Solving unknown primary cancer with earlier diagnosis - the SUPER-ED trial: study protocol for a stepped-wedge cluster randomised controlled trial to support earlier diagnosis for... by Anna Ugalde, Richard W. Tothill, Stephen Quinn, Hui-Li Wong, Owen Prall, Catherine Mitchell, Nilmini Wickramasinghe, Clare Fedele, Natalie Richards, Elizabeth Todio, Cindy Bryant, Louisa G. Collins, Sarah McLean, Hyun Soo Ko, Tim Akhurst, Christopher Steer, Bo Gao, Mark Wong, Chloe Georgiou, Narayan Karanth, Anna Kuchel, Louise Nott, Shamsudheen Padinharakam, Mark Shackleton, Ian M. Collins, Madhu Singh, Rachel Wong, Zee Wan Wong, Alexis Butler, Tharani Sivakumaran, Penelope Schofield, Linda Mileshkin

“…The intervention is a new model of care comprising four key components: standardised diagnostic workup, dedicated cancer care coordinators, virtual multidisciplinary meetings and a website resource for patients, carers and clinicians. …”
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CitySEIRCast: an agent-based city digital twin for pandemic analysis and simulation by Shakir Bilal, Wajdi Zaatour, Yilian Alonso Otano, Arindam Saha, Ken Newcomb, Soo Kim, Jun Kim, Raveena Ginjala, Derek Groen, Edwin Michael

“…Here, we describe how we have coupled advances in the construction of digital or virtual models of real-world cities with an agile, modular, agent-based model of viral transmission and data from navigation and social media interactions, to overcome these challenges in order to provide a new simulation tool, CitySEIRCast, that can model viral spread at the sub-national level. …”
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Factors associated with decreased anal sphincter tone and the accuracy of forced anal examinations to detect individuals having receptive anal intercourse: an observational study by John A Schneider, Alan G Nyitray, Derek Smith, Michael W Ross, Elizabeth Y Chiao, Timothy J Ridolfi, Bridgett Brzezinski, B R Simon Rosser, Aniruddha Hazra, Jenna Nitkowski, Sandrine Sanos, Ever Mkonyi, Lucy Mgopa

“…Compared with individuals having always/mostly insertive anal intercourse, individuals having always/mostly receptive anal intercourse were associated with decreased RT, but not ST, while those equally preferring both insertive and receptive anal intercourse were not associated with decreased RT or ST.Conclusion Decreased sphincter tone is uncommon among SGM who prefer receptive anal intercourse. Given virtually no accuracy, a finger inserted into the anus has no utility to detect individuals practising receptive anal intercourse and thus should not be used as such.Trial registration number NCT04090060.…”
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INNOVATIVE METHODS OF TEACHING HISTORY AT MODERN UNIVERSITIES by A. Yu. Suslov, M. V. Salimgareev, Sh. S. Khammatov

“…The case study of new formats of History studying is described; it is shown that introduction of new formats into educational practice is possible only under the conditions when a teacher masters the ways of organization and conducting discussions, develops an understanding of distance education and virtual training environments. Students, for their part, have to demonstrate high motivation and activity, to find independently required data, to process and analyze information including historical original sources.Practical significance. …”
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Exploring the Impact of Homophily Attitude, Physical, and Social Attractiveness on Purchase Intentions by Honya Ghasemi, Ramin Bashir Khodaparasti, Hooshmand Bagheri Garbollagh

“…Augmented reality applications add a new dimension to the customer experience by covering the customer's face or surroundings with virtual products. Given the omnipresence of smartphones today and customers' responsiveness to new technologies, there is an increasing focus on studying consumer behavior towards emerging technologies. …”
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Does drug dispensing influence patients’ medication knowledge and medication adherence? A systematic review and meta-analysis by Elizabete Priscila Costa Santana, Haidelucia Rodrigues Vieira Javarini, Dyego Carlos Souza Anacleto de Araújo, Sabrina Cerqueira-Santos, Tiago Marques Reis, Genival Araujo dos Santos-Junior, Kérilin Stancine Santos Rocha

