Using the WHO building blocks to examine cross-border public health surveillance in MENA by Laura Buback, Shayanne Martin, Esbeydy Pardo, Farah Massoud, Jesus Formigo, Atousa Bonyani, Noha H. Farag, Zayid K. Almayahi, Kenta Ishii, Susie Welty, Dana Schneider

“…Recommendations emphasize strengthened governance and leadership to facilitate regional cooperation and information sharing, sustainable financing for implementing a One Health approach, utilizing innovative information systems, workforce development to enhance data collection and analysis, and secure supply chains for medicines and vaccines and equitable service delivery for all mobile populations. …”
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Case report: PD-L1-targeted high-affinity natural killer cells and IL-15 superagonist N-803-based therapy extend overall survival of advanced metastatic pancreatic cancer patients by Tara Seery, Lennie Sender, Omid Jafari, Frank Jones, Patricia Spilman, Sandeep B. Reddy, Patrick Soon-Shiong

“…Some patients also received stereotactic body radiation therapy (SBRT), cyclophosphamide, pembrolizumab, nivolumab, and/or experimental ETBX-051 (brachyury) and/or ETBX-061 (MUC1) vaccines. Duration of spIND treatment and responses, for some patients including imaging and carbohydrate antigen 19-9 (CA19-9) levels, and OS from initial diagnosis and the start of spIND therapy were assessed.FindingsThe line/duration of spIND therapy was, for patients 1 through 5, respectively, second line/6.4 months, sixth line/3.5 months, third line/25.4 months, third line/7.4 months, and fourth line/23.2 months. …”
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Antiviral Activity and Underlying Mechanism of <i>Moslae herba</i> Aqueous Extract for Treating SARS-CoV-2 by Yan Feng, Qiong Ge, Jian Gao, Zhuoying Wu, Yunyi Zhang, Haiyan Mao, Beibei Wu, Changping Xu

“…Despite the widespread use of COVID-19 vaccines, there is still a global need to find effective therapeutics to deal with the variants of SARS-CoV-2. …”
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Prevalence of Diarrhea Disease and Associated Factors Among Children Under 5 Years in Geshiyaro Project Implementation Sites in Ethiopia: A Cross‐Sectional Study by Zinabu Assefa Alemu, Aderajew Mekonnen Girmay, Kirubel Tesfaye Teklu, Ermias Alemayehu Adugna, Melaku Gizaw Serte, Tsigereda Assefa Alemayehu, Badasa Wagari Likasa, Benjamin Collyer, Zelalem Mehari, Mihretab Salasibew, Getachew Tollera, Masresha Tessema

“…Besides, it also studied and showed a larger number of children who were not receiving basic vaccines. Therefore, the government and partner organizations should implement effective interventions to increase vaccine coverage and reduce diarrhea.…”
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Strengthening research preparedness for crises: lessons from Norwegian government agencies in using randomized trials and quasi-experimental methods to evaluate public policy inter... by Unni Gopinathan, Ingeborg Elgersma, Therese Dalsbø, Mona Bjørbæk, Atle Fretheim

“…A key takeaway from the coronavirus disease 2019 (COVID-19) pandemic was that although numerous randomized controlled trials (RCTs) focussed on drugs and vaccines, few policy experiments were conducted to evaluate effects of public policy interventions across various sectors on viral transmission and other consequences. …”
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Non-lytic spread of poliovirus requires the nonstructural protein 3CD by David Aponte-Diaz, Jayden M. Harris, Tongjia Ella Kang, Victoria Korboukh, Mohamad S. Sotoudegan, Jennifer L. Gray, Neela H. Yennawar, Ibrahim M. Moustafa, Andrew Macadam, Craig E. Cameron

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Validation of a Real Time PCR for Classical Swine Fever Diagnosis by Natanael Lamas Dias, Antônio Augusto Fonseca Júnior, Anapolino Macedo Oliveira, Érica Bravo Sales, Bruna Rios Coelho Alves, Fernanda Alves Dorella, Marcelo Fernandes Camargos

