Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease by Long Fung Chau, Simon Lillico, Tanja Opriessnig, Rosemary Blake, Luc Tardy, Chen-Hsuin Lee, Scott Maxwell, Claire Warren, Elizabeth Thornton, Catherine L. Mclaughlin, Gerry McLachlan, Christine Tait-Burkard, Sarah Fletcher, Stephen Anderson, Sharon Brown, Louise Gibbard, Thomas Tzelos, Dawn MacMillan-Christensen, J. Kenneth Baillie, David A. Dorward, David J. Griffiths, Finn Grey

“…Abstract Animal models that accurately reflect COVID-19 are vital for understanding mechanisms of disease and advancing development of improved vaccines and therapeutics. Pigs are increasingly recognized as valuable models for human disease due to their genetic, anatomical, physiological, and immunological similarities to humans, and they present a more ethically viable alternative to non-human primates. …”
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Research note: Establishment of a multiplex PCR detection system for different infectious bronchitis virus strain genotypes in laying hens by Changjing Zhao, Cheng Yuan, Qingsen Zhao, Aihong Xia, Yaqing Dong, Shuying Xu, Shihan Chen, Yue Yuan, Yongjuan Wang

“…This study produced a method for the fast detection and identification of five strains of infectious bronchitis virus (IBV), including the currently prevalent wild-type QX and G Ⅵ-1 strains, in addition to the Mass, 4/91, and LDT3 strains that are used as vaccines. Based on the spike 1 (S1) glycoprotein gene sequences of the IBV Mass, QX, G Ⅵ-1, 4/91, and LDT3 strains, five sets of customized primers, showing excellent specificity, were designed and synthesized to target the appropriate conserved sequences. …”
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Comparison of Intranasal Outer Membrane Vesicles with Cholera Toxin and Injected MF59C.1 as Adjuvants for Malaria Transmission Blocking Antigens AnAPN1 and Pfs48/45 by Michael Pritsch, Najib Ben-Khaled, Michael Chaloupka, Sebastian Kobold, Nicole Berens-Riha, Annabell Peter, Gabriele Liegl, Sören Schubert, Michael Hoelscher, Thomas Löscher, Andreas Wieser

“…Purified protein vaccines often require adjuvants for efficient stimulation of immune responses. …”
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Molecular identification of Newcastle disease virus isolated on the poultry farm of the Moscow Oblast in summer of 2022 by А. А. Treshchalina, А. А. Rtishchev, Е. Yu. Shustova, А. V. Belyakova, A. S. Gambaryan, Е. Yu. Boravleva

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Longitudinal Evaluation of Humoral Immunity and Bacterial and Clinical Parameters Reveals That Antigen-Specific Antibodies Suppress Inflammatory Responses in Active Tuberculosis Pa... by Mamiko Niki, Takashi Yoshiyama, Yuji Miyamoto, Masao Okumura, Makoto Niki, Ken-ichi Oinuma, Yukihiro Kaneko, Sohkichi Matsumoto, Yuka Sasaki, Hideo Ogata, Hajime Goto, Shoji Kudoh, Yoshihiko Hoshino

“…A novel tuberculosis vaccine to replace BCG has long been desired. However, recent vaccine trials focused on cell-mediated immunity have failed to produce promising results. …”
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Flunarizine as a Candidate for Drug Repurposing Against Human Pathogenic Mammarenaviruses by Chukwudi A. Ofodile, Ikemefuna C. Uzochukwu, Fortunatus C. Ezebuo, InnocentMary Ejiofor, Mercy Adebola, Innocent Okpoli, Beatrice Cubitt, Haydar Witwit, Chetachi B. Okwuanaso, Ngozi Onyemelukwe, Juan Carlos de la Torre

“…Lassa fever (LF), a viral hemorrhagic fever disease with a case fatality rate that can be over 20% among hospitalized LF patients, is endemic to many West African countries. Currently, no vaccines or therapies are specifically licensed to prevent or treat LF, hence the significance of developing therapeutics against the mammarenavirus Lassa virus (LASV), the causative agent of LF. …”
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2022 TB programme review in Pakistan: strengthening governance, with better patient diagnosis and treatment by M. van den Boom, K. Bennani, C. Sismanidis, C. Gunneberg, L. Khawaja, M.A. Safdar, C. Muhwa, E. Heldal, D.M. Cirillo, A.W. Khan, R. Fatima, B.J. Khan, S. Tahseen, M.G. ElMedrek, Y. Hutin, Pakistan Joint TB Program Review Mission

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Fusion to Flaviviral Leader Peptide Targets HIV-1 Reverse Transcriptase for Secretion and Reduces Its Enzymatic Activity and Ability to Induce Oxidative Stress but Has No Major Eff... by Anastasia Latanova, Stefan Petkov, Yulia Kuzmenko, Athina Kilpeläinen, Alexander Ivanov, Olga Smirnova, Olga Krotova, Sergey Korolev, Jorma Hinkula, Vadim Karpov, Maria Isaguliants, Elizaveta Starodubova

“…Positive outcome was the abrogation of polymerase activity increasing safety of RT-based DNA vaccines. Identification of the molecular determinants of low cellular immunogenicity of RT requires further studies.…”
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Connective tissue disease-associated interstitial lung disease – A multicenter observational study from India by Sham Santhanam, Pravin Patil, Mohit Goyal, C B Mithun, Parthajit Das, Kavitha Mohanasundaram, Neeraj Jain, Vijaya Prasanna, Keerthi Talari, Himanshu Pathak, Parshant Aggarwal, Deepika Ponnuru, Vikram Raj Jain, Sharath Kumar

