were used for feature selection in order to pinpoint the important variables affecting results. …”
Get full text

Single-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma by Yan Liao, Junkai Chen, Hao Yao, Ting Zheng, Jian Tu, Weidong Chen, ZeHao Guo, Yutong Zou, Lili Wen, Xianbiao Xie

“…Multiple analytical algorithms indicated that SLCs were associated with immune cell infiltration and immune checkpoint gene expression. …”
Get full text

Combined Analysis of Transcriptome and Mendelian Randomization Reveals AKT1 and PPARG as Biomarkers Related to Glucose Metabolism in Sepsis by Ma J, Li W, Ma Q, Ding L, Wang Z, Wang R, Huang Y, Ma G, Gao J

“…Jie Ma,1,2,* Wendi Li,3 Qianqian Ma,1 Liying Ding,4 Zhaoyun Wang,1 Rong Wang,1 Yanan Huang,1 Gang Ma,2,* Jun Gao1,* 1Department of Anesthesia and Perioperative Medicine, First People’s Hospital of Yinchuan, The Second Clinical Medical College of Ningxia Medical University, Yinchuan, Ningxia, 750001, People’s Republic of China; 2Department of Anesthesia and Perioperative Medicine, General Hospital of Ningxia Medical University, The First Clinical Medical College of Ningxia Medical University, Yinchuan, Ningxia, 750004, People’s Republic of China; 3Department of Child Rehabilitation Education, Ningxia Rehabilitation Center for the Disabled, Yinchuan, Ningxia, 750002, People’s Republic of China; 4Department of Gynecology, Gynecology Clinic of Li Ying, Wuzhong, Ningxia, 751100, People’s Republic of China*These authors contributed equally to this workCorrespondence: Gang Ma, Department of Anesthesia and Perioperative Medicine, General Hospital of Ningxia Medical University, The First Clinical Medical College of Ningxia Medical University, Yinchuan, Ningxia, 750004, People’s Republic of China, Email magang2671@163.com Jun Gao, Department of Anesthesia and Perioperative Medicine, First People’s Hospital of Yinchuan, The Second Clinical Medical College of Ningxia Medical University, Yinchuan, Ningxia, 750001, People’s Republic of China, Email gaojun1605@sina.comIntroduction: This study aimed to identify diagnostic and therapeutic biomarkers related to glucose metabolism in sepsis, as hyperglycemia and blood glucose fluctuations influence sepsis progression.Methods: Datasets from public databases were analyzed using various methods, including differential expression analysis, PPI network screening, machine learning algorithms and Mendelian randomization. …”
Get full text

Long-term risk of de novo malignancy with tumor necrosis factor alpha (TNF) inhibitor immunosuppression: a multicenter, retrospective cohort study by Conor B. Driscoll, Jordan M. Rich, Christopher Yang, Joseph Nicolas, Dylan Isaacson, Philip Silberman, Xinlei Mi, Sai Kaushik Shakar Ramesh Kumar, Hui Zhang, Steven Belknap, William H. Temps, Edward M. Schaeffer, Shilajit D. Kundu

“…There may need to be differential cancer screening algorithms for patients with different inflammatory conditions and TNF-I exposure.…”
Get full text

Estimation of potato leaf area index based on spectral information and Haralick textures from UAV hyperspectral images by Jiejie Fan, Jiejie Fan, Yang Liu, Yang Liu, Yiguang Fan, Yihan Yao, Riqiang Chen, Mingbo Bian, Yanpeng Ma, Huifang Wang, Haikuan Feng, Haikuan Feng, Haikuan Feng

“…Three types of spectral data—original spectral reflectance (OSR), first-order differential spectral reflectance (FDSR), and vegetation indices (VIs)—along with three types of Haralick textures—simple, advanced, and higher-order—were analyzed for their correlation with LAI across multiple growth stages. A model for LAI estimation in potato at multiple growth stages based on spectral and textural features screened by the successive projection algorithm (SPA) was constructed using partial least squares regression (PLSR), random forest regression (RFR) and gaussian process regression (GPR) machine learning methods. …”
Get full text

Identification of the immune infiltration and biomarkers in ulcerative colitis based on liquid–liquid phase separation-related genes by Zhixing Hong, Shilin Fang, Haihang Nie, Jingkai Zhou, Yuntian Hong, Lan Liu, Qiu Zhao

“…We identified the hub LLPS-RGs (DE-LLPS-RGs) (HSPB3, SLC16A1, TRIM22, SRI, PLEKHG6, GBP1, PADI2) by machine learning algorithms. Hub genes were screened that displayed high prediction accuracy of UC patients. …”
Get full text

Geographic variation in secondary metabolites contents and their relationship with soil mineral elements in Pleuropterus multiflorum Thunb. from different regions by Yaling Yang, Siman Wang, Ruibin Bai, Feng Xiong, Yan Jin, Hanwei Liu, Ziyi Wang, Chengyuan Yang, Yi Yu, Apu Chowdhury, Chuanzhi Kang, Jian Yang, Lanping Guo

“…Conversely, a positive correlation was found between the contents of elements Na, Ce, Ti, and physcion and THSG-5, 2 components that exhibited higher levels in Deqing. Furthermore, an RF algorithm was employed to establish an interrelationship model, effectively forecasting the abundance of the majority of differential metabolites in HSW samples based on the content data of soil mineral elements. …”
Get full text

Key factors determination of hyperuricemia and association analysis among patients with breast cancer: results from NHANES data by Ting-ting Meng, Wen-rui Wang, Yan-qing Zheng, Guan-dong Liu

“…ObjectivesTo explore the factors influencing hyperuricemia in breast cancer patients based on the National Health and Nutrition Examination Survey (NHANES) database.MethodsThe univariate and multivariate generalized linear regression were used to screen the influencing factors of hyperuricemia. Logistic and XGBoost algorithms were used to rank the importance of influencing factors. …”
Get full text

Identification of biomarkers for the diagnosis of type 2 diabetes mellitus with metabolic associated fatty liver disease by bioinformatics analysis and experimental validation by Guiling Wu, Guiling Wu, Sihui Wu, Sihui Wu, Tian Xiong, Tian Xiong, Tian Xiong, You Yao, You Yao, Yu Qiu, Yu Qiu, Yu Qiu, Liheng Meng, Cuihong Chen, Xi Yang, Xi Yang, Xi Yang, Xinghuan Liang, Yingfen Qin

“…Candidate biomarkers were screened using machine learning algorithms combined with 12 cytoHubba algorithms, and a diagnostic model for T2DM-related MAFLD was constructed and evaluated.The CIBERSORT method was used to investigate immune cell infiltration in MAFLD and the immunological significance of central genes. …”
Get full text