Effect of Yanshiqiangxin Decoction on Cardiomyocyte Apoptosis in Heart Failure Rats Based on PI3K/Akt/Caspase-9 Signaling Pathway by ZHU Sixing, YAN Shiyun, XU Yan, QIN Yan, CHEN Liyun, JIA Meijun

“…The gavage dose was calculated as 10 mL/(kg·d) ,the normal group and the model group were given the same volume of distilled water. One day after the last gavage, M-mode echocardiography [left ventricular ejection fraction (LVEF), left ventricular short-axis shortening (LVFS), left ventricular internal dimension diastole (LVIDd) and left ventricular internal dimension systole (LVIDs)] was performed through an ultra-high resolution small animal ultrasound imaging system; B-type natriuretic peptide (BNP) was measured by ELISA method; the apoptosis of cardiomyocytes was observed through laser confocal microscopy and the apoptosis index was calculated; the expression of apoptosis-related proteins Bax, Bcl-2 and PI3K/Akt/Caspase-9 signalling pathway proteins were detected by Western blot method.Results① Cardiac ultrasound test results: compared with the normal group, the left ventricular anterior wall motion waveform of the model group was not obvious, close to linear motion, and LVEF and LVFS decreased significantly (<italic>P</italic>&lt;0.05), LVIDd and LVIDs increased significantly (<italic>P</italic>&lt;0.05), the left ventricle was significantly enlarged and the contractility was reduced. …”
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Biochemical, Histological, and Multi-Omics Analyses Reveal the Molecular and Metabolic Mechanisms of Cold Stress Response in the Chinese Soft-Shelled Turtle (<i>Pelodiscus sinensis... by Liqin Ji, Qing Shi, Chen Chen, Xiaoli Liu, Junxian Zhu, Xiaoyou Hong, Chengqing Wei, Xinping Zhu, Wei Li

“…The Chinese soft-shelled turtle (<i>Pelodiscus sinensis</i>), a type of warm-water reptile, is frequently chosen as the model animal to understand how organisms respond to environmental stressors. …”
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Étude de trois grands tonneaux mis au jour à Reims/Durocortorum (Marne) : le savoir-faire des tonneliers antiques by Pierre Mille, Philippe Rollet

“…On a strip near the right bank of the Vesle river three water wells (Pts 378, Pts 354 and Pts 417) were excavated. …”
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Comprehensive increase in CO₂ release by drying–rewetting cycles among Japanese forests and pastureland soils and exploring predictors of increasing magnitude by Y. Suzuki, Y. Suzuki, S. Hiradate, J. Koarashi, M. Atarashi-Andoh, T. Yomogida, Y. Kanda, H. Nagano

“…<p>It is still difficult to precisely quantify and predict the effects of drying–rewetting cycles (DWCs) on soil carbon dioxide (<span class="inline-formula">CO₂</span>) release due to the paucity of studies using constant moisture conditions equivalent to the mean water content during DWC incubation. The present study was performed to evaluate overall trends in the effects of DWCs on <span class="inline-formula">CO₂</span> release and to explore environmental and soil predictors for variations in the effect size in 10 Japanese forests and pastureland soils variously affected by volcanic ash during their pedogenesis. …”
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Effects of dietary compound acidifier (Biomin) on the growth, anti-oxidation, immunity, and intestinal health of juvenile channel catfish (Ictalurus punctatus) by Junyu Yan, Kai Luo, Bo Wang, Jiaxin He, Can Li, Jiang Zhou, Wenhao Lai, Xin Zhou, Jingwei Ye, Mingzhu Pan, Yingbing Su, Weihua Gao, Kai Guo, Chengmin Zhao

“…Fish were hand-fed to apparent satiation thrice daily for 72 days (water temperature was 25–27℃). The results showed that the WGR (weight giant rate) and SGR (specific growth rate) of channel catfish in the 0.10 % group were significantly increased compared with the control group (P < 0.05). …”
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Evaluating small coronary stents with dual-source photon-counting computed tomography: effect of different scan modes on image quality and performance in a phantom by Thomas Stein, Constantin von zur Muhlen, Niklas Verloh, Till Schürmann, Tobias Krauss, Martin Soschynski, Dirk Westermann, Jana Taron, Elif Can, Christopher L. Schlett, Fabian Bamberg, Christopher Schuppert, Muhammad Taha Hagar

