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  1. 4601
  2. 4602

    Delivery of Prime editing in human stem cells using pseudoviral NanoScribes particles by Thibaut Halegua, Valérie Risson, Julien Carras, Martin Rouyer, Laurent Coudert, Arnaud Jacquier, Laurent Schaeffer, Théophile Ohlmann, Philippe Emmanuel Mangeot

    Published 2025-01-01
    “…In this report, we engineer Nanoscribes, virus-like particles that encapsidate ribonucleoprotein complexes of the Prime Editing system and allow their delivery into recipient cells. …”
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  3. 4603

    Caracterización clínico-epidemiológica de la COVID 19. Centro de aislamiento MICONS. Cienfuegos, 2021 by Juan Rafael Zerquera Rodriguez, Livan Rojas Lantigua, Bárbaro Orlando Pérez Sabina, César Coma García, Keyla Zerquera Rodríguez

    Published 2022-07-01
    “…<br /><strong>Resultados</strong>: predominó el grupo de edades entre 45 a 59 años con el 33,8 %; el 48,4 % de pacientes ingresados en el centro fueron hipertensos; el 23,4 % del total de casos fueron positivos al virus SARS-CoV- 2; los síntomas predominantes fueron la fiebre con un 39,2 %; la tos con un 37,7 % y la cefalea con un 30,1 %. …”
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  4. 4604

    Inflammasome Genes’ Polymorphisms in Egyptian Chronic Hepatitis C Patients: Influence on Vulnerability to Infection and Response to Treatment by Shady Z. K. Estfanous, Sahar A. Ali, Sameh M. Seif, Sameh H. A. Soror, Dalia H. A. Abdelaziz

    Published 2019-01-01
    “…Chronic inflammation is a pivotal contributor to the liver damage mediated by hepatitis C virus (HCV). The NOD-like receptor, pyrin domain-containing 3 (NLRP3) inflammasome is activated by HCV in both hepatocytes and Kupffer cells. …”
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  5. 4605

    Community behavior for mathematical model of coronavirus disease 2019 (COVID-19) by M. Ramli, M. Mukramati, M. Ikhwan, H. Hafnani

    Published 2022-04-01
    “…The implication of this action is that the infected population is decreasing, resulting in less interaction between the susceptible and the infected. In this case, the virus has not vanished from the community, but the use of masks in certain populations or subpopulations is lower than before, which can reduce mask waste in the environment.METHODS: This study expands on a previous MERS-CoV research model using the susceptible-exposed-infected-quarantine-recovery model by incorporating behavioral control, specifically the use of masks and physical distancing as preventive measures. …”
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  6. 4606

    Opportunities for NCD screening and control efforts among people living with HIV/AIDS attending care and treatment clinic at a regional referral hospital in Dar es Salaam by Atuganile Musyani, Grace Mosi, Erik Kinyenje, Mucho Mizinduko, Rogath Kishimba, Meshack Shimwela, Leonard Subi

    Published 2024-12-01
    “…Abstract Background Persons living with human immunodeficiency virus (PLHIV) in Tanzania now live longer and hence are at increased risk of developing noncommunicable diseases (NCDs). …”
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  7. 4607

    Effects of perioperative treatment of resectable adenocarcinoma of esophagogastric junction by immunotherapy (Adebrelimab) combined with chemotherapy (XELOX): protocol for a single... by Yingyi Li, Yuqin Cao, Xipeng Wang, Chengqiang Li, Liqin Zhao, Hecheng Li

    Published 2025-02-01
    “…The exploratory outcomes are the biomarkers related to therapeutic efficacy, such as PD-L1 expression, microsatellite instability (MSI), tumor mutational burden(TMB), Epstein-Barr virus(EBV) infection, and circulating tumor DNA(ctDNA). …”
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  8. 4608
  9. 4609

    Piloting of a Screen-Triage-Treat Surgical Approach Model for Management of Anal Cancer in Liberia by Christopher W. Reynolds, Whitney Lieb, Andrea Schecter, Michael M Gaisa, Stephen K. McGill, Evans L. Adofo, Ann Marie Beddoe

