Expression of genes of cytokines, transcription factors and differentiation antigens in human dendritic cells activated by double-stranded DNA by A. S. Proskurina, K. E. Orishchenko, E. A. Potter, E. V. Dolgova, A. V. Spaselnikova, G. S. Ritter, N. A. Varaksin, T. G. Ryabicheva, O. Y. Leplina, A. A. Ostanin, E. R. Chernykh, S. S. Bogachev

“…One of the most important properties of extracellular double-stranded DNA related to the treatment of various diseases is its ability to activate effector cells of the immune system (anti-tumor and vaccinal immunity) through dendritic cells (DCs). The stimulatory effect of DNA on DCs is mediated by the TLR9 signaling pathway and/or through a system of cytosolic sensors and is manifested by increased expression of MHC class II antigens and costimulatory molecules and by increased synthesis of immunoregulatory cytokines. …”
Get full text

Impacts of COVID-19 on Pregnancy Outcomes: A Retrospective Study by Donna Mendez, Krishna Paul, Jerome L. Yaklic, Dietrich Jehle

“…A subgroup analysis of outcomes was performed based on the mother’s vaccine status. Results: The risks of maternal death (RR = 1.97), maternal intubation (RR = 3.33), and maternal (ICU) admission (RR = 1.76) were significantly higher in pregnant females with COVID-19. …”
Get full text

Loss-of-function variant in MAGT1 leading to XMEN disease in a Colombian patient with a common variable immunodeficiency by Sebastián Gutiérrez-Hincapié, Julio César Orrego, José Luis Franco, Claudia M. Trujillo-Vargas

“…Common variable immunodeficiency is a diagnosis of exclusion in immunodeficient patients with increased susceptibility to infections, hypogammaglobulinemia, deficient response to vaccination, or low percentages of switched memory B cells. …”
Get full text

Feature selection enhances peptide binding predictions for TCR-specific interactions by Hamid Teimouri, Hamid Teimouri, Zahra S. Ghoreyshi, Zahra S. Ghoreyshi, Anatoly B. Kolomeisky, Anatoly B. Kolomeisky, Anatoly B. Kolomeisky, Jason T. George, Jason T. George, Jason T. George, Jason T. George

“…Accurate prediction of peptide binding to TCRs is essential for advancing immunotherapy, vaccine design, and understanding mechanisms of autoimmune disorders.MethodsThis study presents a theoretical approach that explores the impact of feature selection techniques on enhancing the predictive accuracy of peptide binding models tailored for specific TCRs. …”
Get full text

FeLV-induced feline leukemia as a natural model for leukemia pathophysiology study (review) by T. V. Tabakaeva, A. V. Tsybulsky, K. A. Baranchugova, I. V. Galkina, M. Yu. Shchelkanov

“…Immunomodulators and chemotherapy are alsoused. Vaccination isusedas apreventive measure, but commercially available adjuvanted and non-adjuvanted vaccinesdo not confer effective protection from the infection. …”
Get full text

Hospitalization costs for children younger than five years of age for gastroenteritis caused by rotavirus. Cienfuegos Pediatric Hospital, 2018 by Isel de los Ángeles Gázquez Altuna, Anai García Fariñas, Alain Rubén Reyes Sebasco, María Elena Quiñones Hernández, Martha de la Caridad Marrero Araújo, Isabel Pilar Luis Gonzálvez, Nivaldo Linares Pérez

“…<p><strong>Background</strong>: The study of the hospitalization costs for rotavirus gastroenteritis is a strategic issue given the dilemma of introducing or not a rotavirus vaccine in Cuba.<br /><strong>Objective</strong>: to estimate the institutional cost of hospitalization of patients younger than five years of age because of gastroenteritis due to rotavirus.…”
Get full text

Serosurvey of Bovine Viral Diarrhea Virus in Cattle in Southern Japan and Estimation of Its Transmissibility by Transient Infection in Nonvaccinated Cattle by Norikazu Isoda, Satoshi Sekiguchi, Chika Ryu, Kosuke Notsu, Maya Kobayashi, Karin Hamaguchi, Takahiro Hiono, Yuichi Ushitani, Yoshihiro Sakoda

“…Neutralizing antibodies against BVDV-1 and BVDV-2 were detected more frequently in 18 vaccinated farms than in 17 nonvaccinated farms. In the nonvaccinated farms, 9.6%, 1.8%, and 13.8% of the cattle were estimated to have a history of infection with BVDV-1, BVDV-2, and both, respectively. …”
Get full text

Adaptive Immune Response to Model Antigens Is Impaired in Murine Leukocyte-Adhesion Deficiency-1 Revealing Elevated Activation Thresholds In Vivo by Thorsten Peters, Wilhelm Bloch, Oliver Pabst, Claudia Wickenhauser, Claudia Uthoff-Hachenberg, Susanne V. Schmidt, Georg Varga, Stephan Grabbe, Daniel Kess, Tsvetelina Oreshkova, Anca Sindrilaru, Klaus Addicks, Reinhold Förster, Werner Müller, Karin Scharffetter-Kochanek

“…Our findings may stimulate further studies on a modification of vaccination strategies using highly haptenated antigens in individuals suffering from LAD1.…”
Get full text

Combination Antiretroviral Therapy for HIV in Rwandan Adults: Clinical Outcomes and Impact on Reproductive Health up to 24 Months by Brenda Asiimwe-Kateera, Nienke Veldhuijzen, Jean Paul Balinda, John Rusine, Sally Eagle, Joseph Vyankandondera, Julie Mugabekazi, Pascale Ondoa, Kimberly Boer, Anita Asiimwe, Joep Lange, Peter Reiss, Janneke van de Wijgert