“…METHODS: Utilizing a phantom setup mimicking the average patient’s water-equivalent diameter, we examined six distinct coronary stents inflated in a silicon tube, with stent sizes ranging from 2.0 to 3.5 mm, applying four different CT acquisition modes of a dual-source PCD-CT scanner: “high-pitch,” “sequential,” “spiral” (each with collimation of 144 × 0.4 mm and full spectral information), and “ultra-high-resolution (UHR)” (collimation of 120 × 0.2 mm and no spectral information). …”
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Xixin Decoction’s novel mechanism for alleviating Alzheimer’s disease cognitive dysfunction by modulating amyloid-β transport across the blood–brain barrier to reduce neuroinflamma... by Chaokai Yang, Enlong Zhao, Hu Zhang, Liqi Duan, Xinyue Han, Hongli Ding, Yan Cheng, Dengkun Wang, Dengkun Wang, Dengkun Wang, Xiaojing Lei, Xiaojing Lei, Xiaojing Lei, Yongchang Diwu, Yongchang Diwu, Yongchang Diwu

“…Cognitive function was subsequently evaluated using the Morris water maze test. BBB integrity was evaluated using Evans blue staining, and protein expression levels were analyzed via ELISA, Western blotting, and immunofluorescence.ResultsIn vitro experiments revealed that XXD-containing serum, when cultured for 24, 48, and 72 h, could upregulate the expression of P-gp mRNA and protein, downregulate CB1 protein expression, and upregulate CB2 and Mfsd2a protein expression. …”
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Derivation of allometric equations and carbon content estimation in mangrove forests of Malaysia by Waseem Razzaq Khan, Michele Giani, Stanislao Bevilacqua, Shoaib Ahmad Anees, Kaleem Mehmood, M. Nazre, Abdul Aziz Bin Abdul Haddy, Abang Norizan Bin Abang Median, Japanie Bin Bujang, Fatin-Norliyana Mohamad-Ismail, Johar Mohamed, Zaiton Samdin, Rambod Abiri, Tuan-Marina Tuan-Ibrahim, Lydia-Suzieana Mohammad, Hamid-Reza Naji, Seemab Akram, Hazandy Abdul-Hamid, Timothy Dube

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Exometabolomic exploration of culturable airborne microorganisms from an urban atmosphere by R. Jin, W. Hu, W. Hu, P. Duan, M. Sheng, D. Liu, Z. Huang, M. Niu, L. Wu, J. Deng, P. Fu, P. Fu

“…This study provides new insights into the transformation and potential oxidative capacity of atmospheric microorganisms concerning organic matter at air–land/water interfaces. These findings are pivotal for assessing the biogeochemical impacts of atmospheric microorganisms in clouds or following their deposition.…”
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The direct and urinary electrolyte-mediated effects of ambient temperature on population blood pressure: A causal mediation analysis by Ayesha Mukhopadhyay, Momenul Haque Mondol, Mahbubur Rahman, Leanne Unicomb, Rizwana Khan, Hoimonty Mazumder, Mohammad Nahian Ferdous, Emily V. Pickering, Konstantinos C. Makris, Alberto J. Caban-Martinez, Faruk Ahmed, Mohammad Shamsudduha, Fawaz Mzayek, Chunrong Jia, Hongmei Zhang, Anwar Musah, Lora E. Fleming, Matthew P. Smeltzer, Howard H. Chang, John L. Jefferies, Csaba P. Kovesdy, Xichen Mou, Abu Mohd Naser

