Influenza D virus in cattle (review) by S. V. Koteneva, A. G. Glotov, T. I. Glotova, A. V. Nefedchenko

“…There are currently no vaccines or specific treatment for influenza D virus. …”
Get full text

Risk and protective factors for ASF in domestic pigs and wild boar in the EU, and mitigation measures for managing the disease in wild boar by European Food Safety Authority (EFSA), Anette Ella Boklund, Karl Ståhl, Miguel Ángel Miranda Chueca, Tomasz Podgórski, Timothée Vergne, José Cortiñas Abrahantes, Eleonora Cattaneo, Sofie Dhollander, Alexandra Papanikolaou, Stefania Tampach, Lina Mur

“…However, the development of an oral GnRH vaccine for wild boar still requires substantial additional work.…”
Get full text

Inhibition of STING-mediated type I IFN signaling by African swine fever virus DP71L by Lakmal Ranathunga, Sachini Abesinghe, Ji-Won Cha, Niranjan Dodantenna, Kiramage Chathuranga, Asela Weerawardhana, D. K. Haluwana, Nuwan Gamage, Jong-Soo Lee

“…Taken together, these results highlight the important role of DP71L with respect to inhibition of interferon responses and provide guidance for a better understanding of ASFV pathogenesis and the development of live attenuated ASFV vaccines.…”
Get full text

Present and future of cancer nano-immunotherapy: opportunities, obstacles and challenges by Man Wang, Fei Yu, Yuan Zhang

“…Multiple forms of cancer immunotherapy, including immune checkpoint inhibitors (ICIs), adoptive cell therapy and cancer vaccines, have become widely available. However, the effectiveness of these immunotherapies is not much satisfying. …”
Get full text

Antihepatitis B Virus Activity of a Protein-Enriched Fraction from Housefly (Musca domestica) in a Stable HBV-Producing Cell Line by Xuemei Lu, Xiaobao Jin, Jie Wang, Fujiang Chu, Jiayong Zhu

“…Hepatitis B virus (HBV) infection remains a major public health problem. Although several vaccines and therapeutic strategies are currently being implemented to combat HBV virus, effective antiviral therapy against HBV infection has not been fully developed. …”
Get full text

Relationship between RSV-hospitalized children and meteorological factors: a time series analysis from 2017 to 2023 by Shuying Wang, Yifan Wang, Yingxue Zou, Cheng-liang Yin

“…Furthermore, continued research into vaccines and therapeutic drugs remains indispensable for augmenting public health outcomes.…”
Get full text

Replication-transcription complex of coronaviruses: functions of individual viral non-structural subunits, properties and architecture of their complexes by E. L. Mishchenko, V. A. Ivanisenko

“…Severe acute respiratory syndrome CoV (SARS-CoV), Middle East respiratory syndrome CoV (MERS-CoV), and the novel coronavirus (2019-nCoV, SARS-CoV-2) have been identif ied as causing global pandemics. Clinically tested vaccines are widely used to control rapidly spreading, acute, and often severe infections; however, effective drugs are still not available. …”
Get full text

STUDY ON THE ESTIMATION OF SARS-CoV-2 VIRUS PATHOGENS’ TRANSMISSION PROBABILITIES FOR DIFFERENT PUBLIC BUS TRANSPORT SERVICE SCENARIOS by Rafał BURDZIK, Niko SPEYBROECK

“…The study draws on scenarios from the first and second waves of the COVID-19 pandemic in Poland, a period that was devastatingly marked by the lack of available vaccines. This study aims to add value to the scientific community by offering an estimation of the likelihood of SARS-CoV-2 transmission in public transport and a preliminary risk assessment for COVID-19 infection, considering the number of active, non-isolated COVID-19 cases in the Polish population. …”
Get full text

Human migrations, anthropogenic changes, and insect-borne diseases in Latin America by André B. B. Wilke, Priscilla Farina, Marco Ajelli, Angelo Canale, Filipe Dantas-Torres, Domenico Otranto, Giovanni Benelli

“…Key measures include scaling vaccine coverage, especially for dengue and yellow fever; developing vaccines and treatments for neglected diseases; improving housing and sanitation; strengthening vector surveillance and control; fostering community engagement; enhancing data-driven interventions. …”
Get full text

Experimental Immunization Based on Plasmodium Antigens Isolated by Antibody Affinity by Ali N. Kamali, Patricia Marín-García, Isabel G. Azcárate, Antonio Puyet, Amalia Diez, José M. Bautista

“…Vaccines blocking malaria parasites in the blood-stage diminish mortality and morbidity caused by the disease. …”
Get full text

Scoping review of the applications of peptide microarrays on the fight against human infections. by Arthur Vengesai, Maritha Kasambala, Hamlet Mutandadzi, Tariro L Mduluza-Jokonya, Takafira Mduluza, Thajasvarie Naicker

“…<h4>Conclusion</h4>The most important application of peptide microarrays was found to be B-cell epitope mapping or antibody profiling to identify diagnostic and vaccine targets. Immunosignatures identified by random peptide microarrays were found to be applied in the diagnosis of infections and interrogation of vaccine responses. …”
Get full text

