Nonproteinuric Preeclampsia among Women with Hypertensive Disorders of Pregnancy at a Referral Hospital in Southwestern Uganda by Asiphas Owaraganise, Richard Migisha, Wasswa G. M. Ssalongo, Leevan Tibaijuka, Musa Kayondo, Godfrey Twesigomwe, Joseph Ngonzi, Henry Mark Lugobe

“…Nonproteinuric preeclampsia poses even greater diagnostic challenges due to contested diagnostic criteria by the clinical practice guidelines and variable clinical presentation. …”
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Home-based Intervention with Semaglutide Treatment of Neuroleptic-Related Prediabetes (HISTORI): protocol describing a prospective, randomised, placebo controlled and double-blinde... by Peter Haulund Gæde, Jan Frystyk, Niels Bilenberg, Ashok Ainkaran Ganeshalingam, Nicolai Gundtoft Uhrenholt, Sidse Arnfred

“…Exploratory outcomes encompass insulin sensitivity, cardiovascular risk profile, medication adherence, general well-being and physical activity.Ethics and dissemination This study will be carried out in accordance with the Declaration of Helsinki and Good Clinical Practice guidelines. This research has obtained approval from both the Danish Medicines Agency and The Regional Committees on Health Research Ethics for Southern Denmark.Trial registration number NCT05193578 European Clinical Trials Database Number (EudraCT) 2020-004374-22, Regional Ethical Committee number S-20200182.…”
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Surgery versus non-operative treatment for ER-stress unstable Weber-B unimalleolar fractures: a study protocol for a prospective randomized non-inferiority (Super-Fin) trial by Pasi Ohtonen, Tero Kortekangas, Harri Pakarinen, Simo Taimela, Teppo Jarvinen, Ristomatti Lehtola, Hannu-Ville Leskelä, Olli Savola

“…Depending on the trauma and the accompanying soft-tissue injury, these fractures are either stable or unstable. Current clinical practice guidelines recommend surgical treatment for unstable Weber B-type fibula fractures. …”
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Impact of 2014 Japanese practice guidelines on treatment patterns in patients with myasthenia gravis: an insurance claims database study by Akiyuki Uzawa, Shingo Konno, Makoto Samukawa, Izumi Mishiro, Hiroshi Todaka, Kentaro Taki, Céline Quelen, Adrianna Czubin, Renata Majewska, Kunihiko Shiraiwa, Yohei Ohashi

“…Objectives To evaluate changes in oral corticosteroid (OCS) use after the publication of the 2014 Japanese clinical practice guidelines for myasthenia gravis (MG).Design Retrospective cohort study performed in three Japanese health insurance databases: the JMDC database between 2005 and 2021; the DeSC database covering the National Health Insurance (NHI) and the DeSC database covering the Late-Stage Elderly Healthcare Service (LSEHS) between 2014 and 2021. …”
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Voices from the clinic: a qualitative analysis of physiotherapy strategies in musculoskeletal care for knee osteoarthritis patients by Jennifer Nguyen, Justine M. Naylor, Sarah Dennis, Rebecca Livings, Kathryn Mills, Siobhan M. Schabrun, Jeanette M. Thom

“…However, little is known about the extent to which physiotherapists adhere to clinical practice guidelines. This study aimed to explore the perspectives and care patterns of physiotherapists in Sydney, Australia on their delivery of knee osteoarthritis care and how this aligns with the 2019 Osteoarthritis Research Society International (OARSI) guidelines. …”
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Prospective exploration of the effect of adiposity and associated microbial factors on healing and progression of diabetic foot ulcers in Tanzania: study protocol of a longitudinal... by Fredirick Mashili, Agricola Joachim, Mabulla Mchembe, Faraja Chiwanga, Agbor Ako, Zulfiqar Abbas

“…Enrolling 150 participants per group will have a minimum power of 80% to detect a 20% difference in cumulative incidence of complete ulcer healing (at the 5% level of statistical significance) between the normal and high adiposity groups.Ethical considerations and dissemination of results This study will be conducted in compliance with the independent institutional review boards (IRBs), informed consent guidelines, the declaration of Helsinki and International Conference on Harmonisation, Good Clinical Practice Guidelines. Ethical clearance has been granted by the Muhimbili University of Health and Allied Sciences ethical review board (MUHAS Ref. …”
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A Cross-sectional Survey of Physicians to Understand Biomarker Testing and Treatment Patterns in Patients with Prostate Cancer in the USA, EU5, Japan, and China by Christian Gratzke, Himani Aggarwal, Jeri Kim, Holly Chaignaud, Sabine Oskar

