Characterization of the salivary microbiome in healthy individuals under fatigue status by Xianhui Peng, Na Han, Yanan Gong, Lihua He, Yanli Xu, Di Xiao, Tingting Zhang, Yujun Qiang, Xiuwen Li, Wen Zhang, Jianzhong Zhang

“…Bioinformatics analyses encompassed assessment of alpha and beta diversity, identification of differential taxa using Linear discriminant analysis Effect Size (LEfSe) with multi-method cross-validation, construction of microbial co-occurrence networks, and screening of fatigue-associated biomarker genera via the Boruta-SHAP algorithm. …”
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Cathepsin G promotes arteriovenous fistula maturation by positively regulating the MMP2/MMP9 pathway by Lemei Hu, Changqing Zheng, Ying Kong, Zhiqing Luo, Fengzhang Huang, Zhigang Zhu, Quhuan Li, Ming Liang

“…We screened 84 differentially expressed genes (DEGs) and performed the functional enrichment analysis. …”
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A Two-Stage Penalized Logistic Regression Approach to Case-Control Genome-Wide Association Studies by Jingyuan Zhao, Zehua Chen

“…This approach consists of a screening stage and a selection stage. In the screening stage, main-effect and interaction-effect features are screened by using L1-penalized logistic like-lihoods. …”
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High-performance computing for static security assessment of large power systems by Venkateswara Rao Kagita, Sanjaya Kumar Panda, Ram Krishan, P. Deepak Reddy, Jabba Aswanth

“…We perform extensive experiments to evaluate the efficacy of the proposed algorithm. As a result, we establish that the proposed parallel algorithm with high-performance computing (HPC) computing is much faster than the traditional algorithms. …”
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Machine learning and multi-omics analysis reveal key regulators of proneural–mesenchymal transition in glioblastoma by Can Xu, Jin Yang, Huan Xiong, Xiaoteng Cui, Yuhao Zhang, Mingjun Gao, Lei He, Qiuyue Fang, Changxi Han, Wei Liu, Yangyang Wang, Jin Zhang, Ying Yuan, Zhaomu Zeng, Ruxiang Xu

“…The Lasso, Cox, and Step machine learning algorithms were used to construct and screen the optimal risk assessment prognostic model. …”
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Identification of hub genes for the diagnosis associated with heart failure using multiple cell death patterns by Hua‐jing Yuan, Hui Yu, Yi‐ding Yu, Xiu‐juan Liu, Wen‐wen Liu, Yi‐tao Xue, Yan Li

“…Bioinformatics and machine learning algorithms were utilized to screen the HF key genes and PCD‐related HF hub genes, and an HF diagnostic model was constructed on this. …”
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ERBB3-related gene PBX1 is associated with prognosis in patients with HER2-positive breast cancer by Shufen Mo, Haiming Zhong, Weiping Dai, Yuanyuan Li, Bin Qi, Taidong Li, Yongguang Cai

“…Utilizing three distinct machine learning algorithms, we identified three signature genes-PBX1, IGHM, and CXCL13-that exhibited significant diagnostic value within the diagnostic model. …”
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Digital augmentation of aftercare for patients with anorexia nervosa: the TRIANGLE RCT and economic evaluation by Janet Treasure, Katie Rowlands, Valentina Cardi, Suman Ambwani, David McDaid, Jodie Lord, Danielle Clark Bryan, Pamela Macdonald, Eva Bonin, Ulrike Schmidt, Jon Arcelus, Amy Harrison, Sabine Landau

“…However, some feedback was that the intervention offered too little, too late, and that a more personalised intervention would be more helpful. …”
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Improving synergistic drug combination prediction with signature-based gene expression features in oncology by Mozhgan Mozaffarilegha, Sajjad Gharaghani

“…We compared their performance with that of conventional drug signatures and chemical structure-based descriptors.Results:Our results demonstrate that models incorporating DRS features consistently outperform traditional approaches across all evaluated algorithms. …”
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Identification of three T cell-related genes as diagnostic and prognostic biomarkers for triple-negative breast cancer and exploration of potential mechanisms by Zhi-Chuan He, Zheng-Zheng Song, Zhe Wu, Peng-Fei Lin, Xin-Xing Wang

