Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir. by Brandon F Keele, Afam A Okoye, Christine M Fennessey, Benjamin Varco-Merth, Taina T Immonen, Emek Kose, Andrew Conchas, Mykola Pinkevych, Leslie Lipkey, Laura Newman, Agatha Macairan, Marjorie Bosche, William J Bosche, Brian Berkemeier, Randy Fast, Mike Hull, Kelli Oswald, Rebecca Shoemaker, Lorna Silipino, Robert J Gorelick, Derick Duell, Alejandra Marenco, William Brantley, Jeremy Smedley, Michael Axthelm, Miles P Davenport, Jeffrey D Lifson, Louis J Picker

“…The rebound competent viral reservoir (RCVR)-virus that persists during antiretroviral treatment (ART) and can reignite systemic infection when treatment is stopped-is the primary barrier to eradicating HIV. …”
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Clinical Patterns and Outcome of Hepatocellular Carcinoma in Patients with Nonalcoholic Fatty Liver Disease by Seon Young Ahn, Suk Bae Kim, Il Han Song

“…The aim of this study was to compare the clinical patterns and survival outcomes of NAFLD-related HCC patients and those of alcoholic liver disease (ALD)-related or hepatitis B virus (HBV)-related HCC patients. Methods. A total of 622 HCC patients with associated NAFLD (n = 56), ALD (n = 173), or HBV infection (n = 393) were enrolled. …”
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Oral Immunisation With Non‐GMO Surface Displayed SARS‐CoV‐2 Spike Epitopes on Bacteria‐Like Particles Provokes Robust Humoral and Cellular Immune Responses, and Modulated the Gut M... by Robie Vasquez, Ji Hoon Song, Remilyn M. Mendoza, In‐Chan Hwang, Bernadette B. Bagon, Lars Engstrand, Valerie Diane Valeriano, Dae‐Kyung Kang

“…To date, several vaccines have been developed to combat the spread of this virus. Mucosal vaccines using food‐grade bacteria, such as Lactobacillus spp., are promising strategies for developing safe and effective vaccines against SARS‐CoV‐2. …”
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Insights into Omicron: Genomic Characterization and Inpatient Risk Assessment at Single Tertiary Hospital in Indonesia by Turbawaty DK, Komala DR, Andriyoko B

“…Pasteur No. 38, Bandung, West Java, Indonesia, Tel +628122150145, Email dewi.kartika@unpad.ac.idPurpose: Omicron is a variant with the highest number of mutations among all Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) viruses, making whole genome sequencing (WGS) an essential tool for public health surveillance and molecular epidemiology. …”
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Dengue Situation in Bangladesh: An Epidemiological Shift in terms of Morbidity and Mortality by Pulak Mutsuddy, Sanya Tahmina Jhora, Abul Khair Mohammad Shamsuzzaman, S. M. Golam Kaisar, Md Nasir Ahmed Khan

“…In our study, climate changes, such as average rainfall, humidity, and temperature, after 2014, and rapid unplanned urbanization were the strong predictors of an imbalance in the existing ecology that has led to increase in dengue cases in 2016 and the emergence of the chikungunya virus for the first time in Bangladesh in 2017. Although 2018 dengue data are relevant but not included in this study due to study time frame, it is interesting to report an increase in the number of dengue cases in pre (2016) and post (2018, which is highest within 18 years) chikungunya outbreak, which favors the study hypothesis. …”
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Transcriptome Analysis and Phytohormone Profile Reveal Core Phytohormone Regulating Parthenocarpy in Fingered Citron by Qianbin Chen, Jinjian Xu, Xinjian Zou, Yanjun Zhang, Xiaoxian Zhu, Kewei Zhang, Wenrong Chen, Fanglei Liao, Weidong Guo

“…A weighted gene co-expression network analysis (WGCNA) suggested that the interplay between auxin and ABA is crucial for triggering parthenocarpy. Virus-induced gene silencing (VIGS) experiments demonstrated that silencing <i>CmsABI5</i> led to decreased ABA levels, while auxin levels remained unchanged, resulting in disrupted parthenocarpy and increased ethylene levels, indicating a secondary hormonal response. …”
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The pilot study of the features of HIV-1 resistant variants spread using molecular clusters by Alina A. Kirichenko, Dmitry E. Kireev, Yulia N. Sidorina, Natalia D. Abashina, Elena E. Brusentseva, Vasily G. Akimkin