“…The parameters for the validation followed the specifications of the Manual of Diagnostic Tests and Vaccines for Terrestrial Animals of the World Organization for Animal Health (OIE) and the guide ABNT NBR ISO/IEC 17025:2005. …”
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Genomic and Pathogenic Characteristics of Virulent Newcastle Disease Virus Isolated from Chicken in Live Bird Markets and Backyard Flocks in Kenya by Irene N. Ogali, Paul O. Okumu, Erick O. Mungube, Jacqueline K. Lichoti, Stephen Ogada, Grace K. Moraa, Bernard R. Agwanda, Sheila C. Ommeh

“…This information will be useful in the development of specific markers for detection of viruses of genotype V and generation of genotype matched vaccines.…”
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Prospective clinical performance of CoVarScan in identifying SARS-CoV-2 Omicron subvariants by Kenneth Zhu, Manoj Sah, Lenin Mahimainathan, Yan Liu, Chao Xing, Karen Roush, Andrew Clark, Jeffrey SoRelle

“…CoVarScan performs as accurately as WGS with higher sensitivity, allowing its use as a tool to quickly identify variants for epidemiological surveillance and clinical decision-making in the selection of effective therapeutic mAbs.IMPORTANCEAlmost 5 years since the start of the pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern continue to emerge, with mutations conferring new properties like increased transmissibility and resistance to therapeutic monoclonal antibodies and vaccines. Conventionally, whole-genome sequencing (WGS) has characterized new SARS-CoV-2 variants, but results come too late for clinical actionability. …”
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Nucleic Acid Aptamers for Human Norovirus GII.4 and GII.17 Virus-Like Particles (VLPs) Exhibit Specific Binding and Inhibit VLPs from Entering Cells by Cheng C, Sun M, Li J, Xue Y, Cai X, Liu J, Wang X, Xu S, Xie Y, Zhang J

“…Limited by laboratory culture, no vaccines or drugs have been developed against HuNoVs. …”
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Assessing the effect of beta-propiolactone inactivation on the antigenicity and immunogenicity of cluster 2.1 duck Tembusu virus by Kanana Rungprasert, Wikanda Tunterek, Phornphisut Areeraksakul, Duangduean Prakairungnamthip, Chalida Sri-in, Navapon Techakriengkrai, Wijit Banlunara, Christine A. Jansen, Teerawut Nedumpun, Aunyaratana Thontiravong

“…Therefore, developing vaccines based on virus clusters specific to regions is essential. …”
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Serological Diagnosis of <i>Brucella</i> Infection in Cetaceans by Rapid Serum Agglutination Test and Competitive ELISA with <i>Brucella abortus</i> and <i>Brucella ceti</i> as Ant... by Tiziana Di Febo, Gabriella Di Francesco, Carla Grattarola, Luigina Sonsini, Ludovica Di Renzo, Giuseppe Lucifora, Roberto Puleio, Cristina Esmeralda Di Francesco, Camilla Smoglica, Giovanni Di Guardo, Manuela Tittarelli

“…Rose Bengal antigen and smooth lipopolysaccharide (s-LPS) were produced from a field strain of <i>Brucella ceti</i> (“homologous” antigens) and from the reference strain <i>B. abortus</i> S99 (“heterologous” antigens); they are currently used for the diagnosis of brucellosis in cattle, water buffaloes, sheep, goats, and pigs, as recommended in the Manual of Diagnostic Tests and Vaccines for Terrestrial Animals of the World Organization for Animal Health (WOAH). …”
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Treatment of chronic hepatitis B: options, monitoring, special cases and adverse effects by Mateusz Litwin Litwin, Agnieszka Mikosińska, Jakub Parys, Patrycja Kałuziak, Aleksandra Witek, Martyna Kaźmierczak, Stanisław Jesionek, Marta Jajczak, Maciej Mossakowski

“…Despite the availability of effective vaccines, the world is still not free from this problem. …”
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Genetic characteristics of influenza A and B viruses circulating in Russia in 2019–2023 by Svetlana B. Yatsyshina, Anna A. Artamonova, Maria A. Elkina, Anna V. Valdokhina, Victoria P. Bulanenko, Aleksandra A. Berseneva, Vasily G. Akimkin

