Biofilm-Producing Bacteria and Risk Factors (Gender and Duration of Catheterization) Characterized as Catheter-Associated Biofilm Formation by Wani Devita Gunardi, Anis Karuniawati, Rainy Umbas, Saptawati Bardosono, Aida Lydia, Amin Soebandrio, Dodi Safari

“…The presence of PapC as a virulence gene encoding pili correlates with the biofilm formation. …”
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Comparison of Illumina and Oxford Nanopore sequencing data quality for Clostridioides difficile genome analysis and their application for epidemiological surveillance by Semeh Bejaoui, Sofie Holtsmark Nielsen, Astrid Rasmussen, John Eugenio Coia, Dorte Terp Andersen, Tobias Bruun Pedersen, Martin Vad Møller, Marc Trunjer Kusk Nielsen, Dorte Frees, Søren Persson

“…Both sequencing platforms provided comparable, satisfactory results for the detection of virulence genes tcdA, tcdB, cdtAB and in-frame deletions in tcdC. …”
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Deubiquitinase Ubp5 is essential for pulmonary immune evasion and hematogenous dissemination of Cryptococcus neoformans by Guizhen Wang, Yan Liu, Qianyu Li, Changhui Wang, Wei Fang

“…Under host-associated conditions, ubp5Δ mutants exhibited morphological changes, including distorted shapes and cell wall heterogeneity, alongside defects in key virulence factors such as the polysaccharide capsule and melanin. …”
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Molecular Epidemiology of Salmonella enterica in Poultry in South Africa Using the Farm-to-Fork Approach by Melissa A. Ramtahal, Anou M. Somboro, Daniel G. Amoako, Akebe L. K. Abia, Keith Perrett, Linda A. Bester, Sabiha Y. Essack

“…This study describes the prevalence, susceptibility profiles, virulence patterns, and clonality of Salmonella from a poultry flock monitored over six weeks, using the farm-to-fork approach. …”
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Who arrived first? Priority effects on Candida albicans and Pseudomonas aeruginosa dual biofilms by Betsy V. Arévalo-Jaimes, Joana Admella, Eduard Torrents

“…Consecutive colonization increases biofilm virulence and negates C. albicans’ protective effect on P. aeruginosa PAET1 against meropenem treatment. …”
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Prevalence of Avian Pathogenic Escherichia coli (APEC) Clone Harboring sfa Gene in Brazil by Terezinha Knöbl, Andrea Micke Moreno, Renata Paixão, Tânia Aparecida Tardelli Gomes, Mônica Aparecida Midolli Vieira, Domingos da Silva Leite, Jesus E. Blanco, Antônio José Piantino Ferreira

“…AFLP showed a clonal relation between Escherichia coli sfa+ serogroup O6. The virulence genes found in these strains reveal some similarity with extraintestinal E. coli (ExPEC), thus alerting for potential zoonotic risk.…”
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Phenotypic and genotypic screening of multidrug resistant Klebsiella pneumoniae isolated from ready to eat street food in Tanta, Egypt by Hadeer M. Bedair, Mohamed Emara, Shima Mahmoud Ali, Tamer M. Samir, Mahmoud A.F. Khalil

“…Among ESBLs-encoding-genes, bla SHV was the most prevalent (71.4%) while bla TEM and bla CTX−M−2were equally-present (55.8%).The most prevalent virulence genes were mrkD (92.2%) followed by K2 (63.3%). …”
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Fitness costs of Mycobacterium tuberculosis resistant to rifampicin is compensated by rapid Th2 polarization mediated by early and high IL-4 production during mice infection by Ma. Fernanda Arce-Aceves, Roberto Espinosa-Neira, Dulce A. Mata-Espinosa, Jorge A. Barrios-Payan, Hugo G. Castelán-Sánchez, Sofía L. Alcaraz-Estrada, Mauricio Castañón-Arreola, Rogelio Hernández-Pando

“…Abstract It was a general belief that drug resistance in Mycobacterium tuberculosis (Mtb) was associated with lesser virulence, particularly rifampicin resistance, which is usually produced by mutations in the RNA polymerase Beta subunit (RpoB). …”
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Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms by Mie Suzuki Okutani, Shinya Okamura, Tang Gis, Hitomi Sasaki, Suni Lee, Akiho Kashiwabara, Simon Goto, Mai Matsumoto, Mayuko Yamawaki, Toshiaki Miyazaki, Tatsuya Nakagawa, Masahito Ikawa, Wataru Kamitani, Shiro Takekawa, Koichi Yamanishi, Hirotaka Ebina

“…While live-attenuated vaccines are a highly effective modality, they pose a risk of adverse effects, including virulence reversion. In the current study, we constructed a live-attenuated vaccine candidate, BK2102, combining naturally occurring virulence-attenuating mutations in the NSP14, NSP1, spike, and ORF7-8 coding regions. …”
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Using In Silico Methods to Identify Protein Tyrosine Kinase A (PtkA) Homolog in Non-Tuberculous Mycobacteria (NTM) by Swati Jaiswal, Sanjay Kumar

