Fundamentals and Methods for T- and B-Cell Epitope Prediction by Jose L. Sanchez-Trincado, Marta Gomez-Perosanz, Pedro A. Reche

“…There is great interest in identifying epitopes in antigens for a number of practical reasons, including understanding disease etiology, immune monitoring, developing diagnosis assays, and designing epitope-based vaccines. Epitope identification is costly and time-consuming as it requires experimental screening of large arrays of potential epitope candidates. …”
Get full text

Natural compounds may contribute in preventing SARS-CoV-2 infection: a narrative review by Maria Eleonora Bizzoca, Stefania Leuci, Michele Davide Mignogna, Eleonora Lo Muzio, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio

“…To date, excluding the possibility of vaccination, against SARS-CoV-2 infection it is possible to act only with supportive care and non-virus-specific treatments in order to improve the patient's symptoms. …”
Get full text

The Prospects for the Therapeutic Implications of Genetically Engineered Probiotics by Sayyeda Farwa Mazhar, Muhammad Afzal, Ahmad Almatroudi, Samman Munir, Usman Ali Ashfaq, Maria Rasool, Hammad Raza, Hafiz Muhammad Waqas Munir, Muhammad Shahid Riaz Rajoka, Mohsin Khurshid

“…The lactic acid bacilli are predominantly opposite as they already have gained attention owing to their health-promoting benefits and their safety for human consumption; therefore, their use, especially as a delivery agent of vaccines and drugs, is gaining attention. The tailoring of probiotic strains will not only improve the data regarding the probiotic potential of these strains but also clinch the doubts concerning these probiotics. …”
Get full text

In situ-formed cryomicroneedles for intradermal cell delivery by Mengjia Zheng, Tianli Hu, Yating Yang, Xuan Qie, Huaxin Yang, Yuyue Zhang, Qizheng Zhang, Ken-Tye Yong, Wei Liu, Chenjie Xu

“…As a proof-of-concept, we examined the loading and intradermal delivery of three cell types in clinically relevant in vitro and in vivo models, including mesenchymal stem cells for wound healing, melanocytes for vitiligo treatment, and antigen-pulsed dendritic cells for cancer vaccination.…”
Get full text

Abuse potential of fentanyl and fentanyl analogues by Anusha Thumma, Kwadwo Mfoafo, Niloofar Babanejad, Alborz Omidian, Yadollah Omidi, Hamid Omidian

“…Conclusions: By educating patients and physicians, making rescue kits easily accessible, developing vaccines to prevent opioid addiction, and perhaps even creating new tamper-resistant fentanyl formulations, it may be possible to prevent fentanyl misuse, therapeutic errors, and the repercussions that follow.…”
Get full text

Eastern equine encephalitis virus: Pathogenesis, immune response, and clinical manifestations by Bhumika Parashar, Rishabha Malviya, Sathvik Belagodu Sridhar, Tarun Wadhwa, Sirajunisa Talath, Javedh Shareef

“…By collating current knowledge, this review underscores the urgent need for the development of targeted vaccines and therapeutic interventions to mitigate the growing threat of EEEV, particularly in the context of climate change-driven geographical expansion.…”
Get full text

Evaluation of the Primary Healthcare attributes in a municipality located in the countryside of São Paulo State – Brazil by Lislaine Aparecida Fracolli, Marianne Junko Muramatsu, Maria Fernanda Pereira Gomes, Fabiana Rodrigues Zequini Nabão

“…Proper adaptations should be performed during the opening hours of the healthcare centers; facilitating access and appointment scheduling; improve the counter-reference and reference system; offer vaccination and stitch services; and also, improve the communication between professionals and users, review and reformulate the attendance model of the FHS…”
Get full text

National Consensus for the Management of Acute Gastroenteritis in Jordanian Children: Consensus Recommendations Endorsed by the Jordanian Paediatric Society by Mohammed Rawashdeh, Basim Al-Zoubi, Maha Barbar Aliwat, Salma Burayzat, Esam Alhindawi, Ali Attia Al-Matti, Eyad Altamimi

“…The prevention of diarrhoeal diseases should focus on the improvement of nutrition, hygiene, and sanitation, the introduction of routine vaccination against rotavirus, and the adoption of a standardised approach for AGE management (oral rehydration solution (ORS) use±adjunct therapies, continued feeding, and avoiding routine antibiotic use). …”
Get full text

The Disappearance of COVID-19 Data Dashboards: The Case of Ephemeral Data by Melinda Laituri, Yogya Kalra, Chaowei Yang

“…Data dashboards tracked global and country-specific statistics and provided cartographic visualizations of cases, deaths, vaccination rates and other metrics. We examined the role of geospatial data on COVID-19 dashboards in the form of maps, charts, and graphs. …”
Get full text

