Transcriptome analysis reveals that PRV XJ delgE/gI/TK protects against intestinal damage in nose-dropping-infected mice by regulating ECM-ITGA/ITGB-P-FAK by Tong Xu, Yang Zhang, Qian Tao, Lei Xu, Si-Yuan Lai, Yan-Ru Ai, Jian-Bo Huang, Ben-Lu Yang, Ling Zhu, Zhi-Wen Xu

“…The research has important implications for the swine industry and public health by contributing to the development of better vaccines and treatments, ultimately helping to control PRV and prevent its cross-species transmission.…”
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Anti-Ebola virus mAb 3A6 protects highly viremic animals from fatal outcome via binding GP(1,2) in a position elevated from the virion membrane by Kathryn M. Hastie, Zhe Li Salie, Zunlong Ke, Peter J. Halfmann, Lisa Evans DeWald, Sara McArdle, Ariadna Grinyó, Edgar Davidson, Sharon L. Schendel, Chitra Hariharan, Michael J. Norris, Xiaoying Yu, Chakravarthy Chennareddy, Xiaoli Xiong, Megan Heinrich, Michael R. Holbrook, Benjamin Doranz, Ian Crozier, Yoshihiro Kawaoka, Luis M. Branco, Jens H. Kuhn, John A. G. Briggs, Gabriella Worwa, Carl W. Davis, Rafi Ahmed, Erica Ollmann Saphire

“…The findings reported here can guide design of next-generation highly potent anti-EBOV therapeutics and vaccines.…”
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The trend of phylogenetic and epitope variations of SARS-CoV-2 Omicron sub-lineages in Iran by Mehdi Shabani, Ahmad Nejati, Jila Yavarian, Jila Yavarian, Kaveh Sadeghi, Sevrin Zadheidar, Akram Sadat Ahmadi, Monire Ghadirali, Arghavan Zebardast, Adel Abedi, Mohammad Hossein Najmi, Nazanin-Zahra Shafiei-Jandaghi, Talat Mokhtari-Azad

“…The high rate of T-cell epitopes conservation in non-spike proteins among different sub-lineages of the Omicron in this study highlighted the importance of cell-mediated immunity and suggested that non-spike proteins might be more attractive targets for future SARS-CoV-2 vaccines.…”
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Neospora caninum infection specifically suppresses the expression of a host lncRNA XR_001919077.1 to facilitate parasite propagation by modulating host cell mitochondrial function... by Shan-Shan Zhao, De-Liang Tao, Jin-Ming Chen, Ming-Yi Zhang, Xin Yang, Jun-Ke Song, Qun Liu, Guang-Hui Zhao

“…However, due to a poor understanding of the pathogenic mechanisms of N. caninum infection, no effective drugs and vaccines are currently available. Long non-coding RNAs (lncRNAs) have been reported to be important regulators involved in a great number of physiological and pathological processes. …”
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Evaluation of the cross-immunity between Mycobacterium tuberculosis and Mycobacterium abscessus in vitro by Da Xu, Yujie Gu, Guilian Li, Ruihuan Wang, Shiqi Xiao, Hongyang Duan, Jingwei Jiang, Xiuqin Zhao, Kanglin Wan, Xinyue He, Haican Liu, Yongliang Lou

“…Given the abundance of shared antigens between these two pathogens, evaluating the cross-immunization between Mycobacterium tuberculosis and Mycobacterium abscessus has implications for the assessment of tuberculosis vaccines based on nontuberculous mycobacteria (NTM). …”
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From structure prediction to function: defining the domain on the African swine fever virus CD2v protein required for binding to erythrocytes by Ana Luisa Reis, Anusyah Rathakrishnan, Vlad Petrovan, Muneeb Islam, Lynnette Goatley, Katy Moffat, Mai Tuyet Vuong, Yuan Lui, Simon J. Davis, Shinji Ikemizu, Linda K. Dixon

