Factors associated with vaccine default in Southern Ghana based on data from the RTSS malaria vaccine trial in Cape Coast by Vincent Bio Bediako, Josephine Akua Ackah, Theophilus Junior Yankey, Joshua Okyere, Emmanuella Acheampong, Bernard Afriyie Owusu, Wonder Agbemavi, Adanna Uloaku Nwameme, Edward Mberu Kamau, Emmanuel Asampong

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The Modification Effect of Influenza Vaccine on Prognostic Indicators for Cardiovascular Events after Acute Coronary Syndrome: Observations from an Influenza Vaccination Trial by Apirak Sribhutorn, Arintaya Phrommintikul, Wanwarang Wongcharoen, Usa Chaikledkaew, Suntara Eakanunkul, Apichard Sukonthasarn

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Localised swelling at sites of dermal filler injections following administration of Covid-19 vaccines: a systematic review by Chew Lip Ng, Evelyn Yuxin Tay, Alwyn Ray D’Souza

“…Introduction: Localised swelling at sites of filler injections has been reported in the Moderna mRNA-1273 coronavirus disease 2019 (COVID-19) vaccine trial. Methods: We conducted a review of the existing data and literature on the potential pathophysiology for this adverse event and its potential management. …”
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The Efforts to Implement a Malaria Elimination Strategy in The Highly Endemic Malaria Region of Papua Province, Indonesia by Erni Juwita Nelwan

“…Indonesia has recently completed a malaria vaccine trial, the IDSPZV1, which included the PfSPZ Vaccine and PfSPZ-CVac (CQ), conducted among soldiers deployed to Papua Province, New Guinea, for 10 months. …”
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Ex Vivo Restimulation of Human PBMC Expands a CD3+CD4-CD8-γδ+ T Cell Population That Can Confound the Evaluation of CD4 and CD8 T Cell Responses to Vaccination by B. J. Sedgmen, L. Papalia, L. Wang, A. R. Dyson, H. A. McCallum, C. M. Simson, M. J. Pearse, E. Maraskovsky, D. Hung, P. P. Eomois, G. Hartel, M. J. Barnden, S. P. Rockman

“…During the assessment of cell-mediated immunity (CMI) in subjects participating in a large-scale influenza vaccine trial, we identified the expansion of an IFN-γ-producing CD3+CD4-CD8-γδ+ T cell population in the peripheral blood of 90/610 (15%) healthy subjects. …”
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Booster Vaccination against Yellow Fever in Gambian children-(BoVY) -a Phase 3 clinical trial to establish safety and immunogenicity of repeated YF vaccination in healthy Gambian c... by David Jeffries, Caitlin Pley, Beate Kampmann, Mam Nabou Leigh, Julia Strandmark, Ed Clarke, Peter Ndow, Ebrima Kanteh, Amadou Faal, Elishia Roberts

“…Methods This open-label, non-randomised clinical vaccine trial (ClinicalTrials.gov, NCT05332197, registered on 31 March 2022, URL: https://clinicaltrials.gov/study/NCT05332197) will assess the safety and immunogenicity of a booster dose of the licensed 17D YF vaccine in Gambian children. …”
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Navigating vaccination in pregnancy: Qualitative study in 21 ethnically diverse pregnant women. by Mohammad S Razai, Michael Ussher, Lucy Goldsmith, Sally Hargreaves, Pippa Oakeshott

“…We also explored women's attitudes to taking part in vaccine trials during pregnancy and the use of artificial intelligence (AI) to obtain information on vaccines.…”
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UK cancer vaccine advance – Recognising and realising opportunities by Charles Craddock, Philip Earwaker, Matthew Fittall, Elisa Fontana, Divya Ganesh, Marco Gerlinger, Qamar Ghafoor, Robert P Jones, Victoria Kunene, Lennard Lee, Rebecca Lee, Siow-Ming Lee, Mark Linch, Martin Little, Justin Liu, Hayley McKenzie, Russell Petty, David J Pinato, Thomas Powles, Andrew Protheroe, Tim Robinson, Paul J Ross, Kai Keen Shiu, James Spicer, Stefan Symeonides, Michael Tilby, Dale Vimalachandran, Jenny Y Wang, Andrew Wardley, Helen Winter

“…The UK, now regarded for its vaccine capabilities, is an ideal nation for pioneering cancer vaccine trials. This article convened experts to share insights and approaches to navigate the challenges of cancer vaccine development with personalised or precision cancer vaccines, as well as fixed vaccines. …”
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Is a Consensus Case Definition for Viral Associated Lower Respiratory Tract Disease (LRTD) in Clinical Trials Possible? by S. Elizabeth Williams, Bradford Gessner, Elizabeth Begier, Negar Aliabadi, Kumar Ilangovan, Luis Jodar, Cassandra Hall-Murray, Giovanni Checcucci Lisi, Edward Walsh

“…However, the different vaccine trials have used highly variable criteria to define this outcome, leading to difficulty in comparison of vaccine efficacy results between trials. …”
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Adjuvants for peptide-based cancer vaccines by Willem W Overwijk, Hiep Khong