“…Conclusions and clinical implications: Overall, testing rates increased following PARPi approval and updated clinical practice guidelines; yet, there was a wide variation in the proportions of patients with mCRPC recommended for testing, and perceived barriers to testing remain, suggesting unmet needs for patients and physicians. …”
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Predictors of lipoprotein(a) variability in clinical practice and their impact on cardiovascular risk by Hyung Joon Joo, Seung Gyu Yun, Jae Hyoung Park, Soon Jun Hong, Cheol Woong Yu, Seung Yong Shin, Eung Ju Kim

“…Integrating these findings into clinical practice guidelines has the potential to improve cardiovascular risk management at the population level, reduce healthcare disparities, and inform targeted public health interventions aimed at cardiovascular prevention.…”
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Community and Social Context: An Important Social Determinant of Cardiovascular Disease by *Rahul Singh, *Zulqarnain Javed, Tamer Yahya, Javier Valero-Elizondo, Isaac Acquah, Adnan A. Hyder, Muhammad Haisum Maqsood, Zahir Amin, Sadeer Al-Kindi, Miguel Cainzos-Achirica, Khurram Nasir

“…Disease prevention frameworks and clinical practice guidelines in the United States (US) have traditionally ignored upstream social determinants of health (SDOH), which are critical for reducing disparities in cardiovascular disease (CVD)—the leading cause of death in the US. …”
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Metformin for covid-19: systematic review and meta-analysis of randomised controlled trials by Gordon Guyatt, Arnav Agarwal, Qi Zhou, Dena Zeraatkar, Thomas Agoritsas, Reed AC Siemieniuk, Romina Brignardello-Petersen, Nazmul Islam, Per Olav Vandvik, Saifur R Chowdhury, Md Kamrul Hasan, Mahmudur Rahman Chowdhury

“…Objective To summarise the effects of metformin on covid-19 to inform a World Health Organization (WHO) clinical practice guideline.Design Systematic review and meta-analysis.Data sources As part of a living systematic review and network meta-analysis of drug treatments for covid-19 (covid-19 LNMA), a search was performed of the WHO covid-19 database, six Chinese databases, and the Epistemonikos Foundation's Living Overview of the Evidence covid-19 Repository (covid-19 L-OVE).Eligibility criteria for selecting studies Randomised controlled trials that compared metformin with placebo in patients with acute covid-19 infection.Data synthesis Frequentist pairwise meta-analyses were performed using the restricted maximum likelihood random effects model. …”
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Rationale and Design of a Randomized Controlled Trial on Intensive Management of Blood PRESSure and Cholesterol in Elderly Chinese with Hypertension and Atrial FibrillatION (IMPRES... by Wei Zhang, Yi Chen, Qifang Huang, Ji-Guang Wang, Tianyu Xu, Xiaoxia Fu.

“…The procedures set out in this protocol are in accordance with the principles of the Declaration of Helsinki and Good Clinical Practice guidelines. The results will be published following the CONSORT statement in a peer-reviewed scientific journal (Trial registration number: NCT04111419).…”
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A roadmap to increasing access to AQP4-Ig testing for NMOSD: expert recommendations by Raquel Vassão-Araujo, Samira Apóstolos, Angela Marie Jansen, Marco A. Lana-Peixoto, Antonio Pereira Gomes Neto, Mariana Rico-Restrepo, Soniza Vieira Alves-Leon, Douglas Kazutoshi Sato

“…The public healthcare system should ensure the availability and accessibility of AQP4-IgG antibody testing. Clinical practice guidelines for NMOSD diagnosis and treatment must be established. …”
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Large simple randomized controlled trials—from drugs to medical devices: lessons from recent experience by Sergio Buccheri, Stefan James, Marion Mafham, Martin Landray, Tom Melvin, Jonas Oldgren, Richard Bulbulia, Louise Bowman, Lotje Anna Hoogervorst, Perla J. Marang-van de Mheen, Peter Juni, Peter McCulloch, Alan G. Fraser

