Examining antibiotic use in Kenya: farmers’ knowledge and practices in addressing antibiotic resistance by Harrison Rware, Kansiime K. Monica, Mugambi Idah, Makale Fernadis, Ikiror Davis, Wako Buke, Danielsen Solveig, Karanja Daniel, Chacha Duncan, Byskov Morten, Hyams Keith

“…There needs to be an enabling environment driven by (1) effective policy interventions and enforcement to ensure compliance with set guidelines for antibiotic use; (2) research on and deployment of alternatives, such as probiotics, vaccinations and disease prevention measures, (3) continued public awareness raising and education using multiple channels to reach farmers and, (4) strengthened cross-sector, multi-stakeholder collaboration to address the multi-dimensional complexities of AMR.…”
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Burden of scrub typhus among patients with acute febrile illness attending tertiary care hospital in Chitwan, Nepal by Sangita Thapa, Pradip Hamal, Navin Kumar Chaudhary, Lokendra Bahadur Sapkota, Jaya Prasad Singh

“…Infection with scrub typhus was found high and this calls for an urgent need to introduce vaccine against scrub typhus. More sustain and vigorous awareness programmes need to be promoted for early diagnosis, treatment and control.…”
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Diospyros kaki and Citrus unshiu Mixture Improves Disorders of Lipid Metabolism in Nonalcoholic Fatty Liver Disease by Mi-Rae Shin, Sung Ho Shin, Seong-Soo Roh

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Prevalence and correlates of facemask usage during the second wave of COVID-19 pandemic in Uganda. by Nelson Onira Alema, Christopher Okot, Emmanuel Olal, Eric Nzirakaindi Ikoona, Freddy Wathum Drinkwater Oyat, Steven Baguma, Denish Omoya Ochula, Patrick Odong Olwedo, Johnson Nyeko Oloya, Francis Pebalo Pebolo, Pamela Okot Atim, Godfrey Smart Okot, Ritah Nantale, Judith Aloyo, David Lagoro Kitara

“…We conducted a cross-sectional study on 587 adults across nine districts in northern Uganda, across 24 high-volume health facilities offering free COVID-9 vaccines. Respondents were selected from the health facilities using a single-stage systematic sampling method. …”
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17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) Is Neuroprotective and Reduces Motor Impairment and Neuroinflammation in a Murine MPTP Model of Parkinson’s Disease by Ferdinando Nicoletti, Ingrid Philippens, Paolo Fagone, Clarence N. Ahlem, Christopher L. Reading, James M. Frincke, Dominick L. Auci

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Costs and Outcomes of Clostridioides difficile Infections in Germany: A Retrospective Health Claims Data Analysis by Katharina Schley, Kirstin Heinrich, Jennifer C. Moïsi, Dennis Häckl, Dominik Obermüller, Gordon Brestrich, Christof von Eiff, Thomas Weinke

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CRISPR/Cas9-mediated genomic insertion of functional genes into Lactiplantibacillus plantarum WCFS1 by Kamilla Wiull, Lisa K. Haugen, Vincent G. H. Eijsink, Geir Mathiesen

“…ABSTRACT Lactiplantibacillus plantarum, a natural inhabitant of the human body, is a promising candidate vehicle for vaccine delivery. An obstacle in developing bacterial delivery vehicles is generating a production strain that lacks antibiotic resistance genes and contains minimal foreign DNA. …”
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A low pre-existing anti-NS1 humoral immunity to DENV is associated with microcephaly development after gestational ZIKV exposure. by Sebastián Castro-Trujillo, William R Mejía, Katherine Segura, Juanita Castro-Meneses, Rocío Vega, Doris Salgado, Carlos E Fonseca, Ángela M Ortiz, Federico Perdomo-Celis, Irene Bosch, Carlos F Narváez

“…These data are compatible with a protective role of anti-NS1 IgG antibodies against ZIKV infection during pregnancy and highlight the promising role of NS1 as an orthoflavivirus vaccine target in high-risk populations.…”
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Genetic analysis of scab disease resistance in common bean (Phaseolus vulgaris) varieties using GWAS and functional genomics approaches by Shadrack Odikara Oriama, Benard W. Kulohoma, Evans Nyaboga, Y. O. Masheti, Reuben Otsyula

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Knowledge of Health Professionals on Cold Chain Management and Associated Factors in Ezha District, Gurage Zone, Ethiopia by Zeyneba Jemal Yassin, Habtamu Yimer Nega, Behailu Tariku Derseh, Yetnayet Sisay Yehuala, Abel Fekadu Dad

“…Maintaining quality of vaccines has been one of the main challenges of immunization programs in Africa including Ethiopia, and this could mainly be explained by health professional’s knowledge about cold chain management. …”
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Prevalence, Infectivity, and Associated Risk Factors of Hepatitis B Virus among Pregnant Women in Yirgalem Hospital, Ethiopia: Implication of Screening to Control Mother-to-Child T... by Anteneh Amsalu, Getachew Ferede, Setegn Eshetie, Agete Tadewos, Demissie Assegu

