Side-stepping the guardian of the genome: current cancer therapeutics targeting mutant p53 by Iulianna C. Taritsa, Eric T. Fossel

“…These agents can broadly be classified into six categories: the viral approach, direct modifiers of the p53 pathway, epigenetic modifiers of the p53 pathway, synthetic lethal agents, structural reactivators, and immune activating vaccines. Even these strategies have been met with limited success. …”
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COVID-19: Malaysia's fight against this deadly virus by Ke-Yan Loo, Vengadesh Letchumanan

“…This review discusses the alarming COVID-19 situation in Malaysia, the management strategies, and the vaccinations program. …”
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Some statements on medical care in the "new normal" post-covid-19 by Alfredo Darío Espinosa Brito

“…This has been possible thanks to the joint efforts of the whole of society, with its highest authorities ahead, the capacity and dedication of health professionals organized in a vigorous national health system, obtaining and applying effective native drugs and the massive immunization against SARS-COV-2, with our Cuban Abdala and Soberanas vaccines. Comments are made on a group of lessons learned during the pandemic, on the existence of many doubts and questions still unanswered, on the new risks -especially for the most vulnerable- including the so-called post-COVID syndrome, when events are held more massive outbreaks of different kinds, as well as alerting to the frequent appearance of new coronavirus’ variants and recent "waves" of patients in different countries. …”
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Anti-cancer immunotherapy-related cardiotoxicity: preventable and treatable by Wu Helena T., Hsu Vanessa, Win Shwe, Xing Yan

“…This review examines various immunotherapy types, such as immune checkpoint inhibitors, adoptive T-cell therapies, and cancer vaccines, highlighting their cardiovascular risks. …”
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<i>In vitro</i> and <i>in vivo</i> tropism and biodistribution of recombinant simian adenovirus type 25 by Irina V. Vavilova, Tatiana A. Ozharovskaia, Olga V. Zubkova, Olga Popova, Daria V. Voronina, Polina P. Goldovskaya, Denis I. Zrelkin, Alina Sh. Dzharullaeva, Inna V. Dolzhikova, Dmitry V. Shcheblyakov, Denis Yu. Logunov, Alexander L. Gintsburg

“…Recombinant adenoviruses are widely used in the development of vaccines for a variety of infectious diseases. Despite numerous clinical studies, only a few types of human (types 5 and 26) and simian (isolate Y25) adenoviruses are currently used to produce vaccine formulations. …”
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Resurgence of Mumps among Lower Socioeconomic Class of Children in Ahmedabad: A Cross-sectional Study of 115 Cases in a Tertiary Care Center by Dipti V Patel, Zeel Patel, Snehal V Patel, Pooja Gandhi, Gayatri Parmar, Param S Patel

“…No patient was fully vaccinated for mumps. Out of the 15.6% (18 patients) admitted, two patients (1.7%) suffered from mumps complication of orchitis. …”
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Dynamic Roles of RNA and RNA Epigenetics in HTLV-1 Biology by Emily M. King, Amanda R. Panfil

“…This review will highlight the dynamic roles of known RNA and post-transcriptional RNA epigenetic modifications within HTLV-1 biology, including viral <i>hbz</i>, long noncoding RNAs, microRNAs (miRNAs), transfer RNAs (tRNAs), R-loops, N6-methyladenosine (m⁶A) modifications, and RNA-based therapeutics and vaccines.…”
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First isolation and characterization of SARS-CoV-2 from COVID-19 patient of North East India by Aniruddha Jakharia, Biswajyoti Borkakoty, Sumi Pait, Gautam Baruah, Rahul Hazarika, Dipankar Biswas

“…Virus isolation is of paramount importance for development of vaccines, in-vitro screening of antiviral compounds, pathogenesis studies, etc., Many cell lines were studied for amplification and replication of SARS-CoV-2 and Vero cells were found to be ideal cell lines for isolation. …”
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Toll-Like Receptors and RIG-I-Like Receptors Play Important Roles in Resisting Flavivirus by Hong-Yan Guo, Xing-Cui Zhang, Ren-Yong Jia

