Temperature Depended Role of Shigella flexneri Invasion Plasmid on the Interaction with Acanthamoeba castellanii by Amir Saeed, David Johansson, Gunnar Sandström, Hadi Abd

“…Shigella flexneri is a Gram-negative bacterium causing the diarrhoeal disease shigellosis in humans. The virulence genes required for invasion are clustered on a large 220 kb plasmid encoding type three secretion system (TTSS) apparatus and virulence factors such as adhesions and invasion plasmid antigens (Ipa). …”
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Acinetobacter baumannii represses type VI secretion system through a manganese-dependent small RNA-mediated regulation by Somok Bhowmik, Avik Pathak, Shivam Pandey, Kuldip Devnath, Abhiroop Sett, Nishant Jyoti, Timsy Bhando, Jawed Akhter, Saurabh Chugh, Ramandeep Singh, Tarun Kumar Sharma, Ranjana Pathania

“…Furthermore, the derivatives of pAB3 found in recent clinical isolates of A. baumannii harbor expanded antibiotic resistance genes and multiple determinants for virulence factors. Hence, the loss of this plasmid for T6SS activity renders A. baumannii T6+ cells susceptible to antibiotics and compromises their virulence. …”
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Adherence of Helicobacter pylori to the Gastric Mucosa by Marguerite Clyne, Brendan Drumm

“…The mechanism by which H pylori causes disease has not yet been elucidated but adherence to the gastric mucosa is thought to be an important virulence determinant of the organism. What is known about adherence of H pylori to the gastric mucosa is summarized. …”
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Hypervirulent Klebsiella pneumoniae have better clinical outcomes than classical Klebsiella pneumoniae for lower respiratory tract infection patients by Xianxia Zhuo, Zichen Lei, Danni Pu, Yongli Wu, Jiankang Zhao, Bin Cao

“…All these strains underwent annotation for resistance and virulence factors, with 141 strains undergoing mouse infection experiments to assess their virulence. …”
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Distribution of sasX, mupA, and qacA/B genes and determination of genetic relatedness of epidemic methicillin-resistant Staphylococcus aureus strains associated with bloodstream in... by Rui Zhao, Bingyu Du, Lingling Hu, Chenxi Li, Fen Xue, Xing Wang, Changhong Jiang, Jinghua Wang, Yanfeng Zhao

“…IntroductionMethicillin-resistant Staphylococcus aureus (MRSA) exhibits diverse genotypes with varying virulence and resistance profiles, particularly in the context of bloodstream infections (BSI). …”
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Lack of Outer Membrane Protein A Enhances the Release of Outer Membrane Vesicles and Survival of Vibrio cholerae and Suppresses Viability of Acanthamoeba castellanii by Soni Priya Valeru, Salah Shanan, Haifa Alossimi, Amir Saeed, Gunnar Sandström, Hadi Abd

“…It has been shown that V. cholerae expresses outer membrane proteins as virulence factors playing a role in the adherence to interacted host cells. …”
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Examination of the Anaerobic Growth of Campylobacter concisus Strains by Hoyul Lee, Rena Ma, Michael C. Grimm, Stephen M. Riordan, Ruiting Lan, Ling Zhong, Mark Raftery, Li Zhang

“…C. concisus putative virulence proteins were identified using mass spectrometry analysis. …”
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Computational protocol for analyzing whole-genome sequencing data from Staphylococcus aureus clinical isolates by Miquel Sánchez-Osuna, Ivan Erill, Oriol Gasch, Oscar Q. Pich

“…Summary: Analyzing whole-genome sequencing (WGS) data from bacterial isolates is pivotal for understanding virulence and predicting clinical outcomes through association studies. …”
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Prevalence and Characterization of Streptococcus pyogenes Clinical Isolates from Different Hospitals and Clinics in Mansoura by Zeinab M. Helal, Dina E. Rizk, Mohamed M. Adel El-Sokkary, Ramadan Hassan

“…Different isolates were typed serotypically and genotypically by BOX-PCR. Different virulence factors were identified in S. pyogenes isolates. …”
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Pretreatment with serine protease inhibitors impairs Leishmania amazonensis survival on macrophages by Patrícia de Almeida Machado, Pollyanna Stephanie Gomes, Elaine Soares Coimbra, Herbert Leonel de Matos Guedes

“…Serine proteases emerge as important virulence factors in the Leishmania genus, as they participate in important processes involved in their infectivity, virulence, and survival. …”
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Flow cytometry sorting of cells infected with African swine fever virus by A. S. Pershin, I. V. Shevchenko, T. N. Komova, A. Mazloum, N. N. Vlasova, E. O. Morozova, A. S. Igolkin, K. N. Gruzdev

