Optimising primary molecular profiling in non-small cell lung cancer. by R D Schouten, I Schouten, M M F Schuurbiers, V van der Noort, R A M Damhuis, E H F M van der Heijden, J A Burgers, N P Barlo, A S R van Lindert, K W Maas, J J G van den Brand, A A J Smit, J M W van Haarst, B van der Maat, E Schuuring, H Blaauwgeers, S M Willems, K Monkhorst, D van den Broek, M M van den Heuvel

“…Profiling of EGFR and ALK was performed in 69.9% of 136 patients included in the run-in phase, significantly more than real-world data estimates of 55% (p<0.001). Protocolised molecular profiling increased the rate to 77.0% (p = 0.049). …”
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Financing of Preschool Education in Ukraine in 1919–1933: Historical and Legal, Historical and Economic Aspects by S. O. Tkachenko, О. V. Golovko

“…That process was caused by the economic devastation in Ukraine as a result of the First World and Civil Wars, which doomed more than one million children to starvation. …”
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A metabologenomics approach reveals the unexplored biosynthetic potential of bacteria isolated from an Amazon Conservation Unit by Ana Carolina Favacho Miranda de Oliveira, Bruna Domingues Vieira, Rafael de Felício, Lucas da Silva e Silva, Adonney Allan de Oliveira Veras, Diego Assis das Graças, Artur Silva, Rafael Azevedo Baraúna, Daniela Barretto Barbosa Trivella, Maria Paula Cruz Schneider

“…Our findings illustrated the efficacy of the metabologenomics approach in elucidating secondary metabolism and selecting BGCs with chemical novelty.IMPORTANCEThe largest rainforest in the world is globally recognized for its biodiversity. …”
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Effect of delivery hospital busyness on early mortality in small preterm infants: a Finnish population-based cohort study in 2006–2016 by Mika Gissler, Sari Räisänen, Seppo Heinonen, Sture Andersson, Riitta Vilkko, Markus Leskinen

“…We analysed differences in the incidence of selected adverse outcomes between quiet and busy days compared with optimal delivery-volume days by logistic regression followed by crude (ORs) and adjusted ORs (aORs) with 99% CIs.Setting A population-based cohort study based on prospectively collected real-world data from five university hospitals and 21 non-tertiary-level delivery hospitals in Finland, 2006‒2016.Participants 4323 small preterm infants.Primary outcome measures Umbilical cord pH ≤7.05, Apgar score 0–3 points at the age of 1 min, Apgar score 0–3 points at age 5 min, birth asphyxia (International Classification of Diseases-10 code), resuscitation with intubation.Secondary outcome measures Perinatal mortality comprising stillbirths and early neonatal deaths (&lt;7 days).Results Busy days (busy vs optimal) showed no correlation with the primary birth-related outcomes. …”
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Common features of environmentally and socially engaged community programs addressing the intersecting challenges of planetary and human health: mixed methods analysis of survey an... by Linda J. M. Thomson, Linda J. M. Thomson, Ailsa Critten, Victoria Hume, Helen J. Chatterjee, Helen J. Chatterjee

“…Two of the 10 subthemes: ‘Connection to nature in children’ and ‘Relationship with natural world’ within the major theme: ‘Connection to nature’ addressed planetary and human health directly through practices recognizing environmental and human interdependency. …”
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“Inclisiran: Early LDL-C target achievement in a real-life population” by Francesco Briani, Mauro Bagli, Gabriele Venturi, Francesco Bacchion, Antonio Mugnolo

“…Inclisiran, a small interfering RNA, has been observed to effectively and sustainably reduce LDL-C in large randomized controlled trials (RCTs); however, real-world data on its short-term efficacy and use are limited. …”
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Factors associated with hospital length of stay in patients admitted with suspected malaria in Kenya: secondary analysis of a cross-sectional survey by Hillary Kipruto, Beatrice Machini, Jacqueline Chesang, Beatrice Amboko, Thomas N O Achia

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Ambient pollution at hip fracture units and impact on mortality and post-operative delirium: A hormetic effect? by Chika Edward Uzoigwe, Rana Muhammad Anss Bin Qadir, Ahmed Daoub

“…There is increasing awareness of the deleterious effects of ambient pollution. The World Health Organisation (WHO) has recently advocated new safe limits of annual exposure for the three pre-dominant pollutants: fine particulate matter (PM2.5), coarse particulate matter (PM10) and nitrogen dioxide; namely 5μg/m3, 15μg/m3 and 10gμ/m3 respectively. …”
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Accurate Prediction of Advanced Liver Fibrosis Using the Decision Tree Learning Algorithm in Chronic Hepatitis C Egyptian Patients by Somaya Hashem, Gamal Esmat, Wafaa Elakel, Shahira Habashy, Safaa Abdel Raouf, Samar Darweesh, Mohamad Soliman, Mohamed Elhefnawi, Mohamed El-Adawy, Mahmoud ElHefnawi

“…Respectively with the prevalence of chronic hepatitis C in the world, using noninvasive methods as an alternative method in staging chronic liver diseases for avoiding the drawbacks of biopsy is significantly increasing. …”
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Effect of healthy lifestyle score trajectory on all-cause mortality in the late middle-aged and older population: Finding from 17-year retrospective cohort study by Jeong Min Yang, Jieun Hwang