“…Methods A systematic review was conducted in which a literature search was performed in the PubMed/Medline, Biblioteca Virtual da Saúde, Web of Science, and Embase databases, as well as in gray literature. …”
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Immune infiltration landscape and potential drug-targeted implications for hepatocellular carcinoma with ‘progression/hyper-progression’ recurrence by Jing-Xuan Xu, Yue-Xiang Su, Yuan-Yuan Chen, Yi-Yue Huang, Zu-Shun Chen, Yu-Chong Peng, Lu-Nan Qi

“…Co-expression and protein interaction analyses were used to identify characteristic genes in ITM closely associated with type III–IV recurrence, which was matched with drug targets for Huaier granules (HG) and lenvatinib. Virtual docking was used to identify potential therapeutic targets, and the results were verified using single-nuclei RNA sequencing and histological analysis.Results ITM was closely related to type III–IV recurrence and exhibited immunotherapy potential. …”
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Health system costs of a breast cancer early diagnosis programme in a rural district of Rwanda: a retrospective, cross-sectional economic analysis by Lydia E Pace, Lawrence N Shulman, Jean Claude Mugunga, Parsa Erfani, Kayleigh Pavitra Bhangdia, Rashidah Nambaziira, Lysa Carolle Niteka, Jean Marie Vianney Dusengimana, John Ruhumuriza, Marie Louise Uwineza, Vestine Rugema, Cyprien Shyirambere, Melany Rabideau

“…The BCED programme’s start-up and operational costs were high but could be reduced by using local trainers and virtual mentorship. In other districts, decentralising ultrasound and/or biopsies to district hospitals could reduce costs.…”
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Optimizing risk in action: Differences between fixated aim points and movement outcomes in throwing by Stephan Zahno, Damian Beck, Ralf Kredel, André Klostermann, Ernst-Joachim Hossner

“…Methods Participants’ task was to throw balls on a target circle in a virtual reality (VR) setup, gaining 100 points for each hit. …”
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Effect of stress management based self-care counseling on glycemic control in women with gestational diabetes mellitus: a randomized controlled trial study by Atefeh Bagheri-Tirtashi, Fatemeh Nasiri-Amiri, Hajar Adib-Rad, Hossein-Ali Nikbakht, Mahbobeh Faramarzi, Ezzat Kiani

“…The intervention group received 8 virtual counseling sessions once a week for 45–50 min continuously based on stress management, while the control group only received antenatal usual care (AUC). …”
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Les voyages reproductifs vers la Tunisie : l’intime au prisme des pratiques de l’assistance médicale à la procréation by Irene Maffi, Betty Rouland, Carole Wenger

“…In the field of health in general, as in that of infertility in particular, virtual spaces and the existence of these online communities have come to play a prominent role. …”
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Characterizing immune biomarkers and effector CD8+ T-cell exhaustion in pancreatic adenocarcinoma via single-cell RNA sequencing profiling by Rawaa AlChalabi, Raghda Makia, Semaa A. Shaban, Ahmed AbdulJabbar Suleiman

“…We analyzed mutations in the shortlisted biomarkers from The Cancer Genome Atlas (TCGA) and performed in silico mutational analysis using Maestro to evaluate the impact of an IL7R mutation (K110N) on protein function. Virtual screening using a deep learning framework, GNINA, explored the inhibitory features of the anti-inflammatory drugs oxaprozin and celecoxib on IL7R. …”
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Identifying the Dimensions and Consequences of Digital Customer Experience: A Phenomenological Study by Fatemeh Eslahi, Seyed Mohammad Reza Mirahmadi, Mojtaba Aghajani

