Comparative analysis of the Streptococcus pneumoniae competence development in vitro versus in vivo during pneumonia-derived sepsis by Sook Yin Chong, Shi Qian Lew, Tauqeer Alam, Christopher A. Gaulke, Gee W. Lau

“…IntroductionThe Streptococcus pneumoniae (pneumococcus) competence regulon is well-known for regulating genetic transformation but is also important for virulence. Some pneumococcal strains can enter a transient competent state for genetic transformation in an optimized competence-inducing medium when the threshold level of the peptide pheromone competence stimulating peptide is attained; upregulating the expression of three distinct phases of “early”, “late” and “delayed” competence genes. …”
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Laboratory risk assessment of Beauveria bassiana AAD16 on two species of ladybird beetle. by Md Rajib Hasan, Md Rasel Raju, Un Taek Lim

“…Here we assessed the compatibility between ladybird beetles and B. bassiana AAD16. The virulence of the AAD16 strain was compared with that of an available commercial strain, B. bassiana GHA, for two developmental stages (adults and 3rd instar larvae) of two coccinellids, Harmonia axyridis Pallas and Chilocorus spp. …”
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Clinical isolates of Candida auris with enhanced adherence and biofilm formation due to genomic amplification of ALS4. by Jian Bing, Zhangyue Guan, Tianhong Zheng, Zhijie Zhang, Shuru Fan, Craig L Ennis, Clarissa J Nobile, Guanghua Huang

“…Compared to the previously characterized nonaggregative/yeast-form and aggregative-form strains of C. auris, this new Als4-mediated aggregative-form strain of C. auris displays several unique characteristics in terms of its biofilm formation, surface colonization, and virulence.…”
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Exilul „concentraţionar” şi poezia ca libertate by Sorin Ivan

“…Caraion writes a poetry of resistance, a political poetry, of extraordinary virulence, which accuses the communist regime and its dehumanizing ideology of crimes against human being and humanity. …”
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Exploring effector protein dynamics and natural fungicidal potential in rice blast pathogen Magnaporthe oryzae. by Jannatul Ferdousy, Tanjin Barketullah Robin, Mst Sanjida Nasrin, Istiak Ahmed, Tawsif Hossain, Md Mehedi Hasan, Mehrab Hassan Soaeb, Md Ahsanul Tamim, Nusrat Jahan Yeasmin, Ummay Habiba, Nadim Ahmed, Nurul Amin Rani, Md Shishir Bhuyian, Suvarna N Vakare, Abu Tayab Moin, Rajesh B Patil, Mohammad Shahadat Hossain

“…Genetic and genomic studies have identified key genes and proteins, such as AvrPik variants and MAX proteins, that are crucial for the pathogen's virulence. These effector proteins interact with specific alleles of the Pik gene family on rice chromosome 11, modulating the host's immune response. …”
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THE PREVALENCE, ISOLATION, AND ANTIMICROBIAL SUSCEPTIBILITY TESTING OF ENTEROCOCCUS SPECIES FROM VARIOUS CLINICAL SAMPLES IN A TERTIARY CARE HOSPITAL by Turin Afroz

“…Greater understanding is needed regarding Enterococcus stress survival, virulence, and resistance patterns to assess the complexity of disease-causing Enterococcus. …”
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Genomic and Drug Resistance Profile of Bovine Multidrug-Resistant <i>Escherichia coli</i> Isolated in Kazakhstan by Pavel G. Alexyuk, Andrey P. Bogoyavlenskiy, Yergali S. Moldakhanov, Kuralay S. Akanova, Adolat N. Manakbayeva, Timur Kerimov, Vladimir E. Berezin, Madina S. Alexyuk

“…It may also be a source for future comparative studies of the virulence and drug resistance of <i>E. coli</i> isolates.…”
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Predominant Dissemination of PVL-Negative CC89 MRSA with SCCmec Type II in Children with Impetigo in Japan by H. Kikuta, M. Shibata, S. Nakata, T. Yamanaka, H. Sakata, K. Akizawa, K. Kobayashi

“…Furthermore, molecular epidemiological analysis and virulence gene analysis were performed. Results. Of the 136 S. aureus isolates, 122 (89.7%) were MSSA and 14 (10.3%) were MRSA. …”
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Pathogenicity and Whole Genome Sequence Analysis of a Pseudorabies Virus Strain FJ-2012 Isolated from Fujian, Southern China by Xue-min Wu, Qiu-yong Chen, Ru-jing Chen, Yong-liang Che, Long-bai Wang, Chen-yan Wang, Shan Yan, Yu-tao Liu, Jin-sheng Xiu, Lun-jiang Zhou

“…In addition, we identified typical micropathological changes such as multiple gross lesions in infected piglets through pathological analysis and conclude that the FJ-2012 genome is significantly different from known pseudorabies viruses, in which insertions, deletions, and substitutions are observed in multiple immune and virulence genes. In summary, this study shed lights on the molecular basis of the prevalence and pathology of the pseudorabies virus strain FJ-2012. …”
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Exploring glycolytic enzymes in disease: potential biomarkers and therapeutic targets in neurodegeneration, cancer and parasitic infections by Maura Rojas-Pirela, Diego Andrade-Alviárez, Verónica Rojas, Miguel Marcos, Daniel Salete-Granado, Marirene Chacón-Arnaude, María Á. Pérez-Nieto, Ulrike Kemmerling, Juan Luis Concepción, Paul A. M. Michels, Wilfredo Quiñones