The Societal Impact of Herpes Zoster and Postherpetic Neuralgia on Patients, Life Partners, and Children of Patients in Germany by Thomas Weinke, Andrea Glogger, Isabelle Bertrand, Kati Lukas

“…We need to raise the awareness of the general public about the real life impact of HZ and PHN and their often severe, debilitating consequences and the potential benefits from vaccination.…”
Get full text

Hepatitis B Virus in Polish Blood Donors in the Period 2005–2019—Significant Changes in Epidemiology and Demographic Characteristics of Infected Donors by Aneta Kopacz, Dorota Kubicka-Russel, Grzegorz Liszewski, Ewa Sulkowska, Anna Chrzanowska, Paulina Zwolińska, Ewa Noceń, Anna Potępa, Magdalena Łętowska, Piotr Grabarczyk, the Group of Polish Blood Transfusion Centers for Blood Borne Pathogens

“…Pursuant to the WHO guidelines, obligatory vaccination was introduced in 1994–1996 (as a part of hepatitis B prophylaxis for newborns), and in 2000–2011, all 14-year-olds were vaccinated. …”
Get full text

Completely conserved VP2 residue K140 of KREMEN1-dependent enteroviruses is critical for virus-receptor interactions and viral infection by Zeyu Liu, Xue Li, Xiaohong Li, Xingyu Yan, Yuan Tian, Yue Zhao, Kexin Liu, Pei Hao, Shuye Zhang, Chao Zhang

“…Licensed inactivated EV-A71 vaccines do not provide cross-protection against other enteroviruses. …”
Get full text

cGAS/STING signaling pathway in gynecological malignancies: From molecular mechanisms to therapeutic values by Danyang Zhang, Bingxue Zhang

“…Gynecological cancers, including cervical, ovarian, and endometrial malignancies, remain a significant global health burden, exacerbated by disparities in access to preventive measures such as HPV vaccination and routine screening. The cGAS/STING signaling pathway, a pivotal mechanism in innate immunity, detects cytosolic DNA from pathogens or cellular damage, triggering immune responses via type I interferons and inflammatory cytokines. …”
Get full text

Molecular Detection and Characterization of Pasteurella multocida Infecting Camels in Marsabit and Turkana Counties, Kenya by Justus K. Kasivalu, George I. Omwenga, Gabriel O. Aboge

“…Farmers should not underfeed camels, ensure appropriate medication and vaccination programs, and minimize herding of camels in crowded areas especially in wet conditions in order to slow the spread of P. multocida infection.…”
Get full text

Tingkat Pengetahuan, Sikap dan Perilaku Mahasiswi Fakultas Kedokteran Universitas Sumatera Utara Tentang Kanker Serviks by Savira Laniari Putri, Feby Yanti Harahap

“…It can be prevented by HPV vaccination, pap smears examination, or avoidance of risk factors for cervical cancer. …”
Get full text

Acute Cholestatic Hepatitis A Virus Infection Presenting with Hemolytic Anemia and Renal Failure: A Case Report by Robert T. Lapp, Fedja Rochling

“…This case demonstrates the importance of vaccination in high-risk adults. A prompt diagnosis of acute hepatitis A virus infection is essential, as uncommon presentations may delay diagnosis leading to permanent morbidity and potentially death in fulminant cases. …”
Get full text

Decision Support System Based on CoCoSo Method with the Picture Fuzzy Information by Muhammad Qiyas, Muhammad Naeem, Saifullah Khan, Saleem Abdullah, Thongchi Botmart, Tajammul Shah

“…The number of instances of this disease is increasing at an exponential, but there are now commercially accessible COVID-19 vaccines. The weak symptoms of COVID-19 disease, on the other hand, are treated with a variety of antiviral treatments. …”
Get full text

Ignoring Gender-Based Immunometabolic Reprograming, a Risky Business in Immune-Based Precision Medicine by Vijay Kumar

“…On the other hand, reproductive-age females also show a more potent immune response against infections and vaccines than their age-matched males—furthermore, some immune-based therapies, including immune checkpoint inhibitors (ICIs), show gender-based efficacy and adverse events. …”
Get full text

Putative Key Role of Inositol Messengers in Endothelial Cells in Preeclampsia by Sirilaksana Kunjara, Patricia McLean, Laurens Rademacher, Thomas W. Rademacher, Fabiana Fascilla, Stefano Bettocchi, Marco Scioscia

Get full text

Targeted Anticancer Immunotoxins and Cytotoxic Agents with Direct Killing Moieties by Koji Kawakami, Oumi Nakajima, Ryuichi Morishita, Ryozo Nagai

“…Despite the progress of the bioinformatics approach to characterize cell-surface antigens and receptors on tumor cells, it remains difficult to generate novel cancer vaccines or neutralizing monoclonal antibody therapeutics. …”
Get full text