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An indole alkaloid from a tribal folklore inhibits immediate early event in HSV-2 infected cells with therapeutic efficacy in vaginally infected mice.
Published 2013-01-01“…Till date no effective vaccine is available, while the existing therapy frequently yielded drug resistance, toxicity and treatment failure. …”
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3043
Effect of Household Income on Household Welfare in Kitumba Sub-County Kabale District.
Published 2024“…In the study findings on the effect of household income on health accessibility in Kitumba sub-county Kabale District, the highest number of respondents mentioned that households with higher income are more likely to afford regular health check-ups, vaccinations, and preventive screenings, which can detect and address health issues early while the least number of respondents mentioned that higher-income households can more easily afford consultation fees, treatment costs, and surgical procedures, whereas lower-income families might struggle to pay for even basic healthcare services. …”
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3044
Microbial metabolites and immune modulation
Published 2024-12-01“…SCFAs, along with PSA, have shown promise as vaccine adjuvants by boosting antigen-specific immune responses and enhancing both the magnitude and quality of protective immunity. …”
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3045
Prevalence and influencing factors of occupational burnout among healthcare workers in the Chinese mainland during the late 2022 Omicron COVID-19 outbreak: a multicenter cross-sect...
Published 2025-01-01“…Older age, female gender, higher income, more doses of COVID-19 vaccine, a higher level of mindfulness, resilience, and perceived social support were protective factors of occupational burnout. …”
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3046
First Report of SNPs Detection in TMEM154 Gene in Sheep from Poland and Their Association with SRLV Infection Status
Published 2024-12-01“…Since the infection is incurable and no vaccine is available, another approach is necessary to control SRLV infections. …”
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3047
Barriers and drivers to COVID-19 protective behaviours of forcibly displaced myanmar nationals (FDMN)/ rohingya refugees in Cox's bazar, Bangladesh: A scoping review
Published 2025-01-01“…Articles reported on protective behaviors (as a general concept), handwashing, social distancing, isolation/quarantine, mask wearing, testing, treatment and vaccination. Barriers and drivers to these behaviors spanned all four COM factors reflecting both individual and environmental influences. …”
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3048
Standardization and validation of a novel reverse transcriptase polymerase chain reaction method for detecting virulent strains of the infectious bursal disease virus
Published 2025-12-01“…However, due to the constant necessity for the discrimination between already prevalent vaccine strains and new pathogenic strains of this virus, it becomes imperative to have an immediate molecular method targeting a consensus sequence to achieve this task using field samples to reduce costs. …”
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3049
Preventing Severe COVID-19 with Tixagevimab-Cilgavimab in Hematological Patients Treated with Anti-CD20 Monoclonal Antibodies: An International Multicenter Study
Published 2024-12-01“…Results The study revealed a significant reduction in the risk of COVID-19 among patients who received T-C prophylaxis compared to those who did not (11.2% vs 23.4%, p < 0.001), with hazard ratio (HR) of 0.40 (95% CI 0.26–0.63), adjusted for age, sex, vaccination status, baseline HM malignancy and type of anti-CD-20. …”
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3050
Prevalence and factors associated with uptake of pre-exposure prophylaxis amongst women vulnerable to HIV who received HIV antibodies in Antibody Mediated Prevention HVTN703/HPTN08...