“…Models had participant-level random intercepts and were adjusted for age, sex, body mass index (BMI), religion, exercise, smoking status, sleep hours, alcohol consumption, urine creatinine, time trend, household assets, drinking water salinity, and seasonality. For the combined mediators (sodium, potassium, calcium, and magnesium), for every 5°C increase in average daily temperature: the direct effect on systolic BP was −1.42 (95 % CI: −1.94, −0.92) mmHg and urine sodium mediated effect was −0.12 (95 % CI: −0.20, −0.05) mmHg; while urine potassium mediated effect was 0.15 (95 % CI: 0.08, 0.25) mmHg; urine calcium-mediated effect 0.06 (95 % CI: 0.01, 0.12) mmHg; and urine magnesium mediated effect −0.00 (95 % CI: −0.03, 0.02) mmHg. …”
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Determination of Zinc Requirement in Suckling Calves using Some Non-Linear Models by Mohammad Javad Elyasi, Khalil zaboli

“…The calves were fed with whole milk (approximately 10% of birth weight) in two equal meals daily at 08:00 and 19:00 and each calf's specific Zn requirement was supplemented to the evening meal milk in the form of zinc sulphate solution. Starter and fresh water were freely available for the calves throughout the experiment. …”
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Abcb1 is involved in the efflux of trivalent inorganic arsenic from brain microvascular endothelial cells by Man Lv, Ziqiao Guan, Jia Cui, Xinbo Ma, Kunyu Zhang, Xinhua Shao, Meichen Zhang, Yanhui Gao, Yanmei Yang, Xiaona Liu

“…Increased arsenic levels were observed in mice exposed to 25 mg/L or 50 mg/L of sodium arsenite (NaAsO2) in drinking water, and both arsenic uptake and efflux were detected in bEnd.3 cells treated with 16 μmol/L NaAsO2. …”
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Comparative transcriptome analysis reveals molecular mechanisms of resistance in Chinese cabbage to Plasmodiophora brassicae pathotype 11 by Yue Qiu, Yue Qiu, Yue Qiu, Jinhao Zhang, Jinhao Zhang, Chunju Deng, Chunju Deng, Jiasheng Yuan, Jiasheng Yuan, Bowen Wang, Bowen Wang, Han Meng, Han Meng, Mohamed Mohany, Liting Zeng, Liting Zeng, Lanfang Wei, Lanfang Wei, Waqar Ahmed, Guanghai Ji, Guanghai Ji

“…Therefore, our speculation revolves around the potential resistant mechanism of this variety, which inhibits the proliferation of P. brassicae in the roots via secondary metabolites, cell wall, and ROS and also regulates physiological mechanisms mediated by plant hormones such as ABA to adapt to adverse environmental conditions such as water scarcity induced by the pathogen.ConclusionThis study unveils the intricate defense mechanisms potentially activated within Chinese cabbage when confronted with P. brassicae pathotype 11, offering valuable insights for breeding programs and the development of novel strategies for managing clubroot disease in Brassica crops. …”
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Estimating Suitable Areas for Dry Almond (Amygdalus communis L.) Cultivation Development in Fars Province using Geographic Information System (GIS) by Ayatollah Karami, Alireza Salehi, Vida Aliyari

“…These sub-criteria include elevation, land slope, slope aspects, land use, soil texture, seedling growth temperature, minimum temperature during flowering stage, relative humidity flowering stage, growth cycle temperature, fruit formation and ripening stage temperature, mean annual precipitation, distance from the road, distance from water levels and distance from population centers. …”
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New Parameters for Impedance–pH Monitoring in Diagnosing Gastroesophageal Reflux Disease and Predicting its Severity by O. A. Storonova, A. S. Trukhmanov, A. A. Makushina, A. V. Paraskevova, V. T. Ivashkin

“…All of them underwent 24-hour combined esophageal impedance–pH monitoring (Gastroscan-IAM, JSC RPE Istok-Sistema, Fryazino) and high-resolution esophageal manometry using a 22-channel water-perfusion catheter (Solar GI MMS, The Netherlands). …”
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Stability Analysis of Dry Yield of Z. multiflora Boiss. under Drought Stress and Mycorrhizal Fungi Symbiosis by Ashraf Aghababapoor Dehkordi, Sadollah Houshmand, Shahram Mohammady

