Altered Viral Replication and Cell Responses by Inserting MicroRNA Recognition Element into PB1 in Pandemic Influenza A Virus (H1N1) 2009 by Xiaoyue Shen, Wenkui Sun, Yi Shi, Zheng Xing, Xin Su

“…This approach provides an additional layer of biosafety and thus has great potential for the application in the rational development of safer and more effective influenza viral vaccines.…”
Get full text

Thermodynamic qualification of knitted spacer fabrics for use as insulation box insert in the context of refrigerated transport containers in the logistics sector by Julia Klausmann, Thomas Mutschler, Prisca Holderied, Dominik Güther, Thomas Freitag, Matthias Hummel, Martin Zeitler, Oliver van Neerven, Marcus Oliver Weber, Christof Breckenfelder

“…Against the background of the mobility shift towards electric vehicles and the current challenges of temperature-stable transport in the field of pharmaceutical, esp. vaccine logistics in the context of the SARS-CoV-2 pandemic, new, energy-efficient vehicle equipment is needed to maintain cold chains. …”
Get full text

Syrian hamsters (Mesocricetus auratus) as an upper respiratory tract model for respiratory syncytial virus infection by Sophie M. Kolbe, Kate Guilfoyle, Wencke Reineking, Geert van Amerongen, Guido van der Net, Sandra Lockow, Wolfgang Baumgärtner, Martin Ludlow, Albert D.M.E Osterhaus

“…Abstract Respiratory syncytial virus (RSV) is one of the leading causes of respiratory tract infection in children, immunocompromised individuals and older adults. Vaccines have recently been approved for use in adults and although further efforts to develop suitable interventions for children are ongoing, there are limited animal models for RSV infection. …”
Get full text

Therapy of genomic unstable solid tumours (WHO grade 3/4）in clinical stage III/IV using individualised neoantigen tumour peptides-INP trial (individualised neoantigen tumour peptid... by Ling Wang, Xia Chen, Juan Zhao, Jiaxi Tang, Wanyan Tang, Bin Liao, Weiqi Nian

“…Introduction Neoantigens derived from tumour somatic mutations are recognised as ideal vaccine targets. Tumour neoantigens have been studied in a wide range of tumours. …”
Get full text

Mapping of Minimal Motifs of B-Cell Epitopes on Human Zona Pellucida Glycoprotein-3 by Wan-Xiang Xu, Ya-Ping He, Jian Wang, Hai-Ping Tang, Hui-Juan Shi, Xiao-Xi Sun, Chao-Neng Ji, Shao-Hua Gu, Yi Xie

“…The human zona pellucida glycoprotein-3 (hZP3) by virtue of its critical role during fertilization has been proposed as a promising candidate antigen to develop a contraceptive vaccine. In this direction, it is imperative to map minimal motifs of the B cell epitopes (BCEs) so as to avoid ZP-specific oophoritogenic T cell epitopes (TCEs) in the ZP3-based immunogens. …”
Get full text

Evaluation of Cold Chain Management Performance for Temperature-Sensitive Pharmaceuticals at Public Health Facilities Supplied by the Jimma Pharmaceuticals Supply Agency Hub, South... by Diriba Feyisa, Awol Jemal, Temesgen Aferu, Fikadu Ejeta, Alem Endeshaw

“…Forty-seven (47) public health facilities in Southwest Ethiopia were evaluated using checklists adopted from the Logistic Indicators Assessment Tool, Vaccine Management Assessment Tool, and Logistic System Assessment Tool. …”
Get full text

GM-CSF and IL-21-armed oncolytic vaccinia virus significantly enhances anti-tumor activity and synergizes with anti-PD1 immunotherapy in pancreatic cancer by Yujing Xuan, Wenyi Yan, Ruimin Wang, Xibin Wang, Yu Guo, Huilin Dun, Ziyan Huan, Lihua Xu, Ruxia Han, Xianlei Sun, Lingling Si, Nicholas R. Lemoine, Nicholas R. Lemoine, Yaohe Wang, Yaohe Wang, Pengju Wang

“…VVL-GL21 could be used as a therapeutic cancer vaccine.…”
Get full text

Generation of Chicken IgY against SARS-COV-2 Spike Protein and Epitope Mapping by Yan Lu, Yajun Wang, Zhen Zhang, Jingliang Huang, Meicun Yao, Guobin Huang, Yuanyuan Ge, Peichun Zhang, Huaxin Huang, Yong Wang, Huiliang Li, Wen Wang

“…Repurposing approved drugs, developing vaccines and employing passive immunization are three major therapeutic approaches to fighting COVID-19. …”
Get full text

GENOTYPIC DIVERSITY OF DENGUE VIRUS IN AEDES MOSQUITOES COLLECTED FROM DENGUE HOTSPOT AREAS IN KUALA LUMPUR AND SELANGOR, MALAYSIA by Wan Najdah Wan Mohamad Ali, Zurainee Mohamed Nor, Rafidah Ali, Rohani Ahmad, Yvonne Ai-Lian Lim

“…The findings from this study can be utilized to the search for novel genotypes, to the observation of potential genetic alterations in dengue viruses, and to the development of vaccines.…”
Get full text

