The Role of von Willebrand Factor in Vascular Inflammation: From Pathogenesis to Targeted Therapy by Felice Gragnano, Simona Sperlongano, Enrica Golia, Francesco Natale, Renatomaria Bianchi, Mario Crisci, Fabio Fimiani, Ivana Pariggiano, Vincenzo Diana, Andreina Carbone, Arturo Cesaro, Claudia Concilio, Giuseppe Limongelli, Mariagiovanna Russo, Paolo Calabrò

“…Beyond its role in hemostasis, von Willebrand factor (VWF) is an emerging mediator of vascular inflammation. …”
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The Role of von Willebrand Factor Antigen in Predicting Survival of Patients with HBV-Related Cirrhosis by Youmin Pan, Renyong Guo, Yan Lv, Dawei Cui, Jue Xie

“…The model for end-stage liver disease (MELD) scoring system cannot be used to assess the deterioration of patients with liver cirrhosis caused by infection and portal hypertension. Elevated von Willebrand factor antigen (vWF-Ag) in plasma is associated with portal pressure and complications in patients with liver cirrhosis. …”
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Characterization of Zebrafish von Willebrand Factor Reveals Conservation of Domain Structure, Multimerization, and Intracellular Storage by Arunima Ghosh, Andy Vo, Beverly K. Twiss, Colin A. Kretz, Mary A. Jozwiak, Robert R. Montgomery, Jordan A. Shavit

“…von Willebrand disease (VWD) is the most common inherited human bleeding disorder and is caused by quantitative or qualitative defects in von Willebrand factor (VWF). VWF is a secreted glycoprotein that circulates as large multimers. …”
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Corrigendum to “Characterization of Zebrafish von Willebrand Factor Reveals Conservation of Domain Structure, Multimerization, and Intracellular Storage” by Arunima Ghosh, Andy Vo, Beverly K. Twiss, Colin A. Kretz, Mary A. Jozwiak, Robert R. Montgomery, Jordan A. Shavit

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Conventional Rapid Latex Agglutination in Estimation of von Willebrand Factor: Method Revisited and Potential Clinical Applications by Marianor Mahat, Wan Zaidah Abdullah, Che Maraina Che Hussin

“…Measurement of von Willebrand factor antigen (VWF : Ag) levels is usually performed in a specialised laboratory which limits its application in routine clinical practice. …”
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Space and Time Resolved Detection of Platelet Activation and von Willebrand Factor Conformational Changes in Deep Suspensions by Jacopo Biasetti, Kaushik Sampath, Angel Cortez, Alaleh Azhir, Assaf A. Gilad, Thomas S. Kickler, Tobias Obser, Zaverio M. Ruggeri, Joseph Katz

“…This paper introduces fluorescence imaging techniques for space and time resolved detection of platelet activation, von Willebrand factor (VWF) conformational changes, and VWF-platelet interaction in deep suspensions. …”
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Impact of ABO gene polymorphism and von Willebrand factor on genetic susceptibility to acute lymphoblastic leukemia in Egyptian pediatric patients by Elsayed I. Salim, Ahmed N. Shaaban, Amal K. Seleem, Zeinab I. Attia

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von Willebrand factor polymorphism (rs1063856) as a risk factor for portal vein thrombosis in chronic liver diseases by Isis Samy Bedira, Olfat M. Hendy, Moones Abdelaal, Ashraf A. Basuni, Asma Ebrahim Gaber Koshoo, Alzhraa Alkhatib, Sally S. Mandour

Subjects: “…Von Willebrand factor…”
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Dynamics of endothelial function in patients with arterial hypertension with different cardiovascular risk against the background of antihypertensive therapy by N.O. Pertseva, T.S. Turlyun, N.A. Sanina

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Difficulties the Conservative Treatment of Crohn’s Disease Complicated by Autoimmune Hemophilia A by E. L. Belyaeva, O. I. Filippova, A. V. Koloskov, A. A. Naydenov, F. D. Albegova

“…In this connection, the levels of VIII (FVIII) and IX (FIX) coagulation factors and the content of von Willebrand factor antigen were determined. A study was conducted to the antibodies to these factors connecting von Willebrand factor capabilities with type I and III collagen. …”
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Noncanonical effects of vasopressin in angiogenesis by I. I. Khegay

