Innate Immune Defenses in Human Tuberculosis: An Overview of the Interactions between Mycobacterium tuberculosis and Innate Immune Cells by Jonathan Kevin Sia, Maria Georgieva, Jyothi Rengarajan

“…Insights into the human innate immune response to Mtb infection are necessary for providing a rational basis for the augmentation of immune responses against Mtb infection, especially with respect to the generation of effective anti-TB immunotherapeutics and vaccines.…”
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Canine circovirus: an emerging virus of dogs and wild canids by Farzad Beikpour, Arash Letafati, Zahra Ahmadi Fakhr, Nicoal Decaro, Sayed-Hamidreza Mozhgani

“…Prevention strategies are hindered by the lack of targeted vaccines and the virus's resilience in the environment. …”
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A replication-incompetent adenoviral vector encoding for HSV-2 gD2 is immunogenic and protective against HSV-2 intravaginal challenge in mice. by Elisa Rossetti, Marija Vujadinovic, Ella van Huizen, Jeroen Tolboom, Hanneke Schuitemaker, Feng Yao, Roland Zahn, Eirikur Saeland

“…We have designed an adenoviral vector type 35 (Ad35)-based vaccine encoding the HSV-2 major surface antigen gD2 (Ad35.HSV.gD2). …”
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Phylodynamic reconstruction of major chicken infectious anemia virus clades epidemiology, dispersal, and evolution by Giovanni Franzo, Matteo Legnardi, Francesca Poletto, Riccardo Baston, Giulia Faustini, Mattia Cecchinato, Claudia Maria Tucciarone

“…Both clades exhibited no significant competition and similar global patterns, characterized by a progressive increase until about 2000, when a transient decline was observed for some years, potentially reflecting the increasing use of vaccines. Accordingly, although significant selective pressures were shaping viral evolution, comparable strengths were estimated in the two viral populations. …”
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Targeted Anticancer Immunotoxins and Cytotoxic Agents with Direct Killing Moieties by Koji Kawakami, Oumi Nakajima, Ryuichi Morishita, Ryozo Nagai

“…Despite the progress of the bioinformatics approach to characterize cell-surface antigens and receptors on tumor cells, it remains difficult to generate novel cancer vaccines or neutralizing monoclonal antibody therapeutics. …”
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Convalescent plasma therapy in severe coronavirus disease-2019: A narrative review by Rasmi Ranjan Sahoo, Kasturi Hazarika, Prashant Bafna, Manesh Manoj, Anupam Wakhlu

“…Until, a specific antiviral therapy or an effective vaccine is made available, the consideration for use of convalescent blood products, especially plasma, is warranted. …”
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Experimental Investigation on an Absorption Refrigerator Driven by Solar Cells by Zi-Jie Chien, Hung-Pin Cho, Ching-Song Jwo, Chao-Chun Chien, Sih-Li Chen, Yen-Lin Chen

“…Therefore, this system can be expected to be used in remote areas for refrigeration of food and beverages in outdoor activities in remote and desert areas or long-distance road transportation of food or low temperature refrigeration of vaccine to avoid the deterioration of the food or the vaccines.…”
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Innovative Strategies in Oncology: Bacterial Membrane Vesicle-Based Drug Delivery Systems for Cancer Diagnosis and Therapy by Guodong Li, Shuangpeng Pu, Lisiyao You, Yuan Gao, Yuexia Zhong, Huadong Zhao, Dong Fan, Xiyan Lu

“…These OMVs exhibit excellent membrane stability, immunogenicity, safety, and permeability (which makes it easier for them to penetrate into tumour tissue), making them suitable for developing cancer vaccines and drug delivery systems. Recent studies have focused on engineering OMVs to enhance tumour-targeting capabilities, reduce toxicity, and extend circulation time in vivo. …”
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Bacteria as Precision Tools for Cancer Therapy by Carmen Michán, José Prados, Juan‐Luis Ramos

“…Engineered S. typhimurium strains can generate adjuvant flagellin‐antigen complexes that function as in situ vaccines, hence increasing the immunogenic responses within tumour environment. …”
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Specific features of African swine fever control activities in China by M. D. Lozovoy, S. V. Shcherbinin, A. K. Karaulov

“…African swine fever is a highly contagious viral disease of pigs; however, no vaccines are available to control it. Currently the disease causes significant economic damage in many countries. …”
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Feline panleukopenia (review) by A. M. Kiselev, S. V. Shcherbinin, T. S. Galkina

“…Current preventive measures can ensure protection, however, vaccines are used in the absence of adequate testing on cats and dogs (for ethical reasons) and have a number of limitations in use. …”
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Mathematical Analysis of Malaria Epidemic: Asymptotic Stability With Cost-Effectiveness Study by Sacrifice Nana-Kyere, Baba Seidu, Kwara Nantomah