“…Even though people and animals are barraged with flavivirus infection every year, we have not invented either vaccines or antiviral for most flavivirus infections yet. …”
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Coleopteran Antimicrobial Peptides: Prospects for Clinical Applications by Monde Ntwasa, Akira Goto, Shoichiro Kurata

“…AMPs have potential applicability in the development of vaccines. Here, we review coleopteran AMPs, their potential impact on clinical medicine, and the molecular basis of immune defense.…”
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Reformulation of Islamic Law in Indonesia: Study on Indonesian Ulama Council’s Fatwa by Ansori Ansori, Mughni Labib, Marwadi Marwadi

“…Of the many fatwas that have been issued by the MUI, there are a number of fatwas that are formulated such as the fatwa of the pilgrimage and umrah pilgrimage, the initial determination of Ramadan, Shawwal, Zulhijjah, qibla direction, abortion, donation of social funds with prizes (SDSB), and the use of meningitis vaccines for hajj and umrah pilgrims. MUI reformulates the fatwa due to socio-cultural changes in the community and advances in science and technology. …”
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Vectors, Hosts, and the Possible Risk Factors Associated with Severe Fever with Thrombocytopenia Syndrome by Jin-Na Wang, Tian-Qi Li, Qin-Mei Liu, Yu-Yan Wu, Ming-Yu Luo, Zhen-Yu Gong

“…SFTS has become a crucial public health concern because of the heavy burden, lack of vaccines, effective therapies, and high-fatality rate. …”
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Continuous detection of Chikungunya Virus in a passive surveillance system in southern Thailand, 2012-2019. by Aaron Farmer, Kathryn B Anderson, Darunee Buddhari, Thanaporn Hortiwakul, Boonsri Charernmak, Butsaya Thaisomboonsuk, Tippa Wongstitwilairoong, Taweewun Hunsawong, Chonticha Klungthong, Piyawan Chinnawirotpisan, Sarunyou Chusri, Stefan Fernandez

“…Chikungunya virus (CHIKV) infections are distributed across the globe, causing significant and, often, lasting morbidity. CHIKV vaccines are in development, but their evaluation is limited by the unpredictability of CHIKV transmission, which classically manifests as explosive epidemics separated by variable interepidemic periods. …”
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Clinical Outcomes of Specific Immunotherapy in Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis by Jiang Chen, Guo Xiao-Zhong, Xing-Shun Qi

“…Specific immunotherapies, including vaccines with autologous tumor cells and tumor antigen-specific monoclonal antibodies, are important treatments for PC patients. …”
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MODERN ASPECTS OF LYSSAVIRUS CLASSIFICATION by A. Ye. Metlin

“…That's why further investigations of recovered rabies isolates and new vaccine development are of great importance.…”
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Recurrent Herpetic Stromal Keratitis in Mice: A Model for Studying Human HSK by Patrick M. Stuart, Tammie L. Keadle

“…We will document both differences and similarities that derive from this fundamental difference in these models with an eye towards possible vaccines and therapies that demonstrate promise in treating HSK.…”
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The power of health economics and outcomes research (HEOR) in making decisions that matter by Oscar Herrera Restrepo

“… Deciding on approving and granting market access to new medical technologies such as pharmaceutical products, vaccines, or medical devices is a multifactorial research problem. …”
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Metal Complexes and Their Potential Therapeutic Role Against COVID-19: Recent Developments in Drug Designing by Kanwal Ashiq, Bushra Naureen, Sana Ashiq

“…Despite the development of various vaccines, there is still an urgent need to design novel treatments backed with safety data for fighting  SARS-CoV-2 and its various mutants. …”
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Innate Immune Memory: The Latest Frontier of Adjuvanticity by Elfi Töpfer, Diana Boraschi, Paola Italiani

“…This effect has been most extensively investigated for the tuberculosis vaccine strain Bacillus Calmette-Guérin (BCG). Epidemiological studies suggest that this vaccine is associated with a substantial reduction in overall child mortality that cannot be solely explained by prevention of the target disease but that it seems to rely on inducing resistance to other infections. …”
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