“…These findings improve our understanding of virus–host interactions and provide a promising approach to modified live vaccine development.IMPORTANCEA better understanding of the interactions between viruses and their hosts is a crucial step in the development of strategies for controlling viral diseases, such as vaccines and antivirals. …”
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Prevalence and genetic characterization of viral gastroenteritis in hospitalized children aged <5 years in Yunnan Province, China, 2020–2022 by Nan Li, Enfa Qiao, Zhaojun Duan, Lili Li, Lili Jiang, Jianping Cun, Xiaofang Zhou, Zhi Chao Wang, Yongming Zhou, Yihui Cao

“…The authors suggest that monitoring should be strengthened to prevent outbreaks caused by RV G8P[8]. New vaccines, such as the RV G8P[8] genotype, should be considered.…”
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Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system by Sarah Hollingshead, Gareth McVicker, Maria R. Nielsen, YuGeng Zhang, Giulia Pilla, Rebekah A. Jones, Jonathan C. Thomas, Sarah E. H. Johansen, Rachel M. Exley, Ditlev E. Brodersen, Christoph M. Tang

“…This work shows the mechanistic links between plasmid maintenance and tolerance, and has applications in biotech and in the design and evaluation of vaccines against shigellosis.…”
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Identification of Host–Protein Interaction Network of Canine Parvovirus Capsid Protein VP2 in F81 Cells by Hongzhuan Zhou, Huanhuan Zhang, Xia Su, Fuzhou Xu, Bing Xiao, Jin Zhang, Qi Qi, Lulu Lin, Kaidi Cui, Qinqin Li, Songping Li, Bing Yang

“…This study lays the foundation for elucidating the potential function of CPV VP2 protein in the process of viral infection and proliferation which provides a theoretical basis for the design of antiviral agents and vaccines.…”
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Arginase-1-specific T cells target and modulate tumor-associated macrophages by Mads Hald Andersen, Inés Lecoq, Ayako Wakatsuki Pedersen, Evelina Martinenaite, Shamaila Munir Ahmad, Maria Perez-Penco, Lucia Lara de la Torre, Marion Chapellier, Lars Rønn Olsen, Mia Aaboe-Jørgensen, Hannah Jorinde Glöckner, Anne Mette Askehøj Rømer

“…Tumor-conditioned media (TCM) derived from Arg1-vaccinated mice induced significantly higher upregulation of MHC-II on exposed myeloid cells compared with controls. …”
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Utility of 131I-HLX58-Der for the Precision Treatment: Evaluation of a Preclinical Radio-Antibody-Drug-Conjugate Approach in Mouse Models by Liu Y, Wang X, Zhang N, He S, Zhang J, Xu X, Song S

“…Yi Liu,1– 4,&ast; Xiao Wang,1– 3,5,&ast; Ni Zhang,1– 4,&ast; Simin He,1– 4 Jianping Zhang,1– 4 Xiaoping Xu,1– 4 Shaoli Song1– 4 1Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, 200032, People’s Republic of China; 2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, People’s Republic of China; 3Center for Biomedical Imaging, Fudan University, Shanghai, 200032, People’s Republic of China; 4Shanghai Engineering Research Center of Molecular Imaging Probes, Shanghai, 200032, People’s Republic of China; 5State Key Laboratory of Vaccines for Infectious Diseases, Xiang an Biomedicine Laboratory & Center for Molecular Imaging and Translational Medicine, School of Public Health, Shenzhen Research Institute of Xiamen University, Xiamen University, Xiamen, 361102, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Shaoli Song; Xiaoping Xu, Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, 200032, People’s Republic of China, Email shaoli-song@163.com; xxp0012@ustc.eduPurpose: None of the antibody-drug conjugates (ADCs) targeting Claudin 18.2 (CLDN18.2) have received approval from regulatory authorities due to their limited clinical benefits. …”
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Kloning gen virulen Streptococcus agalactiae sebagai bahan dasar vaksin rekombinan by , Sutanti, Retno Damayanti Soejoedono, Irvan Faizal