“…The most actively and efficiently transmitted mutations were K103N, V179E/T, Y181C and G190S, associated with virus resistance to efavirenz and nevirapine.…”
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Flowers: precious food and medicine resources by Xuqiang Liu, Senye Wang, Lili Cui, Huihui Zhou, Yuhang Liu, Lijun Meng, Sitan Chen, Xuefeng Xi, Yan Zhang, Wenyi Kang

“…The pharmacological effects of flower plants are very extensive, mainly including antioxidant, anti-inflammatory, anti-tumor, anti-virus, and hypoglycemic. The mechanisms of anti-inflammatory, anti-tumor and hypoglycemic activities present the characteristics of multi-way and multi-target. …”
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von Willebrand factor polymorphism (rs1063856) as a risk factor for portal vein thrombosis in chronic liver diseases by Isis Samy Bedira, Olfat M. Hendy, Moones Abdelaal, Ashraf A. Basuni, Asma Ebrahim Gaber Koshoo, Alzhraa Alkhatib, Sally S. Mandour

“…Tests for liver and renal function, coagulation profile, complete blood count, hepatitis virus markers, and vWF:Ag level were conducted. The identification of the vWF gene polymorphism (rs1063856) was assessed using real-time PCR. …”
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Huge splenomegaly, a rare presentation of multicentric Castleman’s disease in an HIV-infected patient: a case report and literature review by Malihe Hasannezad, Abdolkarim Haji Ghadery, Sara Ghaderkhani, Armin Vazirian, Fereshteh Ameli, Farid Azmoudeh-Ardalan, Mohammad Reza Rafiian Naini, Ladan Abbasian

“…Nowa­days, multicentric CD is most commonly observed in individuals infected with human immunodeficiency virus (HIV) type 1, in association with Kaposi’s sarcoma. …”
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SIV infection induces alterations in gene expression and loss of interneurons in Rhesus Macaque frontal cortex during early systemic infection by Richard C. Crist, Samar N. Chehimi, Saurabh S. Divakaran, Michael J. Montague, Sébastien Tremblay, Noah Snyder-Mackler, Martin O. Bohlen, Kenneth L. Chiou, Trish M. Zintel, Cayo Biobank Research Unit, Michael L. Platt, Halvor Juul, Guido Silvestri, Matthew R. Hayes, Dennis L. Kolson, Benjamin C. Reiner

“…Preclinical non-human primate simian immunodeficiency virus (SIV) models help address these shortcomings. …”
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Oncogenic mutant KRAS inhibition through oxidation at cysteine 118 by Maximilian Kramer‐Drauberg, Ettore Petrini, Alessia Mira, Enrico Patrucco, Rossella Scardaci, Ilenia Savinelli, Haiyun Wang, Keying Qiao, Giovanna Carrà, Marie‐Julie Nokin, Zhiwei Zhou, Kenneth D. Westover, David Santamaria, Paolo E. Porporato, Chiara Ambrogio

“…Specific reactive oxygen species activate the GTPase Kirsten rat sarcoma virus (KRAS) by reacting with cysteine 118 (C118), leading to an electron transfer between C118 and nucleoside guanosine diphosphate (GDP), which causes the release of GDP. …”
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Immunoreactivity of the SARS-CoV-2 entry proteins ACE-2 and TMPRSS-2 in murine models of hormonal manipulation, ageing, and cardiac injury by Susan Bengs, Alexia Rossi, Martina Haberecker, Nidaa Mikail, Alexander Meisel, Achi Haider, Muriel Grämer, Angela Portmann, Atanas Todorov, Christof Schönenberger, Caroline E. Gebhard, Gabriela M. Kuster, Vera Regitz-Zagrosek, Catherine Gebhard