“…The use of attenuated virus variants enables a thorough  investigation of the factors influencing the virulence of African swine fever virus and the immune  response  to it. …”
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Emergence of mcr-8.1-bearing MDR-hypervirulent Klebsiella pneumoniae ST307 by Jie Sheng, Rory Cave, Mary M. Ter-Stepanyan, Siyu Lu, Yingxiong Wang, Taihang Liu, Hermine V. Mkrtchyan

“…In addition, the Armenian isolates obtained plasmids carrying virulence and AMR genes during the transmission event. …”
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Genome analysis of colistin-resistant Salmonella isolates from human sources in Guizhou of southwestern China, 2019–2023 by Jingtong Wu, Yongxian Wen, Lv You, Xiaoyu Wei, Xiaoyu Wei, Junhua Wang, Ge Zhu, Shijun Li

“…The majority of CL-R isolates contained the virulence factor spvB and a notable diversity in other virulence factors with varied functions. …”
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Isolation, Molecular Characterisation, and Pathogenicity Analysis of a Novel Recombinant ALV‐J Strain Isolated From Chinese Hetian Chickens by Tianyu Lei, Liyun Zhuang, Tingting Dai, Qun Niu, Yinli Bao, Weiming Lin, Cuiqin Huang, Xintian Zheng

“…Recombination with strain ev‐1 and specific 3′ UTR deletions may explain LY2021J's reduced virulence. Continued monitoring and prevention strategies are essential to mitigate ALV‐J's impact.…”
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Genome sequence and evaluation of safety and probiotic potential of Lacticaseibacillus paracasei LC86 and Lacticaseibacillus casei LC89 by Ting Chen, Yunjiao Zhao, Yunjiao Zhao, Yixuan Fan, Yao Dong, Zhonghui Gai

“…The genomes of both LC86 and LC89 were devoid of virulence, antibiotic resistance and pathogenicity genes. …”
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Communication in Fungi by Fabien Cottier, Fritz A. Mühlschlegel

“…We will discuss fungal communication in the context of fundamental biological functions including mating, growth, morphogenesis, and the regulation of fungal virulence determinants. We will address intraspecies but also interkingdom signaling by systematically discussing the sender of the message, the molecular message, and receiver. …”
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The dangerous biology of pathogenic germs by Berche, Patrick

“…The convergence of biotechnologies with other disciplines, including computer science and Artificial Intelligence (AI), may make it possible to carry out dangerous genetic manipulations on pathogenic germs, as the gain-of-function experiments exacerbating virulence, as those carried out on myxoviruses and coronaviruses. …”
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Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms by Mie Suzuki Okutani, Shinya Okamura, Tang Gis, Hitomi Sasaki, Suni Lee, Akiho Kashiwabara, Simon Goto, Mai Matsumoto, Mayuko Yamawaki, Toshiaki Miyazaki, Tatsuya Nakagawa, Masahito Ikawa, Wataru Kamitani, Shiro Takekawa, Koichi Yamanishi, Hirotaka Ebina

“…While live-attenuated vaccines are a highly effective modality, they pose a risk of adverse effects, including virulence reversion. In the current study, we constructed a live-attenuated vaccine candidate, BK2102, combining naturally occurring virulence-attenuating mutations in the NSP14, NSP1, spike, and ORF7-8 coding regions. …”
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Genetic Determinants and Biofilm Properties Useful in Estimation of UTI Pathogenicity of the <i>Escherichia coli</i> Strains Isolated from Free-Living Birds by Bartosz Rybak, Tomasz Jarzembowski, Agnieszka Daca, Beata Krawczyk, Lidia Piechowicz

“…<b>Conclusions</b>: In conclusion, the virulence of <i>E. coli</i> strains isolated from free-living birds is significant, and they can be considered environmental reservoirs of pathogenic strains. …”
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Executioner caspases degrade essential mediators of pathogen-host interactions to inhibit growth of intracellular Listeria monocytogenes by Marilyne Lavergne, Raffael Schaerer, Sara De Grandis, Safaa Bouheraoua, Oluwadamilola Adenuga, Tanja Muralt, Tiffany Schaerer, Léa Chèvre, Alessandro Failla, Patricia Matthey, Michael Stumpe, Dieter Kressler, Pierre-Yves Mantel, Michael Walch

“…With that, we uncovered an underappreciated defense barrier and a non-canonical role of executioner caspases to degrade virulence mediators, thus impairing intracellular Listeria growth.…”
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