“…Well-designed studies robustly inform clinical practice guidelines and decision-making, but administrative obstacles have made it increasingly difficult to conduct informative RCTs. …”
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Treatment Patterns of Patients With Pulmonary Hypertension: A Descriptive Study in Colombia by Manuel Machado‐Duque, Andrés Gaviria‐Mendoza, Luis Fernando Valladales‐Restrepo, Manuel Pacheco, Juan Sebastián Franco, María delRosario Forero, Rubiela Suarez, Oscar Peñuela, Jorge E. Machado‐Alba

“…However, current clinical practice guidelines recommend the use of combined therapy. …”
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Re-evaluating population-level screening recommendations to address increasing early-onset colorectal cancer rates in Australia: a modelling study☆ by J.-B. Lew, J. Worthington, H. Ge, Q. Luo, E. Feletto, K. Canfell, T. Price

“…These analyses supported the 2023 Clinical practice guidelines for the prevention, early detection and management of colorectal cancer: Population Screening, which led to the NBCSP including people aged 45-49 on an opt-in basis from July 2024.…”
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Challenges in amphetamine medication availability for individuals with ADHD: a narrative review of the current state of evidence by Mansour M. Alotaibi, Mansour M. Alotaibi, Naif Z. Alrashdi, Naif Z. Alrashdi, Bakriah Alzubaidi, Marzouq K. Almutairi, Sultan A. Alanazi, Anwar B. Almutairi, Mohammed M. Alqahtani, Mohammed M. Alqahtani

“…Policy reports from national institutions highlight persistent barriers to AMPH access, despite their inclusion in recent clinical practice guidelines. Prescription trends suggest significant treatment gaps for AMPH stimulants.ConclusionThe available evidence suggests a likely shortfall in AMPH-based medications. in Saudi Arabia, despite global and local evidence supporting their efficacy. …”
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Horner syndrome as a complication of ultrasound-guided ablation therapy for thyroid nodules: a scoping review by Tianhao Xie, Tianhao Xie, Yan Fu, Xiaoshi Jin, Xiaoshi Jin, Xiangxiang Ren, Xiangxiang Ren, Jing Zhang, Jing Zhang, Qian Sun, Qian Sun

“…Future prospective studies are needed to clarify incidence rates, long-term prognosis, and refine clinical practice guidelines.…”
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Safety and tolerability of a bevacizumab biosimilar (Effivia®) in adult Mexican patients with cancer: a multicenter, observational, prospective clinical study by Alberto Alfonso Pimentel-Rentería, David Francisco Cantú de León, Eliseo Neftalí De la Cruz, David Suárez, Manuel Rodulfo Segura, José Gustavo Núñez, Livan Delgado-Roche

“…Treatment regimens followed the Clinical Practice Guidelines and the Investigator criteria.ResultsAdult patients (n = 82) were included, 65.8% (n = 54) completed the full 6-cycle treatment, while 34.1% (n = 28) meet the criteria for early discontinuation including disease progression (18.3%), voluntary withdrawal or dropout (7.3%), treatment availability or brand switching (4.9%), and serious adverse events (3.7%). …”
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Prescribing lithium for the management of persons suffering from bipolar disorders: expert consensus based on a Delphi study by Gaia Sampogna, Isabella Berardelli, Umberto Albert, Giulio Perugi, Maurizio Pompili, Alfonso Tortorella, Mirko Manchia, Gabriele Sani, Andrea Fiorillo

“…Our findings should be used to develop clinical practice guidelines and reduce the discrepancy between international guidelines and ordinary care.…”
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Yangxinshi Tablets Versus Trimetazidine on Exercise Tolerance After Percutaneous Coronary Intervention: Rationale and Design of the Double-blind, Randomized HEARTRIP Trial by Yi Li, Jian Zhang, Hong Chen, Yi Zhang, Jing Li, Haichu Yu, Xiaoping Meng, Haitao Yuan, Lili Shao, Yaling Han

“…The procedures set out in this protocol are in accordance with the principles of the Declaration of Helsinki and the Good Clinical Practice guidelines. The results will be published following the guidelines of the CONSORT statement in a peer-reviewed scientific journal (Trial registration number: NCT03809273).…”
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