Art of TIL immunotherapy: SITC’s perspective on demystifying a complex treatment by Robert Brown, Marco Donia, Simon Turcotte, George Coukos, John Mullinax, Brian Gastman, James C Yang, Michael T Lotze, John B A G Haanen, Inge Marie Svane, Stephanie L Goff, Vernon K Sondak, Maartje W Rohaan, Michal Besser, Benjamin Creelan

“…Here, we provide the principles, practice, and required resources underlying the efficient and safe delivery of TIL immunotherapy derived from the clinical expertise of high-volume centers around the world. This article enhances published clinical practice guidelines by providing underlying clinical rationale and data-driven examples to demystify TIL immunotherapy in order to facilitate uptake and improve patient access to this promising treatment modality in clinical and research settings.…”
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Comparative Efficacy of Esketamine vs Sufentanil with Propofol for Sedation in EUS: A Randomized, Controlled Study by Liu C, Wang Y, Yin Y, Wang P, Ji X, Sun J, Zhao S, Jia Y, Liu S, Zhou Z

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Correlation Between Gastroesophageal Reflux Disease and Small Intestinal Bacterial Overgrowth: Analysis of Intestinal Microbiome and Metabolic Characteristics by Wang ZT, Tan WT, Huang JL, Zhang PF, Li Q, Wang MM, Meng MM, Su H, Guo CM, Liu H

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Puerarin Ameliorates the Ferroptosis in Diabetic Liver Injure Through the JAK2/STAT3 Pathway Inhibition Based on Network Pharmacology and Experimental Validation by Fan X, Liu S, Yu J, Hua J, Feng Y, Wang Z, Shen Y, Lan W, Wang J

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Clinical Burden and Healthcare Resource Use of Asthma in Children in the UK by Gouia I, Joulain F, Zhang Y, Morgan CL, Khan AH

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Voriconazole Pharmacokinetics Administered at 4 mg/kg IM and IV in Nursehound Sharks (<i>Scyliorhinus stellaris</i>) Under Human Care by Daniela Cañizares-Cooz, Daniel García-Párraga, Sonia Rubio-Langre, Teresa Encinas, Pablo Morón-Elorza

“…The mean peak plasma concentrations (C_max) ± SEM after IM administration was 3.00 ± 0.23 µg/mL. The volume of distribution (Vd) after IV and IM administration resulted in 1.39 ± 0.09 L/kg and 1.50 ± 0.18 L/kg, respectively, showing no statistically significant differences between the two routes. …”
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Macroscopic and microscopic characteristics of nanosilica sol-based composite grout in sealing fractured argillaceous rock: A comparative study with silica sol and cement slurry by Zhe Xiang, Nong Zhang, Dongjiang Pan, Zhengzheng Xie, Peng Wang, Dongxu Liang

“…The research results show that, for composite grouting (1) The porosity and sealing of the grout-rock cementitious body decrease with increasing particle size of the rock blocks, with a minimum permeability coefficient of 2.34 × 10−8 cm/s; (2) The presence and distribution pattern of multi-level pores of grout in rock fractures can be evaluated using the T2 spectrum of nuclear magnetic resonance (NMR). The pore volume of the cementitious body is mainly provided by large pores <100 ms, and the composite grout has a good sealing effect on the matrix system of the argillaceous rock. (3) There is a dense transition area at the grout-rock interface, formed by the accumulation of nano-materials such as aluminate cement hydration-formed aluminate gel and silica sol. …”
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Synthetic CT generation from CBCT and MRI using StarGAN in the Pelvic Region by Paritt Wongtrakool, Chanon Puttanawarut, Pimolpun Changkaew, Supakiet Piasanthia, Pareena Earwong, Nauljun Stansook, Suphalak Khachonkham

“…Dosimetric evaluation showed a mean dose difference (DD) within 2% for the planning target volume (PTV) and body, with a gamma passing rate (GPR) > 90% under the 2%/2 mm criteria. …”
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Toward zero-excess lithium sulfur batteries: a systematic cell parameter study by Joshua H Cruddos, James B Robinson, Paul R Shearing, Alexander J E Rettie

“…Here we develop a ZELiS battery, comprising a Li _2 S-based composite positive electrode on carbon paper paired with a Ni foil current collector (CC) and evaluate the effects of various CC materials, electrolyte volume to Li _2 S mass ratio and C-rate. The developed cells reproducibly achieve an average Coulombic efficiency of 99% from cycles 2 to 200, and a final capacity of 272 mAh g ^−1 _Li2S at a C/10 rate. …”
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Cardiorenal Involvement in Metabolic Syndrome Induced by Cola Drinking in Rats: Proinflammatory Cytokines and Impaired Antioxidative Protection by Matilde Otero-Losada, Hernán Gómez Llambí, Graciela Ottaviano, Gabriel Cao, Angélica Müller, Francisco Azzato, Giuseppe Ambrosio, José Milei

