The dangerous biology of pathogenic germs by Berche, Patrick

“…The convergence of biotechnologies with other disciplines, including computer science and Artificial Intelligence (AI), may make it possible to carry out dangerous genetic manipulations on pathogenic germs, as the gain-of-function experiments exacerbating virulence, as those carried out on myxoviruses and coronaviruses. …”
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Pulmonary Nocardiosis in an Immunocompetent Patient with Cystic Fibrosis by Lucy Schoen, Jonathan D. Santoro, Carlos Milla, Sumit Bhargava

“…Nocardia spp. are bacteria of low virulence that cause infection classically in immunocompromised hosts with the lungs as the primary site of infection in the majority of cases. …”
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Adherence of Helicobacter pylori to the Gastric Mucosa by Marguerite Clyne, Brendan Drumm

“…The mechanism by which H pylori causes disease has not yet been elucidated but adherence to the gastric mucosa is thought to be an important virulence determinant of the organism. What is known about adherence of H pylori to the gastric mucosa is summarized. …”
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Global asymptotic properties of staged models with multiple progression pathways for infectious diseases by Andrey V. Melnik, Andrei Korobeinikov

“…For example, these models reflect cases when there is considerable difference in virulence, or when only a part of the infected individuals undergoes a treatment whereas the rest remains untreated. …”
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Diagnosis and Treatment of Paracoccidioidomycosis in the Maxillofacial Region: A Report of 5 Cases by Antonio Dionízio De Albuquerque Neto, André Vitor Alves Araújo, Daniel Assunção Cerqueira, Lorenzzo De Angeli Cesconetto, Nilton Provenzano, Eder Magno Ferreira de Oliveira

“…Manifestation of this disease depends on numerous factors, such as microorganism virulence, hormonal profile, genetic predisposition, nutrition, and immune system. …”
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Distribution of sasX, mupA, and qacA/B genes and determination of genetic relatedness of epidemic methicillin-resistant Staphylococcus aureus strains associated with bloodstream in... by Rui Zhao, Bingyu Du, Lingling Hu, Chenxi Li, Fen Xue, Xing Wang, Changhong Jiang, Jinghua Wang, Yanfeng Zhao

“…IntroductionMethicillin-resistant Staphylococcus aureus (MRSA) exhibits diverse genotypes with varying virulence and resistance profiles, particularly in the context of bloodstream infections (BSI). …”
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A comprehensive analysis of in vitro and in vivo genetic fitness of Pseudomonas aeruginosa using high-throughput sequencing of transposon libraries. by David Skurnik, Damien Roux, Hugues Aschard, Vincent Cattoir, Deborah Yoder-Himes, Stephen Lory, Gerald B Pier

“…During in vivo infection there were major losses of strains with Tn inserts in almost all known virulence factors, as well as respiration, energy utilization, ion pumps, nutritional genes and prophages. …”
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An exacerbated phosphate starvation response triggers Mycobacterium tuberculosis glycerol utilization at acidic pH by Claire Healy, Sabine Ehrt, Alexandre Gouzy

“…We show that the virulence-associated inorganic phosphate (Pi) uptake system (Pst-1) regulates the ability of Mtb to replicate in acidic conditions. …”
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Prevalence and Characterization of Streptococcus pyogenes Clinical Isolates from Different Hospitals and Clinics in Mansoura by Zeinab M. Helal, Dina E. Rizk, Mohamed M. Adel El-Sokkary, Ramadan Hassan

“…Different isolates were typed serotypically and genotypically by BOX-PCR. Different virulence factors were identified in S. pyogenes isolates. …”
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Priestia flexa as a Novel Urinary Tract Pathogen in Daloa, Côte d’Ivoire: Insights From Genomic Sequencing by Dého Aristide Gbégbé, Okran Beyosse Christophe Kacou, N’goran Parfait N’zi, Djédoux Maxime Angaman

“…On the other hand, two genes conferring resistance to beta-lactam and tetracyclines as well as nine virulence genes were predicted in the genome of 21LM367. …”
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Host-pathogen interaction in invasive Salmonellosis. by Hanna K de Jong, Chris M Parry, Tom van der Poll, W Joost Wiersinga

“…Plasmids also carry putative virulence-associated genes as well as those responsible for antimicrobial resistance. …”
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Pretreatment with serine protease inhibitors impairs Leishmania amazonensis survival on macrophages by Patrícia de Almeida Machado, Pollyanna Stephanie Gomes, Elaine Soares Coimbra, Herbert Leonel de Matos Guedes

