Prevalence, types, risk factors and clinical correlates of anaemia in older people in a rural Ugandan population. by Joseph O Mugisha, Kathy Baisley, Gershim Asiki, Janet Seeley, Hannah Kuper

“…Clinicians should consider screening older people with HIV or malaria for anaemia. …”
Get full text

High-throughput discovery of genetic determinants of circadian misalignment. by Tao Zhang, Pancheng Xie, Yingying Dong, Zhiwei Liu, Fei Zhou, Dejing Pan, Zhengyun Huang, Qiaocheng Zhai, Yue Gu, Qingyu Wu, Nobuhiko Tanaka, Yuichi Obata, Allan Bradley, Christopher J Lelliott, Sanger Institute Mouse Genetics Project, Lauryl M J Nutter, Colin McKerlie, Ann M Flenniken, Marie-France Champy, Tania Sorg, Yann Herault, Martin Hrabe De Angelis, Valerie Gailus Durner, Ann-Marie Mallon, Steve D M Brown, Terry Meehan, Helen E Parkinson, Damian Smedley, K C Kent Lloyd, Jun Yan, Xiang Gao, Je Kyung Seong, Chi-Kuang Leo Wang, Radislav Sedlacek, Yi Liu, Jan Rozman, Ling Yang, Ying Xu

“…We developed a machine learning algorithm to quantify these two parameters in our misalignment screen (SyncScreener) with existing datasets and used it to screen 750 mutant mouse lines from five IMPC phenotyping centres. …”
Get full text

Atrial fibrillation with thrombotic complications. Justification of the diagnosis and treatment regimen according to evidence-based medicine (clinical case) by L.O. Martymianova, E.P. Kamenska, A.O. Bulyha, K.О. Serdyuk

“…Diagnosis and systematic screening of AF, as well as timely assessment of stroke risk, are of paramount importance for the prognosis of patients, especially in older age groups. …”
Get full text

Mesangial cell-derived CircRNAs in chronic glomerulonephritis: RNA sequencing and bioinformatics analysis by Ji Hui Fan, Xiao Min Li

“…Furthermore, three hub mRNAs (BOC, MLST8, and HMGCS2) from the CeRNA network were screened using LASSO algorithms. GSEA analysis revealed that hub mRNAs were implicated in a great deal of immune system responses and inflammatory pathways, including IL-5 production, MAPK signaling pathway, and JAK-STAT signaling pathway. …”
Get full text

Machine learning in dentistry and oral surgery: charting the course with bibliometric insights by Shuangwei Liu, Yuquan Hao, Shijie Zhu, Liyao Wan, Zhe Yi, Zhichang Zhang

“…Moreover, challenges, such as data availability and security, algorithmic biases, and “black-box models”, must be addressed. …”
Get full text

Will Artificial Intelligence Replace Physicians or Augment Their Capabilities? by Sara Rahmati Roodsari, Alireza Zali, Mohammad Rahmati-Roodsari, Behina Forouzanmehr

“…In medical imaging, deep learning algorithms, especially those trained with genetic algorithms, have demonstrated immense promise to improve the accuracy of pneumonia and COVID-19 diagnosis from chest X-rays. …”
Get full text

Miniaturized Near-Infrared Analyzer for Quantitative Detection of Trace Water in Ethylene Glycol by Qunling Luo, Zhiqiang Guo, Danping Lin, Boxue Chang, Yinlan Ruan

“…To address the limitations of a traditional Fourier-transform infrared (FTIR) spectrometer, including its bulky size, high cost, and unsuitability for on-site industrial detection, this study developed a Fourier-transform near-infrared (FT-NIR) absorption testing system utilizing Micro-Electro-Mechanical System (MEMS) technology for detecting trace water content in ethylene glycol. The modeling performances of three algorithms including Support Vector Machine Regression (SVMR), Principal Component Regression (PCR), and Partial Least Squares Regression (PLSR) were systematically evaluated, with PLSR identified as the optimal algorithm. …”
Get full text

On the construction of a large-scale database of AI-assisted annotating lung ventilation-perfusion scintigraphy for pulmonary embolism (VQ4PEDB) by Amir Jabbarpour, Eric Moulton, Eric Moulton, Sanaz Kaviani, Sanaz Kaviani, Siraj Ghassel, Wanzhen Zeng, Wanzhen Zeng, Ramin Akbarian, Ramin Akbarian, Anne Couture, Aubert Roy, Richard Liu, Yousif A. Lucinian, Nuha Hejji, Nuha Hejji, Sukainah AlSulaiman, Sukainah AlSulaiman, Farnaz Shirazi, Farnaz Shirazi, Eugene Leung, Eugene Leung, Sierra Bonsall, Samir Arfin, Bruce G. Gray, Ran Klein, Ran Klein, Ran Klein, Ran Klein

“…The annotated data was then ingested into Deep Lake, a SQL-based database, for AI model training. Quality assurance involved manual inspections and algorithmic validation.ResultsA query of The Ottawa Hospital's data warehouse followed by initial data screening yielded 2,137 V/Q studies with 2,238 successfully retrieved as DICOM studies. …”
Get full text

Deciphering mitochondrial dysfunction in keratoconus: Insights into ACSL4 from machine learning-based bulk and single-cell transcriptome analyses and experimental validation by Yuchen Cai, Tianyi Zhou, Xueyao Cai, Wenjun Shi, Hao Sun, Yao Fu