“…Compared with W, C rats showed (I) overweight (+8%, p<0.05), hyperglycemia (+11%, p<0.05), hypertriglyceridemia (2-fold, p<0.001), higher AIP (2-fold, p<0.01), and lower Q10 level (−55%, p<0.05); (II) increased LV diastolic diameter (+9%, p<0.05) and volume (systolic +24%, p<0.05), posterior wall thinning (−8%, p<0.05), and larger cardiac output (+24%, p<0.05); (III) glomerulosclerosis (+21%, p<0.05), histopathology (+13%, p<0.05), higher tubular expression of IL-6 (7-fold, p<0.001), and TNFα (4-fold, p<0.001). …”
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Extracellular Lipase from Pseudomonas aeruginosa SB-37: Production by Solid State Fermentation, Immobilization, and Characterization by Titin Haryati, Norman Yoshi Haryono, Dian Nugraheni, Fenti Fatmawati, Alfina Kusuma Dewi, Muhammad Zahran Edlian Syach

“…To obtain high lipase production using SSF methods, we optimized the type of agro-wastes substrates, fermentation time, oil induction percentage and volume of preculture percentage. The optimal condition for lipase production via solid-state fermentation involved a 7% (v/v) preculture of Pseudomonas aeruginosa SB-37, utilizing palm kernel meal as the substrate, supplemented with 6% (v/w) oil induction (soybean oil:tween 80 = 75:25) at 50 °C for 24 h. …”
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Corticosteroid Phobia: A Key Barrier to Treatment in Young Women with Idiopathic Granulomatous Mastitis by Lin W, Wang Q, Liu J, Tan Q

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Single-Cell RNA-Seq Uncovers Cellular Heterogeneity from Deep Fascia in Necrotizing Fasciitis Patients by Wang T, Zhang L, Chen W, Long Y, Zhang Y, Wang L, Hou Z

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Video Laryngoscopy for Endotracheal Intubation: A Consideration for Manual In-Line Stabilization Without Cervical Collar Versus Full Immobilization by Aramvanitch K, Leela-Amornsin S, Tienpratarn W, Nuanprom P, Aussavanodom S, Yuksen C, Boonsri S, Boonjarus N, Sanepim S

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Global Trends in the Incidence and Primary Causes of Femoral Fractures, Excluding Femoral Neck Fractures: A Global Epidemiological Study by Fu F, Liu B, Pu H, Wang Y, Zhang P, Wei S, Gu H, Zhang Q, Ye H

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A New Nanocomposite for Inducing Demineralized Dentin Remineralization by Ban G, Long J, Yan K, Li Q, Huang X, Wei X, Xie F

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Noninvasive Assessment of Liver Fibrosis by Magnetic Resonance Elastography in Patients with Rheumatic Disease on Long-Term Methotrexate Treatment by Arindam Nandy Roy, Anjani Kumar Darapureddy, Yarram Ashok Kumar

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Nanoscale Titanium Oxide Memristive Structures for Neuromorphic Applications: Atomic Force Anodization Techniques, Modeling, Chemical Composition, and Resistive Switching Propertie... by Vadim I. Avilov, Roman V. Tominov, Zakhar E. Vakulov, Daniel J. Rodriguez, Nikita V. Polupanov, Vladimir A. Smirnov

“…The mathematical model allowed us to calculate the processes of oxygen ion transfer to the reaction zone; the growth of the nanostructure due to the oxidation of the titanium film; and the formation of TiO, Ti₂O₃, and TiO₂ oxides in the volume of the growing nanostructure and the redistribution of oxygen vacancies and conduction channel. …”
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Effects of different doses of remimazolam on the quality of sedation and cardiac function in elderly patients: a double-blind randomised controlled study by Liu Minghong, Qizhu Feng, Huichun Chen, Ju Li, Jun Shi

“…However, there was no statistically significant difference (P &gt; 0.05) in BIS values between Group M and Group H; At T1 and T2, the cardiac output and stroke volume in Group M were higher than those in Group H, while the systemic vascular resistance in Group M was lower than that in Group H, with statistically significant differences (P &lt; 0.05); The incidences of bucking when moving and hiccup in Group L were higher than those in Group M and Group H, with statistically significant differences (P &lt; 0.05). …”
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SUMO modified ETV1 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by facilitating CCL2 transcription in esophageal squamous cell carcinoma ce... by Tianci Han, Xiaoqi Guo, Junwei Xie, Wei Tong, Liang Zhang

“…Immunofluorescence double staining was used to detect the tumor-associated macrophage (TAM) infiltration. The tumor volume was recorded and weighed. Transcriptional activity was measured using dual-luciferase assay, chromatin immunoprecipitation (ChIP) assay and DNA pull-down assay. …”
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