Monkeypox: Origin, Transmission, Clinical Manifestations, Prevention, and Therapeutic Options by Sajal Kumar Halder, Arafin Sultana, Mahbubul Kabir Himel, Aparna Shil

“…To stop the propagation of monkeypox, greater research and communication are needed to provide stronger treatments and effective vaccinations.…”
Get full text

Refining minimal engineered receptors for specific activation of on-target signaling molecules by Masashi Miura, Masahiro Kawahara

Get full text

Cardiopulmonary Arrest and Pulmonary Hypertension in an Infant with Pertussis Case Report by Patrick Ovie Fueta, Harry Onoriode Eyituoyo, Oghogho Igbinoba, Jon Roberts

“…Pertussis is a vaccine-preventable disease with an incidence that has been trending upwards in the United States over the last two decades. …”
Get full text

Clinical and Laboratory Findings of 12 Children with Invasive Meningococcal Disease in Pediatric Intensive Care Unit by Eylem Kiral, Ayse Filiz Yetimakman

“…Routine use of meningococcal vaccines during childhood would be a better strategy for controlling IMD in both developing and developed countries.…”
Get full text

Ensuring safe and effective pharmacotherapy: The role of “community pharmacology” in attaining “health for all” from the Indian perspective by Tirthankar Deb, Alapan Das, Bisweswar Ojha, Prasanjit Das

“…Despite India’s enormous progress in vaccine manufacture, supply, and mass immunization through the Universal Immunization Programme (UIP) and Mission Indradhanush, issues remain in incomplete coverage and vaccine hesitancy. …”
Get full text

ACE2 : S1 RBD Interaction-Targeted Peptides and Small Molecules as Potential COVID-19 Therapeutics by Lennox Chitsike, John Krstenansky, Penelope J. Duerksen-Hughes

“…The COVID-19 pandemic that began in late 2019 continues with new challenges arising due to antigenic drift as well as individuals who cannot or choose not to take the vaccine. There is therefore an urgent need for additional therapies that complement vaccines and approved therapies such as antibodies in the fight to end or slow down the pandemic. …”
Get full text

Establishment of <i>Echinococcus granulosus EgM123</i> Recombinant Gene Rabies Virus SRV₉ and Identification of Its Biological Characteristics by Yueqi Yang, Mengdan Hou, Guicheng Su, Xiaoyan Ma, Xiaohui Su, Kunlei Li, Songhan Liu, Luheng Xiao, Jingjing Yao, Jiahao Zhai, Xiaoying Wei, Yang Zhou, Qianqian Lai, Yuwei Dong, Jieyu Liu, Shaohua Zhai

“…The synthesized <i>EgM123</i> recombinant gene rabies virus SRV₉ can function as a vaccine strain for the development of the “Rabies-HD bivalent recombinant gene oral vaccine”, therefore aiding in the prevention and management of rabies and HD in animals.…”
Get full text

Increased serum soluble PD-l1 levels in patients with advanced stages of chronic kidney disease by Ayaka Hayashi, Ayaka Hayashi, Hiroto Ishihara, Mayuko Kawabe, Kazuhiko Kato, Kazuhiko Kato, Akio Nakashima, Akio Nakashima, Izumi Yamamoto, Teppei Sakano, Teppei Sakano, Hiroe Kobashi, Makoto Morita, Makoto Morita, Takashi Yokoo, Mitsuyoshi Urashima

“…In the Vaccine and Cancer cohorts, sPD-L1 levels increased significantly with age (P &lt; 0.001) and male sex (P &lt; 0.001). …”
Get full text

CIMAvax-EGF®, new therapeutic alternative for lung cancer: its application in Cienfuegos by Yoana Herrera Leiva, Teresita Sabatés Llerandi

“…The overall objective of the study is to evaluate the safety and efficacy of the CIMAVAX-EGF therapeutic vaccine for the treatment of patients diagnosed with lung cancer in advanced stages of the disease and, within its specific objectives, to assess overall survival and the treated patients’ life quality.…”
Get full text

Social aspects of the professionalization of midwives in Luxembourg (1800–1940) by Manon Pinatel