“…Such tumor-specific T cell responses could be induced through anti-cancer vaccination; but despite great success in animal models, only a few of many cancer vaccine trials have demonstrated robust clinical benefit. …”
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Longitudinal Evaluation of Humoral Immunity and Bacterial and Clinical Parameters Reveals That Antigen-Specific Antibodies Suppress Inflammatory Responses in Active Tuberculosis Pa... by Mamiko Niki, Takashi Yoshiyama, Yuji Miyamoto, Masao Okumura, Makoto Niki, Ken-ichi Oinuma, Yukihiro Kaneko, Sohkichi Matsumoto, Yuka Sasaki, Hideo Ogata, Hajime Goto, Shoji Kudoh, Yoshihiko Hoshino

“…A novel tuberculosis vaccine to replace BCG has long been desired. However, recent vaccine trials focused on cell-mediated immunity have failed to produce promising results. …”
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Immunogenicity of RSV F DNA Vaccine in BALB/c Mice by Erdal Eroglu, Ankur Singh, Swapnil Bawage, Pooja M. Tiwari, Komal Vig, Shreekumar R. Pillai, Vida A. Dennis, Shree R. Singh

“…Natural RSV infection stimulates the Th1 immune response and activates the production of neutralizing antibodies, while earlier vaccine trials that used UV-inactivated RSV exacerbated the disease due to the activation of the allergic Th2 response. …”
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The Evolution of Dendritic Cell Immunotherapy against HIV-1 Infection: Improvements and Outlook by Hager Mohamed, Vandana Miller, Stephen R. Jennings, Brian Wigdahl, Fred C. Krebs

“…This review summarizes and compares methods and efficacies of a number of DC vaccine trials utilizing autologous dendritic cells loaded with HIV-1 antigens. …”
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COVID-19 vaccine hesitancy: A telephonic survey in patients with systemic lupus erythematosusxs by Reuben Praharsh Kumar, Sandra Manuel, D Elizabeth, Vineeta Shobha

“…Background: Vaccine against COVID-19 is an effective preventive measure; however, systemic lupus erythematosus (SLE) patients were excluded from the vaccine trials, which leads to questions regarding vaccine safety and efficacy, giving rise to vaccine hesitancy. …”
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OMIC Technologies and Vaccine Development: From the Identification of Vulnerable Individuals to the Formulation of Invulnerable Vaccines by Nicola Cotugno, Alessandra Ruggiero, Veronica Santilli, Emma Concetta Manno, Salvatore Rocca, Sonia Zicari, Donato Amodio, Manuela Colucci, Paolo Rossi, Ofer Levy, Federico Martinon-Torres, Andrew J. Pollard, Paolo Palma

“…We will provide examples that show how such information can be useful to identify novel biomarkers of safety and immunogenicity for future vaccine trials. Finally, we will discuss how system biology “OMICs” data can be used to design bioinformatic tools to predict the vaccination outcome providing genetic and molecular “signatures” of protective immune response. …”
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Towards a Rational Design of an Asymptomatic Clinical Herpes Vaccine: The Old, the New, and the Unknown by Aziz Alami Chentoufi, Elizabeth Kritzer, David M. Yu, Anthony B. Nesburn, Lbachir BenMohamed

“…Here we provide a brief overview of past clinical vaccine trials, outline current progress towards developing a new generation “asymptomatic” clinical herpes vaccines, and discuss future mucosal “asymptomatic” prime-boost vaccines that could optimize local protective immunity.…”
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Adjuvanted subunit intranasal vaccine reduces SARS-CoV-2 onward transmission in hamsters by Yongjun Sui, Swagata Kar, Bhavna Chawla, Tanya Hoang, YuanKai Yu, Shannon M. Wallace, Hanne Andersen, Jay A. Berzofsky

“…IntroductionMost COVID-19 vaccine trials have focused on recipient protection, not protection of their contacts, a critical need. …”
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Development and characterization of a reverse genetic system for studying dengue virus serotype 3 strain variation and neutralization. by William B Messer, Boyd Yount, Kari E Hacker, Eric F Donaldson, Jeremy P Huynh, Aravinda M de Silva, Ralph S Baric

“…However this hypothesis is under increased scrutiny and the role of DENV genotypic variation in protection from repeated infection is less certain. As dengue vaccine trials move increasingly into field-testing, there is an urgent need to develop tools to better define the role of genotypic variation in DENV infection and immunity. …”
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Covid-19 vaccine acceptance and hesitancy among medical students of Faisalabad by Mohi Ud Din, Umer Shahid, Abdul Qudoos, Roman Ahmed, Muazzama Sohail, Saima Javed

“…Most of the participants also showed concerns regarding severe adverse effects of these vaccine and on vaccine trials also before making it available for general public. …”
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Understanding human papillomavirus vaccine response and efficacy in people living with HIV: A systematic mixed studies review and meta-analysis. by Alvine M Akumbom, Alanna J Bergman, Howard Strickler, Chakra Budhathoki, Manka Nkimbeng, Raeven Grant, Nancy R Reynolds, Kawsar R Talaat

“…Historically, the efficacy of vaccines has been suboptimal in PWH compared to people without HIV (PWoH).A systematic review of HPV vaccine trials in PWH was conducted using PRISMA guidelines. …”
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