The Constellation of Macrovascular Risk Factors in Early Onset T2DM: A Cross-Sectional Study in Xinjiang Province, China by Mingchen Zhang, Jiangfeng Mao, Ablikm Tuerdi, Xiaoyun Zeng, Li Quan, Shan Xiao, Jun Zhu, Hua Yao

“…The prevalence of macro- and microvascular complications is astonishingly high in these young adults with T2DM. Moreover, young women with T2DM are more susceptible to cardiovascular complications than their male counterpart.…”
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Compulsive Buying Disorder among Medicine, Dentistry, and Nursing Undergraduate Students from Chengalpattu District, Tamil Nadu, India: A Cross-sectional Study by A Hari Narayanan, Vedapriya Dande Rajasekar, Raja Danasekaran, BN Surya, P Manoj, S Madhush Kumar, Rehana Syed, R Harishma

“…With the rise of consumerism and the proliferation of online shopping, compulsive buying has increased, particularly among adolescents and young adults. Aim: To estimate the prevalence of CBD and identify associated risk factors among undergraduate medical, dental, and nursing students. …”
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Affective valence predictors from real-world based short sprint interval training by Stefano Benítez-Flores, Flávio A. de S. Castro, Eduardo Caldas Costa, Daniel Boullosa, Todd A. Astorino

“…Seventeen (7 women/10 men) moderately active young adults (age ​= ​[28.2 ​± ​5.6] years; V˙O2max [maximum oxygen consumption] ​= ​[52.9 ​± ​8.1] mL·kg−1·min−1; BMI [body mass index] ​= ​[24 ​± ​2] kg·m−2) completed four low-volume running sSIT sessions (10 ​× ​4 ​s efforts with 30 ​s of passive recovery). …”
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The global, regional, and national burden of type 2 diabetes mellitus attributable to low physical activity from 1990 to 2021: a systematic analysis of the global burden of disease... by Jiehua Wei, Luying Fan, Zixuan He, Senmao Zhang, Ying Zhang, Xidi Zhu, Fan Xia, Xinli Song, Lizhang Chen, Zhiyong Zou, Tingting Wang

“…Substantial increases in national action are urgently needed to target elder populations especially in low-middle and middle SDI regions, and special efforts should be made to promote physical activity in young adults with LPA.…”
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Higher Long‐Term Visit‐to‐Visit Blood Pressure Variability Is Associated With Severe Cerebral Small Vessel Disease in the General Population by Xinyu Zhao, Ying Hui, Jing Li, Xian‐Quan Shi, Shuohua Chen, Han Lv, Shouling Wu, Zhenchang Wang

“…These associations were modified by age and hypertension status. Among young adults (age < 60 years), high PP variability was associated with severe cSVD burden (OR = 3.33, 95% CI: 1.31–8.44), LA (OR = 3.02, 95% CI: 1.31–6.93), and PVS (OR = 1.86, 95% CI: 1.20–2.88). …”
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Longitudinal Associations between Obesity, Inflammation, and the Incidence of Type 2 Diabetes Mellitus among US Black and White Adults in the CARDIA Study by Sharon H. Jackson, Anna Bellatorre, Timothy McNeel, Anna María Nápoles, Kelvin Choi

“…A cohort of nondiabetic respondents from the Coronary Artery Risk Development in Young Adults (CARDIA) study was followed from 2005-2006 (wave 7) to 2010-2011 (wave 8). …”
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Prognostic Modeling for Bone Sarcomas Based on a Large Prospective Cohort From a Tertiary Care Cancer Center in India by Jyoti Bajpai, Laboni Sarkar, Sushmita Rath, Akash Pawar, Arun Chandrashekharan, Goutam Panda, Dharmpal Jakar, Jaya Ghosh, Siddhartha Laskar, Bharat Rekhi, Nehal Khanna, Jifmi Jose, Mukta Ramdawar, Nilendu Purandare, Prabhat Bhargava, Nivedita Chakrabarty, Kunal Gala, Yogesh Kembhavi, Venkatesh Rangarajan, Shripad Banavali, Sudeep Gupta

“…PURPOSEOutcomes of adolescents and young adults (AYA) with bone sarcomas including osteosarcoma (OGS) and Ewing sarcoma (ES) are affected by various factors including inadvertent previous treatment and poor compliance. …”
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Computational Fluid Dynamics Analysis of Nasal Airway Changes after Treatment with C-Expander by Wang Xiao, Siling Liu, Yanqin Lu, Lei Lei, Ning Liu, Xiaoping Shen, Yuhong He, Ousheng Liu