“…In addition, by creating the online virtual world, social media has transformed communication from traditional methods into a large and online social phenomenon. …”
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Meals, Education, and Gardens for In-School Adolescents (MEGA): study protocol for a cluster randomised trial of an integrated adolescent nutrition intervention in Dodoma, Tanzania by Wafaie W Fawzi, Dongqing Wang, Abbas Ismail, Leonard Kamanga Katalambula, Andrea R Modest, Tara Young, Mary Mwanyika-Sando, Amani Tinkasimile, Dominic Mosha, Augustine Malero, Said Vuai

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The AFFIRM Framework for gender-affirming care: qualitative findings from the Transgender and Gender Diverse Health Equity Study by Meg Quint, Schuyler Bailar, Alexis Miranda, Shalender Bhasin, Devin O’Brien-Coon, Sari L. Reisner

“…Interviews were semi-structured, explored prior and current experiences in healthcare and ideal gender-affirming care models, and conducted virtually via a secure Zoom platform. Analyses were conducted using immersion crystallization and reflexive thematic analysis; interview transcripts were double coded by two coders. …”
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Èdè Àyàn: The Language of Àyàn in Yorùbá Art and Ritual of Egúngún by Oláwọlé Fámúlẹ̀

“…This has continued to make it become virtually impossible for a deeper understanding of Yorùbá art in particular and African art as a whole. …”
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Safety and efficacy of edoxaban monotherapy after bioabsorbable polymer everolimus-eluting stent implantation in a human-like coronary atherosclerotic porcine model by Daisuke Kitano, Suguru Migita, Yuxin Li, Yutaka Koyama, Katsunori Fukumoto, Sayaka Shimodai-Yamada, Akira Onishi, Daiichiro Fuchimoto, Shunichi Suzuki, Yoshiyuki Nakamura, Atsushi Hirayama, Hiroyuki Hao, Yasuo Okumura

“…Outcomes were assessed by optical coherence tomography (OCT), virtual histology intravascular ultrasound (iMap-IVUS), and histology. …”
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PATHOLOGICAL CHANGES IN MICE TREATED WITH CYCLOPHOSPHAMIDE AND EXOGENOUS DNA by E. V. Dolgova, V. P. Nikolin, N. A. Popova, A. S. Proskurina, K. E. Orishchenko, E. A. Alyamkina, Ya. R. Efremov, S. I. Baiborodin, E. R. Chernykh, A. A. Ostanin, S. S. Bogachev, T. S. Gvozdeva, E. M. Malkova, O. S. Taranov, V. A. Rogachev, A. S. Panov, S. N. Zagrebelnyi, M. A. Shurdov

“…Plasmid DNA has the greatest effect on apoptosis induction.The analysis of reduction and restoration of BMC subpopulations as the mice progressed to death revealed a virtually complete loss of the 12–20-mkm fraction of the cell population (about 3–4 % vs. 35–40 % in the control), which corresponds to the maximum leukopenia on day 3 after CP treatment. …”
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Treatment time and learning curve analysis of 1.5 T MR-Linac workflows led by radiation oncologists or therapists by J.M. Westerhoff, F.J. Raaijmakers, L.A. Daamen, E.N. de Groot-van Breugel, L.T.C. Meijers, J.R.N. van der Voort van Zyp, J.J.C. Verhoeff, S. Mook, H.M. Verkooijen, M.P.W. Intven

“…Adapt-to-Shape, ATS) and virtual couch shift (i.e. Adapt-to-Position, ATP) magnetic resonance guided radiotherapy (MRgRT) on a 1.5 Tesla MR-Linac. …”
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Unity in diversity: navigating global connections through cultural exchange by Dwi Mariyono, Annis Nur Alifatul Kamila, Akmal Nur Alif Hidayatullah

“…The research identifies strategies for balancing global unity and cultural diversity, such as hybrid approaches to environmental sustainability, integrating cultural insights into global health and inclusive technological innovations like AI and virtual reality. It also highlights the role of institutions like UNESCO in promoting cultural diplomacy and the challenges in balancing global governance with cultural diversity. …”
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