“…Activated endotheliocytes secrete von Willebrand factor and P-selectin. These proteins are accumulated in Weibel–Palade bodies. …”
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Angiopoietin-2 and D-dimer add prognostic information to clinical risk in pulmonary arterial hypertension by Heather L. Clark, Daniel Lachant, Allison N. Light, Deborah Haight, Samia Lopia, Nigel Mackman, R. James White

“…We generated platelet-free plasma and measured D-dimer, angiopoietin-2, thrombin time, soluble P-selectin, von Willebrand factor, and vascular endothelial growth factor. …”
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Interdependence of coagulation with immunotherapy and BRAF/MEK inhibitor therapy: results from a prospective study by Malte Beckmann, Julian Schlüter, Michael Erdmann, Rafaela Kramer, Sarah Cunningham, Holger Hackstein, Robert Zimmermann, Lucie Heinzerling

“…Additionally, von Willebrand factor activity and tissue factor concentrations increased under immunotherapy. …”
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Von-Willebrand Disease Presenting as Intractable Epistaxis after Nasal Polypectomy by Jeong Jin Park, Chang-Hoon Kim, Jeung-Gweon Lee, Hyung-Ju Cho

“…Von-Willebrand disease (VWD) is one of the platelet dysfunction disorders that results from a deficiency of Von-Willebrand factor, which is essential for hemostasis. …”
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Role of Coagulation Factors in Hepatocellular Carcinoma: A Literature Review by Azeem Azam, Aleksandra Klisic, Filiz Mercantepe, Hamza Faseeh, Tolga Mercantepe, Saira Rafaqat

“…Essential coagulation biomarkers, such as P-selectin, thrombomodulin, <span style="font-variant: small-caps;">d</span>-dimer, prothrombin, and von Willebrand factor, are reviewed for their diagnostic, prognostic, and therapeutic significance. …”
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Successful Aortic Aneurysm Repair in a Woman with Severe von Willebrand (Type 3) Disease by Victoria Campbell, Kevin Marriott, Rex Stanbridge, Abdul Shlebak

“…von Willebrand disease type 3 (VWD3) is a rare but the most severe form of von Willebrand disease; it is due to almost complete lack of von Willebrand factor activity (VWF:RCo). It is inherited as autosomal recessive trait; whilst heterozygote carriers have mild, or no symptoms, patients with VWD3 show severe bleeding symptoms. …”
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Remission of Severe, Relapsed, and Refractory TTP after Multiple Cycles of Bortezomib by Manu R. Pandey, Pankit Vachhani, Evelena P. Ontiveros

“…Acquired thrombotic thrombocytopenic purpura (TTP) is characterized by autoantibodies against a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13). Uncleaved von Willebrand factor (VWF) multimers accumulate and bind to platelets which causes spontaneous microthrombi ultimately causing microangiopathic hemolytic anemia, thrombocytopenia, and end-organ ischemia. …”
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Thrombus composition and its implication in ischemic stroke assessment and revascularization treatments by Juan Marta-Enguita, Florencio J.D. Machado, Josune Orbe, Roberto Muñoz

“…However, other factors such as clot formation time, associated inflammatory status, or activation of additional immune and coagulation pathways (neutrophil extracellular trap [NET] delivery, platelet aggregation, endothelial activation, and von Willebrand Factor release) have been described as determinants in thrombus characteristics. …”
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Plasmodium falciparum Malaria Complicated by Symmetrical Peripheral Gangrene, Bowel Ischemia, Repeated Candidemia, and Bacteraemia by Emeline Masse, Philippe Hantson

“…In addition to laboratory changes consistent with disseminated intravascular coagulation, there was also evidence for a low activity of the von Willebrand factor (VWF) cleaving protease ADAMTS13. Later complications included repeated candidemia and bacteraemia despite appropriate therapy; the origin appeared to be diffuse ischemic injury of the gastrointestinal tract. …”
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Chemigenetic Ca2+ indicators report elevated Ca2+ levels in endothelial Weibel-Palade bodies. by Julian Terglane, Nicole Mertes, Sarah Weischer, Thomas Zobel, Kai Johnsson, Volker Gerke

“…Weibel-Palade bodies (WPB) are secretory organelles exclusively found in endothelial cells and among other cargo proteins, contain the hemostatic von-Willebrand factor (VWF). Stimulation of endothelial cells results in exocytosis of WPB and release of their cargo into the vascular lumen, where VWF unfurls into long strings of up to 1000 µm and recruits platelets to sites of vascular injury, thereby mediating a crucial step in the hemostatic response. …”
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