SARS-CoV-2 active infection and antibodies amongst health personnel during the outbreak in Cameroon: Strengthening the health system for response to future public health emergencie... by Sen Claudine Henriette Ngomtcho, Blaise Mboringong Akenji, Ketina Hirma Tchio-Nighie, Joseph Fokam, Etienne Guenou, Carolle Nsa'Amang Eyebe, Yvan Junior Nzegni Kamkoum, Valdex Derick Ntale Tchoffo, Collins Buh Nkum, Hervé Christian Tchoudjin Paho, Yvette Marie Solange Ebogo, Aude Nanfak, Martin Maidadi-Foudi, Crescence Fouda, Angyiba Serge Andigema, Lilian Nsah Bongdze-Em, Beri Nadin Nfor, Judith Torimiro, Anne Cécile Zoung-Kanyi Bissek, Michel Noubom, Marie Claire Assoumou Okomo, Jérôme Ateudjieu

“…However, around two-fifths of participants have had contact with the virus, indicating that HP remains a population at risk of COVID-19 and other similarly-transmitted epidemic prone diseases, and also an important source of transmission. There is need of vaccine to achieve protectiveness, and optimal response also requires capacity building to improve the health system when challenged by a future pandemic.…”
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Monitoring of hepatitis E virus infection and replication by functional tagging of the ORF2 protein by Maliki Ankavay, Nathalie Da Silva, Angela Pollán, Noémie Oechslin, Katja Dinkelborg, Patrick Behrendt, Darius Moradpour, Jérôme Gouttenoire

“…As treatment options are limited and a vaccine is not universally available, the development of molecular tools to facilitate the identification of new therapeutic strategies is crucial. …”
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Knowledge, attitudes and behaviour towards ticks and tick-borne diseases—A survey among Lyme borreliosis cases in Bavaria in 2019 by Stefanie Böhm, Volker Fingerle, Andreas Beyerlein, Manfred Wildner, Merle M. Böhmer

“…In Bavaria, the average annual incidence of reported cases was 34.3 cases per 100,000 inhabitants between 2013 and 2020, although case numbers were presumed to be substantially higher. Since no vaccine against LB is currently available, prevention focuses on individual protection measures. …”
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Discovery of anti-Ebola virus multi-target inhibitors from traditional Chinese medicine database using molecular screening, biophysical investigation, and binding free energy calcu... by Abbas Khan, Abrar Mohammad Sayaf, Anwar Mohammad, Fahad M. Alshabrmi, Tarek Benameur, Dong-Qing Wei, Kar Kheng Yeoh, Abdelali Agouni

“…The lack of effective treatment or vaccine for this pathogen poses a serious threat to a global pandemic. …”
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Risk of SARS-CoV-2 infection before and after the Omicron wave in a cohort of healthcare workers in Ontario, Canada by Jorge L. Martinez-Cajas, Ann Jolly, Yanping Gong, Gerald Evans, Santiago Perez-Patrigeon, Bradley Stoner, T. Hugh Guan, Beatriz Alvarado

“…In period #2, the hazard of infection was higher among HCWs who had COVID-19-infected children at home, whereas the use of protective measures in the community (maintaining social distance, mask-wearing) and receiving a vaccine booster were associated with reduced risk. …”
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Evaluating the Efficacy of a Serious Game to Deliver Health Education About Invasive Meningococcal Disease: Clustered Randomized Controlled Equivalence Trial by Lauren Bloomfield, Julie Boston, Martin Masek, Lesley Andrew, Donna Barwood, Amanda Devine

“… BackgroundInvasive meningococcal disease (IMD) is a serious, vaccine-preventable infectious disease that can be life-threatening. …”
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Optimizing Tongue Fluid Sampling and Testing Protocols for Enhanced PRRSV Isolation from Perinatal Swine Mortalities by Onyekachukwu Henry Osemeke, Isadora Machado, Elisa De Conti, Mariah Musskopf, Mafalda Pedro Mil-Homens, Samuel Stutzman, Baoqing Guo, Thomas Petznick, Gustavo De-Sousa-E Silva, Phillip Gauger, Jianqiang Zhang, Daniel C. L. Linhares

