Moving “Forward” in Plasmodium Genetics through a Transposon-Based Approach by Bharath Balu

“…Even with certain limitations, the technique has already shown significant promise to increase our understanding of parasite biology needed for rationalized drug and vaccine design. Further improvements to the mutagenesis technique and the design of novel genetic screens should lead us to some exciting discoveries about the critical weaknesses of Plasmodium, and greatly aid in the development of new disease intervention strategies.…”
Get full text

A broadly neutralizing antibody against the SARS-CoV-2 Omicron sub-variants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5 by Zhe Chen, Leilei Feng, Lei Wang, Li Zhang, Binyang Zheng, Hua Fu, Fengdi Li, Ligai Liu, Qi Lv, Ran Deng, YanLi Xu, Yongfeng Hu, Jianhua Zheng, Chuan Qin, Linlin Bao, Xiangxi Wang, Qi Jin

“…With the constant evolution of the virus, Omicron and its subtypes BA.1, BA.2, BA.3, BA.4, and BA.5 have developed the capacity to evade neutralization induced by previous vaccination or infection. This evasion highlights the urgency in discovering new monoclonal antibodies (mAbs) with neutralizing activity, especially broadly neutralizing antibodies (bnAbs), to combat the virus.In the current study, we introduced a fully human neutralizing mAb, CR9, that targets Omicron variants. …”
Get full text

Development, implementation, and evaluation of an innovative clinical trial operations training program for Africa (ClinOps) by Dawit Asmamaw Ejigu, Abebaw Fekadu, Jeremy Whitty, Tsegahun Manyazewal, Pamela Nebeta, Almari Conradie, Brenda Okech, Alice Neequaye, Sinéad Whitty, Jennifer Lehrman, Renee Holt, Rahel Birhane, Mahnaz Vahedi, Helen Demarest, Eyasu Makonnen

Get full text

Knowledge and perceptions about clinical research and its ethical conduct among college students from non-science background: a representative nation-wide survey from India by Jeffrey Pradeep Raj, Suraj Kallarakal Tomy, Amrutha Jose, Aadrika Kashyap, Joseph Varghese Kureethara, Tomy K Kallarakal

“…Thus, we aim to investigate if the pandemic has influenced awareness and attitudes towards CR given the wide mass and social media coverage on drug/vaccine development process.Methods This was an online survey conducted among young adults enrolled as students in a university in south India between 15 September 2022 and 31 October 2022. …”
Get full text

Clinical Outcomes of COVID-19 and Impact on Disease Course in Patients with Inflammatory Bowel Disease by Panu Wetwittayakhlang, Farah Albader, Petra A Golovics, Gustavo Drügg Hahn, Talat Bessissow, Alain Bitton, Waqqas Afif, Gary Wild, Peter L Lakatos

“…After initial infection, 61% of IBD patients received COVID-19 vaccinations. Conclusion. The prevalence of COVID-19 infection among patients with IBD was lower than that in the general population in Canada. …”
Get full text

Facilitators and barriers affecting the implementation of e-health for chronic respiratory diseases in remote settings: a qualitative evidence synthesis by Emil Matias Salmi, Francesca Wanda Basile, Faiz Ahmad Khan, Larry Watt, Rinn Song, Else Margreet Bijker

Get full text

Individual- and Community-Level Risk Factors Associated with Childhood Diarrhea in Ethiopia: A Multilevel Analysis of 2016 Ethiopia Demographic and Health Survey by Setegn Muche Fenta, Teshager Zerihun Nigussie

“…Therefore, integrated child health intervention programs including provisions of toilet facility, access to a clean source of drinking water, educate parents about the importance of breastfeeding, and vaccination have to be strongly implemented in order to reduce the high incidence of childhood diarrhea among children in Ethiopia.…”
Get full text

A machine learning and clustering-based approach for county-level COVID-19 analysis. by Charles Nicholson, Lex Beattie, Matthew Beattie, Talayeh Razzaghi, Sixia Chen

“…This paper employs both supervised and unsupervised methods to identify the critical county-level demographic, mobility, weather, medical capacity, and health related county-level factors for studying COVID-19 propagation prior to the widespread availability of a vaccine. We use this feature subspace to aggregate counties into meaningful clusters to support more refined disease analysis efforts.…”
Get full text

Pertussis Reinfection in an Adult: A Cause of Persistent Cough Not to Be Ignored by Theocharis Koufakis, Anastasia Paschala, Dimitrios Siapardanis

“…Despite the fact that reinfection after natural disease or vaccination is not uncommon, the index of clinical suspicion of pertussis diagnosis in adults remains low. …”
Get full text

