HERGAI: an artificial intelligence tool for structure-based prediction of hERG inhibitors by Viet-Khoa Tran-Nguyen, Ulrick Fineddie Randriharimanamizara, Olivier Taboureau

“…Multiple structure-based artificial intelligence (AI) binary classifiers for predicting hERG inhibitors were developed, employing, as descriptors, protein–ligand extended connectivity (PLEC) fingerprints fed into random forest, extreme gradient boosting, and deep neural network (DNN) algorithms. Our best-performing model, a stacking ensemble classifier with a DNN meta-learner, achieved state-of-the-art classification performance, accurately identifying 86% of molecules having half-maximal inhibitory concentrations (IC50s) not exceeding 20 µM in our challenging test set, including 94% of hERG blockers whose IC50s were not greater than 1 µM. …”
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Analysis and prediction of infectious diseases based on spatial visualization and machine learning by Yunyun Cheng, Yanping Bai, Jing Yang, Xiuhui Tan, Ting Xu, Rong Cheng

“…Finally, a multi algorithm fusion learning model based on stacking technology is proposed to address the problem of poor generalization ability of single algorithm models in prediction; Furthermore, radial basis function network (RBF) was used as a two-level meta learner to fuse the above models, and particle swarm optimization (PSO) was used to optimize RBF parameters to reduce generalization error. …”
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GRK5 as a Novel Therapeutic Target for Immune Evasion in Testicular Cancer: Insights from Multi-Omics Analysis and Immunotherapeutic Validation by Congcong Xu, Qifeng Zhong, Nengfeng Yu, Xuqiang Zhang, Kefan Yang, Hao Liu, Ming Cai, Yichun Zheng

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Increasing clinicians’ suspicion of ATTR amyloidosis using a retrospective algorithm by Jessica Ammon, John Alexander, Woodson Petit-Frere, Deya Alkhatib, Aranyak Rawal, Grace Newman, Oguz Akbiligic, Brian Borkowski, John Jefferies, Isaac B. Rhea

“…Abstract Background This study aimed to increase the index of suspicion for transthyretin amyloidosis (ATTR) among cardiologists leading to increased screening for amyloidosis. Methods A retrospective algorithm was created to identify patients at risk for ATTR. …”
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A comprehensive and bias-free machine learning approach for risk prediction of preeclampsia with severe features in a nulliparous study cohort by Yun C. Lin, Daniel Mallia, Andrea O. Clark-Sevilla, Adam Catto, Alisa Leshchenko, Qi Yan, David M. Haas, Ronald Wapner, Itsik Pe’er, Anita Raja, Ansaf Salleb-Aouissi

“…However, since our model includes various factors that exhibit a positive correlation with PLGF, such as blood pressure measurements and BMI, we have employed an algorithmic approach to disentangle this bias from the model. …”
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Integrated single-cell and bulk RNA dequencing to identify and validate prognostic genes related to T Cell senescence in acute myeloid leukemia by Mengyao Sha, Jun Chen, Haifeng Hou, Huaihui Dou, Yan Zhang

“…Univariate and multivariate regression analyses were performed to screen prognostic genes using the AML Cohort in The Cancer Genome Atlas (TCGA) Database (TCGA-LAML), and risk models were constructed to identify high-risk and low-risk patients. …”
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Translational medicine research on the role of key gene network modulation mediated by procyanidin B2 in the precise diagnosis and treatment of multiple sclerosis by Jian Liu, Meng Pu, Di Guo, Ying Xiao, Jin-zhu Yin, Dong Ma, Cun-gen Ma, Qing Wang

“…Eight machine learning algorithms were employed to screen key genes, and nomograms and ROC curves were constructed to assess the value of the screened biomarker genes in MS diagnosis. …”
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Construction of a novel radioresistance-related signature for prediction of prognosis, immune microenvironment and anti-tumour drug sensitivity in non-small cell lung cancer by Yanliang Chen, Chan Zhou, Xiaoqiao Zhang, Min Chen, Meifang Wang, Lisha Zhang, Yanhui Chen, Litao Huang, Junjun Sun, Dandan Wang, Yong Chen

“…The least absolute shrinkage and selection operator (LASSO) regression and random survival forest (RSF) were used to screen for prognostically relevant RRRGs. Multivariate Cox regression was used to construct a risk score model. …”
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Machine learning based algorithms for virtual early detection and screening of neurodegenerative and neurocognitive disorders: a systematic-review by Milad Yousefi, Matin Akhbari, Zhina Mohamadi, Shaghayegh Karami, Hediyeh Dasoomi, Alireza Atabi, Seyed Amirali Sarkeshikian, Mahdi Abdoullahi Dehaki, Hesam Bayati, Negin Mashayekhi, Shirin Varmazyar, Zahra Rahimian, Mahsa Asadi Anar, Daniel Shafiei, Alireza Mohebbi