“…Mathematical models of infectious diseases have been the steering wheel, driving scientists towards elucidation of the dynamic behaviour of epidemics and providing tailored strategic management of diseases. With the ongoing vaccination programs for vector-borne diseases, the research proposes a nonlinear differential equation model for the malaria disease that provides public health with a shift from the classical understanding of nonpharmaceutical preventive malaria control to pharmaceutical measures of vaccines. …”
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The Application of Single-Cell RNA Sequencing in Vaccinology by Andrés Noé, Tamsin N. Cargill, Carolyn M. Nielsen, Andrew J. C. Russell, Eleanor Barnes

“…The power of single-cell RNA sequencing offers various opportunities to decipher the immune response to infectious diseases and vaccines. Here, we describe the potential uses of single-cell RNA sequencing methods in prophylactic vaccine development, concentrating on infectious diseases including COVID-19. …”
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Abuse potential of fentanyl and fentanyl analogues by Anusha Thumma, Kwadwo Mfoafo, Niloofar Babanejad, Alborz Omidian, Yadollah Omidi, Hamid Omidian

“…Conclusions: By educating patients and physicians, making rescue kits easily accessible, developing vaccines to prevent opioid addiction, and perhaps even creating new tamper-resistant fentanyl formulations, it may be possible to prevent fentanyl misuse, therapeutic errors, and the repercussions that follow.…”
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Role of extracellular vesicles in the pathogenesis of mosquito-borne flaviviruses that impact public health by Pedro Pablo Martínez-Rojas, Verónica Monroy-Martínez, Blanca H. Ruiz-Ordaz

“…This review focuses on the roles of extracellular vesicles in the pathogenesis of mosquito-borne flavivirus diseases: how they contribute to viral cycle completion, cell-to-cell transmission, and cellular responses such as inflammation, immune suppression, and evasion, as well as their potential use as biomarkers or therapeutics (antiviral or vaccines). We highlight the current findings concerning the functionality of extracellular vesicles in different models of dengue virus, Zika virus, yellow fever virus, Japanese encephalitis virus, and West Nile virus infections and diseases. …”
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Profile and complexity of travel medicine consultations in Chile: unicentric cross-sectional study by Thomas Weitzel

“…Objective To analyse the spectrum, vaccination needs and pretravel advice complexity of travellers presenting at a travel medicine clinic in Santiago, Chile.Design Cross-sectional study.Setting Pretravel consultations in a private healthcare centre in Chile, an ‘emerging market’ country in South America.Participants Travellers (n=1341) seeking pretravel advice at the Travel Medicine Program of Clínica Alemana, Santiago, from April 2016 to March 2018.Primary and secondary outcome measures Demographical and travel characteristics, indications for travel vaccines and malaria prophylaxis, and complexity of travel consultations.Results Of 1341 travellers, 51% were female; the median age was 33 years. …”
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Cryo-EM structure of Sudan ebolavirus glycoprotein complexed with its human endosomal receptor NPC1 by Fan Bu, Gang Ye, Hailey Turner-Hubbard, Morgan Herbst, Bin Liu, Fang Li

“…However, unlike EBOV, there are no approved vaccines or treatments for SUDV, and its structural interaction with the endosomal receptor NPC1 remains unclear. …”
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ACE2 : S1 RBD Interaction-Targeted Peptides and Small Molecules as Potential COVID-19 Therapeutics by Lennox Chitsike, John Krstenansky, Penelope J. Duerksen-Hughes

“…The COVID-19 pandemic that began in late 2019 continues with new challenges arising due to antigenic drift as well as individuals who cannot or choose not to take the vaccine. There is therefore an urgent need for additional therapies that complement vaccines and approved therapies such as antibodies in the fight to end or slow down the pandemic. …”
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Bioinformatic Analysis of PTTG Family and Prognosis and Immune Cell Infiltration in Gastric Cancer by Xiao Li, Yanghao Tai, Shuying Liu, Yating Gao, Kaining Zhang, Jierong Yin, Huijuan Zhang, Xia Wang, Xiaofei Li, Dongfeng Zhang

“…Adaptive cell therapy, cancer vaccines, gene therapy, and monoclonal antibody therapy have all been used in gastric cancer with some initial success. …”
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Nanoparticles Modulating the Immune Microenvironment in Breast Cancer Treatment by Guo LJ, Wu J, Lu W, Li J, Wang Y, Yang H, Wang TZ

“…The role of nanoparticles in enhancing immune checkpoint blockade (ICB) and their application in cancer vaccines is also examined. Additionally, we explore the synergistic effects of combining nanoparticles with conventional therapies. …”
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