    Published 2024-12-01
    “…Participants underwent anal self-swabbing for high-risk human papillomavirus (HPV) and offered human immunodeficiency virus (HIV) testing. Those with positive results were offered a screen-triage-treat model through high-resolution anoscopy (HRA) and infrared coagulation (IRC). …”
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  10. 4610

    Th2 Regulation of Viral Myocarditis in Mice: Different Roles for TLR3 versus TRIF in Progression to Chronic Disease by Eric D. Abston, Michael J. Coronado, Adriana Bucek, Djahida Bedja, Jaewook Shin, Joseph B. Kim, Eunyong Kim, Kathleen L. Gabrielson, Dimitrios Georgakopoulos, Wayne Mitzner, DeLisa Fairweather

    Published 2012-01-01
    “…Here, we investigated the role of virus-activated Toll-like receptor (TLR)3 and its adaptor TRIF on the development of autoimmune coxsackievirus B3 (CVB3) myocarditis in mice. …”
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  11. 4611

    Emotions and Behaviors of Children Aged 0-6 during the Period of Epidemic Prevention at Home by Xuechang HE, Hui OUYANG, Hanzhang GUO, Zhuoming CHEN, Longbin SHEN, Jianlin OU

    Published 2020-10-01
    “…Objective:To understand the emotion, behavior and the influencing factors at home epidemic prevention during the epidemic of Corona Virus Disease 2019(COVID-19) in children aged 0-6, and to provide a theoretical basis for the health promotion and family intervention education of that age in similar situations.Methods:On February 24, 2020, a convenient sampling method was used to invite guardians of children aged 0-6 to conduct a online questionnaire survey one month after the government adopted a large-scale outbreak control strategy.Results:The effective rate of the questionnaire was 98.79%(163/165), mainly from Guangdong Province (75.46%). …”
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  12. 4612

    Comparative Analysis of miRNA Expression Profiles of Yak Milk-Derived Exosomes at Different Altitudes by Wenwen Ren, Yongfu La, Xiaoming Ma, Xiaoyun Wu, Xian Guo, Min Chu, Ping Yan, Xianyong Lan, Chunnian Liang

    Published 2025-01-01
    “…These miRNAs were found to be implicated in pathways associated with mammary gland inflammation, virus infection regulation, and heat stress response. …”
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  13. 4613

    Frequent Detection of Anti-Tubercular-Glycolipid-IgG and -IgA Antibodies in Healthcare Workers with Latent Tuberculosis Infection in the Philippines by Umme Ruman Siddiqi, Prisca Susan A. Leano, Haorile Chagan-Yasutan, Beata Shiratori, Hiroki Saitoh, Yugo Ashino, Yasuhiko Suzuki, Toshio Hattori, Elizabeth Freda O. Telan

    Published 2012-01-01
    “…Anti-tubercular-glycolipid-IgG (TBGL-IgG) and -IgA (TBGL-IgA) antibodies, and the QuantiFERON-TB Gold test (QFT) were compared in healthcare workers (HCWs, n=31) and asymptomatic human immunodeficiency virus-carriers (HIV-AC, n=56) in Manila. In HCWs, 48%, 51%, and 19% were positive in QFT, TBGL-IgG, and -IgA, respectively. …”
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  14. 4614

    Prevalence, Antimicrobial Susceptibility Pattern of Bacterial Isolates, and Associated Factors of Urinary Tract Infections among HIV‐Positive Patients at Hiwot Fana Specialized Uni... by Dadi Marami, Senthilkumar Balakrishnan, Berhanu Seyoum

    Published 2019-01-01
    “…Its prevalence is fueled by human immunodeficiency virus (HIV) infection. The emergence of antimicrobial resistance is now widespread and poses a serious clinical threat. …”
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  15. 4615