“…The use of the C-expander is an effective treatment modality for maxillary skeletal deficiencies which can cause ailments and significantly reduce life expectancy in late adolescents and young adults. However, the morphological and dynamic effects on the nasal airway have not been reported. …”
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Increasing prevalence of thyroid autoimmunity in childhood type 1 diabetes in the pre-COVID but not during the COVID era by Vivien Herczeg, Eszter Muzslay, Diána Czipó, Lili Terkovics, Johanna Takács, Réka Garai, Réka Garai, Fanni Kovács, Andrea Luczay, Anna Körner, Péter Tóth-Heyn

“…Our study aimed to analyze the prevalence of thyroid autoimmunity (TA) over a 10-year period spanning pre-pandemic and pandemic years in a population who are regularly screened for thyroid disturbances.Materials and methodsThis single-center retrospective cohort study analyzed data from 1,361 children and young adults with type 1 diabetes (T1D) treated between 2013 and 2022 in Hungary’s largest pediatric endocrinology center. …”
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The role of inflammatory system genes in individual differences in nonverbal intelligence by R. F. Enikeeva, A. V. Kazantseva, Yu. D. Davydova, R. N. Mustafin, Z. R. Takhirova, S. B. Malykh, Y. V. Kovas, E. K. Khusnutdinova

“…Within the framework of the present study, we conducted the association analysis of six SNPs in the genes that encode proteins involved in inf lammatory response regulation in the central nervous system (CRP rs3093077, IL1А rs1800587, IL1B rs16944, TNF/ LTA rs1041981, rs1800629, and P2RX7 rs2230912), with nonverbal intelligence in mentally healthy young adults aged 18– 25 years without cognitive decline with inclusion of sex, ethnicity and the presence of the “risky” APOE ε4 allele as covariates. …”
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Automatic approach-avoidance tendency toward physical activity, sedentary, and neutral stimuli as a function of age, explicit affective attitude, and intention to be active by Farajzadeh, Ata, Goubran, Miriam, Beehler, Alexa, Cherkaoui, Noura, Morrison, Paula, de Chanaleilles, Margaux, Maltagliati, Silvio, Cheval, Boris, Miller, Matthew W., Sheehy, Lisa, Bilodeau, Martin, Orsholits, Dan, Boisgontier, Matthieu P.

“…Using computerized reaction-time tasks assessing automatic attitudes, studies have shown that healthy young adults have faster reaction times when approaching physical activity stimuli than when avoiding them. …”
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Safety and immunogenicity of Ad26.COV2.S in adolescents: Phase 2 randomized clinical trial by Jelena Tica, Veronica V. Rezelj, Benoit Baron, Vitalija van Paassen, Javier Zaidman, Lee Fairlie, Gert Scheper, Mathieu Le Gars, Frank Struyf, Macaya Douoguih, Javier Ruiz-Guiñazú

“…Spike-binding antibody responses were comparable to those elicited in young adults aged 18–25 years who received a standard dose of Ad26.COV2.S in Phase 3 efficacy studies Reduced doses/dose volume of Ad26.COV2.S had an acceptable safety profile and elicited robust humoral immune responses in adolescents aged 12–17 years. …”
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Characteristics of TSPO expression in marmoset EAE by Irene Falk, Dragan Maric, Emily Leibovitch, Pascal Sati, Jennifer Lefeuvre, Nicholas J. Luciano, Joseph Guy, Seung-Kwon Ha, David R. Owen, Franklin Aigbirhio, Paul M. Matthews, Daniel S. Reich, Steven Jacobson

“…Abstract Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) and is a leading non-traumatic cause of disability in young adults. The 18 kDa Translocator Protein (TSPO) is a mitochondrial protein and positron emission tomography (PET)-imaging target that is highly expressed in MS brain lesions. …”
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Monozygotic twins with myocarditis and a novel likely pathogenic desmoplakin gene variant by Antheia Kissopoulou, Eva Fernlund, Christina Holmgren, Eira Isaksson, Jan‐Erik Karlsson, Henrik Green, Jon Jonasson, Rada Ellegård, Hanna Klang Årstrand, Anneli Svensson, Cecilia Gunnarsson