“…Machine learning aids in more precise disease identification, potentially transforming healthcare. …”
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XGBoost Algorithm for Cervical Cancer Risk Prediction: Multi-dimensional Feature Analysis by Sudi Suryadi, Masrizal

“…This study is situated at the intersection of clinical oncology and computational intelligence, exploring the potential of gradient-boosting algorithms to overcome the limitations of conventional screening methodologies. …”
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Forest Aboveground Biomass Estimation Based on Unmanned Aerial Vehicle–Light Detection and Ranging and Machine Learning by Yan Yan, Jingjing Lei, Yuqing Huang

“…In this study, the performance of predictive biomass regression equations and machine learning algorithms, including multivariate linear stepwise regression (MLSR), support vector machine regression (SVR), and k-nearest neighbor (KNN) for constructing a predictive forest AGB model was analyzed and compared at individual tree and stand scales based on forest parameters extracted by Unmanned Aerial Vehicle–Light Detection and Ranging (UAV LiDAR) and variables screened by variable projection importance analysis to select the best prediction method. …”
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Cost-effectiveness analysis of MASLD screening using FIB-4 based two-step algorithm in the medical check-up by Mimi Kim, Huiyul Park, Eileen L. Yoon, Ramsey Cheung, Donghee Kim, Hye-Lin Kim, Dae Won Jun

“…We constructed a hybrid model of the decision tree model and Markov model to compare expected costs and quality-adjusted life-years (QALYs) between ‘screening’ and ‘no screening’ groups from healthcare system perspectives. …”
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Predicting onset of myopic refractive error in children using machine learning on routine pediatric eye examinations only by Yonina Ron, Tchelet Ron, Naomi Fridman, Anat Goldstein

“…This study develops machine learning (ML) models to predict future myopia development. These models utilize easily accessible, non-invasive data gathered during standard eye clinic visits, deliberately excluding more complex measurements such as axial length or corneal curvature. …”
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A large-scale prospective nested case-control study: developing a comprehensive risk prediction model for early detection of pancreatic cancer in the community-based ESPRIT-AI coho... by Chaoliang Zhong, Penghao Li, Jia Zhao, Xue Han, Beilei Wang, Gang Jin

“…Multiple machine learning algorithms were compared, with the best performing algorithm selected for the final predictive model, subsequently validated using a real-world external test cohort. …”
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Performance and limitation of machine learning algorithms for diabetic retinopathy screening and its application in health management: a meta-analysis by Mehrsa Moannaei, Faezeh Jadidian, Tahereh Doustmohammadi, Amir Mohammad Kiapasha, Romina Bayani, Mohammadreza Rahmani, Mohammad Reza Jahanbazy, Fereshteh Sohrabivafa, Mahsa Asadi Anar, Amin Magsudy, Seyyed Kiarash Sadat Rafiei, Yaser khakpour

“…Abstract Background In recent years, artificial intelligence and machine learning algorithms have been used more extensively to diagnose diabetic retinopathy and other diseases. …”
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Identification and validation of aging related genes in osteoarthritis by Jian Du, Jian Du, Tian Zhou, Yanghui Dong, Yunchao Sun, Wei Peng

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Predicting Superaverage Length of Stay in COPD Patients with Hypercapnic Respiratory Failure Using Machine Learning by Zuo B, Jin L, Sun Z, Hu H, Yin Y, Yang S, Liu Z

“…Ten machine learning algorithms were used to develop and validate a model for predicting superaverage length of stay, and the best model was evaluated and selected.Results: We screened 83 candidate variables using the Boruta algorithm and identified 9 potentially important variables, including: cerebrovascular disease, white blood cell count, hematocrit, D-dimer, activated partial thromboplastin time, fibrin degradation products, partial pressure of carbon dioxide, reduced hemoglobin, and oxyhemoglobin. …”
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Accuracy improvement in financial sanction screening: is natural language processing the solution? by Seihee Kim, ShengYun Yang

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Automated Audit and Self-Correction Algorithm for Seg-Hallucination Using MeshCNN-Based On-Demand Generative AI by Sihwan Kim, Changmin Park, Gwanghyeon Jeon, Seohee Kim, Jong Hyo Kim

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To Determine the Risk-Based Screening Interval for Diabetic Retinopathy: Development and Validation of Risk Algorithm from a Retrospective Cohort Study by Jinxiao Lian, Ching So, Sarah Morag McGhee, Thuan-quoc Thach, Cindy Lo Kuen Lam, Colman Siu Cheung Fung, Alfred Siu Kei Kwong, Jonathan Cheuk Hung Chan

“…Methods The retrospective cohort data from 117,418 subjects who received systematic DR screening in Hong Kong between 2010 and 2016 were included to develop and validate the risk algorithm using a parametric survival model. …”
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