“…DNA vaccine is a third generation of vaccines based on the gene encoding a vaccine antigen rather than the antigen itself. …”
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Clinical, pathological, and genotypic analysis of infectious bronchitis virus in broiler chickens in the Abu Dhabi Emirate, United Arab Emirates by Hassan Zackaria Ali Ishag, Abdelnasir Mohammed Adam Terab, Ebrahim Mohamad Abdalsalam Osman, El Tigani Ahmed El Tigani-Asil, El Tigani Ahmed El Tigani-Asil, Mohammed Saleh Albreiki, Oum Keltoum Bensalah, Asma Abdi Mohamed Shah, Abdelmalik Ibrahim Khalafalla

“…This complex scenario of different IBV lineages circulation may account for the persistent outbreaks despite vaccination efforts. The results of the study are crucial for optimum IB vaccination and monitoring strategies or designing new vaccines based on local IBV field strains.…”
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Optimising Xpert-Ultra and culture testing to reliably measure tuberculosis prevalence in the community: findings from surveys in Zambia and South Africa by Richard Hayes, Sarah Fidler, Sian Floyd, María Rupérez, Helen Ayles, Redwaan Vermaak, Kwame Shanaube, Albertus Schaap, Eveline Klinkenberg, Petra de Haas, Barry Kosloff, Thomas Gachie, Pete J Dodd, Chali Wapamesa, Michael J Burnett, Nico Kalisvaart, Tila Mainga, Linda Mureithi

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Immunization with a Synthetic Helicobacter pylori Peptide Induces Secretory IgA Antibodies and Protects Mice against Infection by David Espinosa-Ramos, Diana Caballero-Hernández, Ricardo Gomez-Flores, Armando Trejo-Chávez, Luis Jerónimo Pérez-Limón, Myriam Angélica de la Garza-Ramos, Reyes Tamez-Guerra, Patricia Tamez-Guerra, Cristina Rodriguez-Padilla

“…Furthermore, because there are no vaccines effective against H. pylori, an appropriate vaccine design targeting conserved/essential genes must be identified. …”
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Clinical Characteristics During and After COVID‐19 Infection Among Healthcare Workers During the First Wave of Omicron in Chongqing, China by Haoling Tang, Zhiwei Chen, Tianquan Huang, Pingping Yu, Qiao Tang, Yue Qiu, Yunling Xue, Jing Tang, Nan Cai, Hong Ren, Mingli Peng, Peng Hu

“…Interestingly, females experiencing menstruation or pregnancy exhibited a higher risk of infection, while inhaled vaccines and thymosin demonstrated a protective effect against SARS‐CoV‐2 infection. …”
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Viral Hepatitis B and Its Implications for Public Health in DR Congo: A Systematic Review by Marcellin Mengouo Nimpa, Hermès Karemere, Christian Ngandu, Franck-Fortune Mboussou, M. Carolina Danovaro-Holliday, Dalau Nkamba, André Bita Fouda, Bienvenu Nguejio, Sifa Kakozi, Aimé Mwana-Wabene Cikomola, Jean-Crispin Mukendi, Dieudonné Mwamba, Moise Désiré Yapi, Richard Bahizire Riziki, Cedric Mwanga, John Otomba, Jean Baptiste Nikiema, Boureima Hama Sambo, Daniel Katuashi Ishoso

“…In terms of perception of HBV, the hepatitis B virus is recognized as dangerous, and the majority of people questioned in the various studies were aware that vaccination remains the most effective means of prevention. …”
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Dynamic Challenges of Active Tuberculosis: Prevalence and Risk Factors of Co-Infection in Clinical and Microbiological Characteristics at King Abdulaziz University Hospital, Jeddah... by Mokhtar JA, Attallah DM, Jiman-Fatani AA, Al-Rabia MW, Alqarni MA, Saleh BH, Amboon MM, Altorki TA, Alkuwaity KK, Abujamel T, Kaki R, Albarakati TN, Daghistani H, Ismail MA, Alharbi O, Abu ITM, Alfadil A, Ibrahem K, Mufrrih M, Sait AM

