Insights into Omicron: Genomic Characterization and Inpatient Risk Assessment at Single Tertiary Hospital in Indonesia by Turbawaty DK, Komala DR, Andriyoko B

Get full text

Oral delivery of the non-β-blocking R-carvedilol enantiomer for skin cancer chemoprevention in SKH-1 mice by Pabitra K. Sardar, Steven Yeung, Ruby Tow, Jacqueline Luga, Matthew Huang, Ayaz Shahid, Bradley T. Andresen, Ying Huang

“…While tumor multiplicity varied significantly between groups (p = 0.005325), tumor volume analysis showed no statistical difference. …”
Get full text

Individual-Level Determinants of Self-Care Behaviors and Adaptation to Chronic Illness in Turkish Patients With Chronic Disease: A Single-Center Cross-Sectional Study by Kılıç YF, Yardımcı Gürel T

Get full text

Prognostic importance of human leukocyte antigen DRβ1 gene and protein tyrosine phosphatase nonreceptor Type 22 gene polymorphism in rheumatoid arthritis by Pramod Kumar Verma, Usha Singh, Shyam Kumar Saraf, Narendra Kumar Singh

Get full text

The analysis of thermal performance of radiation life support system based on experimental data by V. I. Karagusov, A. V. Zinovieva

“…Their development requires a fairly large amount of initial data, such as the parameters of the premises, the required temperature, volume, thermal insulation of walls, floors and ceilings, the design of windows and doors, orientation to the cardinal points, the angles of inclination of the roof slopes, etc. …”
Get full text

Bimodal Patterns of Locomotor Activity and Sleep in Drosophila: A Model for Their Simulation by Putilov AA, Verevkin EG, Petrovskii DV, Zakharenko LP

Get full text

One-Year Outcomes in Subjects Developing Macular Neovascularization While Undergoing Avacincaptad Pegol Therapy for Geographic Atrophy by Rush RB, Klein W, Rush SW, Reinauer R

Get full text

Balloon dilation for the treatment of male urethral strictures: a systematic review and meta-analysis by Tianyu Cai, Xiaoyu Li, Jian Lin, Chunru Xu, Xing Ji, Zhenpeng Zhu, Zhenke Guo

“…The aim of this study was to review and discuss the safety, efficacy and factors influencing the clinical application of balloon dilation for the treatment of male urethral strictures.Design Systematic review and meta-analysis.Data sources Embase, Medline, Web of Science, Cochrane Library and Scopus were searched for publications published before 17 July 2022.Study selection Two independent researchers screened and assessed the results, and all clinical studies on balloon dilation for the treatment of urethral strictures in men were included.Data extraction and synthesis The success rate, rate of adverse events, International Prostate Symptom Scores, maximum uroflow (Qmax) and postvoid residual urine volume were the main outcomes. Stata V.14.0 was used for statistical analysis.Results Fifteen studies with 715 patients were ultimately included in this systematic review. …”
Get full text

Population pharmacokinetics of iruplinalkib in healthy volunteers and patients with solid tumors by Guihong Yang, Yimei Wang, Huimin Zhao, Ziyi Jiang, Shansong Zheng, Mingjing Ge, Meimei Si, Xiaoyan Kang

“…Baseline body weight, time‐varying albumin, time‐varying creatinine clearance, and time‐varying lactate dehydrogenase were significant covariates of apparent clearance from the central compartment (CL/F) while baseline body weight was a significant covariate of apparent volume of the central compartment (V1/F). Given the small or modest effect of all statistically significant covariates on iruplinalkib exposure at steady‐state, no covariate was expected to have clinically meaningful effects on iruplinalkib exposure. …”
Get full text

The Importance of Physiochemical Processes in Decarbonisation Technology Applications Utilizing the Subsurface: A Review by Ieva Kaminskaite, Sandra Piazolo, Andy R. Emery, Nicholas Shaw, Quentin J. Fisher

“…The Earth’s subsurface not only provides a wide range of natural resources but also contains large pore volume that can be used for storing both anthropogenic waste and energy. …”
Get full text

Association of a Common Variant at 10q26 and Benign Prostatic Hyperplasia Aggressiveness in Han Chinese Descent by Xin Gu, Tao Huang, Ding Xu, Liujian Duan, Yang Jiao, Jian Kang, S. Lilly Zheng, Jianfeng Xu, Jielin Sun, Jun Qi

“…Associations between rs2252004 and clinical parameters including International Prostate Symptom Score (IPSS), total prostate volume (TPV), total PSA (tPSA), and free PSA (fPSA) were evaluated by linear regression. …”
Get full text

Evaluation of cellular and physiological alterations of cells from Mytilus galloprovincialis exposed to benzisothiazolinone by Federica Impellitteri, Kristian Riolo, Giorgia Zicarelli, Miriam Porretti, Cristiana Roberta Multisanti, Giuseppe Piccione, Alessia Giannetto, Caterina Faggio

