Towards designing improved cancer immunotherapy targets with a peptide-MHC-I presentation model, HLApollo by William John Thrift, Nicolas W. Lounsbury, Quade Broadwell, Amy Heidersbach, Emily Freund, Yassan Abdolazimi, Qui T. Phung, Jieming Chen, Aude-Hélène Capietto, Ann-Jay Tong, Christopher M. Rose, Craig Blanchette, Jennie R. Lill, Benjamin Haley, Lélia Delamarre, Richard Bourgon, Kai Liu, Suchit Jhunjhunwala

“…Abstract Based on the success of cancer immunotherapy, personalized cancer vaccines have emerged as a leading oncology treatment. …”
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Regulation of Tumor Immunity by Tumor/Dendritic Cell Fusions by Shigeo Koido, Sadamu Homma, Eiichi Hara, Yoshihisa Namiki, Akitaka Takahara, Hideo Komita, Eijiro Nagasaki, Masaki Ito, Toshifumi Ohkusa, Jianlin Gong, Hisao Tajiri

“…The goal of cancer vaccines is to induce antitumor immunity that ultimately will reduce tumor burden in tumor environment. …”
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Two Years of SARS-CoV-2 Omicron Genomic Evolution in Brazil (2022–2024): Subvariant Tracking and Assessment of Regional Sequencing Efforts by Ueric José Borges de Souza, Fernando Rosado Spilki, Amilcar Tanuri, Paulo Michel Roehe, Fabrício Souza Campos

“…This study examines the genomic diversity of SARS-CoV-2 in Brazil after the worst phase of the pandemic, the wider adoption of routine vaccination, and the abolishment of other non-pharmacological preventive measures from July 2022 to July 2024 using 55,951 sequences retrieved from the GISAID database. …”
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The length of price&reimbursement negotiation procedures in Italy in the period 2021-2023 was independent from the price of medicines by Raffaella Cocciolo, Paola Turella, Daniela Pilunni, Pierluigi Navarra

“…Biosimilars, generics, gene therapies, Sars-Cov-2 vaccines and medicines with no negotiated price at the datalock of December 2023 were excluded from the analysis. …”
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The Prospects for the Therapeutic Implications of Genetically Engineered Probiotics by Sayyeda Farwa Mazhar, Muhammad Afzal, Ahmad Almatroudi, Samman Munir, Usman Ali Ashfaq, Maria Rasool, Hammad Raza, Hafiz Muhammad Waqas Munir, Muhammad Shahid Riaz Rajoka, Mohsin Khurshid

“…The lactic acid bacilli are predominantly opposite as they already have gained attention owing to their health-promoting benefits and their safety for human consumption; therefore, their use, especially as a delivery agent of vaccines and drugs, is gaining attention. The tailoring of probiotic strains will not only improve the data regarding the probiotic potential of these strains but also clinch the doubts concerning these probiotics. …”
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Torovirus infection in animals: a review by V. А. Mischenko, A. V. Mischenko, T. B. Nikeshina, Yu. V. Brovko, А. I. Kushlubaeva

“…Despite the high activity and field effectiveness of vaccines against rotavirus and coronavirus infections and viral diarrhea, massive neonatal calf diarrheas causing significant economic losses were registered in a number of large-scale livestock farms. …”
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Salmonella Typhimurium derived OMV nanoparticle displaying mixed heterologous O-antigens confers immunogenicity and protection against STEC infections in mice by Xiaoping Bian, Yaolin Chen, Wenjin Zhang, Xinyu Liu, Meihong Lei, Haoxiang Yuan, Mengru Li, Qing Liu, Qingke Kong

“…Abstract Shiga toxin-producing Escherichia coli (STEC) is one of the major pathogens responsible for severe foodborne infections, and the common serotypes include E. coli O157, O26, O45, O103, O111, O121, and O145. Vaccination has the potential to prevent STEC infections, but no licensed vaccines are available to provide protection against multiple STEC infections. …”
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Simple and Fail-safe Method to Transform Miniprep Escherichia coli Strain K12 Plasmid DNA Into Viable Agrobacterium tumefaciens EHA105 Cells for Plant Genetic Transformation by Beenzu Siamalube, Emmanuel Ehinmitan, Maina Ngotho, Justus Onguso, Steven Runo

“…Plants are genetically engineered to develop disease-free varieties, knock out unsettling traits for crop improvement, or incorporate an antigenic protein to make the plant a green factory for edible vaccines. The method’s robustness was validated through successful transformations, demonstrating its effectiveness as a standard approach for researchers working in plant biotechnology. …”
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Mendelian Susceptibility to Mycobacterial Diseases (MSMD) in a 13-Year-Old Ethiopian Girl with Autosomal Dominant Interferon Gamma Receptor 1(IFN-γ R1) Defect: A Clinical Diagnosti... by Netsanet Azene Gebeyehu, Solomie Jebessa Deribessa, Freeman Alexandra, Messay Tesfaye Demissie, W Mihretu Gebre, Aklilu Melaku Gebremariam, Dagmawit Mitiku Engliz, Tizita Yosef Kidane, Lidya Million Bekele, Abate Yeshidinber Weldetsadik

