The structural basis of protective and nonprotective human monoclonal antibodies targeting the parainfluenza virus type 3 hemagglutinin-neuraminidase by Rose J. Miller, Ian A. Durie, Aaron D. Gingerich, Mohamed A. Elbehairy, Abigail G. Branch, Riley G. Davis, Nada Abbadi, Melinda A. Brindley, Jarrod J. Mousa

“…Abstract Parainfluenza virus 3 (PIV3) infection poses a substantial risk to vulnerable groups including infants, the elderly, and immunocompromised individuals, and lacks effective treatments or vaccines. This study focuses on targeting the hemagglutinin-neuraminidase (HN) protein, a structural glycoprotein of PIV3 critical for viral infection and egress. …”
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COVID-19: Understanding the New Variants of Concern by Ke-Yan Loo, Vengadesh Letchumanan

“…The first variant was Alpha, followed by the discovery of Beta, Gamma, Delta, and Omicron, being the latest variant of concern. Although vaccines were distributed worldwide to reduce the severity of the disease when infected with SARS-CoV-2, the emergence of new variants raised doubts about the efficacy of the available vaccines. …”
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Breastfeeding and Neonatal Age Influence Neutrophil-Driven Ontogeny of Blood Cell Populations in the First Week of Human Life by Sebastiano Montante, Rym Ben-Othman, Nelly Amenyogbe, Asimenia Angelidou, Anita van den Biggelaar, Bing Cai, Yixuan Chen, Alansana Darboe, Joann Diray-Arce, Rebecca Ford, Olubukola Idoko, Amy Lee, Mandy Lo, Kerry McEnaney, Mehrnoush Malek, David Martino, Geraldine Masiria, Oludare A. Odumade, William Pomat, Casey Shannon, Kinga Smolen, The EPIC Consortium, Al Ozonoff, Peter Richmond, Scott Tebbutt, Ofer Levy, Beate Kampmann, Ryan Brinkman, Tobias Kollmann

“…Breastfeeding, and at a smaller scale neonatal vaccination, were associated with changes in peripheral blood neutrophil and monocyte cell counts. …”
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Leveraging mRNA technology for antigen based immuno-oncology therapies by Wei Zheng, Michele Ceccarelli, Charalampos S Floudas, Siranush Sarkizova

“…While this review centers on therapeutic mRNA vaccines targeting existing tumors, it does not cover preventative vaccines. …”
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Brief communication: gaps and opportunities in HIV research in Venezuela by Jesús A. Morgado, María G. Medina, Rafael N. Guevara, Martín Carballo, Jaime R. Torres, Fhabián S. Carrión-Nessi, David A. Forero-Peña

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Experience on postmortem minimally invasive tissue sampling to ascertain the cause of death determination in South African children: A case for implementing as standard of care by J du Toit, K Storath, I Dunn, P Makekeng, M Moosa, K Mothibi, N Umuneza, C A Rees, D Blau, S Lala, Y Adam, S Velaphi, M Hale, P Swart, J Wadula, L Mothibi, A Wise, V Baba, P Jaglal, S Mahtab, S Madhi, Z Dangor

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Self-replicating recombinant virus-like particles of lentivirus proliferating in glioblastoma cells and normal human macrophages by Herman D. Moshkoff, Andrey E. Moshkoff, Dmitry A. Moshkoff

“…Both attenuated and inactivated vaccines are used in disease control. Inactivated vaccines are very diverse and include whole cell and acellular vaccines containing protein target antigens or nucleic acids encoding target antigens. …”
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Genotype Diversity of Newcastle Disease Virus in Nigeria: Disease Control Challenges and Future Outlook by Muhammad Bashir Bello, Khatijah Mohd Yusoff, Aini Ideris, Mohd Hair-Bejo, Ben P. H. Peeters, Abdurrahman Hassan Jibril, Farouk Muhammad Tambuwal, Abdul Rahman Omar

“…We then discuss the challenges of ND control as a result of the wide genetic distance between the currently circulating NDV isolates and the commonest vaccines used to combat the disease in the country. …”
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Association between childhood immunisation coverage and proximity to health facilities in rural settings: a cross-sectional analysis of Service Provision Assessment 2013–2014 facil... by Ahmad Reza Hosseinpoor, Nicole E Johns, Mike Chisema, M Carolina Danovaro-Holliday, Katherine Kirkby, Anne Schlotheuber, Messeret Shibeshi, Samir V Sodha, Boston Zimba