“…This individual often assumed the role of midwife, vaccinator, doctor of the poor or paediatric nurse. …”
Get full text

Rubella and Congenital Rubella Syndrome in the Philippines: A Systematic Review by Anna Lena Lopez, Peter Francis N. Raguindin, Maria Asuncion Silvestre, Xenia Cathrine J. Fabay, Ariel B. Vinarao, Ricardo Manalastas

“…To provide baseline information on rubella and CRS prior to routine vaccine introduction in the Philippines. Methods. …”
Get full text

Beyond immortality: Epstein–Barr virus and the intricate dance of programmed cell death in cancer development by Arezoo Esmaeili, Prankur Awasthi, Samira Tabaee

“…Furthermore, the insights gleaned from this review could catalyze the design of vaccines aimed at preventing EBV infection or curtailing its oncogenic impact. …”
Get full text

Identification of CTL Epitopes on Efflux Pumps of the ATP-Binding Cassette and the Major Facilitator Superfamily of Mycobacterium tuberculosis by Yan Lin, Yu Dong, Yanfeng Gao, Ranran Shi, Yubing Li, Xiuman Zhou, Wenwen Liu, Guodong Li, Yuanming Qi, Yahong Wu

“…The epitopes identified here provide a foundation for the diagnosis and treatment of patients infected with drug resistant and the future development of a multiepitope vaccine.…”
Get full text

The rapid rise of SARS‐CoV‐2 Omicron subvariants with immune evasion properties: XBB.1.5 and BQ.1.1 subvariants by Danyi Ao, Xuemei He, Weiqi Hong, Xiawei Wei

“…We expounded on the mechanisms underlying mutations and immune escape from neutralizing antibodies from vaccinated or convalescent COVID‐19 individuals and therapeutic monoclonal antibodies (mAbs) and proposed strategies for prevention against BQ.1 and XBB sublineages.…”
Get full text

Mucosal immune response in biology, disease prevention and treatment by Xiaoxue Zhou, Yuchen Wu, Zhipeng Zhu, Chu Lu, Chunwu Zhang, Linghui Zeng, Feng Xie, Long Zhang, Fangfang Zhou

“…The review also addresses the challenges in developing mucosal vaccines, which aim to induce specific immune responses while maintaining tolerance to non-pathogenic microbes. …”
Get full text

Nonviral targeted mRNA delivery: principles, progresses, and challenges by Xi He, Guohong Li, Letao Huang, Haixing Shi, Sha Zhong, Siyu Zhao, Xiangyu Jiao, Jinxiu Xin, Xiaoling Yin, Shengbin Liu, Zhongshan He, Mengran Guo, Chunli Yang, Zhaohui Jin, Jun Guo, Xiangrong Song

“…Abstract Messenger RNA (mRNA) therapeutics have garnered considerable attention due to their remarkable efficacy in the treatment of various diseases. The COVID‐19 mRNA vaccine and RSV mRNA vaccine have been approved on the market. …”
Get full text

Moments that matter: childhood pain treatment shapes pain for life—we can do better every time in every child by Rebeccah Slater, Suellen Walker, Christopher Eccleston, Carlo Bellieni, Tanvi Hirekodi, Ricardo Carbajal, Lucinda Smart, William Laughey, Maria M. Cobo, Stefan Friedrichsdorf

“…Abstract Background Needle procedures, such as vaccinations, blood draws, and intravenous cannulation, are the most frequent source of childhood pain, causing fear and reducing the uptake of medical procedures. …”
Get full text

Antiviral and Immunoenhancing Properties of 7-Thia-8-Oxoguanosine and Related Guanosine Analogues by Donald F Smee, Howard B Cottam, Brahma S Sharma, Ganesh D Kini, Ganapathi R Revankar, Emmanuel A Ojo-Amaize, Robert W Sidwell, Weldon B Jolley, Roland K Robins

“…TOGuo also has adjuvant activity, since its use in combination with a killed Ll210 leukemia cell vaccine greatly reduced the mortality of mice inoculated with live Ll210 leukemia cells compared with the vaccine used alone. …”
Get full text

Role of Infection in Neurologic and Psychiatric Diseases by Marylou V. Solbrig, Guey Chuen Perng

Get full text