Integrated analysis of single-cell RNA-seq and spatial transcriptomics to identify the lactylation-related protein TUBB2A as a potential biomarker for glioblastoma in cancer cells... by Yifan Xu, Chonghui Zhang, Jinpeng Wu, Pin Guo, Nan Jiang, Chao Wang, Yugong Feng

“…Notably, the expression levels of these three hub genes and the lactylation level of TUBB2A in GBM tissues were significantly higher compared to those in normal tissues.ConclusionsWe propose and validate a IQR lactylation screening method that provides potential insights for GBM therapy and an effective framework for developing gene screening models applicable to other diseases and pathogenic mechanisms.…”
Get full text

Bioinformatics analysis of potential targets influencing the prognosis of OSCC by ZOU Xian, SONG Tao

“…The Timer website was used to analyze the relationship between hub genes and immune cell infiltration and immune checkpoints. Based on Lasso-Cox algorithm, a prognostic risk model of related genes was constructed. …”
Get full text

Exploring biomarkers and molecular mechanisms of Type 2 diabetes mellitus promotes colorectal cancer progression based on transcriptomics by Simin Luo, Yuhong Zhu, Zhanli Guo, Chuan Zheng, Xi Fu, Fengming You, Xueke Li

“…The diagnostic performance was assessed by supplementing external datasets to draw ROC curves on the diagnostic model. The diagnostic model was further screened for key genes by prognostic analysis. …”
Get full text

Technical Code Analysis of Geomagnetic Flaw Detection of Suppression Rigging Defect Signal Based on Convolutional Neural Network by Gang Zhao, Changyu Han, Zhongxiang Yu, Zhipan Li, Guoao Yu, Hongmei Zhang, Dadong Zhao, Zhengyi Jiang

“…The single-stage object detection algorithm YOLOv5 (You Only Look Once) based on convolutional neural network model calculation is used, the scale detection layer and positioning loss function of the YOLOv5 algorithm are improved and optimized, and the improved YOLOv5 algorithm is used for experiments. …”
Get full text

Photon Counting Based on Solar-Blind Ultraviolet Intensified Complementary Metal-Oxide-Semiconductor (ICMOS) for Corona Detection by Yan Wang, Yunsheng Qian, Xiangyu Kong

“…Then, applying photon counting statistics, a theoretical probability model of the photon numbers is obtained. Meanwhile, through analyzing the structure of the photon events considering both pixel and temporal resolution, two photon counting algorithms are proposed. …”
Get full text

Integrated multiomics analysis and machine learning refine molecular subtypes and prognosis for thyroid cancer by Peng Zhang, Meizhong Qin, Fen Li, Kunpeng Hu, He Huang, Cuicui Li

“…Abstract Background Thyroid cancer (THCA) exhibits high molecular heterogeneity, posing challenges for precise prognosis and personalized therapy. Most existing models rely on single-omics data and limited algorithms, reducing robustness and clinical value. …”
Get full text

The value of habitat analysis based on 18F-PSMA-1007 PET/CT images for prostate cancer risk grading by Yang Wang, Hongyue Zhao, Zhehao Lyu, Linhan Zhang, Wei Han, Zeyu Wang, Jiafu Wang, Xinyue Zhang, Shibo Guo, Peng Fu, Changjiu Zhao

“…Independent risk factors were screened and a combined model was constructed to predict GS grade by univariate logistic regression followed by multivariate logistic regression of habitat (1–4) and clinical factors (SUVmax, tPSA, fPSA/tPSA, age). …”
Get full text

3D Film Animation Image Acquisition and Feature Processing Based on the Latest Virtual Reconstruction Technology by Siwei Wu, Shan Xiao, Yihua Di, Cheng Di

“…Finally, the target 3D face is reconstructed using the feature points of the target face for model matching. The experimental results show that the algorithm reconstructs faces with high realism and accuracy, and the algorithm can reconstruct expression faces.…”
Get full text

An estimation method of lightning-voltage sag severity based on adaptive association rule mining by WANG Ying, LEI Lei, HU Wenxi, XIAO Xianyong

“…The key condition attributes that affect voltage sag severity are screened by attribute reduction algorithm. An association rule mining algorithm based on parameter adaption is proposed, which overcomes the problem that the results of traditional association rules mining methods are affected by non-uniform data. …”
Get full text

Predicting radiation pneumonitis in lung cancer using machine learning and multimodal features: a systematic review and meta-analysis of diagnostic accuracy by Zhi Chen, GuangMing Yi, XinYan Li, Bo Yi, XiaoHui Bao, Yin Zhang, XiaoYue Zhang, ZhenZhou Yang, Zhengjun Guo

“…By selecting multiple machine learning algorithm frameworks and competing for the best combination model based on research goals, the reliability and accuracy of the radiation pneumonitis prediction model can be greatly improved. …”
Get full text