“…Serine proteases emerge as important virulence factors in the Leishmania genus, as they participate in important processes involved in their infectivity, virulence, and survival. …”
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Flow cytometry sorting of cells infected with African swine fever virus by A. S. Pershin, I. V. Shevchenko, T. N. Komova, A. Mazloum, N. N. Vlasova, E. O. Morozova, A. S. Igolkin, K. N. Gruzdev

“…The use of attenuated virus variants enables a thorough  investigation of the factors influencing the virulence of African swine fever virus and the immune  response  to it. …”
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Genome-wide association study analysis of single nucleotide variants in L. infantum associated with IL-6 inflammatory response in visceral leishmaniasis by Amanda Miranda da Silva, Kátia Silene Sousa Carvalho, Caio Andrey Bezerra Januário, Raquel Gomes de Sena Carneiro Caldas, Bianka Lopes da Silva Paulino, Débora Cavalcante Braz, Dorcas Lamounier Costa, Gabriel da Luz Wallau, Wilson Jose da Silva Junior, Carlos Henrique Nery Costa

“…The clinical manifestations of VL vary among patients, influenced by host factors and the virulence of the Leishmania infantum parasite. Considering that severe VL may result from an exaggerated inflammatory response, this study investigated whether IL-6 could serve as a biomarker to identify pro-inflammatory virulence factors. …”
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High-quality draft genome and characterization of commercially potent probiotic strains by Ayesha Sulthana, Suvarna G. Lakshmi, Ratna Sudha Madempudi

“…The genomic analysis of all the strains confirmed the absence of genes encoding putative virulence factors, antibiotic resistance, and the plasmids.…”
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Emergence of mcr-8.1-bearing MDR-hypervirulent Klebsiella pneumoniae ST307 by Jie Sheng, Rory Cave, Mary M. Ter-Stepanyan, Siyu Lu, Yingxiong Wang, Taihang Liu, Hermine V. Mkrtchyan

“…In addition, the Armenian isolates obtained plasmids carrying virulence and AMR genes during the transmission event. …”
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Genome analysis of colistin-resistant Salmonella isolates from human sources in Guizhou of southwestern China, 2019–2023 by Jingtong Wu, Yongxian Wen, Lv You, Xiaoyu Wei, Xiaoyu Wei, Junhua Wang, Ge Zhu, Shijun Li

“…The majority of CL-R isolates contained the virulence factor spvB and a notable diversity in other virulence factors with varied functions. …”
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Characterization of Shigella flexneri serotype 6 strains from geographically diverse low- and middle-income countries by Caitlin E. Gabor, Charlotte E. Chong, Jose M. Lemme-Dumit, Tracy H. Hazen, Kate S. Baker, Karen L. Kotloff, Irene N. Kasumba, Sharon M. Tennant, Henry Badji, M. Jahangir Hossain, Richard Omore, Benjamin Ochieng, Alex O. Awuor, Billy Ogwel, Jane Juma, Eileen M. Barry, David A. Rasko

“…We identified Sf6 specific factors, including a potential novel Shigella virulence factor (type II secretion system). Additionally, we identified established Shigella virulence genes (ospG) and metabolic genes (rutABCDEFGR) that were absent in Sf6 strains while present in the majority of 728 non-Sf6 strains. …”
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Black Women’s Radical Religious Epistemologies in Mahogany and Steepled Towers by CL Nash, Carol Marie Webster, Geeta Patel

“…Weaving an eclectic spectrum of spiritual practices and beliefs, these essays offer the basis of radical religious epistemologies that enable Black women living under a range of circumstances, in several regions of the world, to find a pathway through the virulence they inhabit within their everyday lives. …”
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Human infective endocarditis and septic shock caused by Streptococcus suis serotype 1 by Wei Yang, Chun Yang, Xiaoxiong Lu

“…Abstract Streptococcus suis(SS) infection is a zoonotic acute infectious disease, SS infective endocarditis is relatively rare, there is no case report of Streptococcus suis Serotype 1(SS1) causing mitral valve infection.The rapid progression of this patient’s infection and the severe damage to the valve structure differ from the previous understanding of the relatively low virulence of SS1. Early diagnosis and selection of the correct antibiotic treatment according to the drug sensitivity is very important. …”
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