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721
Evaluating the potential of anti-dsRNA antibodies as an alternative viral sensing tool in encephalitides of different species
Published 2025-03-01“…Molecular methods like multiplex PCR and microarrays are considered to be often less sensitive than Next Generation Sequencing, whereas the latter is time-consuming and costly. …”
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722
Transcriptomic analysis of neural stem and progenitor cells in comparison with glioblastoma stem cells
Published 2023-12-01“…To conduct a comparative transcriptomic analysis of CD133+-NSPCs and CD133+-GSCs to study the molecular genetic differences between the phenotypes of these cells and identify potential targets for therapeutic effects on GSCs.Materials and methods. Used: highly sensitive transcriptomic analysis on high-density microarrays, cellular technologies, modern bioinformatics analysis.Results. …”
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723
GPX3 promotes cisplatin resistance in TNBC by manipulating ROS-TGFB1-ZEB2
Published 2025-07-01“…The correlation between the expression level of GPX3, TGFB1, and ZEB2 was analyzed using breast cancer microarrays and the TCGA database. The effect of GPX3 on platinum sensitivity in TNBC was studied using a mouse xenograft model. …”
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724
Phosphoribosyl transferase domain containing 1: A prognostic biomarker in testicular germ cell tumors
Published 2025-06-01“…Immunohistochemistry on tissue microarrays validated PRTFDC1’s predictive value in clinical samples. …”
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725
Targeting Mesothelin Enhances Personalized Neoantigen Vaccine Induced Antitumor Immune Response in Orthotopic Pancreatic Cancer Mouse Models
Published 2025-03-01“…Abstract The immunosuppressive microenvironment in pancreatic cancer, characterized by low tumor‐specific T cells and excessive fibrosis, limits the effectiveness of immunotherapy. Here, three datasets and multi‐immunofluorescence staining of tissue microarrays in pancreatic cancer indicate that mesothelin (MSLN) expression negatively correlates with cytotoxic T cells in tumor. …”
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726
Silibinin attenuates ferroptosis in acute kidney injury by targeting FTH1
Published 2024-11-01“…Finally, the inhibitory effects of silibinin on ferroptosis were reversed by knocking down FTH1 in vitro. …”
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727
Platelet-derived exosomal LINC00183 facilitate colorectal cancer malignant progression driven by histone lactylation through stabilizing ENO1
Published 2025-08-01“…Analysis of CRC tissue microarrays and TCGA-CRC patient data indicated that LINC00183 is often overexpressed in CRC, in association with advanced tumor stage and poor survival. …”
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728
Identification of vascular and hematopoietic genes downstream of etsrp by deep sequencing in zebrafish.
Published 2012-01-01“…Several novel genes expressed in vasculature have been identified through transcriptional profiling of zebrafish embryos overexpressing etsrp by microarrays. Here we re-examined this transcriptional profile by Illumina RNA-sequencing technology, revealing a substantially increased number of candidate genes regulated by etsrp. …”
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729
The transcription factor SOX18 regulates the expression of matrix metalloproteinase 7 and guidance molecules in human endothelial cells.
Published 2012-01-01“…Knock-down of SOX18 using RNA interference was then used to confirm the effect of the transcription factor on selected genes that included the guidance molecules ephrin B2 and semaphorin 3G. …”
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730
Distribution of Recessive Genetic Defect Carriers in Holstein Friesian Cattle: A Polish Perspective
Published 2024-11-01“…The studies were performed using Illumina Infinium microarrays. Among both bulls and cows, the highest numbers of carriers were detected for HH5 (appropriately 6.7% and 5.4%). …”
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731
The Impact of Antenatal and Postnatal Factors on the Development of the Pulmonary Microvasculature in Preterm Infants
Published 2025-05-01“…<b>Methods</b>: The investigation analyzed 67 cases of preterm infants, whose lifespans ranged from 1 day to 149 days. After selecting the cases from the autopsy database, two lung tissue microarrays were created. …”
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732
Advanced strategies for screening and identifying RNA-targeted small molecules: Bridging therapeutic potential and innovation
Published 2025-05-01“…However, their dynamic nature and structural complexity have historically posed challenges in developing small molecules with high affinity and selectivity. In recent years, significant advancements in screening methodologies, such as high-throughput screening (HTS), small molecule microarrays (SMMs), and DNA-encoded libraries (DELs), have facilitated the identification of RNA-binding small molecules with enhanced specificity. …”
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733
Genetic heterogeneity in familial forms of genetic generalized epilepsy: from mono- to oligogenism
Published 2024-11-01“…Moreover, a polygenic mode of inheritance is suspected in most cases. We performed SNP microarrays and whole exome sequencing in 20 families from Sudan, focusing on those with at least four affected members. …”
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734
Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based i...
Published 2013-01-01“…Genome-wide association (GWA) studies have been limited by the reliance on common variants present on microarrays or imputable from the HapMap Project data. …”
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735
A nomogram for predicting 3-year total weight loss percentage following LSG: insights from visceral adipose tissue inflammatory methylation sites
Published 2025-07-01“…Comparative analyses of 850K methylation microarrays from VAT samples were performed to identify methylation sites associated with INF-related genes. …”
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736
urg1: a uracil-regulatable promoter system for fission yeast with short induction and repression times.
Published 2008-01-01“…<h4>Methodology/principal findings</h4>We used S. pombe microarrays to identify three neighbouring genes (urg1, urg2, and urg3) whose transcript levels rapidly and strongly increased in response to uracil, a condition which otherwise had little effect on global gene expression. …”
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737
Elucidation of Dysregulated Pathways Associated With Hypoxia in Oestrogen Receptor‐Negative Breast Cancer
Published 2024-12-01“…Methods Immunohistochemistry was performed to identify the prognostic role of CAIX protein expression in ER− tissue microarrays (TMAs) (n = 191). CAIX‐positive samples (n = 37) were transcriptionally profiled by TempO‐Seq and analysed by STRING. …”
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738
Decoding the prognostic landscape of LUAD: the interplay between N6-methyladenosine modification and immune microenvironment
Published 2024-12-01“…A risk score model was constructed using least absolute shrinkage and selection operator regression and validated in two independent cohorts and LUAD tissue microarrays. …”
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739
Applicability of epigenetic age models to next-generation methylation arrays
Published 2024-10-01“…As new methylation microarrays are developed and older models discontinued, existing epigenetic clocks might become obsolete. …”
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740
NONO regulates m5C modification and alternative splicing of PTEN mRNAs to drive gastric cancer progression
Published 2025-03-01“…Abstract Background The effect of m5C modification on oncogene mRNAs has been well studied, while little is known about its influence on mRNAs of tumor suppressor genes (TSGs). …”
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