Intratumoral and peritumoral CT radiomics in predicting anaplastic lymphoma kinase mutations and survival in patients with lung adenocarcinoma: a multicenter study by Weiyue Chen, Guihan Lin, Ye Feng, Yongjun Chen, Yanjun Li, Jianbin Li, Weibo Mao, Yang Jing, Chunli Kong, Yumin Hu, Minjiang Chen, Shuiwei Xia, Chenying Lu, Jianfei Tu, Jiansong Ji

“…The GPTV3 radiomics model using a support vector machine algorithm achieved the best predictive performance, with the highest average AUC of 0.811 in the validation sets. …”
Get full text

Role of arachidonic acid metabolism in osteosarcoma prognosis by integrating WGCNA and bioinformatics analysis by Yaling Wang, Peichun HSU, Haiyan Hu, Feng Lin, Xiaokang Wei

“…An AA metabolism predictive model of the five AAMRGs were established by Cox regression and the LASSO algorithm. …”
Get full text

The Effect of Arctic Sea‐Ice Loss on Extratropical Cyclones by Stephanie Hay, Matthew D. K. Priestley, Hao Yu, Jennifer L. Catto, James A. Screen

Get full text

Predicting cardiotoxicity in drug development: A deep learning approach by Kaifeng Liu, Huizi Cui, Xiangyu Yu, Wannan Li, Weiwei Han

“…We used four types of molecular fingerprints and descriptors combined with machine learning and deep learning algorithms, including Gaussian naive Bayes (NB), random forest (RF), support vector machine (SVM), K-nearest neighbors (KNN), eXtreme gradient boosting (XGBoost), and Transformer models, to build predictive models. …”
Get full text

A Dynamic Adaptive Ensemble Learning Framework for Noninvasive Mild Cognitive Impairment Detection: Development and Validation Study by Aoyu Li, Jingwen Li, Yishan Hu, Yan Geng, Yan Qiang, Juanjuan Zhao

“…To address the challenges (eg, the curse of dimensionality and increased model complexity) posed by high-dimensional features, we developed a dynamic adaptive feature selection optimization algorithm to identify the most impactful subset of features for classification performance. …”
Get full text

Global trends in machine learning applications for single-cell transcriptomics research by Xinyu Liu, Zhen Zhang, Chao Tan, Yinquan Ai, Hao Liu, Yuan Li, Jin Yang, Yongyan Song

“…Research hotspots concentrated on random forest (RF) and deep learning models, showing transition from algorithm development to clinical applications (e.g., tumor immune microenvironment analysis). …”
Get full text

The CD163 + tissue-infiltrating macrophages regulate ferroptosis in thyroid-associated ophthalmopathy orbital fibroblasts via the TGF-β/Smad2/3 signaling pathway by Xuemei Li, Siyi Wang, Hanwen Cao, Simin Xu, Chao Xiong, Jinhai Yu, Yunxiu Chen, Zhangjun Ren, Min Li, Ying Hu, Puying Gan, Qihua Xu, Yaohua Wang, Hongfei Liao

“…Finally, potential clinical drugs targeting CD163 + macrophages with high ferroptosis activity in TAO were predicted using the Random Walk with Restart (RWR) algorithm combined with the DGIdb database. Results We first utilized TAO-related datasets from the GEO database, combined with the FerrDb ferroptosis database, to identify changes in iron metabolism genes during TAO progression through differential expression analysis, screening 7 key ferroptosis-related proteins. …”
Get full text

Time-Distributed Vision Transformer Stacked With Transformer for Heart Failure Detection Based on Echocardiography Video by Mgs M. Luthfi Ramadhan, Adyatma W. A. Nugraha Yudha, Muhammad Febrian Rachmadi, Kevin Moses Hanky Jr Tandayu, Lies Dina Liastuti, Wisnu Jatmiko

“…This study proposed a novel deep learning model consisting of a time-distributed vision transformer stacked with a transformer. …”
Get full text

A FixMatch Framework for Alzheimer’s Disease Classification: Exploring the Trade-Off Between Supervision and Performance by Al Hossain, Umme Hani Konok, MD Tahsin, Raihan Ul Islam, Mohammad Rifat Ahmmad Rashid, Mohammad Shahadat Hossain, Karl Andersson

“…While experienced medical professionals can often identify AD through conventional assessment methods, limited resources and growing patient populations make large-scale and rapid screening increasingly necessary. In this work, we explore whether the FixMatch algorithm—a semi-supervised learning approach—can aid in classifying Alzheimer’s Disease (AD), Mild Cognitive Impairment (MCI), and Cognitively Normal (CN) by using the ADNI fMRI dataset of 5,182 images. …”
Get full text

Factors Influencing Misinformation Propagation: A Systemic Review by HAN Xi, LIAO Ke

“…This study constructs an integrated model of the influencing factors for misinformation propagation, which can provide direction for targeted interventions and algorithm design to mitigate the spread of misinformation. …”
Get full text