“…Isolating PRRSV is essential for identifying infectious viruses and for vaccine formulation. This study evaluated the potential of using tongue fluid (TF) from perinatal piglet mortalities for PRRSV isolation. …”
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Comparison of clinical and virological features in pediatric and adult dengue cases at Insein General Hospital during Myanmar’s 2022 dengue season by Htin Lin, Mya Myat Ngwe Tun, Yin Mon Wint Zin, Khin Theingi Myint, Win Kay Khine, Khine Mya Nwe, Aye Aye Thant, Thin Thin Shwe, Win Mar, Khin Sandar Aye, Khaing Moe Aung, Yuki Takamatsu, Wah Wah Aung, Yi Yi Kyaw, Takeshi Urano, Kouichi Morita, Hlaing Myat Thu

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<i>In vitro</i> and <i>in vivo</i> tropism and biodistribution of recombinant simian adenovirus type 25 by Irina V. Vavilova, Tatiana A. Ozharovskaia, Olga V. Zubkova, Olga Popova, Daria V. Voronina, Polina P. Goldovskaya, Denis I. Zrelkin, Alina Sh. Dzharullaeva, Inna V. Dolzhikova, Dmitry V. Shcheblyakov, Denis Yu. Logunov, Alexander L. Gintsburg

“…Recombinant adenoviruses are widely used in the development of vaccines for a variety of infectious diseases. Despite numerous clinical studies, only a few types of human (types 5 and 26) and simian (isolate Y25) adenoviruses are currently used to produce vaccine formulations. …”
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Extracellular vesicles from fifth-stage larval Angiostrongylus cantonensis upregulate cholesterol biosynthesis and suppress NLRP2-associated inflammatory responses in mouse astrocy... by Chien-Ju Cheng, Lian-Chen Wang, Lichieh Julie Chu, Kuang-Yao Chen, Ching-Yun Huang, Kuo-Lun Lan, Kuo-Yang Huang

“…This study highlights the immunomodulatory roles of L5 EVs in non-permissive hosts, suggesting their potential as therapeutic targets and vaccine candidates against A. cantonensis.…”
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Methods to Adjust for Confounding in Test-Negative Design COVID-19 Effectiveness Studies: Simulation Study by Elizabeth AK Rowley, Patrick K Mitchell, Duck-Hye Yang, Ned Lewis, Brian E Dixon, Gabriela Vazquez-Benitez, William F Fadel, Inih J Essien, Allison L Naleway, Edward Stenehjem, Toan C Ong, Manjusha Gaglani, Karthik Natarajan, Peter Embi, Ryan E Wiegand, Ruth Link-Gelles, Mark W Tenforde, Bruce Fireman

“… BackgroundReal-world COVID-19 vaccine effectiveness (VE) studies are investigating exposures of increasing complexity accounting for time since vaccination. …”
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Duke Research at Pickett: The evolution of a free-standing research site partnering with communities toward health equity advancement by Laura Van Althuis, Sally Taylor, Debra Freeman, Stephanie Freel, Lynn Sutton, Kenisha Bethea, Leatrice Martin, Amanda McMillan, Diane Williams Garber, Keisha Bentley-Edwards, Nadine Barrett, Denise C. Snyder, Susanna Naggie

“…Catalyzed by the COVID-19 pandemic, Duke Research at Pickett, a 22 000-square-foot building with a laboratory, 30 exam rooms, and on-site parking, opened in October 2020 to support vaccine and treatment trials. Upon the lifting of many COVID-19 restrictions, and in partnership with the Research Equity and Diversity Initiative (READI) Community Advisory Council, the building was transformed to encourage community gatherings, education, and training programs. …”
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Large-scale screening of HIV-1 T-cell epitopes restricted by 12 prevalent HLA-A allotypes in Northeast Asia and universal detection of HIV-1-specific CD8+ T cells by Yan Ding, Jialai Yan, Ling Huang, Jinhong Yu, Yandan Wu, Chuanlai Shen, Anning Fang

“…BackgroundAlthough the immune response of host T cells to human immunodeficiency virus (HIV) significantly influences the progression of the infection, the development of T-cell-based vaccines and therapies, as well as the clinical evaluation of specific T-cell functions, is currently markedly hindered by the absence of broad-spectrum, functionally validated HIV T-cell epitopes that account for the polymorphisms of the human leukocyte antigen (HLA) within an indicated geographic population. …”
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Resurgence of Mumps among Lower Socioeconomic Class of Children in Ahmedabad: A Cross-sectional Study of 115 Cases in a Tertiary Care Center by Dipti V Patel, Zeel Patel, Snehal V Patel, Pooja Gandhi, Gayatri Parmar, Param S Patel