“…Only 36 (5.8%) of the 620 patients were vaccinated with influenza as well as both the conjugate and the polysaccharide pneumococcal vaccines. …”
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Assessing the resilience of child immunisation programmes using geospatial modelling and interrupted time series analysis in Ethiopia and Kenya amidst the COVID-19 pandemic: tracki... by McEwen Khundi, Themba Mzembe, Michael Give Chipeta, Chimwemwe Chifungo, Nyovani Janet Madise, Chifuniro Somanje Mankhwala, Tabitha Ngwira, Maame B Peterson

“…The resilience of child immunisation was due to the implementation of community-based healthcare, mobile vaccinations and collaboration and partnerships for mass vaccination campaigns. …”
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Is differential cleaning needed for SARS-CoV-2 beyond standard procedures? A systematic review by Uduak Okomo, Ememobong N. Aquaisua, Osamagbe Asemota, Deborah Ndukwu, Josephine E. Egbung, Ekpereonne B. Esu, Olabisi A. Oduwole, John E. Ehiri

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Serological Evidence of Infectious Laryngotracheitis Infection and Associated Risk Factors in Chickens in Northwestern Ethiopia by Mastewal Birhan, Ashenafi Syoum, Saddam Mohammed Ibrahim, Tewodros Fentahun, Addisu Mohammed, Nega Berhane, Molalegne Bitew, Esayas Gelaye, Malede Birhan Atanaw, Belayneh Getachew, Bereket Dessalegn, Anmaw Shite Abat, Kassahun Berrie, Kassaye Adamu, Takele Abayneh

“…Furthermore, molecular confirmation and characterization of the virus from ILT suggestive cases should be considered to justify the use of ILT vaccines.…”
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Gardnerella vaginalis-binding IgA in the urethra of sexually experienced males by Rachel Liu, R. M. Galiwango, Daniel Park, Sanja Huibner, Maliha Aziz, Aggrey Anok, James Nnamutete, Yahaya Isbirye, John Bosco Wasswa, Deo Male, Godfrey Kigozi, Aaron A. R. Tobian, Jessica L. Prodger, Cindy Liu, Bryan Coburn, Rupert Kaul

“…Prospective studies of the host-microbe relationship in the urethra may have implications for the development of vaccines against sexually-transmitted bacteria. Video Abstract…”
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Public Health Messaging on Twitter During the COVID-19 Pandemic: Observational Study by Ashwin Rao, Nazanin Sabri, Siyi Guo, Louiqa Raschid, Kristina Lerman

“…ResultsOur analyses revealed that PHEs focused more on masking, health care, education, and vaccines, whereas pseudoexperts discussed therapeutics and lockdowns more frequently (P<.001). …”
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Benefits, challenges, and best practices of collaborative partnerships among health supply chain stakeholders in Rwanda: a cross-sectional study by Anitha Tuyishime, Innocent Hahirwa, Kato Jonas Njunwa, John Nyiligira

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Mobile health clinics in a rural setting: a cost analysis and time motion study of La Clínica in Oregon, United States by Abigail Higgins, Middy Tilghman, Tracy Kuo Lin

“…Of all procedures, 31.3% were vaccinations (N = 438), 27.0% were Covid-19 related (N = 377), 12.8% were outside referrals (N = 179), and 11.8% were point of care testing. …”
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A persona-based exploration of rabies post-exposure prophylaxis seeking behavior and its implication for communication strategic planning: Evidence from Thailand by Jitjayang Yamabhai, Patoo Cusripituck, Teerawan Mingbualuang, Nareerat Sangkachai, Wimwiga Sakchainanon, Chanatda Tungwongjulaniam, Onphirul Yurachai, Ratana Theerawat, Anuwat Wiratsudakul

“…Individuals classified within the positive trend strongly advocate for seeking rabies vaccines in the event of a dog bite. Meanwhile, individuals who have a neutral inclination are more likely to contemplate getting vaccinated following a dog bite, particularly if the injury is substantial. …”
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Preassembled complexes of hAgo2 and ssRNA delivered by nanoparticles: a novel silencing gene expression approach overcoming the absence of the canonical pathway of siRNA processing... by Shimaa A. E-S. El-Sayed, Mohamed A. Rizk, Hang Li, Uday Kumar Mohanta, Iqra Zafar, Shengwei Ji, Zhuowei Ma, Thom Do, Yongchang Li, Daisuke Kondoh, Jerzy Jaroszewski, Xuenan Xuan

“…Due to the lack of efficacy of the currently used chemical drugs, poor tick control, and lack of effective vaccines against Babesia, novel control strategies are urgently needed. …”
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Transcriptome analysis of ovarian cancer uncovers association between tumor-related inflammation/immunity and patient outcome by Jingfang Wang, Wenrui Zhu, Xia Li, Yuanyuan Wu, Wenhui Ma, Yangzhou Wang, Weihong Zhao, Fang Wei, Wenhao Wang

“…With the rapid development of PD-1/PD-L1, CTLA-4, oncolytic viruses, cancer vaccines, adoptive cell therapy, etc., tumor immunotherapy has provided new opportunities for the treatment of ovarian cancer.MethodsThis study used comprehensive transcriptome analysis across multiple databases to gather gene transcripts and clinical features of normal ovarian samples and tissue samples from ovarian cancer. …”
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The peculiar characteristics and advancement in diagnostic methodologies of influenza A virus by Muhammad Asif Raza, Muhammad Asif Raza, Muhammad Awais Ashraf, Muhammad Awais Ashraf, Muhammad Nabeel Amjad, Muhammad Nabeel Amjad, Ghayyas Ud Din, Ghayyas Ud Din, Bei Shen, Yihong Hu, Yihong Hu

“…Despite the development of vaccines and antiviral drugs, IAV is still a major cause of respiratory illnesses and deaths. …”
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