“…The essential oil of this plant has antioxidant, antifungal, and antimicrobial properties and is used as a preservative in the food industry. Water scarcity is a significant limiting factor for crop growth and production. …”
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Sustainability index analysis for environmentally low-input integrated farming by E. Widjaja, B.N. Utomo, A.D. Santoso, Y.P. Erlambang, . Surono, M.A. Firmansyah, S. Handoko, E. Erythrina, M.N. Rofiq, D. Iskandar, N.A. Sasongko, T. Rochmadi, N. Abbas, M. Hanif, Y.S. Garno, F.D. Arianti, N.D. Suretno, M. Askinatin, C.O.I. Hastuti, F. Fahrodji

“…Based on the findings, the factors that should be considered included 1) Efficiency in the utilization of water during egg, 2) fertilizer production and effectiveness of using fuel and electricity during the production and marketing, 3) an Industry manager level of education, 4) the ease by which raw materials can be obtained for the integration industry, 5) potential for increasing the low-input integrated agricultural farming, 6) the availability of integration industry facilities, infrastructure and level of expertise needed by managers in the people's integration sector, 7) Financial institutions' existence.CONCLUSION: Multidimensional mapping showed that the low-input integrated agricultural farming in the dry land of Pangkalan Lada District was running sustainably, with an average sustainability index of 86.10 percent. …”
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Protective Mechanism of Alisol A 24-Acetate on Brain Microvascular Endothelial Cells in Mice with Cerebral Ischemia-Reperfusion Injury by TRPM2/Akt/GSK3β Pathway by LI Huihong, DENG Yunfei, WEI Wei, ZHAN Zengtu, LIN Libin, XUE Xiehua

“…Modified neurological severity score (mNSS) was used to evaluate neurological deficit; novel object recognition test (NORT) and Morris water maze (MWM) were used to evaluate the cognitive function; immunofluorescence was used to detect the expression of CD31 in cortex; Western blot was used to detect zonula occludens-1 (ZO-1), Occludin, Claudin-5, phosphorylated nuclear factor kappa-B (p-NF-κB), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), transient receptor potential melastatin-2 (TRPM2), phosphorylated protein kinase B (p-Akt), phosphorylated glycogen synthetase kinase-3β (p-GSK3β) protein expression levels.Results(1) Neurological function: compared with the sham surgery group, mNSS in the model group significantly increased at the 1st, 3rd, 5th and 7th day (<italic>P</italic>&lt;0.05); compared with the model group, mNSS in the 24A group significantly decreased at the 3rd and 7th day (<italic>P</italic>&lt;0.05). (2) Cognitive function: compared with the sham surgery group, the NORT recognition index at 1st and 24th hour in the model group was significantly lower (<italic>P</italic>&lt;0.05); compared with the model group, the 1-hour and 24-hour NORT recognition index in the 24A group significantly increased (<italic>P</italic>&lt;0.05). …”
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The Role of Potassium Phosphite in Enhancing the Activity of Defense Enzymes in Rice Infected by Sheath Blight by Milad Habibi Daronkolaei, Mohammad Ali Tajick Ghanbary, Valiollah Babaeizad, Heshmatollah Rahimian, Ali Dehestani

“…Conclusion: CAT catalyzes the conversion of hydrogen peroxide into water and oxygen, protecting the plant against oxidative damage caused by pathogens. …”
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Investigation of the Prevalence of Infectious Myonecrosis Virus (IMNV) from 2022 to 2023 by Ruidong XU, Jitao XIA, Ping LI, Xingtong YU, Liang YAO, Wenqiang LI, Tianchang JIA, Qingli ZHANG

“…These samples included major farmed shrimp species, such as Penaeus vannamei, P. japonicas, P. chinensis, and Macrobrachium rosenbergii, as well as live feed, other aquatic economic species, and culture water. TaqMan real-time quantitative fluorescence RT-PCR (TaqMan RT-qPCR) was used for molecular detection. …”
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