“…No patient was fully vaccinated for mumps. Out of the 15.6% (18 patients) admitted, two patients (1.7%) suffered from mumps complication of orchitis. …”
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Incidence and predictors of respiratory tract infections among birth cohorts in Ethiopia, 2023 by Fekade Demeke Bayou, Mastewal Arefaynie, Anissa Mohammed, Abiyu Abadi Tareke, Awoke Keleb, Natnael Kebede, Yawkal Tsega, Bayu Hailemariam Mersha, Abel Endawkie, Shimels Derso Kebede, Kaleab Mesfin Abera, Eyob Tilahun Abeje, Ermias Bekele Enyew, Chala Daba, Lakew Asmare

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Klebsiella pneumoniae derived outer membrane vesicles mediated bacterial virulence, antibiotic resistance, host immune responses and clinical applications by Lifeng Li, Xinxiu Xu, Ping Cheng, Zengyuan Yu, Mingchao Li, Zhidan Yu, Weyland Cheng, Wancun Zhang, Huiqing Sun, Xiaorui Song

“…We also deliberated on the potential of K. pneumoniae OMVs in vaccine development, as diagnostic biomarkers, and as drug nanocarriers. …”
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Proficiency, Clarity, and Objectivity of Large Language Models Versus Specialists’ Knowledge on COVID-19's Impacts in Pregnancy: Cross-Sectional Pilot Study by Nicola Luigi Bragazzi, Michèle Buchinger, Hisham Atwan, Ruba Tuma, Francesco Chirico, Lukasz Szarpak, Raymond Farah, Rola Khamisy-Farah

“…Overall, ChatGPT-4, Microsoft Copilot, and Google Bard generally provided accurate, updated information on COVID-19 and vaccines in maternal and fetal health, aligning with health guidelines. …”
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Seroprevalence of SARS-CoV-2 Infection Among People Living with HIV in Libreville, Gabon by Samira Zoa-Assoumou, Hervé M’boyis-Kandem, Pelagie Saphou-Damon, Davy Ulrich Leger Mouangala, Guy-Francis Nzengui, Marina Mbani-Okoumba, Claudine Kombila-Koumavor, Gael Mourembou, Brama Ibrahim, Angelique Ndjoyi-Mbiguino

“…However, having a detectable viral load (<i>p</i> = 0.0001), being vaccinated (COVID-19 vaccine, <i>p</i> = 0.04), and a history of COVID-19 (<i>p</i> < 0.0001) symptoms were associated with a higher risk of having anti-SARS-CoV-2 antibodies. (4) Conclusions: By early 2023, PLHIV in Gabon had high rates of SARS-CoV-2 seropositivity. …”
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Pulmonary aspergillosis in US Veterans with COVID-19: a nationwide, retrospective cohort study by Kaitlin Swinnerton, Nathanael R. Fillmore, Ikwo Oboho, Janet Grubber, Mary Brophy, Nhan V Do, Paul A Monach, Westyn Branch-Elliman

“…Selected clinical characteristics included age >70, receipt of immune-compromising drugs, hematologic malignancy, chronic respiratory disease, vaccination status, and vaccine era. Multivariate logistic regression was used to estimate the independent effects of these variables via adjusted odds ratios (aOR). …”
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Prevalence, Incidence and Predictors of Anal HPV Infection and HPV-Related Squamous Intraepithelial Lesions in a Cohort of People Living with HIV by Margherita Sambo, Alessandra Bailoni, Federico Mariani, Massimo Granai, Natale Calomino, Virginia Mancini, Anna D’Antiga, Francesca Montagnani, Mario Tumbarello, Stefano Lazzi, Franco Roviello, Massimiliano Fabbiani

“…A CD4 cell count > 500/mmc was an independent predictor of HPV clearance. HPV vaccination was performed on 30.9% of patients. A trend toward an increased clearance of HPV genotypes included in 9-valent vaccine was observed in vaccinated patients (40.6% versus 30.8% in unvaccinated, <i>p</i> = 0.079). …”
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