Seizure prophylaxis following aneurysmal subarachnoid haemorrhage (SPSAH): study protocol for a multicentre randomised placebo-controlled trial of short-term sodium valproate proph... by Qiaowei Wu, Yuqi Chen, Chao You, Yuchen Li, Bowen Sun, Jianmin Zhang, Xin Hu, Pei Wu, Mei Fang, Zhiyi Xie, Honggang Wu, Shancai Xu, Bo Pang, Niandong Zheng

“…All analyses are by intention-to-treat.Ethics and dissemination This study will be conducted according to the principles of Declaration of Helsinki and good clinical practice guidelines. This trial involves human participants and has been approved by the ethics committee of West China Hospital. …”
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Race as a prognostic factor of breast mucinous carcinoma by Dingyuan Wang, Yang Wang, Songlin Gao, Rongshou Zheng, Guijian Wu, Jianping Wang, Can Lu, Kena Bu, Chun Zhang, Wanqing Chen, Bailin Zhang

“…The goal was to help formulate more personalized clinical practice guidelines for the management of this rare malignancy. …”
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Implementing a pharmacogenetic-driven algorithm to guide dual antiplatelet therapy (DAPT) in Caribbean Hispanics: protocol for a non-randomised clinical trial by Dagmar F Hernandez-Suarez, Kyle Melin, Frances Marin-Maldonado, Hector J Nunez, Ariel F Gonzalez, Lorena Gonzalez-Sepulveda, Sona Rivas-Tumanyan, Hetanshi Naik, Gualberto Ruaño, Stuart A Scott, Jorge Duconge

“…The study will be carried out in compliance with the Declaration of Helsinki and International Conference on Harmonization Good Clinical Practice Guidelines. Findings will be published in a peer-reviewed journal and controlled access to experimental data will be available.Trial registration number NCT03419325; Pre-results.…”
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Association between the number of retrieved lymph nodes and demographic/tumour-related characteristics in colorectal cancer: a systematic review and meta-analysis by Rui Zhang, Jing Yang, Min Zhang, Qianqian Liu, Min Huang, Yuping Bai, Tingting He, Ziru Zhao, Mengyuan Jiang, Haitong Zhao

“…Objective Clinical practice guidelines recommend retrieving at least 12 lymph nodes for correct staging in colorectal cancer. …”
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Combined 25-hydroxyvitamin D concentrations and physical activity on mortality in US stroke survivors: findings from the NHANES by Junqi Liao, Jingyi Chen, Huimin Wu, Qing Zhu, Xiaogang Tang, Li Li, Aimei Zhang, Peiyi Mo, Yan Liu, Xinyi Yang, Yang Han, Zhaoyao Chen, Wenlei Li, Yuan Zhu, Minghua Wu

“…These findings provide new ideas and possibilities for the prevention and treatment of cardiovascular and cerebrovascular diseases, offering a reference for development of clinical practice guidelines in the future.…”
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Protocol for a double-blinded randomised controlled trial and process evaluation of a digital psychotherapeutic app in Singapore to improve symptom burden in patients with dermatol... by Nick Sevdalis, Jose M Valderas, Valencia Long, Mark Jean-Aan Koh, Liang Shen, Phillip Phan, Ellie Choi, Nisha Suyien Chandran, Mayank Dalakoti, Ziying Vanessa Lim, Jia Yi Chua, Cyrus S Ho, Kean J Hsu

“…Statistical analysis will be carried out on an intention-to-treat basis, and missing data will be analysed using last observation carried forward.All participants will receive both verbal and written study information that aligns with Good Clinical Practice guidelines. Ethical approval has been obtained from the National Healthcare Group’s Domain Specific Review Board (reference number: 2022/00751). …”
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Vegetarian dietary patterns and cardiovascular risk factors and disease prevention: An umbrella review of systematic reviews by Matthew J. Landry, Katelyn E. Senkus, A Reed Mangels, Nanci S. Guest, Roman Pawlak, Sudha Raj, Deepa Handu, Mary Rozga

“…As vegetarian dietary patterns are increasingly being included within clinical practice guidelines, there is a need to review the most recent evidence regarding if and how these dietary patterns mitigate CVD risk. …”
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Investigating the nutritional status, outcomes and needs of adolescents and young adults (AYA) following a cancer diagnosis: protocol for a mixed-methods study by Andrew Murnane, Erin Laing, Belinda Steer, Jeremy Lewin, Heather Gilbertson, Elizabeth Mount, Mary-Anne Silvers, Jenelle Loeliger, Jodie Bartle, Kristin Mellett, June Savva, Pasquale L. Fedele, Lisa M. Orme, Leanne Super, Karla Gough, Kate Thompson