“…Two different concentrations (B1: 0.03 µg/L; B2: 0.3 µg/L) were tested at two different times of exposure (T1: 1 h; T2: 3 h) to evaluate the viability of cells, the phagocytic activity (haemocytes), the regulation volume decrease (RVD on DG cells) capability. Moreover, the cytoprotective mechanisms related to oxidative stress and detoxification were evaluated through the expression analysis by qPCR of key genes involved in these pathways. …”
Get full text

Environmental sustainability profiles assessment of HPLC stability indicating method for quantitation of piracetam and vincamine in pharmaceutical medications by Samya Sh. Alenezi, Ayman A. Gouda, Ragaa El Sheikh, Niaf A. Badahdah, Muneer E Alzuhiri, Ali H. Magrabi, Asim L. Jilani, Ahmed S. Darwish

“…The mobile phase consists of 0.05 M potassium dihydrogen phosphate buffer pH 3.5:ethanol absolute (60:40, by volume), at a flow rate of 1.0 ml/min. Detection was implemented at 220 nm, considering the concentration levels of 80–550 and 4.0–28 μg/ml for piracetam and vincamine, respectively. …”
Get full text

Extracellular vesicles in sputum of children with cystic fibrosis pulmonary exacerbations by Elad Ben-Meir, Lina Antounians, Shafinaz Eisha, Felix Ratjen, Augusto Zani, Hartmut Grasemann

“…Improvement in lung function (percent predicted forced expiratory volume in 1 s (ppFEV1)) with PEx therapy correlated with NE EV content (r=0.657, p=0.001). …”
Get full text

Isobaric (vapour + liquid) equilibria of binary Pb-Sn and Sb-Sn system AT2Pa by Gao J., Xu J., Yang B., Kong L., Xu B., You Y.

“…The activity coefficient of Pb-Sn and Sb-Sn alloys was calculated by using the molecular interaction volume model (MIVM). The maximum average relative deviation Si and maximum average standard deviation Si* are ±1.34% and ±0.009, respectively, which indicates that the calculation of the activity coefficient of the Pb- Sn and Sb-Sn alloys by MIVM is reliable. …”
Get full text

Jiangzhi Granule Ameliorates JNK-Mediated Mitochondrial Dysfunction to Reduce Lipotoxic Liver Injury in NASH by Jiang Y, Xu J, Ding J, Liu T, Liu Y, Huang P, Wang Q, Zheng P, Song H, Yang L

Get full text

«Talgenism» in the Digital Age: A Domestic History of cMOOC by M. A. Babaeva, E. B. Golubev

“…This made it possible to give the “learning theory of the digital age” a noticeable “historical volume”. The roots of the modern connectivism of massive open online courses have been discovered in Russia. …”
Get full text

Effect of muti-scale thermoelectric magnetic convection on the mushy zone evolution of Al-10 wt%Zn alloy during thermal annealing by Zekun Wang, Sansan Shuai, Chenglin Huang, Yuan Hou, Chaoyue Chen, Tao Hu, Songzhe Xu, Jiang Wang, Zhongming Ren

“…In addition, TSMF can promote the coarsening process of the mushy zone, and with the increase of magnetic field intensity, the length of mushy zone became shorter, and the volume fraction of liquid phase decreased. Numerical simulations were conducted to analyze thermoelectric magnetic convection (TEMC) effects at three scales, including the solid-liquid interface (∼8 mm), inside the liquid droplets (∼80 μm), and the tip of the dendrites (∼350 μm), respectively. …”
Get full text

Sulforaphane Wrapped in Self-Assembled Nanomicelle Enhances the Effect of Sonodynamic Therapy on Glioma by Yihong Li, Xuejie Yang, Zhen Wei, Heng Niu, Liyang Wu, Caijing Chen, Huina Liu, Ting Cai, Huadong Fan

“…In animal experiments, besides a significant reduction in tumor volume and a delay in losing body weight, H&E staining showed a massive infiltration of neutrophils adjacent to the tumor sites, indicating this novel nanocomplex SFN@RB@SPM can synergistically augment SDT efficacy, partially by enhancing the antitumor function of innate immunity.…”
Get full text

Unresectable Hepatic Metastasis of Uveal Melanoma: Hepatic Chemosaturation with High-Dose Melphalan—Long-Term Overall Survival Negatively Correlates with Tumor Burden by R. Brüning, M. Tiede, M. Schneider, P. Wohlmuth, H. Weilert, K. Oldhafer, A. Stang

“…Median OS was 16.7 months after the first PHP-M treatment and 26.4 months after initial diagnosis. Low hepatic tumor volume (median of 10 mL vs. 150 mL) was an independent predictor of favorable OS (hazard ratio (95% confidence interval): 0.190 (0.041, 0.893); p<0.05), and female patients were at a lower risk compared with males (0.146 (0.017, 1.240)). …”
Get full text