“…Objectives Despite significant progress in childhood vaccination coverage globally, substantial inequality remains. …”
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Antigen Gene Transfer to Human Plasmacytoid Dendritic Cells Using Recombinant Adenovirus and Vaccinia Virus Vectors by Hetty J. Bontkes, Janneke J. Ruizendaal, Marco W. J. Schreurs, Duco Kramer, Chris J. L. M. Meijer, Erik Hooijberg

“…Recombinant adenoviruses (RAd) and recombinant vaccinia viruses (RVV) expressing tumour-associated antigens (TAA) are used as anti-tumour vaccines. It is important that these vaccines deliver the TAA to dendritic cells (DC) for the induction of a strong immune response. …”
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An Overview of the Skin Microbiome, the Potential for Pathogen Shift, and Dysbiosis in Common Skin Pathologies by Anita Smith, Roberta Dumbrava, Noor-Ul-Huda Ghori, Rachael Foster, James Campbell, Andrew Duthie, Gerard Hoyne, Marius Rademaker, Asha C. Bowen

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Prevalence of Borrelia burgdorferi sensu lato infection in the Czech Republic by Roman Chlibek, Jan Smetana, Kateřina Kybicová, Martina Malikova, Frederick J. Angulo, Alexandra Loew-Baselli, Ye Tan, Aleš Ondřejíček, Gordon Brestrich, Andreas Pilz, Jennifer C. Moïsi, James H. Stark

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High-performance laser speckle contrast image vascular segmentation without delicate pseudo-label reliance by Shenglan Yao, Huiling Wu, Suzhong Fu, Shuting Ling, Kun Wang, Hongqin Yang, Yaqin He, Xiaolan Ma, Xiaofeng Ye, Xiaofei Wen, Qingliang Zhao

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Moringa oleifera Flower Extract Suppresses the Activation of Inflammatory Mediators in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages via NF-κB Pathway by Woan Sean Tan, Palanisamy Arulselvan, Govindarajan Karthivashan, Sharida Fakurazi

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Recent advances and future technologies in nano-microplastics detection by Ajinkya Nene, Sorour Sadeghzade, Stefano Viaroli, Wenjie Yang, Ucheaga Paul Uchenna, Abhishek Kandwal, Xinghui Liu, Prakash Somani, Massimiliano Galluzzi

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COVID-19: An Update on the Latest Therapeutic Agents by Ke-Yan Loo, Loh Teng-Hern Tan, Jodi Woan-Fei Law, Kar-Wai Hong, Kok-Gan Chan, Vengadesh Letchumanan

“…Vaccines against the viral infection started rolling out in late 2020, and the distribution of the vaccines worldwide managed to reduce the symptoms of COVID-19 and prevent outbreaks in local communities. …”
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Canada’s National Advisory Committee on Immunization: Celebrating 50 Years by Shalini Desai, Shainoor J lsmail, Robert Lerch, Bryna F Warshawsky, Ian Gemmill

“…Vaccines have saved more lives than any other innovation in modern medicine. …”
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Advances in Immunotherapy for Melanoma: A Comprehensive Review by Carmen Rodríguez-Cerdeira, Miguel Carnero Gregorio, Adriana López-Barcenas, Elena Sánchez-Blanco, Beatriz Sánchez-Blanco, Gabriella Fabbrocini, Brunilda Bardhi, Ardiana Sinani, Roberto Arenas Guzman

“…Several types of vaccines, including peptide, viral, and dendritic cell vaccines, are currently under investigation for the treatment of melanoma. …”
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Suppression of Proinflammatory Cytokines and Mediators in LPS-Induced RAW 264.7 Macrophages by Stem Extract of Alternanthera sessilis via the Inhibition of the NF-κB Pathway by Katyakyini Muniandy, Sivapragasam Gothai, Khaleel M. H. Badran, S. Suresh Kumar, Norhaizan Mohd Esa, Palanisamy Arulselvan

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A comprehensive method on black-legged tick larvae and nymph feeding on mice to study Lyme disease transmission and acquisition by Aaron Scholl, Bingjie Li, John Dennis, Sandip De

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