“…Purpose: Recently, the World Health Organization has emphasized the importance of a healthy lifestyle in reducing severe illnesses and premature mortality. …”
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A look at the global educational crisis through the lens of experience of the history of science. Part II. The structure of general education content by V. L. Gapontsev, V. A. Fedorov, Ye. M. Dorozhkin

“…Among them, one can mention the attempts to launch “Concepts of the Modern Natural Science” and “Scientific World View” courses, discussion of possibilities to use synergetics in pedagogy and active discussion of use of the ideas of symmetry within various disciplines – from humanitarian to science, technology, engineering and mathematics (STEM). …”
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A numerical model for duricrust formation by water table fluctuations by C. Fenske, C. Fenske, J. Braun, J. Braun, F. Guillocheau, C. Robin

“…They form in tropical to arid environments and can be currently observed all around the world in areas such as Europe, Africa, South America, India, and Australia. …”
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Transformer-Based Person Detection in Paired RGB-T Aerial Images With VTSaR Dataset by Xiangqing Zhang, Yan Feng, Nan Wang, Guohua Lu, Shaohui Mei

“…Aerial-based person detection poses a significant challenge, yet it is crucial for real-world applications like air-ground linkage search and all-weather intelligent corescuing. …”
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Post-marketing safety surveillance for the recombinant zoster vaccine (Shingrix), vaccine adverse event reporting system, United States, October 2017–April 2024 by Yamin Shu, Wenxin Cheng, Xucheng He, Liu Huang, Wei Chen, Qilin Zhang

“…Further studies are needed to continue generating real-world safety data and further characterize RZV-AE pairs systematically.…”
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Translational Science in Vascular Aging: From Bench to Bedside—Insights from a VascAgeNet Roundtable by Elisabetta Bianchini, Lynn Roth, Pierre Boutouyrie, Smriti Badhwar, Achim Schwarz, Vincenzo Gemignani, Rosa Maria Bruno, Bernhard Hametner, Chloe Park, Giacomo Pucci, Ioana Mozos, Dimitrios Terentes-Printzios, Rachel E. Climie, Andrea Guala, Jordi Alastruey, Christopher C. Mayer

“…Pragmatic and registry-based clinical trials offer viable alternatives to traditional randomized controlled trials, facilitating real-world applicability. The regulatory landscape, particularly for software medical devices, must evolve to keep pace with technological advancements like artificial intelligence. …”
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Beyond COVID-19, the case for collecting, analysing and using sex-disaggregated data and gendered data to inform outbreak response: a scoping review by Simone E Carter, Shirin Heidari, Leah Zilversmit Pao, Marie-Amelie Degail, Marie Meudec, McKinzie Gales, Emelie Love Yonally Phillips, Christine Dubray, Clara Rodriguez Ribas Elizalde, M Ruby Siddiqui

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Optimizing water-use efficiency under elevated CO₂: A meta-analysis of crop type, soil modulation, and enrichment methods by Ali Mokhtar, Hongming He, Samar Attaher, Ali Salem, Muneer Alam

“…Key findings reveal that: (1) C₃ crops, such as potato and tomato, show significantly greater increases in WUE compared to C₄ crops like maize, with effect sizes of 13.96 and 7.02 for plant-level WUE (WUEₚ), suggesting that C₃ crops may be more advantageous in water-limited environments due to reduced photorespiration under eCO₂; (2) soil type substantially modulates WUE responses, with clay soils, due to their high water-holding capacity, demonstrating the highest WUE enhancements (effect sizes of 7.87 for WUEₚ and 12.54 for yield WUE, WUEᵧ), while sandy soils, characterized by rapid drainage, showed limited improvements; and (3) greenhouse and growth chamber studies displayed the highest WUE improvements, while FACE experiments, which better replicate real-world conditions, indicated smaller WUE increases due to environmental variability, underscoring the need for a hybrid approach that merges controlled data with field insights to develop practical, water-efficient agricultural strategies. …”
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Prescribing practices of corticosteroids in outpatient dermatology department of Injibara General Hospital, north-West Ethiopia, 2024 by Alemu Bezabih Tegegnie, Tamiru Alene, Workineh Tamir, Meaza Molla Sineshaw

“…BackgroundCorticosteroids are among the most frequently prescribed drugs in the world because they are extremely effective for the relief of symptoms of many inflammatory and immune disorders and other conditions. …”
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Long term cost-effectiveness analysis of IDegLira in the treatment of type 2 diabetes patients compared to GLP-1RA added to basal insulin after IDegLira entered the national reimbu... by Dunming Xiao, Junling Weng, Lei Zhang, Chang Xing, Yan Wei, Yingyao Chen

“…<h4>Background</h4>Degludec insulin liraglutide injection is the world's first and only approved basal insulin GLP-1RA injection in China (GLP-1RA stands for Glucagon-Like Peptide-1 Receptor Agonist. …”
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Diagnosis of the current Moroccan cumin seeds, related production issues and recommended actions for its development by Abdelmonaim Homrani Bakali, El Mustapha Sekkour, Ahmed Sabri, Eimad dine Tariq Bouhlali, Brahim Ouahzizi, Mohamed Hemmi, Kaoutar El Amraoui, Lalla laaziza Ichir, Adil Essarioui

“…Cumin is a high-potential crop with great demand all over the world. Consequently, its cultivation is expanding rapidly worldwide, including in Morocco, where it is increasingly grown as an alternative cash crop, particularly in oases. …”
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