“…Among the study participants, 35.4% were aware of MTCT of HBV and only 12 (2.5%) have taken HBV vaccine. Conclusions. High prevalence of HBsAg and HBeAg as well as low awareness and practices of HBV prevention methods suggests that perinatal transmission of HBV might be the prevailing mode of HBV transmission in the study area. …”
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Retrospective study on the cumulative incidence of milk fever in parturient cows: a case study in the United Arab Emirates by Shaikha Ahmed Alshehhi, Temesgen Mohammed, Aboma Zewude, Berecha Bayissa, Asha Antony, Berhanu Adnew Degafa, Gobena Ameni

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Targeted therapy and immunotherapy for gastric cancer: rational strategies, novel advancements, challenges, and future perspectives by Dong Luo, Yunmei Liu, Zhengmao Lu, Lei Huang

“…Innovative immunotherapy modalities, including adoptive immune cell therapy, tumor vaccines, and non-specific immunomodulators therapy, and oncolytic viruses have shown promise in early-stage clinical trials for GC. …”
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An indole alkaloid from a tribal folklore inhibits immediate early event in HSV-2 infected cells with therapeutic efficacy in vaginally infected mice. by Paromita Bag, Durbadal Ojha, Hemanta Mukherjee, Umesh Chandra Halder, Supriya Mondal, Nidhi S Chandra, Suman Nandi, Ashoke Sharon, Mamta Chawla Sarkar, Sekhar Chakrabarti, Debprasad Chattopadhyay

“…Till date no effective vaccine is available, while the existing therapy frequently yielded drug resistance, toxicity and treatment failure. …”
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Effect of Household Income on Household Welfare in Kitumba Sub-County Kabale District. by Kakuru, Richard

“…In the study findings on the effect of household income on health accessibility in Kitumba sub-county Kabale District, the highest number of respondents mentioned that households with higher income are more likely to afford regular health check-ups, vaccinations, and preventive screenings, which can detect and address health issues early while the least number of respondents mentioned that higher-income households can more easily afford consultation fees, treatment costs, and surgical procedures, whereas lower-income families might struggle to pay for even basic healthcare services. …”
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Microbial metabolites and immune modulation by Hassan Ghasemi

“…SCFAs, along with PSA, have shown promise as vaccine adjuvants by boosting antigen-specific immune responses and enhancing both the magnitude and quality of protective immunity. …”
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Prevalence and influencing factors of occupational burnout among healthcare workers in the Chinese mainland during the late 2022 Omicron COVID-19 outbreak: a multicenter cross-sect... by Shu Jing, Zhenwei Dai, Yijin Wu, Xin Liu, Ling Zhang, Xiaoyang Liu, Tianrui Ren, Jiaqi Fu, Xu Chen, Wenjun Wang, Xiaofen Gu, Li Ma, Shaokai Zhang, Yanqin Yu, Li Li, Zhili Han, Xiaoyou Su, Youlin Qiao

“…Older age, female gender, higher income, more doses of COVID-19 vaccine, a higher level of mindfulness, resilience, and perceived social support were protective factors of occupational burnout. …”
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First Report of SNPs Detection in TMEM154 Gene in Sheep from Poland and Their Association with SRLV Infection Status by Magdalena Materniak-Kornas, Katarzyna Piórkowska, Katarzyna Ropka-Molik, Adrianna Dominika Musiał, Joanna Kowalik, Anna Kycko, Jacek Kuźmak

“…Since the infection is incurable and no vaccine is available, another approach is necessary to control SRLV infections. …”
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In Silico Screening of Putative Corynebacterium pseudotuberculosis Antigens and Serological Diagnosis for Caseous Lymphadenitis in Sheep by Enzyme-Linked Immunosorbent Assay by Daniela Droppa-Almeida, Caroline de Santana Ferreira, Ioná Brito, Sibele Borsuk, Jorge Alberto López Rodríguez, Isabel Bezerra Lima-Verde, Francine Ferreira Padilha

“…In this context, several strategies in an attempt to discover new antigens to compose diagnosis assays or vaccines are fundamental. Therefore, this study aimed to use bioinformatics software to evaluate the critical chemical characteristics of unknown proteins of C. pseudotuberculosis by selecting them for heterologous expression in Escherichia coli. …”
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Standardization and validation of a novel reverse transcriptase polymerase chain reaction method for detecting virulent strains of the infectious bursal disease virus by Vladimir Longa-Bobadilla, Phillip Ormeño-Vásquez, Manuel Criollo-Orozco, Luis Tataje-Lavanda, Katherine Huamán-Gutierrez, Ángela Montalván, Mirko Zimic, Manolo Fernández-Sanchez, Manolo Fernández-Díaz

“…However, due to the constant necessity for the discrimination between already prevalent vaccine strains and new pathogenic strains of this virus, it becomes imperative to have an immediate molecular method targeting a consensus sequence to achieve this task using field samples to reduce costs. …”
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