Immunoassay–mass spectrometry to identify Brucella melitensis by Amirreza Sharif, Ramin Bagheri Nejad, Alireza Ghassempour

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Colon Cancer Genetic and Epigenetic Changes, Etiopathogenesis, Risk Factors, Treatment: Literature Review by Gabrielė Ūbaitė, Aurelija Remeikaitė, Justas Žilinskas

“…Innovations such as CRISPR/Cas9 offer new avenues for targeted treatments, while advances in vaccines and liquid biopsy techniques are improving immune response activation and disease monitoring. …”
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Detection of Mycobacterium avium subspecies paratuberculosis in dairy cattle from Shahrekord, Iran by M. Rahmani Dehkordi, Z. Hemati, M. Ghorbanpour, R. Goethe, L. Abdolmohammadi Khiav

Case report: Kinetics of viral load, immunoglobulins, and cytokines in a fatal case of Crimean-Congo hemorrhagic fever virus by Moufid Mhamadi, Moufid Mhamadi, Ousseynou Sene, Arfang Diamanka, Moundhir Mhamadi, Marie Pedapa Mendy, Andy Mahine Diouf, Mignane Ndiaye, Mamadou Aliou Barry, Samba Niang Sagne, Mahfouz Cissé Traoré, Amadou Alpha Sall, Gamou Fall, Ndongo Dia, Oumar Faye

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Brucella induces an unfolded protein response via TcpB that supports intracellular replication in macrophages. by Judith A Smith, Mike Khan, Diogo D Magnani, Jerome S Harms, Marina Durward, Girish K Radhakrishnan, Yi-Ping Liu, Gary A Splitter

“…The Brucella intracellular replicative niche in macrophages and dendritic cells thwarts immune surveillance and complicates both therapy and vaccine development. Currently, host-pathogen interactions supporting Brucella replication are poorly understood. …”
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High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery. by Nathalie Aulner, Anne Danckaert, Eline Rouault-Hardoin, Julie Desrivot, Olivier Helynck, Pierre-Henri Commere, Hélène Munier-Lehmann, Gerald F Späth, Spencer L Shorte, Geneviève Milon, Eric Prina

“…<h4>Background/objectives</h4>Human leishmaniases are parasitic diseases causing severe morbidity and mortality. No vaccine is available and numerous factors limit the use of current therapies. …”
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The problem of conservation of gene pools of domesticated animals by Yu. A. Stolpovskiy, I. A. Zakharov-Gezekhus

“…The arguments in favor of preserving local breeds are: 1) economic factors, such as moderation of quality requirements for food products, moderation of hygienic and climatic conditions (new types of diseases, vaccines, changes in the external environment), necessity to keep a reserve for successful breeding, opportunity to use local breeds in harsh environmental conditions; 2) scientific factors, in particular, possibility of studying the gene pool of local breeds in order to reconstruct the evolution of domesticated species (exploring local breeds can reveal the mechanisms of the evolutionary processes, ontogeny, behavior patterns, natural and artificial selection); 3) cultural and historical factors related to the fact that native breeds represent living monuments of traditional culture of the population. …”
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Examining Effects of the COVID-19 National Lockdown on Ambient Air Quality Across Urban India by Chimurkar Navinya, Girish Patidar, Harish C. Phuleria

“…Abstract Lockdown seems the most effective way to prevent the spread of Coronavirus disease (COVID-19) as no vaccine is currently available in the market to cure it. …”
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Impact of Social Assistance Grants for Empowerment on Standards of Living of Elderly Persons in Kabale Municipality Kabale District. by Naturinda, Suzan

“…The study results on the effect of social assistance grants for empowerment on the health of the elderly in Kabale Municipality, the highest number of respondents mentioned that social assistance grants for empowerment can help to alleviate financial stress which leads to better physical health outcomes for elderly persons while the least number of respondents mentioned that social assistance grants for empowerment help elderly individuals stay healthy since they can be able to purchase vaccines and have good health. The study findings on the effect of social assistance grants for empowerment on the consumption of elderly in Kabale Municipality, the highest number of respondents mentioned that social assistance grants for empowerment can alleviate financial stress and uncertainty for elderly individuals, allowing them to budget more effectively and plan for future consumption needs while the least number of respondents mentioned that social assistance grants for empowerment allows elderly persons to allocate more of their funds towards consumption for better health. …”
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CaMKII-dependent non-canonical RIG-I pathway promotes influenza virus propagation in the acute-phase of infection by Shinichiro Hama, Miho Watanabe-Takahashi, Hiroki Nishimura, Jumpei Omi, Masakazu Tamada, Takashi Saitoh, Katsumi Maenaka, Yuta Okuda, Aoi Ikegami, Asami Kitagawa, Koudai Furuta, Kana Izumi, Eiko Shimizu, Takashi Nishizono, Makoto Fujiwara, Tomohiro Miyasaka, Shigeo Takamori, Hiroshi Takayanagi, Keizo Nishikawa, Toshihiko Kobayashi, Noriko Toyama-Sorimachi, Makoto Yamashita, Toshiya Senda, Takatsugu Hirokawa, Haruhiko Bito, Kiyotaka Nishikawa

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Perspectives from the 2nd International Post-Tuberculosis Symposium: mobilising advocacy and research for improved outcomes by B.W. Allwood, R. Nightingale, G. Agbota, S. Auld, G.P. Bisson, A. Byrne, R. Dunn, D. Evans, G. Hoddinott, G. Günther, Z. Islam, J.C. Johnston, G. Kalyatanda, C. Khosa, S. Marais, G. Makanda, O.M. Mashedi, J. Meghji, C. Mitnick, C. Mulder, E. Nkereuwem, O. Nkereuwem, O.B. Ozoh, A. Rachow, K. Romanowski, J.A. Seddon, I. Schoeman, F. Thienemann, N.F. Walker, D.T. Wademan, R. Wallis, M.M. van der Zalm