“…PtkA is a crucial protein tyrosine kinase that regulates bacterial growth, stress response, and virulence by phosphorylating various substrates in <i>Mtb</i>. …”
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Identification and characterization of the functional tetrameric UDP-glucose pyrophosphorylase from Klebsiella pneumoniae by Isabel Ramón Roth, Pavel Kats, Timm Fiebig, Françoise Routier, Roman Fedorov, Larissa Dirr, Jana I. Führing

“…Targeting the respective molecular interfaces, which are absent in human UGP, could provide a means of selectively inhibiting the bacterial virulence factor UGP and potentially rendering pathogenic species avirulent.IMPORTANCEThe enzyme uridine diphosphate-glucose pyrophosphorylase (UGP) is important for the virulence of bacterial pathogens and, therefore, a potential drug target. …”
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Genotypic and Phenotypic Characterizations of Methicillin-Resistant Staphylococcus aureus (MRSA) on Frequently Touched Sites from Public Hospitals in South Africa by Siyethaba Mkhize, Daniel G. Amoako, Christiana O. Shobo, Oliver T. Zishiri, Linda A. Bester

“…This study aimed to ascertain the prevalence, genetic relatedness, antibiotic resistance, and virulence profile of MRSA on some frequently touched hospital sites in South Africa. …”
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Genotypic and Phenotypic Assessment of Hyaluronidase among Type Strains of a Select Group of Staphylococcal Species by Mark E. Hart, Morgan J. Hart, Anna J. Roop

“…Hyaluronidases degrade hyaluronic acid, a major polysaccharide of the extracellular matrix of tissues, and are considered important for virulence in a number of Gram-positive and -negative bacteria. …”
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Une bactérie multirésistante avant l’ère des antibiotiques : l’agent de la mélioïdose by Buisson, Yves

“…These adaptation mechanisms are also the virulence factors that make melioidosis serious, in particular the efflux pumps that are the main support for its multi-resistance to antibiotics.…”
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Antibiotic Susceptibility Pattern and Biofilm Formation in Clinical Isolates of Enterococcus spp. by Sridevi Shridhar, Biranthabail Dhanashree

“…It produces different virulence factors. Enterococcus surface protein (esp) is a virulence factor that helps in the adhesion, but its role in biofilm formation is still contradictory. …”
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Incidence, Antibiotic Susceptibility and Characterization of Vibrio parahaemolyticus Isolated from Seafood in Selangor, Malaysia by Vurmila Venggadasamy, Loh Teng-Hern Tan, Jodi Woan-Fei Law, Hooi-Leng Ser, Vengadesh Letchumanan, Priyia Pusparajah

“…This study aims to investigate the presence of V. parahaemolyticus, their virulence, antibiotic profiles, and plasmid profiles from 77 different kinds of shellfish samples collected from wet markets and supermarkets in Selangor, Malaysia. …”
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Executioner caspases degrade essential mediators of pathogen-host interactions to inhibit growth of intracellular Listeria monocytogenes by Marilyne Lavergne, Raffael Schaerer, Sara De Grandis, Safaa Bouheraoua, Oluwadamilola Adenuga, Tanja Muralt, Tiffany Schaerer, Léa Chèvre, Alessandro Failla, Patricia Matthey, Michael Stumpe, Dieter Kressler, Pierre-Yves Mantel, Michael Walch

“…With that, we uncovered an underappreciated defense barrier and a non-canonical role of executioner caspases to degrade virulence mediators, thus impairing intracellular Listeria growth.…”
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Characterization of pPCP1 Plasmids in Yersinia pestis Strains Isolated from the Former Soviet Union by Chythanya Rajanna, Tamara Revazishvili, Mohammed H. Rashid, Svetlana Chubinidze, Lela Bakanidze, Shota Tsanava, Paata Imnadze, Kimberly A. Bishop-Lilly, Shanmuga Sozhamannan, Henry S. Gibbons, J. Glenn Morris, Alexander Sulakvelidze

“…Given pla's role in Y. pestis virulence, this difference may have important implications for the strain's virulence.…”
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Activation of three targets by a TAL effector confers susceptibility to bacterial blight of cotton by Brendan W. Mormile, Yan Yan, Taran Bauer, Li Wang, Rachel C. Rivero, Sara C. D. Carpenter, Catherine Danmaigona Clement, Kevin L. Cox, Lin Zhang, Xiyu Ma, Terry A. Wheeler, Jane K. Dever, Ping He, Adam J. Bogdanove, Libo Shan

“…Collectively, our findings elucidate the rapid evolution of TALEs in Xanthomonas field isolates and highlight the virulence mechanism wherein TALEs induce multiple S genes to promote pathogenicity.…”
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Whole-genome sequencing-based characterization of Salmonella enterica Serovar Enteritidis and Kentucky isolated from laying hens in northwest of Iran, 2022–2023 by Shirin Vakili, Mehri Haeili, Adel Feizi, Kiarash Moghaddasi, Maryam Omrani, Arash Ghodousi, Daniela Maria Cirillo

“…The presence of numerous virulence determinants, SPIs and ARGs in the examined NTS isolates poses a significant risk for food safety. …”
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