“…Abstract Myocarditis most often affects otherwise healthy athletes and is one of the leading causes of sudden death in children and young adults. Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetically determined heart muscle disorder with increased risk for paroxysmal ventricular arrhythmias and sudden cardiac death. …”
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Generational trends in education and marriage norms in rural India: evidence from the Pune Maternal Nutrition Study by Akanksha A. Marphatia, Akanksha A. Marphatia, Jonathan C. K. Wells, Alice M. Reid, Marios Poullas, Aboli Bhalerao, Pallavi Yajnik, Chittaranjan S. Yajnik

“…We aimed to investigate changes in social norms across generations in rural Maharashtra, India.MethodsTo understand the status quo, we identified education levels and marriage ages typical of contemporary young adults in rural Maharashtra using the National Family Health Survey. …”
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Sex-specific alterations in creatine metabolism in cellular compartments of peripheral blood leukocytes in type 1 diabetes by Nina Alchujyan, Elena Aghajanova, Nina Movsesyan, Arthur Melkonyan, Artashes Guevorkian, Armen Andreasyan, Margarita Hovhannisyan

“…A total of 270 Armenian participants were enrolled in the study and were divided into two age groups: Group I - included children and preadolescents; and Group II - included adolescents and young adults. Within each group, the participants were further categorized based on sex and disease duration: Recent-onset T1D (RO-T1D), and Long-term T1D (LT-T1D). …”
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Inter-session Reliability of Magnetic Nerve Stimulation and Within-Session comparison to Electrical Nerve Stimulation in Evaluating Neuromuscular Function of Knee Extensor Muscles by Romina Ledergerber, Martin Keller

“…Methods This study compares ENS to MNS (validity) and evaluates inter-session reliability in sixteen healthy young adults (11 females, 5 males). Data on resting single twitches (RS), 3-5 superimposed twitches (ST) during maximal voluntary contractions of knee extensors, and resting doublet twitches (RD) were assessed using both MNS and ENS. …”
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Emotion dysregulation and impulsivity as overlapping symptoms in adult Attention-Deficit/Hyperactivity Disorder and Borderline Personality Disorder: severity profiles and associati... by Eszter Kenézlői, Lívia Balogh, Szilvia Somogyi, Evelyn E. Lévay, Zsuzsa Halmai, Zsófia Nemoda, Zsolt S. Unoka, János M. Réthelyi

“…Our aims were to describe their differences in the above conditions, investigate their associations with childhood traumatization, and to explore the potential mediation of emotion dysregulation and impulsivity between childhood traumas and personality functioning. Methods Young adults between 18 and 36 years diagnosed with aADHD (n = 100) and BPD (n = 63) were investigated with structured clinical interviews, while age-matched healthy controls (n = 100) were screened for psychiatric disorders. …”
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Prevalence and health consequences of nonmedical use of tramadol in Africa: A systematic scoping review. by Saidou Sabi Boun, Olumuyiwa Omonaiye, Sanni Yaya, Sanni Yaya

“…These groups include: 1) young adults/active populations with varying degrees of prevalence ranging from 1.9% to 77.04%, 2) professionals, where drivers exhibit a relatively high prevalence of tramadol NMU, ranging from 7.2% to 35.1%, and commercial motorcyclists, with a prevalence of 76%, 3) patients, who have a high rate of tramadol NMUs, with prevalence rates ranging from 77.1% to 92%, 4) academics, with a considerable rate of tramadol misuse among substance-using undergraduates (74.2%) and substance-using high school students (83.3%), and 5) other individuals impacted in various ways. …”
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Systematic preclinical evaluation of CD33-directed chimeric antigen receptor T cell immunotherapy for acute myeloid leukemia defines optimized construct design by Haiying Qin, Nirali N Shah, Terry J Fry, Lila Yang, John A Chukinas, Samiksha Tarun, Marie Pouzolles, Christopher D Chien, Lisa M Niswander, Anthony R Welch, Sarah K Tasian, Naomi A Taylor

“…Based on this rigorous preclinical evaluation, our validated clinical grade lintuzumab-CD28/CD3ζ CD33CART immunotherapy is now under evaluation in a first-in-child/first-in-human phase 1 clinical trial for children and adolescents/young adults with relapsed/refractory AML.Trial registration number clinicaltrials.gov; NCT03971799.…”
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