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Knowledge, willingness to provide service and preparedness for monkeypox infection among medical practitioners working in Bangladesh: a multicentred cross-sectional study by Mohammad Jahid Hasan, Salwa Islam, Mir Susmita Zaman, Jannatul Fardous, Shehab Uddin Al Abid, Tamanna Tabassum, Monirul Hasan, Mohiuddin Sharif

“…A majority (91.4%) knew monkeypox is transmitted human-to-human, followed by sexual (55.1%) and vertical transmission (34.8%), but only 19.5% were aware of vaccine availability. Overall, about half of the respondents (57%) showed a good knowledge of monkeypox and the remainder (43%) had poor knowledge. …”
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Comparing personality traits of healthcare workers with and without long COVID: Cross‐sectional study by Keiko Sakai, Seiichiro Tarutani, Takehiko Okamura, Hiroshi Yoneda, Tatsuhito Kawasaki, Masatoshi Takeda

“…Fewer participants in the COVID‐19 group had had COVID‐19 vaccinations. The long COVID group had higher number of symptoms at time of illness and higher NEO Five Factor Inventory Neuroticism scores than the non‐long COVID group. …”
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Optimizing Tongue Fluid Sampling and Testing Protocols for Enhanced PRRSV Isolation from Perinatal Swine Mortalities by Onyekachukwu Henry Osemeke, Isadora Machado, Elisa De Conti, Mariah Musskopf, Mafalda Pedro Mil-Homens, Samuel Stutzman, Baoqing Guo, Thomas Petznick, Gustavo De-Sousa-E Silva, Phillip Gauger, Jianqiang Zhang, Daniel C. L. Linhares

“…Isolating PRRSV is essential for identifying infectious viruses and for vaccine formulation. This study evaluated the potential of using tongue fluid (TF) from perinatal piglet mortalities for PRRSV isolation. …”
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Detection and decontamination of Mycoplasma in cultured cells and viral strains by Glaucia Prado de Andrade, Natália Hettwer Pedroso, Alice Becker, Vinicius Soares dos Santos, Juciane Bonella, José Valter Joaquim Silva Júnior, Rudi Weiblen, Eduardo Furtado Flores

“…ABSTRACT: Contamination of biological products with Mycoplasma spp. represents a major problem for laboratories and vaccine industry. Herein, we investigated Mycoplasma spp. contamination in cell cultures and viral strains maintained at the Virology Section of the Universidade Federal de Santa Maria and evaluated drugs and protocols for decontamination. …”
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Computational Study of the Phytochemical Constituents from Uncaria tomentosa Stem Bark against SARS-CoV-2 Omicron Spike Protein by Oscar Herrera-Calderon, Abdulrahman M. Saleh, Andres F. Yepes-Perez, Nada H. Aljarba, Saad Alkahtani, Gaber El-Saber Batiha, Renan Dilton Hañari-Quispe, Haydee Chavez, Josefa Bertha Pari-Olarte, Eddie Loyola-Gonzales, José Santiago Almeida-Galindo, José Francisco Kong-Chirinos, Taoufiq Benali

“…The SARS-CoV-2 Omicron variant has spread rapidly and is considered the predominant variant in the world, and its main characteristic is related to evade immunity from natural infection or vaccines, due to its multiple mutations in the spike protein. …”
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Evaluation of the cross-immunity between Mycobacterium tuberculosis and Mycobacterium abscessus in vitro by Da Xu, Yujie Gu, Guilian Li, Ruihuan Wang, Shiqi Xiao, Hongyang Duan, Jingwei Jiang, Xiuqin Zhao, Kanglin Wan, Xinyue He, Haican Liu, Yongliang Lou

“…Given the abundance of shared antigens between these two pathogens, evaluating the cross-immunization between Mycobacterium tuberculosis and Mycobacterium abscessus has implications for the assessment of tuberculosis vaccines based on nontuberculous mycobacteria (NTM). …”
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The Ability of Combined Flavonol and Trihydroxyorganic Acid to Suppress SARS-CoV-2 Reproduction by Andrey Bogoyavlenskiy, Pavel Alexyuk, Madina Alexyuk, Vladimir Berezin, Irina Zaitseva, Elmira Omirtaeva, Adolat Manakbayeva, Yergali Moldakhanov, Elmira Anarkulova, Anar Imangazy, Kuralay Akanova, Zhumagali Koshemetov, Nurkul Orazymbetova, Bakyt Umuraliyev

“…The global burden of COVID-19 continues to rise, and despite significant progress in vaccine development, there remains a critical need for effective treatments for the severe inflammation and acute lung injury associated with SARS-CoV-2 infection. …”
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A panel of cancer testis antigens in squamous cell carcinoma of the lung, head and neck, and esophagus: implication for biomarkers and therapeutic targets by Lin Li, Xin Zhang, Jiayao Yan, Jingyi Guo, Fangcen Liu, Xiao Wei, Qin Liu, Kongcheng Wang, Baorui Liu

“…The results suggest that cancer testis antigens could be feasible vaccine targets in squamous cell carcinoma.…”
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Baicalein inhibits PRRSV through direct binding, targeting EGFR, and enhancing immune response by Jing Wu, Qi Lu, Jing Hou, Yueqin Qiu, Min Tian, Li Wang, Kaiguo Gao, Xuefen Yang, Zongyong Jiang

“…The current commercial vaccines have limited effectiveness, and there are strict restrictions on the use of antiviral chemical drugs. …”
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