“…Jawahir A Mokhtar,1– 3 Dalya M Attallah,2 Asif Ahmad Jiman-Fatani,1,2 Mohammed W Al-Rabia,1 Mona Abdulrahman Alqarni,1 Bandar Hasan Saleh,1,2 Maysaa Mohammed Amboon,4 Tarfa A Altorki,3,4 Khalil K Alkuwaity,3,4 Turki Abujamel,3,4 Reham Kaki,5,6 Taghreed Nassir Albarakati,7 Hussam Daghistani,8,9 Mazen A Ismail,10 Ohood Alharbi,11 Ibrahim Ismail Mohammed Abu,12 Abdelbagi Alfadil,1,13 Karem Ibrahem,1,2 Mohammed Mufrrih,4,14 Ahmad M Sait4,9 1Department of Clinical Microbiology and Immunology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Clinical Microbiology Laboratory, King Abdulaziz University Hospital, Jeddah, 21589, Saudi Arabia; 3Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; 4Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; 5Department of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; 6Department of Infectious Disease & Infection Control and Environmental Health, King Abdulaziz University Hospital, Jeddah, Saudi Arabia; 7Microbiology Unite in King Fahd General hospital Jeddah (KFHJ), Jeddah, Saudi Arabia; 8Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University Jeddah, Jeddah, 21589, Saudi Arabia; 9Regenerative Medicine Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; 10Department of Medical Education, Faculty of Medicine, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; 11Department of Microbiology and Parasitology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia; 12Department of Community Medicine, Faculty of medicine, King Abdulaziz University, Jedda, 21589, Saudi Arabia; 13Centre of Research Excellence for Drug Research and Pharmaceutical Industries, King Abdulaziz University, Jeddah, Saudi Arabia; 14Special Infectious Agents Unit BSL-3, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi ArabiaCorrespondence: Karem Ibrahem, Department of Clinical Microbiology and Immunology, Faculty of Medicine, King Abdulaziz University, P.O. …”
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scRNA-seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with uncomplicated malaria by Collins M. Morang’a, Riley S. Drake, Riley S. Drake, Riley S. Drake, Riley S. Drake, Vincent N. Miao, Vincent N. Miao, Vincent N. Miao, Vincent N. Miao, Nancy K. Nyakoe, Dominic S. Y. Amuzu, Vincent Appiah, Yaw Aniweh, Yaw Bediako, Saikou Y. Bah, Alex K. Shalek, Alex K. Shalek, Alex K. Shalek, Alex K. Shalek, Gordon A. Awandare, Thomas D. Otto, Lucas Amenga-Etego

“…To date, prevention efforts, particularly those related to vaccine development, have been hindered by an incomplete understanding of which factors impact host immune responses resulting in these divergent outcomes. …”
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Unveiling microbial communities with EasyAmplicon: A user‐centric guide to perform amplicon sequencing data analysis by Salsabeel Yousuf, Hao Luo, Meiyin Zeng, Lei Chen, Tengfei Ma, Xiaofang Li, Maosheng Zheng, Xin Zhou, Liang Chen, Jiao Xi, Hongye Lu, Huiluo Cao, Xiaoya Ma, Bian Bian, Pengfan Zhang, Jiqiu Wu, Renyou Gan, Baolei Jia, Linyang Sun, Zhicheng Ju, Yunyun Gao, Waqar Afzal Malik, Chuang Ma, Hujie Lyu, Yahui Li, Huiyu Hou, Yuanping Zhou, Defeng Bai, Yao Wang, Haifei Yang, Jiani Xun, Shengda Du, Tianyuan Zhang, Xiulin Wan, Kai Peng, Shanshan Xu, Tao Wen, Tong Chen, Yong‐Xin Liu

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