Household transmission of SARS-CoV-2 in five US jurisdictions: Comparison of Delta and Omicron variants. by Julia M Baker, Jasmine Y Nakayama, Michelle O'Hegarty, Andrea McGowan, Richard A Teran, Stephen M Bart, Lynn E Sosa, Jessica Brockmeyer, Kayla English, Katie Mosack, Sanjib Bhattacharyya, Manjeet Khubbar, Nicole R Yerkes, Brooke Campos, Alina Paegle, John McGee, Robert Herrera, Marcia Pearlowitz, Thelonious W Williams, Hannah L Kirking, Jacqueline E Tate

“…In the multivariable model, a pattern of increased transmission risk was observed with increased time since a household contact's last COVID-19 vaccine dose in Delta households, although confidence intervals overlapped (0-3 months relative risk = 0.8, confidence interval: 0.5-1.2; 4-7 months relative risk = 1.3, 0.9-1.8; ≥8 months relative risk = 1.2, 0.7-1.8); no pattern was observed in Omicron households. …”
Get full text

Anti-DENV-ED3 antibody cross-talks generate immune interference among the four DENVs by Md. Din Islam, Sanjida Yesmin, Tahmina Sharmin, Md. Ayoub Khan, Yutaka Kuroda, M. Monirul Islam

“…Such intrinsic features of DENV1~4 ED3s may lead to ‘antigen interference’, limiting both the understanding of dengue etiology and the success of dengue vaccine development, which needs to neutralize all four DENV serotypes equivalently.…”
Get full text

Incompatible Aedes aegypti male releases as an intervention to reduce mosquito population-A field trial in Puerto Rico. by Liliana Sánchez-González, Jacob E Crawford, Laura E Adams, Grayson Brown, Kyle R Ryff, Mark Delorey, Jose Ruiz-Valcarcel, Nicole Nazario, Nexilianne Borrero, Julieanne Miranda, Sara N Mitchell, Paul I Howell, Johanna R Ohm, Charlie Behling, Brian Wasson, Craig Eldershaw, Bradley J White, Vanessa Rivera-Amill, Roberto Barrera, Gabriela Paz-Bailey

“…Without widely available vaccines, mosquito control is the primary tool for fighting the spread of these viruses. …”
Get full text

Molecular Epidemiology of Human Norovirus Variants from Outbreaks in Zhejiang Province, China, during 2021 by Yi Sun, Yongjuan Yuan, Haiyan Mao, Lingxuan Su, Qiong Ge, Jian Gao, Changping Xu, Liming Gong

“…Continued molecular surveillance of noroviruses should be strengthened in our further efforts to the development of vaccines.…”
Get full text

Finanční zajištění židovských uprchlíků v době první světové války v Čechách by Klára Habartová

“…To prevent the spread of infectious diseases, the refugees were vaccinated, given medical checkups and inspected to ensure they were clean. …”
Get full text

COVID-19 in patients presenting with malaria-like symptoms at a primary healthcare facility in Accra, Ghana. by Issabella Asamoah, Mildred Adusei-Poku, Priscilla Vandyck-Sey, Allen Steele-Dadzie, Atta Senior Kuffour, Albert Turkson, Ivy Asantewaa Asante, Kantanka Addo-Osafo, Quaneeta Mohktar, Bright Adu, Yaw A Afrane, Kwamena W C Sagoe

“…One hundred and thirteen (37.8%) of the study participants had prior exposure to SARS CoV-2 and (34/51) 66.7% of Astrazeneca vaccinated patients had no IgG antibody.<h4>Conclusion</h4>It may be difficult to use clinical characteristics to distinguish between patients with COVID-19 having malaria-like symptoms. …”
Get full text

Cross-sectional study of personal protective equipment use, training and biosafety preparedness among healthcare workers during the first months of the SARS-CoV-2 pandemic in Brazi... by Kerstin Muner, Julia Kilgour, Tatiana Ometto, Ana Pérola Drulla Brandão, Andrea Pires dos Santos, Ana Marcia Sá Guimarães

Get full text

A Narrative Review of Key Risk Factors for Severe Illness Following SARS-CoV-2, Influenza Virus, and Respiratory Syncytial Virus Infection by Angela Branche, Mayur Ramesh, Beverly Francis

“…Mutual risk factors for severe outcomes are also highlighted; these similarities indicate that cohesive risk reduction strategies may also be feasible, particularly since vaccines are available for each of these respiratory viruses. …”
Get full text

Mapping C. difficile TcdB interactions with host cell-surface and intracellular factors using proximity-dependent biotinylation labeling by Jennifer S. Ward, Karl J. Schreiber, John Tam, Ji-Young Youn, Roman A. Melnyk

“…Further characterizing the intoxication mechanisms of these proteins is important for the development of vaccines and treatments for toxin-mediated disease. …”
Get full text

IL-18 Blockage Reduces Neuroinflammation and Promotes Functional Recovery in a Mouse Model of Spinal Cord Injury by Easmin Begum, Md Rashel Mahmod, Md Mahbobur Rahman, Fumiko Fukuma, Takeshi Urano, Yuki Fujita

Get full text

Histopathological Insights into Granulomatous Lesions: A Comprehensive Study by Archana Kumari, Irbinder K. Bali, Ayushi Chauhan, Falguni Chitkara, Deepika Wadhera

“…Despite the broad use of Bacillus Calmette-Guerin (BCG) vaccine, infections, including tuberculosis (TB), remain the primary cause of granulomatous lesions in our community.…”
Get full text