“…Differentially expressed genes (DEGs) between TNBC and other BRCA subtypes were intersected with T cell-related genes to identify candidate biomarkers. Machine learning algorithms were used to screen for key hub genes, which were then used to construct a logistic regression (LR) model. …”
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Exploring pesticide risk in autism via integrative machine learning and network toxicology by Ling Qi, Jingran Yang, Qiao Niu, Jianan Li

“…Each combination of 1–23 targets was used to construct predictive models using eight different machine learning algorithms. …”
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Machine learning-derived prognostic signature integrating programmed cell death and mitochondrial function in renal clear cell carcinoma: identification of PIF1 as a novel target by Guangyang Cheng, Zhaokai Zhou, Shiqi Li, Fu Peng, Shuai Yang, Chuanchuan Ren

“…Finally, a novel RCC prognostic marker PIF1 was identified in model genes. The knockdown of PIF1 in vitro inhibited the progression of renal carcinoma cells. …”
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Identification and validation of the diagnostic biomarker MFAP5 for CAVD with type 2 diabetes by bioinformatics analysis by Qiang Shen, Lin Fan, Chen Jiang, Dingyi Yao, Xingyu Qian, Fuqiang Tong, Zhengfeng Fan, Zongtao Liu, Nianguo Dong, Chao Zhang, Jiawei Shi

“…Machine learning (ML) algorithms were employed to screen potential biomarkers. …”
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Signatures of Six Autophagy‐Related Genes as Diagnostic Markers of Thyroid‐Associated Ophthalmopathy and Their Correlation With Immune Infiltration by Qintao Ma, Yuanping Hai, Jie Shen

“…The combined six‐gene model also showed good diagnostic efficacy (AUC = 0.948). …”
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Identifying and Validating an Acidosis-Related Signature Associated with Prognosis and Tumor Immune Infiltration Characteristics in Pancreatic Carcinoma by Pingfei Tang, Weiming Qu, Dajun Wu, Shihua Chen, Minji Liu, Weishun Chen, Qiongjia Ai, Haijuan Tang, Hongbing Zhou

“…Univariate Cox regression and the Kaplan–Meier method were applied to screen for prognostic genes. The least absolute shrinkage and selection operator (LASSO) Cox regression was used to establish the optimal model. …”
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Novel insights into the molecular mechanisms of sepsis-associated acute kidney injury: an integrative study of GBP2, PSMB8, PSMB9 genes and immune microenvironment characteristics by Haiting Ye, Xiang Zhang, Pengyan Li, Mei Wang, Ruolan Liu, Dingping Yang

“…Immune cell infiltration was analyzed using the CIBERSORT algorithm, and potential associations between the hub genes and clinicopathological features were explored based on the Nephroseq database. …”
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Cell death-related signature genes: risk-predictive biomarkers and potential therapeutic targets in severe sepsis by Yanan Li, Yuqiu Tan, Zengwen Ma, Zengwen Ma, Weiwei Qian, Weiwei Qian

“…Further combining cell death-related gene screening and four machine learning algorithms (including LASSO-logistic, Gradient Boosting Machine, Random Forest and xGBoost), nine SeALAR-characterized cell death genes (SeDGs) were screened and a risk prediction model based on SeDGs was constructed that demonstrated good prediction performance. …”
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Opening closed doors: using machine learning to explore factors associated with marital sexual violence in a cross-sectional study from India by Anita Raj, Abhishek Singh, Nandita Bhan, Lotus McDougal, Nabamallika Dehingia, Julian McAuley

“…Analyses included iterative thematic analysis (L-1 regularised regression followed by iterative qualitative thematic coding of L-2 regularised regression results) and neural network modelling.Outcome measure Participants reported their experiences of sexual violence perpetrated by their current (or most recent) husband in the previous 12 months. …”
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Improving the accuracy of remotely sensed TSS and turbidity using quality enhanced water reflectance by a statistical resampling technique by Kunwar Abhishek Singh, Dongryeol Ryu, Meenakshi Arora, Manoj Kumar Tiwari, Bhabagrahi Sahoo

“…The statistical resampling approach based on GMM was applied to Sentinel-2 (S2) imagery to produce input to Machine Learning (ML) algorithms to retrieve the TSS and turbidity for target river sections. …”
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Characterization and stratification of risk factors of stroke in people living with HIV: A theory-informed systematic review by Martins Nweke, Nombeko Mshunqane

“…Predictive and preventative models should target factors with a high causality index and low investigative costs. …”
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