Antiviral and Immunoenhancing Properties of 7-Thia-8-Oxoguanosine and Related Guanosine Analogues by Donald F Smee, Howard B Cottam, Brahma S Sharma, Ganesh D Kini, Ganapathi R Revankar, Emmanuel A Ojo-Amaize, Robert W Sidwell, Weldon B Jolley, Roland K Robins

“…Its spectrum of action includes interferon-sensitive viruses such as alphaviruses, bunyaviruses, corona viruses, flaviviruses, picornaviruses and, to a lesser extent, herpesviruses. …”
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Acciones de vigilancia y control ante un caso de COVID-19 en el Policlínico José Luis Chaviano de Cienfuegos, Cuba by Dania Lázara Pedraza Alejo, Morayma Almeida Morales, Javier Alejandro Hernández Sánchez, Berena Hidalgo Cruz, Alain González Gil, Imandra María García Méndez

“…Las medidas adoptadas en el área de salud I del municipio de Cienfuegos estuvieron encaminadas a detener la transmisión y prevenir el contagio, reduciendo el riesgo de exposición al virus. Se ha demostrado que todas las medidas fueron inmediatas y escalables, en función de la situación epidemiológica concreta.…”
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Subthalamic hGAD65 Gene Therapy and Striatum TH Gene Transfer in a Parkinson’s Disease Rat Model by Deyu Zheng, Xiaohua Jiang, Junpeng Zhao, Deyi Duan, Huanying Zhao, Qunyuan Xu

“…Here, a PD rat model is used for the in vivo gene therapy of a recombinant adeno-associated virus (AAV2) containing a human glutamic acid decarboxylase 65 (rAAV2-hGAD65) gene delivered to the subthalamic nucleus (STN). …”
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Multiple Organ Failure Associated with SARS-CoV-2 Infection in a Child with Down Syndrome: Is Trisomy 21 Associated with an Unfavourable Clinical Course? by Perla Idalia Vazquez-Hernández, Alan Cárdenas-Conejo, Manuel Alejandro Catalán-Ruiz, Karla Navar-Gallegos, Emilio Zenteno-Salazar, Jose Rafael-Parra-Bravo, Ranferi Aragon-Nogales, Maribel Ibarra-Sarlat, Juan Carlos Núñez-Enríquez

“…Our aim is to describe the unfavorable clinical course of a child with DS infected with SARS-CoV-2 virus. Case. Female, 2 years old, karyotype 47,XX,+21[30], previously diagnosed with a cyanotic congenital heart disease (tricuspid atresia and infundibular pulmonary stenosis, type Ib) who started with diarrhea, developed shortness of breath, and cyanosis and was admitted to the hospital presenting low-oxygen saturation (33%) requiring invasive mechanical ventilation support. …”
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Modification of Gene Expression Involved in Alkaloid Production in Opium Poppy by VIGS Combined With Pretreatment of Macerozyme Enzyme by Deniz Ece Özcan, Deniz Köm, Ozan Doğan, Semiha Erişen, Selma Onarici

“…This study explores a novel approach to manipulating alkaloid biosynthesis pathways by integrating virus‐induced gene silencing (VIGS) with macerozyme enzyme pretreatment. …”
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Neglected tropical diseases in Yemen: a systematic review of epidemiology and public health challenges by Ibrahim Ahmed Ahmed Alhothily, Rahmat Dapari, Nazri Che Dom

“…Dengue virus, hepatitis B and C viruses were the most prominent viral pathogens, while bacterial NTDs were primarily caused by Escherichia coli, cholera, and Salmonella. …”
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Study of COVID-19 cases with real data analysis by Wedad Albalawi, Kottakkaran Sooppy Nisar, Nadir Omer, Adnan Aslam, Takasar Hussain, Muhammad Ozair, Shahid Hussain, Nida Hameed

“…In this work, patients of corona virus disease 2019, known as COVID-19, have been studied in Pakistan and its neighboring countries Iran, India and Afghanistan through the mathematical model in the form of coupled system of five ordinary differential equations. …”
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Fast and Sensitive Detection of SARS-CoV-2 Nucleic Acid Using a Rapid Detection System Free of RNA Extraction by Liang Ma, Yanyan Fan, Xiaomu Kong, Yongwei Jiang, Hong Huang, Meimei Zhao, Yi Liu, Peng Gao, Yong Cui, Yongtong Cao

“…The limit of detection (LoD) was determined using a negative nasopharyngeal swab matrix spiked with different concentrations of SARS-CoV-2 virus; a total of 734,337 reference sequences of viral genomes from GenBank were used for the in-silico analysis to assess the inclusivity of the assay. …”
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E-Selectin/AAV Gene Therapy Promotes Myogenesis and Skeletal Muscle Recovery in a Mouse Hindlimb Ischemia Model by Antoine J. Ribieras, Yulexi Y. Ortiz, Yan Li, Nga T. Le, Carlos T. Huerta, Francesca A. Voza, Hongwei Shao, Roberto I. Vazquez-Padron, Zhao-Jun Liu, Omaida C. Velazquez

“…C57BL/6J mice were treated with intramuscular E-selectin/adeno-associated virus serotype 2/2 gene therapy (E-sel/AAV) or LacZ/AAV2/2 (LacZ/AAV) as control and then subjected to femoral artery coagulation. …”
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Peptide Antigen Modifications Influence the On-Target and Off-Target Antibody Response for an Influenza Subunit Vaccine by Megan C. Schulte, Adam C. Boll, Agustin T. Barcellona, Elida A. Lopez, Adam G. Schrum, Bret D. Ulery