“…Results will inform future clinical practice guidelines and interventional nutrition research targeting patients identified at greater risk of nutritional complications.…”
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Assessing TDApp: An AI-based clinical decision support system for ADHD treatment recommendations by Evgenia Baykova, Òscar Raya, Cristina Lombardía, Begoña Gonzalvo, Inés Andreu, David Losada, Tania Falkenhain, Ruth Cunill, Domènec Serrano, David Rigau, David Ramírez-Saco, Beatriz López, Xavier Castells

“…IntroductionClinical practice guidelines (CPGs) have several limitations, namely: obsolescence, lack of personalization, and insufficient patient participation. …”
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Recommendations for the management of functional dyspepsia from the SEGHNP working group on motility and functional gastrointestinal disorders by Miguel Ángel Carro Rodríguez, Inmaculada Hidalgo Montes, Carmen Jovani Casano, Aránzazu Recio Linares, Etna Masip Simó, Gloria Rodrigo Garcia, Andrés Bodas Pinedo

“…As a result, there is evidence of substantial heterogeneity in the management of these patients due, in part, to the absence of clinical practice guidelines on this disease. Material and methods: A group was formed that consisted of 19 members of the working group on motility and functional gastrointestinal disorders (FGIDS) of the SEGHNP. …”
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The observational EURACAN prospective clinical registry dedicated to epithelioid hemangioendothelioma: The protocol of an international and collaborative effort on an ultra-rare en... by Anna Maria Frezza, Hugh Leonard, Ninna Aggerholm-Pedersen, Giuseppe Badalamenti, Paolo Baili, Giacomo G Baldi, Sebastian Bauer, Serena Bazzurri, Irene Benzonelli, Alexia Bertuzzi, Jean-Yves Blay, Giuseppe Bianchi, Simone Bonfarnuzzo, Christophe Bouvier, Kyetil Boye, Javier Martin Broto, Antonella Brunello, Domenico Campanacci, Paolo G Casali, Carlo Cicala, Elisa Crotti, Lorenzo D'Ambrosio, Angelo Paolo Dei Tos, Nils Dieckmann, Armelle Dufresne, Stephanie Elston, Virginia Ferraresi, Stefano Gabellini, Claudia Giani, Vincenzo Giannusa, Melissa Gil Sanjines, Teresa Grassani, Alessandro Gronchi, Paolo Lasalvia, Stefan Lindskog, Nadia Hindi, Matilde Ingrosso, Andrei Ivanescu, Robin Jones, Iwona Lugowska, Julia Ketzer, Anna Mariuk-Jarema, Alessandro Mazzocca, Laura Monteleone, Carlo Morosi, Andrea Napolitano, Francesca Nardozza, Elisabetta Neri, Maria Nilsson, Andri Papakonstantinou, Sandro Pasquali, Marta Sbaraglia, Federico Scolari, Joanna Szkandera, Claudia Valverde, Bruno Vincenzi, Salvatore Vizzaccaro, Federica Zuccheri, Silvia Stacchiotti, Annalisa Trama

“…VariablesFull details on patients and disease features, treatment and outcome will be collected, according to common clinical practice guidelines developed and shared with all the contributing centers. …”
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Guided self-determination intervention versus attention control for people with type 2 diabetes in outpatient clinics: a protocol for a randomised clinical trial by Christian Gluud, Jane Lindschou, Thordis Thomsen, Janus C Jakobsen, Vibeke Zoffmann, Anne Sophie Mathiesen, Tine Bruhn Skytte, Bodil Rasmussen, Emilie Marqvorsen, Mette Rothmann

“…Data will be collected using REDCap and analysed using Stata V.16.Ethics and dissemination The trial will be conducted in compliance with the protocol, the Helsinki Declaration in its latest form, International Harmonisation of Good Clinical Practice guidelines and the applicable regulatory requirement(s). …”
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Validation of a questionnaire to assess complexity of palliative care needs in primary care in Malaga, Spain: a study protocol by Jose Miguel Morales-Asencio, Rafael Gomez-Garcia, Pilar Barnestein-Fonseca, Francisca Leiva-Fernandez, Auxiliadora Fernández-López, Maria Luisa Martín-Roselló, Virginia Patricia Aguiar-Leiva

“…This protocol was conducted without patient or public participation.Ethics and dissemination This study evaluates a novel, co-designed tool to diagnose PC complexity to inform practice recommendations for a more efficient allocation of resources that may be included in future clinical practice guidelines. The study has been approved by the Provincial Research Ethics Committee of Málaga as of July 2023 and will be conducted in accordance with the principles established in the Declaration of Helsinki, the Council of Europe Convention on Human Rights and Biomedicine, and the requirements established in Spanish legislation. …”
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Web-Based Human Papillomavirus Education and Professional Skills Intervention for Health Care Providers: Protocol for a Randomized Controlled Trial by Jacob Martinez, Jacquelin I Cordero, Meagan Whitney, Katie L LaRoche, Gabriel Frietze, Eva M Moya, Kristin Gosselink