“…These viruses are monitored annually around the world, including Russia, to determine the dominant genetic groups and select the strains to be included in influenza vaccines. Objectives of the study include: analysis of influenza virus circulation in Russia in 2019–2023, phylogenetic and molecular analysis of hemagglutinin (HA) sequences of influenza viruses, detection of mutations associated with drug resistance to neuraminidase (NA) inhibitors and M2-protein (M2) ion channel inhibitors. …”
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Viral Mimetic Bacterial Outer Membrane Vesicles for Targeting Angiotensin-Converting Enzyme 2 by Ahn G, Yoon HW, Jeong JH, Kim YH, Shin WR, Song MS, Ahn JY

“…Experiments in mice, Ag43β 700_RBD OMVs was successfully proven to be safe and effective; they produced a detectable level of nAbs with 39– 58% neutralisation and reduced viral titres in the lungs and brain without weight loss.Conclusion: The developed viral mimetic Ag43β 700_RBD OMVs may therefore be applied as a nanovesicle-theranostic platform for further emerging infectious disease-related diagnosis, vaccination, and treatment. Keywords: outer membrane vesicle, antigen 43 autotransporters, targeted delivery vehicle, theranostics, angiotensin-converting enzyme 2…”
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First detection and molecular characterization of porcine epidemic diarrhea virus (PEDV) in India: evidence of a new variant in Karnataka by Jagadish B. Hiremath, M. Swathi, R. Ramamoorthy, M. Shijili, Damini Sharma, Divakar Hemadri, H. B. Chethankumar, K. P. Suresh, Sharanagouda S. Patil, Shivasharanappa Nayakvadi, S. P. Satheesha, B. R. Shome, Baldev Raj Gulati

“…Understanding PEDV’s genetic diversity and evolution is essential to develop area-specific vaccines to mitigate the disease impact on India’s pig population.…”
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Large-scale screening of HIV-1 T-cell epitopes restricted by 12 prevalent HLA-A allotypes in Northeast Asia and universal detection of HIV-1-specific CD8+ T cells by Yan Ding, Jialai Yan, Ling Huang, Jinhong Yu, Yandan Wu, Chuanlai Shen, Anning Fang

“…BackgroundAlthough the immune response of host T cells to human immunodeficiency virus (HIV) significantly influences the progression of the infection, the development of T-cell-based vaccines and therapies, as well as the clinical evaluation of specific T-cell functions, is currently markedly hindered by the absence of broad-spectrum, functionally validated HIV T-cell epitopes that account for the polymorphisms of the human leukocyte antigen (HLA) within an indicated geographic population. …”
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The prevalence and distribution of malaria in Mpumalanga Province before and during COVID-19 (2017 - 2022) by I Kleinhans, S Mahanjana, F Els, M Mabona, L A Pitso, G Malatje, G Kok, J Raman

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RBD-displaying OMV nanovaccine boosts immunity against SARS-CoV-2 by Rang Feng, Ruo-Yi Xue, Chang Liu, Guo-Cheng Li, Yan Deng, Zhe Jin, Jing-Yi Liu, Shan-Shan Zhang, Hao Cheng, Man-Ying Guo, Quan-Ming Zou, Hai-Bo Li

“…Importantly, the induced antibodies effectively inhibited the binding of RBD to human angiotensin-converting enzyme 2 (hACE2) and neutralized SARS-CoV-2 pseudoviruses. Conclusions This vaccine platform offers an alternative strategy for developing recombinant subunit vaccines against SARS-CoV-2, potentially enhancing immune responses and improving vaccine efficacy. …”
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Proficiency, Clarity, and Objectivity of Large Language Models Versus Specialists’ Knowledge on COVID-19's Impacts in Pregnancy: Cross-Sectional Pilot Study by Nicola Luigi Bragazzi, Michèle Buchinger, Hisham Atwan, Ruba Tuma, Francesco Chirico, Lukasz Szarpak, Raymond Farah, Rola Khamisy-Farah

“…Overall, ChatGPT-4, Microsoft Copilot, and Google Bard generally provided accurate, updated information on COVID-19 and vaccines in maternal and fetal health, aligning with health guidelines. …”
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