Calreticulin as an Adjuvant In Vivo to Promote Dendritic Cell Maturation and Enhance Antigen-Specific T Lymphocyte Responses against Melanoma by Zheng Gong, Ming Chen, Jie Miao, Chao-Jie Han, Qiao Zhong, Fang-Yuan Gong, Xiao-Ming Gao

“…Our results demonstrate that CRT/39-272 can be used as a potential new adjuvant for tumor vaccines, and this finding may be useful in tumor vaccine development.…”
Get full text

Identification of CTL Epitopes on Efflux Pumps of the ATP-Binding Cassette and the Major Facilitator Superfamily of Mycobacterium tuberculosis by Yan Lin, Yu Dong, Yanfeng Gao, Ranran Shi, Yubing Li, Xiuman Zhou, Wenwen Liu, Guodong Li, Yuanming Qi, Yahong Wu

“…The epitopes identified here provide a foundation for the diagnosis and treatment of patients infected with drug resistant and the future development of a multiepitope vaccine.…”
Get full text

Proline isomerization modulates the bacterial IsdB/hemoglobin interaction: an atomic force spectroscopy study by Francesca Pancrazi, Omar De Bei, Francesco Lavecchia di Tocco, Marialaura Marchetti, Barbara Campanini, Salvatore Cannistraro, Stefano Bettati, Anna Rita Bizzarri

“…Abstract Iron surface determinant B (IsdB), a Staphylococcus aureus (SA) surface protein involved in both heme iron acquisition from host hemoglobin (Hb) and bacterial adhesion, is a proven virulence factor that can be targeted for the design of antibacterial molecules or vaccines. Recent single-molecule experiments on IsdB interaction with cell adhesion factors revealed an increase of the complex lifetime upon applying a stronger force (catch bond); this was suggested to favor host invasion under shear stress. …”
Get full text

Dengue severity by serotype and immune status in 19 years of pediatric clinical studies in Nicaragua. by Federico Narvaez, Carlos Montenegro, Jose G Juarez, José Victor Zambrana, Karla Gonzalez, Elsa Videa, Sonia Arguello, Fanny Barrios, Sergio Ojeda, Miguel Plazaola, Nery Sanchez, Daniel Camprubí-Ferrer, Guillermina Kuan, Gabriela Paz Bailey, Eva Harris, Angel Balmaseda

“…<h4>Conclusions</h4>These findings demonstrate differences in dengue severity by serotype and immune status and emphasize the critical need for a dengue vaccine with balanced effectiveness against all four serotypes, particularly as existing vaccines show variable efficacy by serotype and serostatus.…”
Get full text

Sealless Production Ultracentrifuge and Its Magnetically Self-Bearing Openable Motors for Purification in Viral Nanotechnology by Emanuel J. Hubmann, Daniel Steinert, Thomas Nussbaumer, Johann W. Kolar

“…Viral nanotechnology enables new possibilities for gene therapies and vaccines. However, the manufacturing of viral vectors lacks a satisfactory production capable method for purification of full capsids. …”
Get full text

Sunitinib Combined with Th1 Cytokines Potentiates Apoptosis in Human Breast Cancer Cells and Suppresses Tumor Growth in a Murine Model of HER-2pos Breast Cancer by Nirmala Ghimirey, Chase Steele, Brian J. Czerniecki, Gary K. Koski, Loral E. Showalter

“…To explore the possibility of combining targeted drugs with Th1-polarizing vaccines, we undertook a study to examine the impact of combining Th1 cytokines with the relatively broad-spectrum receptor tyrosine kinase antagonist, sunitinib. …”
Get full text

ANALYSIS OF CHANGES IN AFRICAN SWINE FEVER VIRUS GENETIC STRUCTURE AND BIOLOGICAL PROPERTIES DURING ADAPTATION TO CONTINUOUS CELL CULTURE by Ali Mazloum, N. G. Zinyakov, A. S. Pershin, I. V. Shevchenko, I. Yu. Zhukov, D. N. Fedoseyeva, D. V. Sharypova, A. S. Igolkin, N. N. Vlasova

“…Identifcation of such genes will enable preparation of deletion mutant ASF virus strains as well as development and testing of pilot safe vaccines based on the said virus strains. Comparative analysis of the virus biological characteristics and detection of differences in its genome structure affecting certain phenotypic features is a main method used for the virus basic pathogenicity and immunogenicity examination. …”
Get full text

The problem of norovirus infection in animals (literature review) by V. А. Mischenko, A. V. Mischenko, T. B. Nikeshina, O. N. Petrova, Yu. V. Brovko, A. I. Kushlubaeva

“…The investigations of the etiology of numerous diarrhea cases revealed rota-, corona-, parvo-, enteroviruses and bovine viral diarrhea virus in fecal samples from calves. Inactivated vaccines have been developed in the Russian Federation to prevent viral diarrhea in cattle. …”
Get full text

The Silent Threat of Human Metapneumovirus: Clinical Challenges and Diagnostic Insights from a Severe Pneumonia Case by Rubens Carmo Costa-Filho, Felipe Saddy, João Luiz Ferreira Costa, Leandro Reis Tavares, Hugo Caire Castro Faria Neto

“…Routine incorporation of hMPV testing into clinical protocols could improve the diagnosis and resource use. The development of vaccines, such as the IVX-A12 in phase II trials, offers hope for targeted prevention, underscoring the need for further research and therapeutic innovations.…”
Get full text