“…Although energy transduction by glucose metabolism is the main function of this pathway, involvement in virulence, growth, pathogen–host interactions, immunomodulation and adaptation to environmental conditions are other functions attributed to this metabolic pathway. …”
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Two-component system GrpP/GrpQ promotes pathogenicity of uropathogenic Escherichia coli CFT073 by upregulating type 1 fimbria by Xueping Li, Yu Pang, Lingyan Jiang, Le Liu, Jiarui Zhou, Chen Jin, Qian Wang, Hongmin Sun, Qing Li, Zhen Chen, Jingliang Qin, Jianwei Mu, Bin Liu, Qiyue Zhang, Yutao Liu, Lu Feng, Lei Wang

“…This study revealed a new pathway for virulence activation in response to host cues, providing further insight into UPEC pathogenesis and a promising target for UTI treatment.…”
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Targeting quorum sensing for manipulation of commensal microbiota by Zachary Ziegert, Matthew Dietz, Max Hill, Marjais McBride, Elizabeth Painter, Mikael H. Elias, Christopher Staley

“…Extensive work using simple systems and single strains of bacteria have revealed a role for QS in the regulation of virulence factors and biofilm formation; however, less is known about QS dynamics among communities, especially in vivo. …”
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Potency of the Consortium of Pseudomonad fluorescent pf-142 and Bacillus mycoides Isolates Against Bacterial Wilt Disease In-Vitro by Yosua Nathanael Itona Sagala, Endang Triwahyu Prasetyawati, Yenny Wuryandari

“…Based on the study, it was known that R. solanacearum caused wilting in chili pepper plants with high virulence. Pseudomonad fluorescent pf-142 and B. mycoides did not produce an inhibition zone, indicating that both were compatible. …”
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A comparative study of replicative properties of antitumor recombinant vaccinia viruses on human glioblastoma cell culture U87 and monkey kidney cell culture CV-1 by R. A. Maksyutov, I. V. Kolosova, T. V. Tregubchak, I. A. Razumov, S. N. Shchelkunov

“…Furthermore, the virus with five virulence genes deleted (genes encoding hemagglutinin, γ-interferonbinding protein, thymidine kinase, complementbinding protein and Bcl2-like inhibitor of apoptosis), which has significantly lower reactogenicity and neurovirulence compared to the original strain LIVP of VACV, was studied. …”
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Persistent Cutibacterium (Formerly Propionibacterium) acnes Bacteremia and Refractory Endocarditis in a Patient with Retained Implantable Pacemaker Leads by M. Freedman, J. O. Aflatooni, R. Foster, P. G. Haggerty, C. J. Derber

“…Cutibacterium (formerly Propionibacterium) acnes (C. acnes) is a commensal bacteria commonly found on the human skin and in the mouth. While the virulence of C. acnes is low in humans, it does produce a biofilm and has been identified as an etiologic agent in a growing number of implant-associated infections. …”
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Synthesis and Evaluation of In Vitro Antibacterial and Antitumor Activities of Novel N,N-Disubstituted Schiff Bases by Heng Luo, Yu-fen Xia, Bao-fei Sun, Li-rong Huang, Xing-hui Wang, Hua-yong Lou, Xu-hui Zhu, Wei-dong Pan, Xiao-dong Zhang

“…Moreover, we observed that the antibacterial action of 1a might be associated with the regulation of the expression of key virulence genes in S. aureus. Compound 1c resulted in a strong apoptotic activity against leukemia cells, also affecting the cell cycle distribution. …”
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Advancements in the development of antivirals against SARS-Coronavirus by Mrityunjay Kumar, Mirza Sarwar Baig, Kanchan Bhardwaj, Kanchan Bhardwaj

“…The existence of animal reservoirs of coronaviruses continues to pose a risk of re-emergence with improved fitness and virulence. Given the high death rate (up to 70 percent) and the high rate of severe sickness (up to 68.7 percent in long-COVID patients), it is even more critical to identify new therapies as soon as possible. …”
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Biofilm removal mediated by Salmonella phages from chicken-related sources by Zhenzhen Ning, Lingling Zhang, Linlin Cai, Xinglian Xu, Ying Chen, Huhu Wang

“…Complete genome sequence analysis revealed that the genomes of phage CW1 is composed of 41763 bp with 58 open reading frames (ORFs) and a holin-endolysin system and it does not encode any virulence or lysogeny. A phage cocktail consisted of CW1 (with the broadest spectrum of 70.49 %) and CW11, M4 and M10 (with a high lytic activity of more than 67.11 %) was established. …”
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Noncanonical calcium binding motif controls folding of HopQ1, a Pseudomonas syringae type III secretion effector, in a pH-dependent manner by Fabian Giska, Wojciech Rymaszewski, Malgorzata Lichocka, Marcin Piechocki, Jakub Kwiatkowski, Jarosław Poznański, Magdalena Górecka, Magdalena Krzymowska

“…Abstract Virulence of many gram-negative bacteria relies upon delivery of type three effectors into host cells. …”
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Pyoverdine, the Major Siderophore in Pseudomonas aeruginosa, Evades NGAL Recognition by Mary E. Peek, Abhinav Bhatnagar, Nael A. McCarty, Susu M. Zughaier

“…P. aeruginosa produces a major siderophore known as pyoverdine, found to be important for bacterial virulence and biofilm development. We report that pyoverdine did not bind to NGAL, as measured by tryptophan fluorescence quenching, while enterobactin bound to NGAL effectively causing a strong response. …”
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