“…Hub genes were further screened and validated by multiple machine learning (ML) algorithms, followed by a comprehensive visualization of single-cell atlas and immune landscape. …”
Get full text

Exploring Mechanisms of Lang Qing Ata in Non-Alcoholic Steatohepatitis Based on Metabolomics, Network Pharmacological Analysis, and Experimental Validation by Li S, Zhu H, Zhai Q, Hou Y, Yang Y, Lan H, Jiang M, Xuan J

“…These discoveries were further validated in subsequent mouse models. An HFHC-induced NASH mouse model was used to validate the therapeutic effects and potential mechanisms of LQAtta on NASH.Results: From the UHPLC-MS/MS analysis of LQAtta, a total of 1518 chemical components were identified, with 106 of them being absorbed into the bloodstream. …”
Get full text

Microarray profile of circular RNAs identifies CBT15_circR_28491 and T helper cells as new regulators for deep vein thrombosis by Weiwei Chen, Ying Zhu, Sihua Niu, Yan Zhou, Jian Chang, Shujie Gan

“…Finally, a DVT rat model was established to verify the expression of critical circRNAs and hub genes using real-time quantitative PCR.ResultsA total of 421 circRNAs and 1,082 mRNAs were differentially expressed in DVT. …”
Get full text

Maternal factors associated with early-onset neonatal sepsis among caesarean-delivered babies at Mbarara Regional Referral Hospital, Uganda: a case-control study by James M. Maisaba, Richard Migisha, Asiphas Owaraganise, Leevan Tibaijuka, David Collins Agaba, Joy Muhumuza, Joseph Ngonzi, Stella Kyoyagala, Musa Kayondo

“…We enrolled mother-baby pairs for both groups, obtaining maternal data via structured questionnaires The diagnosis of EONS was made using the WHO Young Infant Integrated Management of Childhood Illnesses algorithm. …”
Get full text

Beyond identification of familial hypercholesterolemia: Improving downstream visits and treatments in a large health care system by Harin Lee, Tarun Kadaru, Ruth Schneider, Taylor Triana, Carol Tujardon, Colby Ayers, Mujeeb Basit, Zahid Ahmad, Amit Khera

“…Patients whose PCP was contacted were more likely to have adjustments made to their lipid lowering medication(s) (p = 0.016), be diagnosed with FH (p = 0.025), and have a follow-up visit (p = 0.033). …”
Get full text

Estimation of the aboveground carbon stocks based on tree species identification in Saihanba plantation forest by Ao Zhang, Xiaohong Wang, Xin Gu, Xiangyao Xu, Xintong Gao, Linlin Jiao

“…The results were shown that: 1) The identification effect of Scheme IV, as ascertained by screening three types of effective feature vectors based on the random forest algorithm, was the most effective, with an overall accuracy (OA) and kappa coefficient of 89.7% and 0.863, respectively. …”
Get full text

Artificial intelligence technology in ophthalmology public health: current applications and future directions by ShuYuan Chen, Wen Bai, Wen Bai

“…Key issues include interoperability with electronic health records (EHR), data security and privacy, data quality and bias, algorithm transparency, and ethical and regulatory frameworks. …”
Get full text

Advancements in Machine Learning (ML): Transforming the Future of Blood Cancer Detection and Outcome Prediction by Wiebke Rösler, Michael Roiss, Corinne Widmer

“…The diagnosis and treatment of hematologic malignancies are becoming more and more complex. Growing knowledge of pathophysiology, diagnostic methods and, last but not least, treatment options offer many opportunities for patients, but integrating the growing amount of knowledge into daily practice can be challenging. …”
Get full text

A Pervasive Respiratory Monitoring Sensor for COVID-19 Pandemic by Xiaoshuai Chen, Shuo Jiang, Zeyu Li, Benny Lo

“…Three modes (coughing, breathing and others) will be conducted to detect coughing and estimate different respiration rates. …”
Get full text

Robust Bi-CBMSegNet framework for advancing breast mass segmentation in mammography with a dual module encoder-decoder approach by Yu Wang, Mudassar Ali, Tariq Mahmood, Amjad Rehman, Tanzila Saba

“…Current target detection algorithms have limited applications and low accuracy. …”
Get full text

Machine learning for clustering and classification of early knee osteoarthritis using single-leg standing kinematics by Ui-Jae Hwang, Kyu Sung Chung, Sung-Min Ha

“…This study investigated the application of machine learning techniques to single-leg standing (SLS) kinematics to classify and predict EOA. (1) To identify distinct groups based on SLS kinematic patterns using unsupervised learning algorithms, (2) to develop supervised learning models to predict EOA status, and (3) to identify the most influential kinematic variables associated with EOA. …”
Get full text

Assessing the causal effect of inflammation‐related genes on myocarditis: A Mendelian randomization study by Huazhen Xiao, Hongkui Chen, Wenjia Liang, Yucheng Liu, Kaiyang Lin, Yansong Guo

“…The GWAS data (finn‐b‐I9 MYOCARD) contained single nucleotide polymorphisms (SNPs) data from 117 755 myocarditis samples (16 379 455 SNPs, 829 cases vs. 116 926 controls). Five algorithms [MR‐Egger, weighted median, inverse variance weighted (IVW), simple mode, and weighted mode regression] were employed for the MR analysis, with IVW as the primary method, and sensitivity analysis was conducted. …”
Get full text