“…Tailored web-based educational programs for health care professionals, designed to address regional and patient population characteristics, may be a promising approach to enhancing the real-world implementation of clinical practice guidelines. Trial RegistrationClinicalTrials.gov NCT05120869; http://clinicaltrials.gov/ct2/show/NCT05120869 International Registered Report Identifier (IRRID)PRR1-10.2196/60790…”
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Diagnostic value of multiparametric ultrasound and the EU-TIRADS system for differentiation of focal thyroid lesions by A. V. Pomortsev, O. S. Tokarenko

“…In 2020, the EU-TIRADS system (2017) was included in Russian Clinical Practice Guidelines. Shear wave elastography (SWE) increases the diagnostic efficacy of ultrasonic B-mode examination of thyroid nodules and can be recommended to be included in the current classification system. …”
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The Effectiveness of Virtual Reality–Based Mindfulness Interventions for Managing Stress, Anxiety, and Depression: Protocol for a Systematic Review and Meta-Analysis of Randomized... by Ravi Shankar, Anjali Bundele, Amartya Mukhopadhyay

“…The findings will inform clinical practice guidelines for integrating VR-based mindfulness, guide technology development specifications, and establish evidence-based recommendations for health care policy regarding therapeutic VR reimbursement and regulatory frameworks. …”
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Association of serum 25-hydroxyvitamin D concentrations with risk of dementia among individuals with type 2 diabetes: A cohort study in the UK Biobank. by Tingting Geng, Qi Lu, Zhenzhen Wan, Jingyu Guo, Liegang Liu, An Pan, Gang Liu

“…Serum 25(OH)D ≥ 75 nmol/L was considered sufficient, according to the Endocrine Society Clinical Practice Guidelines. Incidence of all-cause dementia, AD, and VD cases was ascertained using electronic health records (EHRs). …”
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Intrapleural fibrinolysis and DNase versus video-assisted thoracic surgery (VATS) for the treatment of pleural empyema (FIVERVATS): protocol for a randomised, controlled trial – su... by Najib Rahman, Babu Naidu, Eihab O Bedawi, Zaigham Saghir, Uffe Bodtger, Bo Martin Bibby, Christian B Laursen, Thomas Decker Christensen, Morten Bendixen, Søren Helbo Skaarup, Jens-Ulrik Jensen, Rene Horsleben Petersen, Merete Christensen, Peter Licht, Kirsten Neckelmann, Lars B Møller, Morten Hornemann Borg, Sten Langfeldt, Stefan M W Harders

“…The research project is carried out in accordance with the Helsinki II Declaration, European regulations and Good Clinical Practice Guidelines. The Scientific Ethics Committees for Denmark and the Danish Data Protection Agency have provided permission. …”
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Advances in diagnostic assays for Clostridioides difficile infection in adults by Dong-ang Liu, Dong-ang Liu, Shiyu Chen, Shiyu Chen, Ruiyao Hu, Ruiyao Hu, Yuting Qiu, Yuting Qiu, Keyi Chen, Keyi Chen, Yue Xu, Yue Xu, Jinghua Yuan, Jinghua Yuan, Xinling Zhang, Xinling Zhang, Xiaoping Li, Xiaoping Li

“…Since publication of a review of the diagnosis of CDI in adults, new clinical diagnostic assays have become available and clinical practice guidelines were updated. This paper presents a comprehensive review of contemporary laboratory diagnostic approaches for CDI in adult patients, with a focus on the utilisation and potential advancements of five sophisticated methodologies, CRISPR in conjunction with nucleic acid amplification tests (NAATs), gene sequencing technology, ultra-high performance liquid chromatography-mass spectrometry, Raman spectroscopy, and real-time cell analysis (RTCA). …”
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Economic evaluations of maternal health interventions: a scoping review [version 2; peer review: 2 approved] by Sher Ting Chim, Steve McDonald, Rana Islamiah Zahroh, Katherine E. Eddy, Alexander Eggleston, Joshua P. Vogel, Doris Chou, Olufemi T. Oladapo, Caroline S. E. Homer, Nick Scott, Elizabeth Sebastian, Chloe Bykersma

“…Background Evidence on the affordability and cost-effectiveness of interventions is critical to decision-making for clinical practice guidelines and development of national health policies. …”
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