Interplay between tumor mutation burden and the tumor microenvironment predicts the prognosis of pan-cancer anti-PD-1/PD-L1 therapy by Wuyuan Liao, Wuyuan Liao, Wuyuan Liao, Xinwei Zhou, Xinwei Zhou, Hansen Lin, Hansen Lin, Zihao Feng, Zihao Feng, Xinyan Chen, Yuhang Chen, Yuhang Chen, Minyu Chen, Minyu Chen, Mingjie Lin, Mingjie Lin, Gaosheng Yao, Gaosheng Yao, Jinwei Chen, Jinwei Chen, Haoqian Feng, Haoqian Feng, Yinghan Wang, Yinghan Wang, Zhiping Tan, Zhiping Tan, Youyan Tan, Jun Lu, Jun Lu, Pengju Li, Pengju Li, Jinhuan Wei, Jinhuan Wei, Li Luo, Li Luo, Liangmin Fu, Liangmin Fu, Liangmin Fu

“…By incorporating the interaction between TMB and the TME, our model provides a more accurate prediction of patient prognosis and treatment response across multiple cancer types. …”
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Hyperspectral estimation of chlorophyll density in winter wheat using fractional-order derivative combined with machine learning by Chenbo Yang, Chenbo Yang, Meichen Feng, Juan Bai, Hui Sun, Rutian Bi, Lifang Song, Chao Wang, Yu Zhao, Wude Yang, Lujie Xiao, Meijun Zhang, Xiaoyan Song

“…In conclusion, based on the winter wheat ChD data set and the corresponding canopy hyperspectral data set, combined with 3 FOD calculation methods, 1 band screening method, and 8 modeling algorithms, this study constructed hyperspectral monitoring models for winter wheat ChD. …”
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Remote clinical decision support tool for Parkinson’s disease assessment using a novel approach that combines AI and clinical knowledge by Harel Rom, Ori Peleg, Yovel Rom, Anat Mirelman, Gaddi Blumrosen, Inbal Maidan

“…Conclusions Our results demonstrate the feasibility of using advanced AI in a clinical decision support tool for PD diagnosis, suggesting a novel approach for home-based screening to identify PD patients. This method represents a significant innovation, transforming clinical knowledge into practical algorithms that can serve as effective screening tools. …”
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An integrated bioinformatic investigation of succinic acid metabolism related genes in ccRCC followed by preliminary validation of SLC25A4 in tumorigenesis by Dong Yue, Fengyun Dong, Sen Wang, Miao Zheng

“…The univariate Cox algorithm, LASSO, and multivariate Cox analysis were performed to obtain biomarkers and build a prognostic model. …”
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Development and validation of a 3-D deep learning system for diabetic macular oedema classification on optical coherence tomography images by Mingzhi Zhang, Tsz Kin Ng, Yi Zheng, Guihua Zhang, Jian-Wei Lin, Ji Wang, Jie Ji, Peiwen Xie, Yongqun Xiong, Hanfu Wu, Cui Liu, Huishan Zhu, Jinqu Huang, Leixian Lin

“…The deep learning (DL) performance was compared with the diabetic retinopathy experts.Setting Data were collected from Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Chaozhou People’s Hospital and The Second Affiliated Hospital of Shantou University Medical College from January 2010 to December 2023.Participants 7790 volumes of 7146 eyes from 4254 patients were annotated, of which 6281 images were used as the development set and 1509 images were used as the external validation set, split based on the centres.Main outcomes Accuracy, F1-score, sensitivity, specificity, area under receiver operating characteristic curve (AUROC) and Cohen’s kappa were calculated to evaluate the performance of the DL algorithm.Results In classifying DME with non-DME, our model achieved an AUROCs of 0.990 (95% CI 0.983 to 0.996) and 0.916 (95% CI 0.902 to 0.930) for hold-out testing dataset and external validation dataset, respectively. …”
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Machine Learning–Based Prediction of Early Complications Following Surgery for Intestinal Obstruction: Multicenter Retrospective Study by Pinjie Huang, Jirong Yang, Dizhou Zhao, Taojia Ran, Yuheng Luo, Dong Yang, Xueqin Zheng, Shaoli Zhou, Chaojin Chen

“…ConclusionsWe have developed and validated a generalizable random forest model to predict postoperative early complications in patients undergoing intestinal obstruction surgery, enabling clinicians to screen high-risk patients and implement early individualized interventions. …”
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Wearable Artificial Intelligence for Sleep Disorders: Scoping Review by Sarah Aziz, Amal A M Ali, Hania Aslam, Alaa A Abd-alrazaq, Rawan AlSaad, Mohannad Alajlani, Reham Ahmad, Laila Khalil, Arfan Ahmed, Javaid Sheikh

“…To statistically synthesize performance and efficacy results, more reviews are needed. Technology companies should prioritize advancements such as deep learning algorithms and invest in wearable AI for treating sleep disorders, given its potential. …”
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Evaluation of machine learning methods for prediction of heart failure mortality and readmission: meta-analysis by Hamed Hajishah, Danial Kazemi, Ehsan Safaee, Mohammad Javad Amini, Maral Peisepar, Mohammad Mahdi Tanhapour, Arian Tavasol

“…In total, 346 machine learning models were evaluated, with the most common algorithms being random forest, logistic regression, and gradient boosting. …”
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IMPROVEMENT OF ADAPTATION TO STRUCTURES REMOVABLE DENTURES IN PATIENTS WITH ISCHEMIC HEART DISEASE by N.A. Ryabushko, V.N. Dvornik, I.V. Pavlish, G.N. Balya