“…We applaud the Rwandan government for having strengthened family planning and PMTCT services and for having introduced HPV vaccination in recent years, but additional work is needed to strengthen STI and HPV-related cancer screening and management in the HIV-positive population.…”
Get full text

Proteomic Identification of Heat Shock-Induced Danger Signals in a Melanoma Cell Lysate Used in Dendritic Cell-Based Cancer Immunotherapy by Fermín E. González, Alexey Chernobrovkin, Cristián Pereda, Tamara García-Salum, Andrés Tittarelli, Mercedes N. López, Flavio Salazar-Onfray, Roman A. Zubarev

“…During the last decade, we demonstrated that vaccination of advanced melanoma patients with autologous tumor antigen presenting cells (TAPCells) loaded with an allogeneic heat shock- (HS-) conditioned melanoma cell-derived lysate (called TRIMEL) is able to induce an antitumor immune response associated with a prolonged patient survival. …”
Get full text

homeRNA self-blood collection enables high-frequency temporal profiling of presymptomatic host immune kinetics to respiratory viral infection: a prospective cohort studyResearch in... by Fang Yun Lim, Hannah G. Lea, Ashley M. Dostie, Soo-Young Kim, Tammi L. van Neel, Grant W. Hassan, Meg G. Takezawa, Lea M. Starita, Karen N. Adams, Michael Boeckh, Joshua T. Schiffer, Ollivier Hyrien, Alpana Waghmare, Erwin Berthier, Ashleigh B. Theberge

Get full text

Assessing microbial biodiversity in oil palm seedlings using oil palm waste compost mixed media by Siti Suliza Salamat, Mohd Zulkhairi Mohd Yusoff, Mohd Ali Hassan Hassan, Mohd Huzairi Mohd Zainuddin, Yoshihito Shirai, Ahmad Husni Mohd Hanif, Mohd Shahkhirat Norizan, Fatini Mat Arisah, Mohammed Abdillah Ahmad Farid, Toshinari Maeda, Mohd Noor Mat Isa, Mohd Faizal Abu Bakar

Get full text

Testing of chickens experimentally infected with A/H9N2 avian influenza virus isolates for their immune responses by O. S. Osipova, M. A. Volkova, S. V. Frolov, D. B. Andreychuk, I. A. Chvala

“…According to literature data, immune response activated by vaccination induces the reverse dynamics towards to increase in CD4⁺/CD8⁺ ratio. …”
Get full text

Overview of animal infectious disease situation in the Republic of Dagestan in 2023 by M. M. Mikailov, N. R. Budulov, Sh. A. Gunashev, E. A. Yanikova

“…Anti-epizootic measures taken in the past year included a total of 93.8 million vaccinations and 6.2 million tests performed in the diagnostic institutions. …”
Get full text

Features and Functionalities of Medical Mobile Applications for the Endemic Phase of COVID‐19: Review and Content Analysis by Mei Jun Loy, Khang Wen Goh, Norliza Osili, Long Chiau Ming, Jagjit Singh Dhaliwal, Andi Hermansyah, Yaser Mohammed Al-Worafi, Kah Seng Lee

“…Functionality assessment wise, 79.3% included information regarding COVID-19, 12.1% included COVID-19 contact tracing, 17.2% had vaccination status, a health authority maintained 50%, 31.0% included COVID-19 statistics, and 25.8% were able to report ART/PCR test. …”
Get full text

Assessment of knowledge and practices of exclusive breastfeeding among rural women during the COVID-19 pandemic in Egypt: a cross sectional study by Noura El-Gamel, Amina El-Nemer

“…A total of 98.3% of rural women had never made skin-to-skin contact, and 79.2% of them had not been vaccinated against COVID-19. Additionally, a statistically significant association between good knowledge and practice with highly educated women aged 26–30 years, with a monthly income of 4000–6000 L.E was found. …”
Get full text

Teenage Pregnancy: Impact of the Integral Attention Given to the Pregnant Teenager and Adolescent Mother as a Protective Factor for Repeat Pregnancy by Maria José Carvalho Sant'Anna, Kepler Alencar Mendes Carvalho, Amanda Melhado, Verônica Coates, Hatim A. Omar

“…One year after birth, 67.5% studied, 50% worked, 55.1% lived with the partner, 77% correctly used contraceptives, every child lived with their mothers and their vaccinations were up to date. The results demonstrate that the global attention given to the health of adolescent mothers and pregnant adolescents is a protective factor for pregnancy relapse and quality of life.…”
Get full text

Preparation of a Novel ACS/CS/EDTA Composite from Sugarcane Bagasse for Enhanced Adsorption of Carbon Dioxide by Quang Minh Pham, Xuan Son Nghiem, Thang Le Minh, Anh-Tuan Vu

Get full text

Anti-Tn Monoclonal Antibody Ameliorates Hyperoxia-Induced Kidney Injury by Suppressing Oxidative Stress and Inflammation in Neonatal Mice by Julie Chi Chow, Hsiu-Chu Chou, Jaulang Hwang, Chung-Ming Chen

“…Maternal immunization with the Tn vaccine increases serum anti-Tn antibody titers and attenuates hyperoxia-induced kidney injury in neonatal rats. …”
Get full text

Pediatric Sickle Cell Disease in Sudan: Complications and Management by Meysaa Talha, Bashier Osman, Safa Abdalla, Hind Mirghani, Iman Abdoon

“…Prophylactic penicillin was prescribed for 15% of patients, and 41.1% were immunized with pneumococcal vaccine (PPSV23). Most patients had been scheduled for planned follow-up visits every 3–6 months (93.2%). …”
Get full text