    Continuous ambulatory peritoneal dialysis technique failure in adult patients treated at a tertiary hospital in central South Africa: a retrospective analytical study by Tshifhiwa B. Sikhipha, Claire Barrett, Nicoline van Zyl, Cornel van Rooyen, Feziwe B. Bisiwe

    Published 2025-01-01
    “…Hypertension was the leading cause of ESKD (n = 47; 51.6%), followed by human immunodeficiency virus- (HIV-) associated conditions (n = 18; 19.8%). …”
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  16. 4616

    Peripheral lncRNA NEAT-1, miR374b-5p, and IL6 panel to guide in COVID-19 patients' diagnosis and prognosis. by Marwa A Ali, Olfat G Shaker, Eman M Ezzat, El Shaimaa Gomaa Ali, Mahmoud I Aboelor, Mona I Ahmed, Essam A Hassan, Doaa Y Ali, Heba Mostafa Ahmed, Abeer A Khalefa, Rasha A Hussein, Ahmed Fathy Elkhateeb, Esam Ali Mohamed

    Published 2024-01-01
    “…<h4>Background</h4>The SARS-CoV-2 virus's frequent mutations have made disease control with vaccines and antiviral drugs difficult; as a result, there is a need for more effective coronavirus drugs. …”
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  17. 4617

    Differences in HIV infection trends in two regions of Cameroon with a longstanding HIV epidemic: insights from 2012 and 2022 by Yannick F. Ngoume, Urmes C. Teagho, Brice Eselacha, Oumarou H. Goni, Dell-Dylan Kenfack, Mérimé Tchakoute, Georges Nguefack-Tsague, Marcel Tongo, Marcel Tongo

    Published 2025-02-01
    “…IntroductionTo achieve the UNAIDS 95-95-95 target by 2025, it is of great importance to test and diagnose individuals infected with HIV; especially those residing in communities with limited access to health and in areas with a longstanding HIV epidemic, where the virus has been circulating since the early phase of the pandemic. …”
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  18. 4618

    A comparative cohort study of post-COVID-19 conditions based on physical examination records in ChinaResearch in context by Zhong Liu, Boqiang Hu, Tao Zeng, Cuiping You, Nan Li, Yongjing Liu, Jie Zhang, Chenbing Liu, Piaopiao Jin, Xiaoxi Feng, Jun Chen, Jinyan Huang

    Published 2025-02-01
    “…Summary: Background: Coronavirus disease-2019 (COVID-19), caused by SARS-CoV-2 virus infection, is characterized as a multisystem disease, potentially yielding multifaceted consequences on various organs at multiple levels. …”
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  19. 4619

    Experiencia en autopsias de fallecidos con la COVID-19 en el Hospital Militar Central “Dr. Luis Díaz Soto” by Teresita Montero González, José Hurtado de Mendoza Amat, Yusleidys Fraga Martínez, Liem Laguna Oliva, Leticia del Rosario Cruz, Yamile Torres Gómez

    Published 2020-11-01
    “…La mortalidad por la COVID-19 como causa de muerte afectó a menos de la mitad de los casos estudiados, con expresión respiratoria y cardiaca por la acción del virus. …”
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  20. 4620

    Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease by Long Fung Chau, Simon Lillico, Tanja Opriessnig, Rosemary Blake, Luc Tardy, Chen-Hsuin Lee, Scott Maxwell, Claire Warren, Elizabeth Thornton, Catherine L. Mclaughlin, Gerry McLachlan, Christine Tait-Burkard, Sarah Fletcher, Stephen Anderson, Sharon Brown, Louise Gibbard, Thomas Tzelos, Dawn MacMillan-Christensen, J. Kenneth Baillie, David A. Dorward, David J. Griffiths, Finn Grey

    Published 2025-01-01
    “…Following challenge, clinical signs consistent with COVID-19, including fever, coughing and respiratory distress were observed, with virus replication detected in the nasal turbinates, trachea and lungs up to the study endpoint, seven days post-infection. …”
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