“…Abstract Previous work indicates that SARS-CoV-2 virus entry proteins angiotensin-converting enzyme 2 (ACE-2) and the cell surface transmembrane protease serine 2 (TMPRSS-2) are regulated by sex hormones. …”
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Insights into expression and localization of HPV16 LCR-associated transcription factors and association with LCR activity in HNSCC by Nikita Aggarwal, Divya Janjua, Apoorva Chaudhary, Udit Joshi, Tanya Tripathi, Chetkar Chandra Keshavam, Joni Yadav, Arun Chhokar, Alok Chandra Bharti

“…Notably, HPV-positive HNSCC exhibits a more favorable prognosis, particularly when the virus is transcriptionally active. This study aimed to elucidate the role of key transcription factors in activating the HPV long control region (LCR), responsible for its oncogenic potential. …”
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Under-nutrition and its associated factors among adult second-line antiretroviral treatment users in Northern Ethiopia by Seteamlak Adane Masresha, Atitegeb Abera Kidie, Getahun Fentaw Mulaw, Fentaw Wassie Feleke, Mesfin Wudu Kassaw, Tadesse Mamo Dejene, Aychew Kassie Gidafie, Fassikaw Kebede Bizuneh

“…Abstract Background Despite advancements in Human Immunodeficiency Virus (HIV) treatment and care, undernutrition remains a significant concern, accelerating disease progression and risk of Acquired Immune Deficiency Syndrome (AIDS)-related deaths. …”
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Symptomatic neurosyphilis in HIV-negative patients: a retrospective cohort study by Qiaoer Chen, Qiaoer Chen, Weiqi Wu, Lu Wang, Honghong Huang, Lingxing Wang

“…Few studies have focused on human immunodeficiency virus (HIV)-negative patients with symptomatic neurosyphilis, and the clinical outcomes and factors influencing the outcomes are unclear. …”
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Prognostic assessment of early-stage liver cirrhosis induced by HCV using an integrated model of CX3CR1-associated immune infiltration genes by Haozheng Cai, Jing Zhang, Chuwen Chen, Junyi Shen, Xiaoyun Zhang, Wei Peng, Chuan Li, Haopeng Lv, Tianfu Wen

“…However, its role in hepatitis C virus (HCV)-induced early-stage liver cirrhosis remains unexplored. …”
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Epidemiological and clinical characteristics of hospitalized pediatric patients with Mycoplasma pneumoniae pneumonia before and after the COVID-19 pandemic in China: a retrospectiv... by Yuqian Zhang, Chenglei Su, Yang Zhang, Shuo Ding, Xianliang Yan, Jianguo Zhang, Zhimin Tao

“…With significance, the post-COVID group had more occurrences of cough and expectoration and higher incidences of influenza A/B virus (IAV/IBV) co-infection than the pre-COVID group. …”
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Unlocking the Potential of RNA Sequencing in COVID-19: Toward Accurate Diagnosis and Personalized Medicine by Heba M. Saad Eldien, Abdulrahman H. Almaeen, Ahmed Abo El Fath, Ahmed E. Taha, Rehab Ahmed, Hassabelrasoul Elfadil, Helal F. Hetta

“…In critically ill patients, RNAseq has been crucial for identifying key genes that may predict patient outcomes, guiding therapeutic decisions, and assessing the long-term effects of the virus. Additionally, RNAseq has helped in understanding the persistence of viral RNA after recovery, offering new insights into the management of post-acute sequelae, including long COVID. …”
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Experiencias de la pesquisa activa estudiantil. Policlínico docente Fabio D´Celmo. Caonao. Cienfuegos. by Lian Roque Roque, Annia Iglesias Armenteros, Leticia Bouza Cabrera, Juana Bello Alpízar, Grisell Menéndez Rodríguez, Miriam Martín Ojeda

“…En el Consultorio Médico Nro. 15, del Consejo Popular Guaos, una paciente resultó positiva al virus SARS-CoV-2, único caso positivo de COVID 19 en esta área de salud; los estudiantes contribuyeron a su detección y a la pesquisa de los 39 casos sospechosos que generó este foco. …”
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