Stimulation of Innate and Adaptive Immunity by Using Filamentous Bacteriophage fd Targeted to DEC-205 by Luciana D’Apice, Valerio Costa, Rossella Sartorius, Maria Trovato, Marianna Aprile, Piergiuseppe De Berardinis

“…The filamentous bacteriophage fd, codisplaying antigenic determinants and a single chain antibody fragment directed against the dendritic cell receptor DEC-205, is a promising vaccine candidate for its safety and its ability to elicit innate and adaptive immune response in absence of adjuvants. …”
Get full text

Novel coronavirus 2019-nCoV: Could this virus become a possible global pandemic by Vengadesh Letchumanan, Nurul-Syakima Ab Mutalib, Bey-Hing Goh, Learn-Han Lee

“…At this point, there is no specific drug or vaccine to treat infected patients besides supportive care. …”
Get full text

HIV and Malnutrition: Effects on Immune System by Shalini Duggal, Tulsi Das Chugh, Ashish Kumar Duggal

“…Continuous research is being done in many parts of the world regarding its treatment and vaccine development, and a lot of money has flown into this. …”
Get full text

Du gouvernement des conduites à l'appropriation par les publics : un éclairage par la communication publique sanitaire by Caroline Ollivier-Yaniv, Nataly Botero, Myriam Hernandez Orellana

“…This interview traces the intellectual and academic path that led her to work on health and prevention communication, through fields such as HIV, cancer, smoking and vaccination. Her research includes the particular interest of addressing both discursive productions of institutions (prevention campaigns, public reports, links between political and media actors) and the reception and appropriation of these messages by institutional audiences. …”
Get full text

Availability of Veterinary Drugs Residues and Associated Impact on Vulture Health in Asia by Dau L. Bohra

“…Rabies infection is lethal unless vaccination immediately after exposure. The collapse in India’s vulture population occurred because of unintended poisoning following the availability of cheap generic versions of diclofenac for human use till 2008.…”
Get full text

Development and Validation of Chlamydia muridarum Mouse Models for Studying Genital Tract Infection Pathogenesis by Yihui Wang, Zixuan Han, Luying Wang, Xin Sun, Qi Tian, Tianyuan Zhang

“…Animal infection models play significant roles in the study of bacterial pathogenic mechanisms and host–pathogen interactions, as well as in evaluating drug and vaccine efficacies. Chlamydia trachomatis is responsible for infections in various mucosal tissues, including the eyes and urogenital, respiratory, and gastrointestinal tracts. …”
Get full text

Trafficked Proteins—Druggable in Plasmodium falciparum? by Jasmin Lindner, Kamila Anna Meissner, Isolmar Schettert, Carsten Wrenger

“…Annually this parasitic disease leads to more than half a million deaths; most of these are children in Africa. An effective vaccine is not available, and the treatment of the disease is solely dependent on chemotherapy. …”
Get full text

Tetanus Complicated by Dysautonomia: A Case Report and Review of Management by Nishant Sharma, Si Li, Metlapalli Venkata Sravanthi, Dan Kazmierski, Yichen Wang, Amit Sharma, Pragya Dhaubhadel

“…Tetanus is a life-threatening infectious neurological disorder that is now a rare disease due to the institution of wide-spread vaccination strategies. We present an uncommon case of generalized severe tetanus with consequent respiratory failure requiring mechanical ventilation, which was associated with dysautonomia. …”
Get full text

[IN1438] Dengue and Dengue Virus in Florida by Yasmin V. Ortiz, Daniel W. Pérez-Ramos, Eric P. Caragata, Panpim Thongsripong

“…The biology and ecology of the primary vectors, Aedes aegypti and Aedes albopictus, play  important roles in the disease's transmission cycle. No vaccine and no specific antiviral treatments are yet available, and diagnosis is difficult because dengue symptoms overlap with those of other, similar febrile illnesses. …”
Get full text

COVID-19 Situation in Thailand by Yi-He Kuai, Hooi-Leng Ser

“…The health authorities in Thailand are constantly promoting the COVID-19 vaccination plan to achieve herd immunity against the coronavirus. …”
Get full text

Helicobacter pylori: Basic Mechanisms to Clinical Cure by ABR Thomson, CN Williams

“…Therapy of H pylori infection is complicated and involves dual therapy with an antibiotic plus a protein pump inhibitor, such as omeprazole 20 mg bid plus amoxicillin 1 g bid for two weeks, triple or quadruple therapy with bismuth, two antibiotics and an H2-receptor antagonist. Vaccination against H pylori is on the far horizon.…”
Get full text