“…The proposed health care was a complex algorithm to use: softener oral "Corsodyl" - 3-5 times a day after meals; clean teeth and dentures 2 times a day (morning and bedtime) toothpaste "Parodontax" and the bath solution Rinhra 3-5 times a day, with dryness in the mouth For the functional assessment made dentures were designed by us and proposed to use two methods of assessing patients to adapt designs removable dentures: • Objective evaluation - "Method of determining the degree of adaptation to the designs of removable dentures," Ukraine patent for utility model №101852 of 12.10.15; • Subjective evaluation - "Method of accelerated determination adaptation of patients to removable dentures designs using screening test" certificate of registration of copyright Ukraine №59280 15.04.2015. …”
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Optimized Allocation of Flood Control Emergency Materials Based on Loss Quantification by Wei Wang, Yunqing Wang, Li Huang, Yue Song

“…The center of gravity method is used to address demand when constructing the quantitative function of out‐of‐stock loss. The NSGA‐II algorithm was selected to generate the results after the method comparison to ultimately determine the Pareto solution of the model. …”
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Optimizing the dynamic treatment regime of outpatient rehabilitation in patients with knee osteoarthritis using reinforcement learning by Sijia Liu, Jiawei Luo, Chengqi He

“…Then, based on the key features screened out, a dynamic treatment recommendation system was constructed by using deep reinforcement learning algorithms, including Deep Deterministic Policy Gradien(DDPG), Deep Q-Network(DQN) and Batch-Constrained Q-learning(BCQ). …”
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A method for the identification of lactate metabolism-related prognostic biomarkers and its validations in non-small cell lung cancer by Weiyang Yang, Miao Gu, Yabin Zhang, Yunfan Zhang, Tao Liu, Di Wu, Juntao Deng, Min Liu, Youwei Zhang

“…The existing methods for the construction of prognosis prediction models are mostly based on single models such as linear models, SVM, and decision trees. …”
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Sialyltransferase-related genes as predictive factors for therapeutic response and prognosis in cervical cancer by Jia Shao, Can Zhang, Yaonan Tang, Aiqin He, Xiangyan Cheng

“…Cox regression analysis and “glmnet” R package were applied to establish the relevant risk model. “MCPcounter” R package, ESTIMATE algorithm and TIMER online tools were used to depict the tumor immune microenvironment in CC. …”
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Machine Learning and Interpretability Study for Predicting 30-Day Unplanned Readmission Risk of Schizophrenia: A Retrospective Study by Tan Y, Chen G, Wang S, Zhan X, Cheng R, Qiao L, Zhang Z, Liu Y

“…Models were constructed after screening variables using the multiple linear regression and feature importance methods. …”
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A machine learning framework for predicting cognitive impairment in aging populations using urinary metal and demographic data by Fengchun Ren, Xiao Zhao, Qin Yang, Huaqiang Liao, Yudong Zhang, Xuemei Liu

“…Ultimately, a user-friendly webserver was deployed for the predictive model and is freely accessed at http://bio-medical.online/admxp/.DiscussionThe associated webserver enables accessible risk screening and underpins precision prevention strategies in aging populations.…”
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Empowering Healthcare: TinyML for Precise Lung Disease Classification by Youssef Abadade, Nabil Benamar, Miloud Bagaa, Habiba Chaoui

“…These findings highlight the potential of TinyML to provide accessible, reliable, and real-time diagnostic tools, particularly in remote and underserved areas, demonstrating the transformative impact of integrating advanced AI algorithms into portable medical devices. This advancement facilitates the prospect of automated respiratory health screening using lung sounds.…”
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DEVELOPMENT OF SOFTWARE SYSTEM FOR MONITORING OF STRESS CORROSION CRACKING OF THE PIPELINE UNDER TENSION by Z. K. Abaev, B. A. Bachiev

“…The working algorithm of developed program and the screen forms are presented.…”
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Defining disease phenotypes using national linked electronic health records: a case study of atrial fibrillation. by Katherine I Morley, Joshua Wallace, Spiros C Denaxas, Ross J Hunter, Riyaz S Patel, Pablo Perel, Anoop D Shah, Adam D Timmis, Richard J Schilling, Harry Hemingway

“…<h4>Results</h4>The phenotype algorithm incorporated 286 codes: 201 Read, 63 BNF, 18 ICD-10, and four OPCS-4. …”
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Joint analysis of single-cell RNA sequencing and bulk transcriptome reveals the heterogeneity of the urea cycle of astrocytes in glioblastoma by Minfeng Tong, Qi Tu, Lude Wang, Huahui Chen, Xing Wan, Zhijian Xu

“…For bulk RNA-seq, univariate Cox and LASSO analyses were undertaken to screen prognostic genes, while multivariate Cox regression analysis was applied to set up a prognostic model. …”
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Inflammation-related 5-hydroxymethylation signatures as markers for clinical presentations of coronary artery disease by Jing Xu, Hangyu Chen, Jingang Yang, Yanmin Yang, Yuan Wu, Jun Zhang, Jiansong Yuan, Tianjie Wang, Tao Tian, Jia Li, Xueyan Zhao, Xiaojin Gao, Jie Lu, Lin Li, Lei Zhang, Xuehui Li, Long Chen, Chuan He, Chaoran Dong, Jian Lin, Weixian Yang, Yuejin Yang

“…Using machine learning algorithms, we identified inflammation-related 5hmC modifications associated with disease severity and constructed a classification model based on key hydroxymethylated markers. …”
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