“…This provides preliminary evidence that the PAM-induced on-target antibodies will at minimum be able to recognize the influenza virus upon exposure.…”
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Efficacy and safety of immunotherapy in locally advanced or metastatic pulmonary lymphoepithelioma-like carcinoma: a multicenter retrospective study by Xiongwen Yang, Yi Xiao, Yubin Zhou, Hao Hu, Huiyin Deng, Jian Huang, Maoli Liang, Zihao Yuan, Longyan Dong, Shaohong Huang

“…Background: Pulmonary lymphoepithelioma-like carcinoma (pLELC) is a rare subtype of non-small-cell lung cancer that predominantly affects younger, non-smoking individuals in southern and southeast Asia, where Epstein–Barr virus (EBV) prevalence is high. The efficacy and safety of immunotherapy in pLELC, especially in second-line settings, remain inadequately explored. …”
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Enfermedad periodontal como factor agravante de los pacientes con la COVID-19 by Yaday Guerra Duarte, Mirkey Estrada Castillo, Clara Doncel Pérez

“…A finales de diciembre del 2019, fue reportado en Wuhan, China, un nuevo virus causante de una neumonía atípica, denominado SARS-CoV-2, cuya enfermedad se nombró COVID-19. …”
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Zoonotic Babesia: A scoping review of the global evidence. by Kaitlin M Young, Tricia Corrin, Barbara Wilhelm, Carl Uhland, Judy Greig, Mariola Mascarenhas, Lisa A Waddell

“…Zoonotic Babesia is vectored by Ixodes ticks and is commonly transmitted in North America by Ixodes scapularis, the tick species responsible for transmitting the pathogens that also cause Lyme disease, Powassan virus, and anaplasmosis in humans. Predicted climate change is expected to impact the spread of vectors, which is likely to affect the distribution of vector-borne diseases including human babesiosis.…”
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Gestações e Puerpérios arriscados: narrativas oficiais do Governo brasileiro acerca de maternidades consideradas indesejáveis face às emergências sanitárias do Zika e da Covid-19... by Raquel Lustosa, Ana Claudia Camargo

“… Em 2015 e 2016, o Brasil vivenciou um pico de notificações de bebês nascidos com a Síndrome Congênita do Zika Vírus (SCZV). A “ameaça global” não era a doença do Zika em si, mas estar grávida (ou a possibilidade de engravidar) (Fleischer; Carneiro, 2017; Diniz, 2016). …”
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Empathic love therapy for adolescents living with HIV in Surabaya, Indonesia by Erika Martining Wardani, Riezky Faisal Nugroho, Siti Nurjanah, Syiddatul Budury, Iis Noventi

“…Introduction Adolescents with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) do not only experience physical pain. …”
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Reflections on COVID-19: A Literature Review of SARS-CoV-2 Testing by Chin Shern Lau, Helen M. L. Oh, Tar Choon Aw

“…To this day it is difficult to identify a true neutralizing antibody test for the virus. An appropriate antibody level that would confer protective immunity against the plethora of new variants remains elusive. …”
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Pregnancy-Specific Concerns and Psychological Impact of COVID-19 on Antenatal Women by Sanjay Singh, Vinod G Nair, Virendra Vikram Singh, Shyamji Tiwari, Devendra Arora, Madhusudan Dey, Ravindu Tiwari, Sreeni V Nair

“…Pregnant women, being a vulnerable group, are grossly affected by these changing environmental scenarios. The spread of Corona Virus infection itself and the subsequent nation-wide lockdown in India, just like many other countries, has caused a serious impact on antenatal patients. …”
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Thymosin β4 Protects against Cardiac Damage and Subsequent Cardiac Fibrosis in Mice with Myocardial Infarction by Fei Wang, Yajuan He, Naijuan Yao, Litao Ruan, Zhen Tian

“…The effects of intraperitoneal adeno-associated virus-Tβ4 (AAV-Tβ4) on ligation-induced AMI in mice were studied using cardiac function parameters, and RT-PCR, Western blot, HE staining, Masson staining, and IHC were used to assess the degree of myocardial fibrosis. …”
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Predicting the Number of COVID-19 Sufferers in Malang City Using the Backpropagation Neural Network with the Fletcher–Reeves Method by Syaiful Anam, Mochamad Hakim Akbar Assidiq Maulana, Noor Hidayat, Indah Yanti, Zuraidah Fitriah, Dwi Mifta Mahanani

“…COVID-19 spreads through direct contact, wherein the infected individual spreads the COVID-19 virus through cough, sneeze, or close contacts. Predicting the number of COVID-19 sufferers becomes an important task in the effort to curb the spread of COVID-19. …”
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CCR5-ligand decorated rilpivirine lipid-based nanoparticles for sustained antiretroviral responses by Milankumar Patel, Sudipta Panja, Lubaba A. Zaman, Pravin Yeapuri, Shaurav Bhattarai, Santhi Gorantla, Linda Chang, Alonso Heredia, Piotr Walczak, Brandon Hanson, Samuel M. Cohen, Bhavesh D. Kevadiya, Howard E. Gendelman

“…Abstract Antiretroviral therapy (ART) improves the quality of life for those living with the human immunodeficiency virus type one (HIV-1). However, poor compliance reduces ART effectiveness and leads to immune compromise, viral mutations, and disease co-morbidities. …”
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