“…MSMD is characterized by vulnerability to less virulent mycobacteria, such as Bacillus Calmette-Guérin (BCG) vaccine strains, as well as environmental mycobacteria (EM). …”
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Colon Cancer Genetic and Epigenetic Changes, Etiopathogenesis, Risk Factors, Treatment: Literature Review by Gabrielė Ūbaitė, Aurelija Remeikaitė, Justas Žilinskas

“…Innovations such as CRISPR/Cas9 offer new avenues for targeted treatments, while advances in vaccines and liquid biopsy techniques are improving immune response activation and disease monitoring. …”
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Global progress, challenges and strategies in eliminating public threat of viral hepatitis by Sihui Zhang, Fuqiang Cui

“…While improving the coverage of vaccine use, drugs for treating hepatitis B are not only becoming more effective, but also decreasing in price. …”
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Using spectrometric analysis for indirect estimation of 146S component concentration while measuring FMDV RNA amount by M. I. Doronin, D. V. Mikhalishin, N. Ye. Kamalova, A. V. Borisov

“…Prevention and control measures include mass vaccination of susceptible animals and control of post-vaccination immunity level. …”
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Eastern equine encephalitis virus: Pathogenesis, immune response, and clinical manifestations by Bhumika Parashar, Rishabha Malviya, Sathvik Belagodu Sridhar, Tarun Wadhwa, Sirajunisa Talath, Javedh Shareef

“…By collating current knowledge, this review underscores the urgent need for the development of targeted vaccines and therapeutic interventions to mitigate the growing threat of EEEV, particularly in the context of climate change-driven geographical expansion.…”
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Recent advancements in the diverse roles of polymerase-associated proteins in the replication and pathogenesis of Newcastle disease virus by Jinghang Zhou, Yuqi Duan, Menglan Liu, Jinyang Liu, Zenglei Hu, Zhiqiang Duan

“…This review aims to enhance our understanding of the complex functions of polymerase-associated proteins in NDV replication and pathogenesis and to contribute to the development of more effective vaccines and antiviral drugs against NDV challenges.…”
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Optimizing a low-temperature preservation technique for Bacillus anthracis strains by A. P. Rodionov, E. A. Artemeva, L. A. Melnikova, D. M. Sahibullina

“…The currently used anthrax vaccines are produced using various strains of Bacillus anthracis. …”
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The problem of conservation of gene pools of domesticated animals by Yu. A. Stolpovskiy, I. A. Zakharov-Gezekhus

“…The arguments in favor of preserving local breeds are: 1) economic factors, such as moderation of quality requirements for food products, moderation of hygienic and climatic conditions (new types of diseases, vaccines, changes in the external environment), necessity to keep a reserve for successful breeding, opportunity to use local breeds in harsh environmental conditions; 2) scientific factors, in particular, possibility of studying the gene pool of local breeds in order to reconstruct the evolution of domesticated species (exploring local breeds can reveal the mechanisms of the evolutionary processes, ontogeny, behavior patterns, natural and artificial selection); 3) cultural and historical factors related to the fact that native breeds represent living monuments of traditional culture of the population. …”
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CD4 T-Cell-Independent Antibody Response Reduces Enterovirus 71 Lethality in Mice by Decreasing Tissue Viral Loads by Li-Chiu Wang, Chia-Min Kao, Pin Ling, Ih-Jen Su, Tung-Miao Chang, Shun-Hua Chen

“…Collectively, our results show that the CD4 T-cell-independent antibody response promotes the survival of EV71-infected mice and suggest great potential for the use of vaccines and neutralizing antibodies to reduce fatal symptoms in patients.…”
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Klebsiella pneumoniae Biofilms and Their Role in Disease Pathogenesis by Maria Eduarda Souza Guerra, Giulia Destro, Brenda Vieira, Alice S. Lima, Lucio Fabio Caldas Ferraz, Anders P. Hakansson, Michelle Darrieux, Thiago Rojas Converso

“…Some of these molecules could be used in future vaccines against this bacterium. However, there is still a lack of in vivo models to evaluate the contribution of biofilm development to disease pathogenesis. …”
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Flow cytometry sorting of cells infected with African swine fever virus by A. S. Pershin, I. V. Shevchenko, T. N. Komova, A. Mazloum, N. N. Vlasova, E. O. Morozova, A. S. Igolkin, K. N. Gruzdev

“…The disease control is hindered  by the lack of commercially available and effective vaccines, which, in its turn, is attributable  to the insufficient knowledge of ASF pathogenesis  and immune defense against the disease. …”
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Impact of Social Assistance Grants for Empowerment on Standards of Living of Elderly Persons in Kabale Municipality Kabale District. by Naturinda, Suzan

“…The study results on the effect of social assistance grants for empowerment on the health of the elderly in Kabale Municipality, the highest number of respondents mentioned that social assistance grants for empowerment can help to alleviate financial stress which leads to better physical health outcomes for elderly persons while the least number of respondents mentioned that social assistance grants for empowerment help elderly individuals stay healthy since they can be able to purchase vaccines and have good health. The study findings on the effect of social assistance grants for empowerment on the consumption of elderly in Kabale Municipality, the highest number of respondents mentioned that social assistance grants for empowerment can alleviate financial stress and uncertainty for elderly individuals, allowing them to budget more effectively and plan for future consumption needs while the least number of respondents mentioned that social assistance grants for empowerment allows elderly persons to allocate more of their funds towards consumption for better health. …”
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