Published 2024-04-01“…The AMP study evaluated the safety and efficacy of Vaccine Research Center 01 broadly neutralising monoclonal antibody in reducing acquisition of HIV-1 infection in women in sub-Saharan Africa. …”
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Epidemiology and response to the COVID-19 pandemic in the Dadaab Refugee Camp Complex, Kenya, March 2020–December 2022
Published 2025-01-01“…Testing capacity was bolstered, quarantine and isolation facilities established, and vaccination initiated. Conclusions: Despite a low AR and UNHCR's swift and comprehensive response, refugees' CFR was high, underscoring their vulnerability and need for targeted interventions during epidemic responses.…”
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3052
Clinical presentation and predictors of hospital mortality of diphtheria in Nigeria, July 2023 to April 2024: a single-center study
Published 2025-01-01“…Although antitoxin and vaccination were related to outcomes, they did not predict hospitalization death.…”
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Prevalence and determinants of persistent symptoms after infection with SARS-CoV-2: protocol for an observational cohort study (LongCOVID-study)
Published 2022-07-01“…Secondary outcomes include effect of vaccination prior to infection on persistent symptoms, loss of health-related quality of life (HRQoL) and risk factors for persisting symptoms following infection with SARS-CoV-2.Ethics and dissemination The Utrecht Medical Ethics Committee (METC) declared in February 2021 that the Medical Research Involving Human Subjects Act (WMO) does not apply to this study (METC protocol number 21-124/C). …”
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Mixed-methods reproductive health knowledge, attitudes and practices survey of IDPs, returnees and host communities in Jonglei State, South Sudan
Published 2025-01-01“…For respondents with children<2 years of age, 68·9% (95% CI 64·7 to 72·7) had received three doses of Penta valent vaccine. Females and males reported similar lifetime GBV rates.Conclusion Conflict and flooding in the remote survey areas are significant barriers to MNCH. …”
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3055
Development of the cultural tailoring score (CTS): a scoring instrument to assess cultural tailoring of health messaging
Published 2025-12-01“…It is based on research demonstrating the importance of: (1) Levels of engagement of the intended audience in the production, (2) use of understandable and culturally meaningful language, incorporation of (3) surface cultural cues and (4) deeper cultural constructs, (5) presence of a narrative to bind the information and cultural elements into a relatable story, and (6) factors associated with concrete psychological construal level (“now,” “here,” “you”).Methods We document a trial of the cultural tailoring score conducted by graduate students identifying as Filipino, Haitian, or Hispanic/Latinx reviewing 17 ads promoting COVID-19 vaccine that had been pretested during the pandemic for perceived effectiveness with convenience samples of these same ethnic groups.Results We achieved a combined Spearman’s Rank Correlation rho of 0.45 between the cultural tailoring score and perceived effectiveness ranking of all 17 ads (individual cultural groupings range from Spearman’s rho 0.45 to 0.90), suggesting that cultural components were moderately to strongly associated with perceived effectiveness. …”
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Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traitsResearch in context
Published 2025-02-01“…Summary: Background: Aging increases disease susceptibility and reduces vaccine responsiveness, highlighting the need to better understand the aging immune system and its clinical associations. …”
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Antimicrobial susceptibility profiles of Mycoplasma hyosynoviae strains isolated from five European countries between 2018 and 2023
Published 2025-01-01“…In the absence of a commercial vaccine improvement of housing conditions and antibiotic therapy are the only options to alleviate the clinical signs. …”
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Perceptions, Uses, and Information Sources of Medical Cannabis Among Patients With Cancer
Published 2025-03-01“…This latter subcohort was significantly more likely to identify as Hispanic/Latino (38.5% vs 9.9%, P = .009) and less likely to be up to date on COVID-19 vaccinations (30.8% vs 8.5%, P = 0.044). Identifying as Hispanic/Latino remained significantly associated with strongly agreeing or agreeing that MC can cure cancer on bivariate analysis (odds ratio, 6.528; 95% CI, 1.477-28.715; P = .012). …”
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Defining indicators for disease burden, health outcomes, policies and barriers and facilitators to health services for migrant populations in the Middle East and North African regi...
Published 2024-07-01“…This protocol describes a suite of seven systematic reviews that aim to identify, appraise and synthesise the available evidence on the burden and health outcomes, policies and access (barriers and facilitators) related to these mobile populations in the region.Methods Seven systematic reviews will cover three questions to explore the: (1) burden and health outcomes, (2) policies and (3) healthcare barriers and facilitators for the following seven disease areas in migrants in the MENA region: tuberculosis, HIV and hepatitis B and C, malaria and neglected tropical diseases, diabetes, mental health, maternal and neonatal health, and vaccine-preventable diseases. We will search electronic databases for studies in any language (year 2000–2023), reference-check relevant publications and cross-check included studies with experts. …”
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BIOTECHNOLOGICAL SYSTEM FOR THE SEARCH OF SUBSTANCES WITH POTENTIAL ACTIVITY AGAINST CORONAVIRUS
Published 2024-12-01“…Conclusions: As a result of the conducted research, the vaccine virus IBV H-120 was successfully adapted to cultivation conditions in ВНК-21 cell cultures, using primary trypsinized chicken embryo fibroblast cells as an intermediate system. …”
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